Caracterización química y morfológica de Allium tuncelianum (Amaryllidaceae) y potenciales antioxidantes y anticolinesterasa

Alzheimer’s disease is the main reason for dementia, which increases with age. Cholinesterase inhibition and antioxidant potentials of extracts and essential oils from bulbs of A. tuncelianum (Kollmann) Özhatay & al., an endemic species to Tunceli (easthern Turkey), were evaluated. The fraction extracted of ethyl acetate had the highest phenolics level, 1,1-diphenyl-2-picrylhydrazyl, and thiobarbituric acid antioxidant capacity. Also, the ethyl acetate fraction presented the highest acetylcholinesterase (15.98 ± 2.76%), and butyrylcholinesterase inhibition (47.33 ± 3.27%). Diallyl disulfide (49.8%), diallyl trisulfide (27.9%) and allyl methyl trisulfide (6.9%) were found to be the major components of essential oil. This paper shows that the ethyl acetate fraction of A. tuncelianum could be a potent source of antioxidant and anticholinesterase components.La enfermedad de Alzheimer es la causa principal de la demencia, cuya aparición aumenta según la edad. Se evaluaron la inhibición de la colinesterasa y el potencial antioxidante de los extractos y los aceites esenciales de los bulbos de A. tuncelianum (Kollmann) Özhatay & al., una especie endémica de Tunceli (este de Turquía). La fracción extraida de acetato de etilo presentó los niveles más altos de fenoles, 1,1-difenil- 2-picrilhidrazilo y capacidad antioxidante, ácido tiobarbitúrico. Asimismo, la fracción de etil acetato presentó la mayor capacidad de inhibición de acetilcolinesterasa (15.98 ± 2.76%) y butirilcolinesterasa (47.33 ± 3.27%). El disulfuro de dialilo (49.8%), el trisulfuro de dialilo (27.9%) y el trisulfuro de metil alilo (6.9%) fueron los componentes principales del aceite esencial. Este artículo muestra que la fracción de etil acetato de A. tuncelianum podría ser una fuente potencial novedosa de componentes antioxidantes y anticolinesterasa

The potential positive effects of coenzyme Q10 on the regeneration of peripheral nerve injury

Peripheral nerve injuries (PNIs) constitute a significant concern as they predominantly affect young and productive age groups of the population, causing social and economic pressure on patients. PNIs are a global problem that can result in disability because of the disruption of nerve function. PNI leads to a reduction in nerve conduction velocity, which worsens or impairs the mobility of the innervated area. Managing PNI remains a major clinical challenge. Coenzyme Q10 (CoQ10) is a lipid-soluble antioxidant first identified in 1957. It is an important antioxidant necessary for the organs to maintain their normal function and the body’s chemical processes. It scavenges free radicals and reduces oxidative stress. Studies showed that antioxidants such as CoQ10 a potent antioxidant, help the regeneration of PNIs. It has been observed to increase the myelination process in nerve fibres and promote nerve regeneration in rats after injury. Therefore, this review handles the current positive effects of CoQ10 on peripheral nerve regeneration following injury

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

İş Sağlığı ve Güvenliği Algısının İş Stresi Üzerindeki Etkisi: Kamu Hastanesinde Bir Araştırma

Bu çalışmanın amacı iş sağlığı ve güvenliği (İSG) algısının iş stresi üzerindeki etkisini analiz etmektir. Bunun için İstanbul’da faaliyet gösteren bir kamu hastanesinde çalışmakta olan 326 sağlık personelinin İSG’ye ilişkin algıları ile iş stresi düzeylerine ilişkin veriler anket yoluyla toplanmıştır. Elde edilen veriler istatistiksel olarak çoklu ve basit regresyon analizleri yoluyla incelenmiştir. İSG’nin iş yerinde sağlanması ile ilgili devletin sorumlulukları, hastane yönetiminin sorumlulukları ve çalışanların sorumlulukları olmak üzere üç boyutlu olarak değerlendirilmiştir. Yapılan basit regresyon analizi İSG’nin iş stresi üzerinde negatif ve anlamlı bir etkiye sahip olduğunu göstermiştir. Ancak çoklu regresyon analizi sonuçlarına göre hastane yönetiminin İSG alanında sorumluluklarını yerine getirdiği algısı iş stresi üzerinde negatif bir etkiye sahipken, devletin sorumlulukları boyutunda pozitif ve anlamlı bir etki ortaya çıkmıştır. Çalışanların sorumlulukları boyutunun ise anlamlı bir etkiye sahip olmadığı görülmüştür

Mental health states of the refugee women in the 10-year visiting process: an assessment in context of the sociocultural adaptation

Abstract Background In this study, it is aimed to determine the relationship between the sociocultural adaptation levels and the mental states of women who fled their countries due to the war and settled in Turkey. In this context, the study was carried out with descriptive, cross-sectional, and relational design. In the study, 948 refugee women living in Turkey were interviewed. Personal information form, Brief Symptom Inventory, and Sociocultural Adaptation Scale were used in the interviews. In the analysis of the data, SPSS package program was used, and descriptive statistics were made with linear regression. Results As a result of the study, it was determined that 47% of refugee women were illiterate, 70% had poor Turkish speaking level, and 51% could not establish good relations with Turkish people. The mean age of the women was 28.78 ± 7.01, the mean anxiety score was 24.33 ± 7.86, the mean depression score was 23.95 ± 8.1, the mean negative self-concept score was 23.85 ± 8.05, the mean somatization score was 14.99 ± 5.77, the mean hostility score was 13.63 ± 4.29, and the mean sociocultural adaptation score was 53.15 ± 16.94. Conclusion It was determined that the sociocultural adaptation level of refugee women is low. In addition, it has been determined that women experience psychological symptoms such as anxiety, depression, somatization, negative self-perception, and hostility intensely, and these symptoms are more common in refugee women with low sociocultural adaptation level

İş sağlığı ve güvenliği algısının çalışan memnuniyeti üzerindeki etkisi: Kamu hastanesinde bir araştırma

Her yönden sağlıklı ve güvenli bir ortamda çalışmak temel bir insan ve çalışan hakkıdır. Bu hakkın ulusal ve uluslararası mevzuatta giderek daha detaylı ve anlamlı bir şekilde tanındığını, ve iş sağlığı ve güvenliği (İSG)’nin bugün çalışma hayatının ayrılmaz bir parçası olduğunu görmekteyiz. Teknolojik gelişmelerin birçok alanda insan gücünün yerini alabilecek makineleri üretebildiği günümüzde, sağlık sektörünün değişmeyeni insan kaynağı, yani sağlık çalışanlarıdır. Sağlık sektörü ayrıca verdiği hizmetin hayati olması, hata kabul etmemesi ve sürekli ulaşılabilir olması gerekliliği yönünden diğer hizmet sektörlerinden ayrılmaktadır. Bu durum aynı zamanda riskli bir iş kolu olan sağlık sektörü üzerine yapılacak İSG çalışmalarının önemini ortaya koymaktadır. Bu çalışmanın amacı İSG algısının çalışan memnuniyeti üzerine etkisini analiz etmektir. Bunun için İstanbul’da faaliyet gösteren bir kamu hastanesinde çalışmakta olan 326 sağlık personelin İSG’ye ilişkin algıları ile çalışan memnuniyeti düzeylerine ilişkin veriler anket yoluyla toplanmıştır. Elde edilen veriler istatistiksel olarak çoklu ve basit regresyon analizleri yoluyla incelenmiştir. İSG’nin iş yerinde sağlanması, konuyla ilgili devletin sorumlulukları, hastane yönetiminin sorumlulukları ve çalışanların sorumlulukları olmak üzere üç boyutlu olarak değerlendirilmiştir. Yapılan basit regresyon analizi ile İSG’nin çalışan memnuniyeti üzerinde anlamlı ve pozitif bir etkisi olduğu tespit edilmiştir. Çoklu regresyon analizi sonuçlarına göre ise İSG’nin alt boyutlarından hastane yönetiminin sorumluluklarını yerine getirmesi çalışan memnuniyeti üzerinde pozitif bir etkiye sahipken, devletin ve çalışanların sorumlulukları boyutlarının anlamlı bir etkiye sahip olmadığı görülmüştür.Working in a safe and healthy environment in every respect is a fundamental human and labor right. This right has been increasingly recognized in a more detailed and meaningful way by a number of national and international laws and regulations. Occupational health and safety (OHS) has become an inseparable part of the working life. Today, technology produces any kind of machinery replacing many human jobs. But the human resource in health sector, i.e. healthcare workers, cannot be replaced. Health sector is also different from other services sectors because it provides continuous life-sustaining service and making a mistake would be literally a matter of life and death. Therefore the importance of working on OHS in health sector which is also a highly risky line of work becomes evident. The aim of this study is to analyze the effect of OHS on employee satisfaction in hospital employees. Data were collected through a questionnaire completed by 326 employees working in a public hospital in Istanbul and analyzed statistically by means of simple and multiple regression. OHS is considered to have three dimensions: The responsibilities of the state, the hospital management and the employees themselves in ensuring OHS in the workplace. The results of simple regression analysis showed that OHS had a positive effect on employee satisfaction. Multiple regression analysis revealed that while the positive perception of hospital management had a positive impact on employee satisfaction, other dimensions of OHS did not have any significant relationship with employee satisfaction

The Effect of the Perception of Occupational Health and Safety on Job Stress: A Research in A Public Hospital

Bu çalışmanın amacı iş sağlığı ve güvenliği (İSG) algısının iş stresi üzerindeki etkisini analiz etmektir. Bunun için İstanbul’da faaliyet gösteren bir kamu hastanesinde çalışmakta olan 326 sağlık personelinin İSG’ye ilişkin algıları ile iş stresi düzeylerine ilişkin veriler anket yoluyla toplanmıştır. Elde edilen veriler istatistiksel olarak çoklu ve basit regresyon analizleri yoluyla incelenmiştir. İSG’nin iş yerinde sağlanması ile ilgili devletin sorumlulukları, hastane yönetiminin sorumlulukları ve çalışanların sorumlulukları olmak üzere üç boyutlu olarak değerlendirilmiştir. Yapılan basit regresyon analizi İSG’nin iş stresi üzerinde negatif ve anlamlı bir etkiye sahip olduğunu göstermiştir. Ancak çoklu regresyon analizi sonuçlarına göre hastane yönetiminin İSG alanında sorumluluklarını yerine getirdiği algısı iş stresi üzerinde negatif bir etkiye sahipken, devletin sorumlulukları boyutunda pozitif ve anlamlı bir etki ortaya çıkmıştır. Çalışanların sorumlulukları boyutunun ise anlamlı bir etkiye sahip olmadığı görülmüştür

The effects of curcumin and blueberry on axonal regeneration after peripheral nerve injury

The purpose of this study was to analyze the axonal regeneration and therapeutic effects of curcumin and blueberry administration following peripheral nerve injury using stereological, electron microscopic and electrophysiological methods. Animals in were assigned into one of four groups - control (Cont), injury (Inj), injury+curcumin (Cur) and injury+blueberry (Blue). Following the induction of sciatic nerve crush injury (75 Newtons for 5 s) in the Inj, Cur, and Blue groups, the rats in the Cur group received intraperitoneal injection of 30 mg/kg curcumin (Sigma C1386) and the rats in the Blue group received 4 g/kg blueberry by gavage over a four-week period. The rats in the Cont and Inj groups were not exposed to any substance. All animals were given standard chow. Sciatic functional index analyses were performed on the 14th and 28th days after injury, and electromyography (EMG) results were recorded. Stereological analysis of the nerve was performed under light microscopy. Light and electron microscopies were used for the histopathological evaluation of the sciatic nerve. Analysis of myelinated axon numbers revealed no significant differences between the Inj group and the Cur and Blue groups. However, a significant difference was observed between the Blue and Inj groups in terms of axonal areas. EMG test results differed between the Blue and the Inj groups (p < 0.05), but no significant difference was observed between the Inj and Cur groups. Electron microscopic analysis revealed protective effects of curcumin and blueberry treatment after injury. The use of the curcumin and blueberry may represent a supportive approach to the protection of nerve fibers after peripheral nerve crush injury.Ondokuz Mayıs UniversityOndokuz Mayis University project management office, Samsun, Turke