164 research outputs found
A Study of Work Experience Attitudes of Business and Office Teachers in Vocational Region XII
A thesis presented to the Business Education Graduate Committee at Morehead State University in partial fulfillment of the requirements for the Degree of Master of Business Education by Deborah Karen Couch on July 15, 1975
Healthcare Analytics Leadership: Clinical & Business Intelligence Plan Development
Future healthcare leaders require expert knowledge and practical capabilities in the evaluation, selection, application and ongoing oversight of the best types of analytics to create continuous learning healthcare systems. These systems may result in continuously improving the demonstrable quality, safety and efficiency of healthcare organizations.
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Population Health Intelligence describes a new discipline whose role is to collect, organize, harmonize, analyze, disseminate and act upon the data available to clinicians, health system leaders, the pharmaceutical and biotechnology industry, and healthcare payers.
This webinar on Analytics Leadership will demonstrate how to create and implement Clinical & Business Intelligence Plans that transform data into actionable organizational insights.
Agenda Introduction Healthcare Analytics Leadership: Clinical & Business Intelligence Plan Development Population Health Intelligence
Presentation: 53:3
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Correlations between psychological tests and physiological responses during fear conditioning and renewal
Background: Anxiety disorders are characterized by specific emotions, thoughts and physiological responses. Little is known, however, about the relationship between psychological/personality indices of anxiety responses to fear stimuli. Methods: We studied this relationship in healthy subjects by comparing scores on psychological and personality questionnaires with results of an experimental fear conditioning paradigm using a visual conditioned stimulus (CS). We measured skin conductance response (SCR) during habituation, conditioning, and extinction; subsequently testing for recall and renewal of fear 24 hours later. Results: We found that multiple regression models explained 45% of the variance during conditioning to the CS+, and 24% of the variance during renewal of fear to the CS+. Factors that explained conditioning included lower levels of conscientiousness, increased baseline reactivity (SCL), and response to the shock (UCR). Low levels of extraversion correlated with greater renewal. No model could be found to explain extinction learning or extinction recall to the CS+. Conclusions: The lack of correlation of fear extinction with personality and neuropsychological indices suggests that extinction may be less determined by trait variables and cognitive state, and may depend more on the subjectâs current emotional state. The negative correlation between fear renewal and extraversion suggests that this personality characteristic may protect against post-treatment relapse of symptoms of anxiety disorders
Physical Activity, Sedentary Time, and Diet as Mediators of the Association Between TV Time and BMI in Youth
Bejarano, C. M., Carlson, J. A., Conway, T. L., Saelens, B. E., Glanz, K., Couch, S. C., Cain, K. L., & Sallis, J. F. , Physical Activity, Sedentary Time, and Diet as Mediators of the Association Between TV Time and BMI in Youth, American Journal of Health Promotion, 35(5), pp. 613â623. Copyright © 2021 The Author(s). DOI: 10.1177/0890117120984943.Purpose:
This study examined dietary indicators, sedentary time, and physical activity as potential mediators of the association between TV time and BMIz in youth.
Design:
Cross-sectional study in 2 independent samples of youth.
Setting:
Data collection occurred by mail and telephone for adolescents and either at home or in medical settings for children.
Sample:
928 youth ages 12-16 and 756 youth ages 6-12 and a parent.
Measures:
TV time, snacking/eating while watching TV, and a 3-day dietary recall were assessed via child/parent report. Physical activity and sedentary time were assessed by accelerometer wear.
Analysis:
Direct and indirect associations (through 8 diet and activity variables) of TV time with BMIz were tested in boys and girls in each sample.
Results:
TV time had a positive association with BMIz in 6-12 year old boys and girls. Direct associations emerged between TV time and the diet/activity variables, and between diet/activity variables and BMIz. Snacking/eating while watching TV had a significant positive association with BMIz in younger boys and mediated the association between TV time and BMIz (ÎČ = .06, p = .019; 25% attenuation).
Conclusions:
Snacking/eating while watching TV may be a possible reason TV time is consistently associated with obesity in youth. Targeting reductions in TV time and associated snacking could improve health impacts
Synaptic Clustering of PSD-95 Is Regulated by c-Abl through Tyrosine Phosphorylation
The c-Abl tyrosine kinase is present in mouse brain synapses, but its precise synaptic function is unknown. We found that c-Abl levels in the rat hippocampus increase postnatally, with expression peaking at the first postnatal week. In 14 d in vitro hippocampal neuron cultures, c-Abl localizes primarily to the postsynaptic compartment, in which it colocalizes with the postsynaptic scaffold protein postsynaptic density protein-95 (PSD-95) in apposition to presynaptic markers. c-Abl associates with PSD-95, and chemical or genetic inhibition of c-Abl kinase activity reduces PSD-95 tyrosine phosphorylation, leading to reduced PSD-95 clustering and reduced synapses in treated neurons. c-Abl can phosphorylate PSD-95 on tyrosine 533, and mutation of this residue reduces the ability of PSD-95 to cluster at postsynaptic sites. Our results indicate that c-Abl regulates synapse formation by mediating tyrosine phosphorylation and clustering of PSD-95
G515, Revisited. I. Stellar Populations And Evidence Of Nuclear Activity In A Luminous "E+A" Galaxy
We present multiwavelength observations of the very luminous "E+A" galaxy
known as G515 (J152426.55+080906.7), including deep K_s imaging, spatially
resolved H-alpha spectroscopy, and radio observations. The data, together with
detailed spectral synthesis of the galaxy's integrated stellar population, show
that G515 is a ~1 Gyr old post-merger, post-starburst galaxy. We detect no
Balmer line emission in the galaxy, although there is a small amount of
[NII]6548,6583A emission. The galaxy's H I mass has a 2-sigma upper limit of
1.0 * 10^9 solar masses. IRAS detections in the 60-micron and 100-micron bands
indicate a far infrared luminosity of ~5.8 * 10^10 solar luminosities. A small
amount (~3 mJy) of radio continuum flux, which appears to be variable, has been
detected. The data suggest that G515 may have once been an ultraluminous
infrared galaxy, and may harbor a weak, dust-obscured active nucleus.Comment: 25 pages, 7 figures, accepted to Ap
The role of CB1 in intestinal permeability and inflammation
The endocannabinoid system has previously been shown to play a role in the permeability and inflammatory response of the human gut. The goal of our study was to determine the effects of endogenous anandamide (AEA) and 2-arachidonoyl glycerol (2-AG) on the permeability and inflammatory response of intestinal epithelium under normal, inflammatory, and hypoxic conditions. Human intestinal mucosa was modeled using Caco-2 cells. Human tissue was collected from planned colorectal resections. Accumulation of AEA and 2-AG was achieved by inhibiting their metabolizing enzymes URB597 (a fatty acid amide hydrolase inhibitor) and JZL184 (a monoacylglycerol lipase inhibitor). Inflammation and ischemia were simulated with TNF-a and IFN-g and oxygen deprivation. Permeability changes were measured by transepithelial electrical resistance. The role of the CB1 receptor was explored using CB1-knockdown (CB1Kd) intestinal epithelial cells. Endocannabinoid levels were measured using liquid chromatographyâmass spectrometry. Cytokine secretion was measured using multiplex and ELISA. URB597 and JZL184 caused a concentration-dependent increase in permeability via CB1 (P < 0.0001) and decreased cytokine production. Basolateral application of JZL184 decreased permeability via CB1 (P < 0.0001). URB597 and JZL184 increased the enhanced (worsened) permeability caused by inflammation and hypoxia (
Galaxy Zoo: Passive Red Spirals
We study the spectroscopic properties and environments of red spiral galaxies
found by the Galaxy Zoo project. By carefully selecting face-on, disk dominated
spirals we construct a sample of truly passive disks (not dust reddened, nor
dominated by old stellar populations in a bulge). As such, our red spirals
represent an interesting set of possible transition objects between normal blue
spirals and red early types. We use SDSS data to investigate the physical
processes which could have turned these objects red without disturbing their
morphology. Red spirals prefer intermediate density regimes, however there are
no obvious correlations between red spiral properties and environment -
environment alone is not sufficient to determine if a spiral will become red.
Red spirals are a small fraction of spirals at low masses, but are a
significant fraction at large stellar masses - massive galaxies are red
independent of morphology. We confirm that red spirals have older stellar popns
and less recent star formation than the main spiral population. While the
presence of spiral arms suggests that major star formation cannot have ceased
long ago, we show that these are not recent post-starbursts, so star formation
must have ceased gradually. Intriguingly, red spirals are ~4 times more likely
than normal spirals to host optically identified Seyfert or LINER, with most of
the difference coming from LINERs. We find a curiously large bar fraction in
the red spirals suggesting that the cessation of star formation and bar
instabilities are strongly correlated. We conclude by discussing the possible
origins. We suggest they may represent the very oldest spiral galaxies which
have already used up their reserves of gas - probably aided by strangulation,
and perhaps bar instabilities moving material around in the disk.Comment: MNRAS in press, 20 pages, 15 figures (v3
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