Identifying the Opportunities for the Design of Digital Platforms: A Topic Modelling Approach

Aquaculture is one of the fast-growing food-producing agriculture subsectors. However, the digital infrastructures developed in aquaculture are self-organising platforms i.e. they do not rely on a centralized intermediary for monitoring, coordinating activities or for overseeing transactions. Hence, the main objective of this research paper is to identify the challenges farmers face in an entire supply chain for designing a digital platform for the aquaculture domain. The main problems faced by the farmers include water quality issues, disease outbreak, lack of proper information regarding suitable insurance policies etc. We have identified eight such issues that the farmers face in an entire harvest period and also prioritized them. The results from our study could be used for the further advancement of an integrative perspective in the design and implementation of the digital platform for aquaculture

Oncogenic Pathway Combinations Predict Clinical Prognosis in Gastric Cancer

Many solid cancers are known to exhibit a high degree of heterogeneity in their deregulation of different oncogenic pathways. We sought to identify major oncogenic pathways in gastric cancer (GC) with significant relationships to patient survival. Using gene expression signatures, we devised an in silico strategy to map patterns of oncogenic pathway activation in 301 primary gastric cancers, the second highest cause of global cancer mortality. We identified three oncogenic pathways (proliferation/stem cell, NF-κB, and Wnt/β-catenin) deregulated in the majority (>70%) of gastric cancers. We functionally validated these pathway predictions in a panel of gastric cancer cell lines. Patient stratification by oncogenic pathway combinations showed reproducible and significant survival differences in multiple cohorts, suggesting that pathway interactions may play an important role in influencing disease behavior. Individual GCs can be successfully taxonomized by oncogenic pathway activity into biologically and clinically relevant subgroups. Predicting pathway activity by expression signatures thus permits the study of multiple cancer-related pathways interacting simultaneously in primary cancers, at a scale not currently achievable by other platforms

SOCIOMATERIAL PERSPECTIVE OF DIGITAL PLATFORMS

In this research review we analyse digital platforms through the lens of sociomateriality. Sociomateriality integrates the material features of the technology and the goals of the human agencies which mutually interact to enrich the features of the technology further. Digital platforms are characterised by their unique layered modular architecture which constitutes the materiality. Sociality consists of user goals and user behaviour in association with platforms. In this review we analyse how each component of a platform and the goals of the platform users are interlocked. This review identifies three areas for future research which can be studied through the sociomateriality lens i) The governance of platforms by understanding the IS capabilities of the complements ii) Exploration on the concept of platform forking iii) Identifying design choices for digital nudging in the case of user interface design

Digitally Enabled Shrimp Farming: A Service-Dominant Logic View

Digital technologies have made a significant impact in agriculture, helping farmers access information from a wide range of markets and get better prices for their products. In particular, aquaculture and shrimp culture are some of the fastest-growing agricultural sub-sectors providing food for the world‘s growing population. The shrimp supply chain in developing countries like India is not efficient and hence unsustainable. The main challenge in aquaculture is the uncertainty found in all stages, including supply, production and distribution. Our study seeks to address the following questions: what are the sources of information inefficiency in the shrimp supply chain? How could a service dominant-logic view of the shrimp farming supply chain inform digitally-enabled innovation in a developing country context? The core contribution of this work is a framework theoretically informed by service-dominant logic and information requirements of the key stakeholders

BESS patient care pathway:Tennis elbow

This article provides a guidance summary for the management of lateral elbow tendinopathy (LET) using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system of the rating quality of the literature and grading the strength of available evidence. The process began by assembling a guideline development group of volunteers including orthopaedic surgeons, trainees, physiotherapists, rheumatologists, radiologists and patients. Virtual meetings were organised to set out explicit PICO questions, including specification of all important outcomes (including patient reported tennis elbow evaluation (PRTEE) as an important primary outcome) to determine the clinical effectiveness of common treatment options for LET compared with no treatment or placebo. Clinical librarian searched (date 31 April 2022) for available systematic reviews and randomised controlled trials reviewing the management of the LET January 2011 onwards and evidence was collected and summarized using explicit GRADE criteria for rating the quality of evidence that include study design, risk of bias, imprecision, inconsistency, indirectness, and magnitude of effect. Recommendations were characterized as strong or weak (alternative terms conditional or discretionary) according to the quality of the supporting evidence and the balance between desirable and undesirable consequences of alternative management options. This informative summary provides the quality of available evidence for the management of LET.</p