The Relationship Between the Mid-Point and Most-Prominent Point on the Labial Curve of Upper Anterior Teeth

Objectives: This study investigates coincidence of the most-prominent point and the mid-point on upper anterior teeth in relation to the use of straight-wire appliances. Materials and Methods: Alginate impressions of the upper jaw were obtained from forty Caucasian patients. Impressions were cast using hard dental stone. The teeth on each upper study model (canine to canine) were marked along the facial axis of the clinical crown (FACC line) then separated using a very thin diamond disc. Each tooth was mounted on a glass slide using sticky wax and cut into two halves down this FACC line. Images were acquired of the sections and a straight line connecting the gingival margin and the incisal edge was drawn on the flat cut surfaces (now the proximal crosssectional view). From this line, perpendicular lines were drawn at the mid-point and most prominent point to the labial curve. Coincidence rate was calculated or whether the most prominent point was gingival or incisal to the mid-point. Results: Approximately 80% of upper central incisors had coincident mid- and most-prominent points. Upper lateral incisors and canine teeth had approximately 50% coincidence. The vast majority of cases without coincidence showed the most-prominent point incisal to the mid-point for all tooth kinds with just 5% or less gingival. Conclusions: The high proportions of non-coincident examples found suggest that clinicians should be aware of individual variation and that this may possibly effect 3rd order alignment. </jats:p

Radial Velocity Studies of Close Binary Stars.XIII

Radial-velocity measurements and sine-curve fits to the orbital radial velocity variations are presented for ten close binary systems: EG Cep,V1191 Cyg, V1003 Her, BD+7_3142, V357 Peg, V407 Peg, V1123 Tau, V1128 Tau, HH UMa, and PY Vir. While most of the studied eclipsing systems are contact binaries, EG Cep is a detached or a semi-detached double-lined binary and V1003 Her is a close binary of an uncertain type seen at a very low inclination angle. We discovered two previously unknown triple systems, BD+7_3142 and PY Vir, both with late spectral-type (K2V) binaries. Of interest is the low-mass ratio (q = 0.106) close binary V1191 Cyg showing an extremely fast period increase; the system has a very short period for its spectral type and shows a W-type light curve, a feature rather unexpected for such a low mass-ratio system.Comment: Accepted by AJ. 19 pages including 5 figure

Radial Velocity Studies of Close Binary Stars. XV

Radial-velocity measurements and sine-curve fits to the orbital radial velocity variations are presented for the last eight close binary systems analyzed the same way as in the previous papers of this series: QX And, DY Cet, MR Del, HI Dra, DD Mon, V868 Mon, ER Ori, and Y Sex. For another seven systems (TT Cet, AA Cet, CW Lyn, V563 Lyr, CW Sge, LV Vir and MW Vir) phase coverage is insufficient to provide reliable orbits but radial velocities of individual components were measured. Observations of a few complicated systems observed throughout the DDO close-binary program are also presented; among them an especially interesting is the multiple system V857 Her which - in addition to the contact binary - very probably contains one or more sub-dwarf components of much earlier spectral type. All suspected binaries which were found to be most probably pulsating stars are briefly discussed in terms of mean radial velocities and projected rotation velocities (v sin i) as well as spectral type estimates. In two of them, CU CVn and V752 Mon, the broadening functions show a clear presence of non-radial pulsations. The previously missing spectral types for the DDO I paper are given here in addition to such estimates for most of the program stars of this paper.Comment: submitted to A

International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways.

Primary biliary cirrhosis (PBC) is a classical autoimmune liver disease for which effective immunomodulatory therapy is lacking. Here we perform meta-analyses of discovery data sets from genome-wide association studies of European subjects (n=2,764 cases and 10,475 controls) followed by validation genotyping in an independent cohort (n=3,716 cases and 4,261 controls). We discover and validate six previously unknown risk loci for PBC (Pcombined<5 × 10(-8)) and used pathway analysis to identify JAK-STAT/IL12/IL27 signalling and cytokine-cytokine pathways, for which relevant therapies exist