247 research outputs found
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Functional Relationships between Kinetic, Flow, and Geometrical Parameters in a High-Temperature Chemical Microreactor.
Computational fluid dynamics (CFD) simulations and isothermal approximation were applied for the interpretation of experimental measurements of the C10H7Br pyrolysis efficiency in the high-temperature microreactor and of the pressure drop in the flow tube of the reactor. Applying isothermal approximation allows the derivation of analytical relationships between the kinetic, gas flow, and geometrical parameters of the microreactor, which, along with CFD simulations, accurately predict the experimental observations. On the basis of the obtained analytical relationships, a clear strategy for measuring rate coefficients of (pseudo) first-order bimolecular and unimolecular reactions using the microreactor was proposed. The pressure- and temperature-dependent rate coefficients for the C10H7Br pyrolysis calculated using variable reaction coordinate transition state theory were invoked to interpret the experimental data on the pyrolysis efficiency
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Low-temperature formation of polycyclic aromatic hydrocarbons in Titan’s atmosphere
The detection of benzene in Titan’s atmosphere led to the emergence of polycyclic aromatic hydrocarbons (PAHs) as potential nucleation agents triggering the growth of Titan’s orange-brownish haze layers. However, the fundamental mechanisms leading to the formation of PAHs in Titan’s low-temperature atmosphere have remained elusive. We provide persuasive evidence through laboratory experiments and computations that prototype PAHs like anthracene and phenanthrene (C14H10) are synthesized via barrierless reactions involving naphthyl radicals (C10H7•) with vinylacetylene (CH2=CH–C≡CH) in low-temperature environments. These elementary reactions are rapid, have no entrance barriers, and synthesize anthracene and phenanthrene via van der Waals complexes and submerged barriers. This facile route to anthracene and phenanthrene—potential building blocks to complex PAHs and aerosols in Titan—signifies a critical shift in the perception that PAHs can only be formed under high-temperature conditions, providing a detailed understanding of the chemistry of Titan’s atmosphere by untangling elementary reactions on the most fundamental level
Effective Lagrangian approach to vector mesons, their structure and decays
An improved update of the structure and decays of , and
mesons based on a chiral SU(3) Lagrangian, including anomaly terms is
presented. We demonstrate that a consistent and quantitatively successful
description of both pion and kaon electromagnetic form factors can be achieved.
We also discuss the cross section, the Dalitz
decay and aspects of and mixing. Relations to previous versions of the Vector Meson Dominance
model will be examined.Comment: 35 pages, TeX, 14 ps figures, submitted to Z.Phys.
Archiving multi-epoch data and the discovery of variables in the near infrared
We present a description of the design and usage of a new synoptic pipeline
and database model for time series photometry in the VISTA Data Flow System
(VDFS). All UKIRT-WFCAM data and most of the VISTA main survey data will be
processed and archived by the VDFS. Much of these data are multi-epoch, useful
for finding moving and variable objects. Our new database design allows the
users to easily find rare objects of these types amongst the huge volume of
data being produced by modern survey telescopes. Its effectiveness is
demonstrated through examples using Data Release 5 of the UKIDSS Deep
Extragalactic Survey (DXS) and the WFCAM standard star data. The synoptic
pipeline provides additional quality control and calibration to these data in
the process of generating accurate light-curves. We find that 0.6+-0.1% of
stars and 2.3+-0.6% of galaxies in the UKIDSS-DXS with K<15 mag are variable
with amplitudes \Delta K>0.015 magComment: 30 pages, 31 figures, MNRAS, in press Minor changes from previous
version due to refereeing and proof-readin
Preclinical activity and determinants of response of the GPRC5DxCD3 bispecific antibody talquetamab in multiple myeloma.
Cell surface expression levels of GPRC5D, an orphan G protein-coupled receptor, are significantly higher on multiple myeloma (MM) cells, compared with normal plasma cells or other immune cells, which renders it a promising target for immunotherapeutic strategies. The novel GPRC5D-targeting T-cell redirecting bispecific antibody, talquetamab, effectively kills GPRC5D+ MM cell lines in the presence of T cells from both healthy donors or heavily pretreated MM patients. In addition, talquetamab has potent anti-MM activity in bone marrow (BM) samples from 45 patients, including those with high-risk cytogenetic aberrations. There was no difference in talquetamab-mediated killing of MM cells from newly diagnosed, daratumumab-naïve relapsed/refractory (median of 3 prior therapies), and daratumumab-refractory (median of 6 prior therapies) MM patients. Tumor cell lysis was accompanied by T-cell activation and degranulation, as well as production of pro-inflammatory cytokines. High levels of GPRC5D and high effector:target ratio were associated with improved talquetamab-mediated lysis of MM cells, whereas an increased proportion of T cells expressing PD-1 or HLA-DR, and elevated regulatory T-cell (Treg) counts were associated with suboptimal killing. In cell line experiments, addition of Tregs to effector cells decreased MM cell lysis. Direct contact with bone marrow stromal cells also impaired the efficacy of talquetamab. Combination therapy with daratumumab or pomalidomide enhanced talquetamab-mediated lysis of primary MM cells in an additive fashion. In conclusion, we show that the GPRC5D-targeting T-cell redirecting bispecific antibody talquetamab is a promising novel antimyeloma agent. These results provide the preclinical rationale for ongoing studies with talquetamab in relapsed/refractory MM
Lignin biomarkers as tracers of mercury sources in lakes water column
This study presents the role of specific terrigenous organic compounds as important vectors of mercury (Hg) transported from watersheds to lakes of the Canadian boreal forest. In order to differentiate the autochthonous from the allochthonous organic matter (OM), lignin derived biomarker signatures [Lambda, S/V, C/V, P/(V ? S), 3,5-Bd/V and (Ad/Al)v] were used. Since lignin is exclusively produced by terrigenous plants, this approach can give a non equivocal picture of the watershed inputs to the lakes. Moreover, it allows a characterization of the source of OM and its state of degradation. The water column of six lakes from the Canadian Shield was sampled monthly between June and September 2005. Lake total dissolved Hg concentrations and Lambda were positively correlated, meaning that Hg and ligneous inputs are linked (dissolved OM r2 = 0.62, p\0.0001; particulate OM r2 = 0.76, p\0.0001). Ratios of P/(V ? S) and 3,5-Bd/V from both dissolved OM and particulate OM of the water column suggest an inverse relationship between the progressive state of pedogenesis and maturation of the OM in soil before entering the lake, and the Hg concentrations in the water column. No relation was found between Hg levels in the lakes and the watershed flora composition—angiosperm versus gymnosperm or woody versus non-woody compounds. This study has significant implications for watershed management of ecosystems since limiting fresh terrestrial OM inputs should reduce Hg inputs to the aquatic systems. This is particularly the case for largescale land-use impacts, such as deforestation, agriculture and urbanization, associated to large quantities of soil OM being transferred to aquatic systems
Orthogonal rotation in PCAMIX
Kiers (1991) considered the orthogonal rotation in PCAMIX, a principal
component method for a mixture of qualitative and quantitative variables.
PCAMIX includes the ordinary principal component analysis (PCA) and multiple
correspondence analysis (MCA) as special cases. In this paper, we give a new
presentation of PCAMIX where the principal components and the squared loadings
are obtained from a Singular Value Decomposition. The loadings of the
quantitative variables and the principal coordinates of the categories of the
qualitative variables are also obtained directly. In this context, we propose a
computationaly efficient procedure for varimax rotation in PCAMIX and a direct
solution for the optimal angle of rotation. A simulation study shows the good
computational behavior of the proposed algorithm. An application on a real data
set illustrates the interest of using rotation in MCA. All source codes are
available in the R package "PCAmixdata"
Cluster Lenses
Clusters of galaxies are the most recently assembled, massive, bound
structures in the Universe. As predicted by General Relativity, given their
masses, clusters strongly deform space-time in their vicinity. Clusters act as
some of the most powerful gravitational lenses in the Universe. Light rays
traversing through clusters from distant sources are hence deflected, and the
resulting images of these distant objects therefore appear distorted and
magnified. Lensing by clusters occurs in two regimes, each with unique
observational signatures. The strong lensing regime is characterized by effects
readily seen by eye, namely, the production of giant arcs, multiple-images, and
arclets. The weak lensing regime is characterized by small deformations in the
shapes of background galaxies only detectable statistically. Cluster lenses
have been exploited successfully to address several important current questions
in cosmology: (i) the study of the lens(es) - understanding cluster mass
distributions and issues pertaining to cluster formation and evolution, as well
as constraining the nature of dark matter; (ii) the study of the lensed objects
- probing the properties of the background lensed galaxy population - which is
statistically at higher redshifts and of lower intrinsic luminosity thus
enabling the probing of galaxy formation at the earliest times right up to the
Dark Ages; and (iii) the study of the geometry of the Universe - as the
strength of lensing depends on the ratios of angular diameter distances between
the lens, source and observer, lens deflections are sensitive to the value of
cosmological parameters and offer a powerful geometric tool to probe Dark
Energy. In this review, we present the basics of cluster lensing and provide a
current status report of the field.Comment: About 120 pages - Published in Open Access at:
http://www.springerlink.com/content/j183018170485723/ . arXiv admin note:
text overlap with arXiv:astro-ph/0504478 and arXiv:1003.3674 by other author
Nonlinear phononics: A new ultrafast route to lattice control
To date, two types of coupling between electromagnetic radiation and a
crystal lattice have been identified experimentally. One is direct, for
infrared (IR)-active vibrations that carry an electric dipole. The second is
indirect, it occurs through intermediate excitation of the electronic system
via electron-phonon coupling, as in stimulated Raman scattering. Nearly 40
years ago, proposals were made of a third path, referred to as ionic Raman
scattering (IRS). It was posited that excitation of an IR-active phonon could
serve as the intermediate state for a Raman scattering process relying on
lattice anharmonicity as opposed to electron phonon interaction. In this paper,
we report an experimental demonstration of ionic Raman scattering and show that
this mechanism is relevant to optical control in solids. The key insight is
that a rectified phonon field can exert a directional force onto the crystal,
inducing an abrupt displacement of the atoms from the equilibrium positions
that could not be achieved through excitation of an IR-active vibration alone,
for which the force is oscillatory. IRS opens up a new direction for the
coherent control of solids in their electronic ground state, different from
approaches that rely on electronic excitations.Comment: 10 manuscript pages, 3 figure
Rapid Global Expansion of Invertebrate Fisheries: Trends, Drivers, and Ecosystem Effects
BACKGROUND: Worldwide, finfish fisheries are receiving increasing assessment and regulation, slowly leading to more sustainable exploitation and rebuilding. In their wake, invertebrate fisheries are rapidly expanding with little scientific scrutiny despite increasing socio-economic importance. METHODS AND FINDINGS: We provide the first global evaluation of the trends, drivers, and population and ecosystem consequences of invertebrate fisheries based on a global catch database in combination with taxa-specific reviews. We also develop new methodologies to quantify temporal and spatial trends in resource status and fishery development. Since 1950, global invertebrate catches have increased 6-fold with 1.5 times more countries fishing and double the taxa reported. By 2004, 34% of invertebrate fisheries were over-exploited, collapsed, or closed. New fisheries have developed increasingly rapidly, with a decrease of 6 years (3 years) in time to peak from the 1950s to 1990s. Moreover, some fisheries have expanded further and further away from their driving market, encompassing a global fishery by the 1990s. 71% of taxa (53% of catches) are harvested with habitat-destructive gear, and many provide important ecosystem functions including habitat, filtration, and grazing. CONCLUSIONS: Our findings suggest that invertebrate species, which form an important component of the basis of marine food webs, are increasingly exploited with limited stock and ecosystem-impact assessments, and enhanced management attention is needed to avoid negative consequences for ocean ecosystems and human well-being
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