Auxiliary Part of Ligand Mediated Unique Coordination Chemistry of Copper (II)

Six N,N,O-donor Schiff-base ligands, HL1-HL6, [HL1/HL2/HL3= {2-(2-piperazin-1-yl)ethylimino)methyl)-4-(Cl/H/Me)-phenol}; HL4/HL5/HL6={2-(2-morpholine/piperidine/ pyrrolidine 1-yl)ethylimino)methyl)-4-chlorophenol}, have been designed by combining 5-R-2-hydroxy-benzaldehyde, (R=Cl/H/Me) and N-(2-aminoethyl)-Y, (Y=piperazin/morpholine/ piperidine/pyrrolidine) with the view to explore the role of R and X (part of Y excluding coordinating N) on the coordination chemistry of Cu (II) in presence of bromide as counter anion. HL1-HL6 formed in situ on reaction with Cu(II)Br2 produce complexes 1\u20136, respectively. Complex 1, [Cu(II)2Cu(I)2(L1)(MeOH)2Br7.30], is a mixed valence Cu(I)-Cu(II) species having phenyl ring brominated at ortho position with 0.65 occupancy. Complexes 2\u20134 are mononuclear species with general formula [Cu{L2/L3/L4)}Br2]. Complexes [Cu3(L5)Br4] (5) and [Cu3(L6)Br4] (6) are trinuclear species having similar structure but exhibit different magnetic property, 5 is ferro- (J= +16.64 cm1 ) and 6 is antiferromegnetic (J= \u201311.76 cm1). The influence of R and X on bromination, magnetic property and nuclearity issues have been rationalized by DFT calculations

Characterization of greater middle eastern genetic variation for enhanced disease gene discovery

The Greater Middle East (GME) has been a central hub of human migration and population admixture. The tradition of consanguinity, variably practiced in the Persian Gulf region, North Africa, and Central Asia1-3, has resulted in an elevated burden of recessive disease4. Here we generated a whole-exome GME variome from 1,111 unrelated subjects. We detected substantial diversity and admixture in continental and subregional populations, corresponding to several ancient founder populations with little evidence of bottlenecks. Measured consanguinity rates were an order of magnitude above those in other sampled populations, and the GME population exhibited an increased burden of runs of homozygosity (ROHs) but showed no evidence for reduced burden of deleterious variation due to classically theorized ‘genetic purging’. Applying this database to unsolved recessive conditions in the GME population reduced the number of potential disease-causing variants by four- to sevenfold. These results show variegated genetic architecture in GME populations and support future human genetic discoveries in Mendelian and population genetics

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

A Novel Hydrogen-bonded Zigzag Chain Manganese(III) Complex: Synthesis, Crystal Structure and Magnetic Properties

The synthesis, crystal structure and magnetic properties of [Mn(III) Single crystal X-ray diffraction studies showed the structure to consist of [MnL(H 2 O) 2 ] + octahedra, with trans-coordinated water molecules, which are linked into infinite helices by hydrogen bonds. The distorted octahedral manganese(III) centre contains an N 2 O 2 O 2 coordination sphere made up of the Schiff base ligand in the equatorial plane. In the axial direction, an elongation of the trans Mn-O water bonds to 2.165(2) and 2.187(2)Å is observed. Such elongations are typical of d 4 systems but in this case may also be attributed to the poorer donor power of the water molecules

A Rare Pathogen in a Burn Patient: Pantoea agglomerans

Children with burn injuries are prone to increased risk for infection. Pantoea agglomerans is a particularly uncommon microorganism related to burn wound infections. A previously healthy, 28-month-old-boy was admitted with scald due to hot water. His general condition was moderate with normal vital signs. He had full thickness (right anterior forearm, 1.5%) and partial thickness (upper part of left arm, 0.5%; left anterior forearm, 2%; right thigh, 1%; right leg, 0.5%; left thigh, 0.5%; and left leg, 1%) burn wounds with totally estimated surface area percentage of 7%. Laboratory findings (hemogram, C-reactive protein, erythrocyte sedimentation rate, and blood biochemistry) were unremarkable. As well as hemodynamic stabilization and nutritional support, daily dressing with silver sulfadiazine was performed. Ten days later, grafting was carried out as the wound on right anterior forearm did not heal. Prophylactic intravenous cefazolin treatment (50mg/kg/day) was started. Four days after operation, he had 38.8°C fever and wound infection was realized. Gram stain of the swab revealed gram negative rods. Antibiotic treatment changed to ceftriaxone (75 mg/kg/day). While blood culture was negative, swab culture grew Pantoea agglomerans, resistant to cefazolin, sensitive to ceftriaxone. His fever subsided after 24 hours of ceftriaxone treatment and he was discharged on the 10th day. His immunological investigation was normal. One week later on control examination, his lesion was epithelized. Burn wound infections in pediatric age group can be caused by rare organisms. Other than presence of immunodeficiency, a graft tissue may ease this situation. [Med-Science 2016; 5(3.000): 878-83

Articulation in English Language Curricula: A Systematic Analysis from Basic Education to Secondary Education

Despite many studies on English language curricula over the last two decades in Turkey, any analysis of articulation in the curricula has not been found. Articulation, which addresses the inter-relatedness of a curriculum in many ways, both vertically and horizontally, ensures planning of student's development holistically and the transfer of learning from one education level to another. In this study, basic education and secondary education English language curricula published in 2018 were systematically examined in terms of articulation by looking for an answer to the question To what extent do the English curricula attain the horizontal and vertical across the school levels? specifically. Guideline Questions for Determining Articulation which were developed through the literature review and expert opinions, were used in the study adopting a document analysis. The data were analyzed according to descriptive analysis. The findings display that the English language curricula from basic education to secondary education reflect the culture of the target language in a very limited way and that the interdisciplinarity of the curricula is weak. Therefore, it is concluded that the curricula have attained horizontal articulation partially. In terms of vertical articulation, although continuity and sequence across the grades are mostly achieved, the study uncovered the problems about the assessment of four skills in an integrated way, the progress of learning outcomes from lower-to higher-order thinking skills, the coordination of the language proficiency aimed as the final outcome at the school levels as well as the assessment of them. Consequently, the study revealed that both the horizontal and vertical (especially across the school levels) articulation of the curricula are not fully ensured. Various implications have been made to strengthen the articulation of English language curricula

Operating Room Educational Climate Scale for Surgical Specialty Residents: Scale Development and Validation

AIM: To develop a scale in Turkish language for evaluating the surgical specialty residents' perceptions of educational climate in the operating room, with an emphasis on learning in the operating suite and planning the relevant change for improved and standardized training. MATERIAL and METHODS: Three surgeons from different disciplines provided expert opinions and a focus group meeting was held on the necessity, scope, and specificity of the items. The 5-point Likert type draft scale consisted of 28 items including ten negative statements scored reversely and having total scores ranging between 28-140 points. There were 5 subscales: educational process, teamwork, communication, operating room infrastructure, and surgical skills education. For assessing the validity and reliability, 172 surgical specialty residents from three hospitals in different locations were asked to answer the paper-based scale items anonymously. Confirmatory factor analysis (CFA) was used to test validity, whereas Cronbach's alpha reliability coefficients were calculated for internal consistency. RESULTS: CFA revealed a chi-square, standard deviation, chi-square/standard deviation, and a p-value of 783.73, 340, 2.27, and 0.001, respectively. Cronbach's alpha coefficient for educational process, teamwork, communication, operating room infrastructure, and surgical skills education subscales were calculated to be 0.61, 0.61, 0.63, 0.70, and 0.72, respectively. Cronbach's alpha coefficient for all items was 0.89. Results indicated acceptable construct validity and internal consistency of the scale. CONCLUSION: The newly developed scale was proven as a reliable and valid measurement instrument that can be used within the Turkish health system setting for assessing and improving the educational climate in the operating room

Distribution and Location of Endocrine Cells in the Pancreas of the Sparrowhawk, Accipiter nisus

WOS: 000333080000022The distribution and location of endocrine cells were determined in the dorsal, ventral, and splenic lobes of sparrowhawk pancreas using immunohistochemical methods. In this study, pancreatic tissues were stained with anti-insulin, anti-glucagon, anti-somatostatin, anti-gastrin, and anti-serotonin primary antibodies using the streptavidin-biotin-peroxidase method. The results showed that the numbers of glucagon-(alpha cell), insulin-(beta cell), and somatostatin-(delta cell) releasing cells were high and located in the splenic lobe of the pancreas. These endocrine cells were grouped into alpha, beta, and mixed islets. Alpha islets were mainly composed of alpha and delta cells and also occasionally beta cells. Beta islets contained numerous beta cells and a few delta and alpha cells. Furthermore, in the exocrine tissue were showed as only one cell or 2-3 gastrin immunopositive cell groups, whereas serotonin immunopositive cells were not found anywhere in the exocrine and endocrine pancreas. In conclusion, the endocrine islet types, endocrine cell localizations and lobe numbers of pancreas in sparrowhawks are similar to predator bird species, but are determined different to domestic fowls

Electrochemical Evaluation of Titanium (IV) Oxide/Polyacrylonitrile Electrospun Discharged Battery Coals as Supercapacitor Electrodes

KOCAK, Cagdas/0000-0003-2195-7218WOS: 000564583100001The TiO(2)nanoparticles are electrospun with polyacrylonitrile (PAN) polymer solution onto the discharged battery coal (DBC) electrode and the results are evaluated as a supercapacitor. the morphology and chemical composition of the synthesized TiO(2)nanoparticles and PAN+TiO(2)nanocomposite fibers were characterized by Scanning electron microscopy, thermogravimetry and FTIR analysis. Supercapacitor measurements and electrochemical characterizations of the electrodes examined by cyclic voltammetry and electrochemical impedance spectroscopy. Electrochemical measurements showed that the best current value was obtained from PAN and TiO(2)coated DBC. the performances of both PAN and PAN+TiO(2)coated DBC electrodes were investigated as supercapacitors. PAN+TiO2/DBC showed the best specific capacitance value of 156.00 F g(-1)and PAN/DBC showed 74.93 F g(-1). in addition, PAN+TiO2/DBC exhibited reliable stability performance over 2000.00 cycles