Oscillator Phase Noise and Small-Scale Channel Fading in Higher Frequency Bands

This paper investigates the effect of oscillator phase noise and channel variations due to fading on the performance of communication systems at frequency bands higher than 10GHz. Phase noise and channel models are reviewed and technology-dependent bounds on the phase noise quality of radio oscillators are presented. Our study shows that, in general, both channel variations and phase noise can have severe effects on the system performance at high frequencies. Importantly, their relative severity depends on the application scenario and system parameters such as center frequency and bandwidth. Channel variations are seen to be more severe than phase noise when the relative velocity between the transmitter and receiver is high. On the other hand, performance degradation due to phase noise can be more severe when the center frequency is increased and the bandwidth is kept a constant, or when oscillators based on low power CMOS technology are used, as opposed to high power GaN HEMT based oscillators.Comment: IEEE Global Telecommun. Conf. (GLOBECOM), Austin, TX, Dec. 201

Calculation of the Performance of Communication Systems from Measured Oscillator Phase Noise

Oscillator phase noise (PN) is one of the major problems that affect the performance of communication systems. In this paper, a direct connection between oscillator measurements, in terms of measured single-side band PN spectrum, and the optimal communication system performance, in terms of the resulting error vector magnitude (EVM) due to PN, is mathematically derived and analyzed. First, a statistical model of the PN, considering the effect of white and colored noise sources, is derived. Then, we utilize this model to derive the modified Bayesian Cramer-Rao bound on PN estimation, and use it to find an EVM bound for the system performance. Based on our analysis, it is found that the influence from different noise regions strongly depends on the communication bandwidth, i.e., the symbol rate. For high symbol rate communication systems, cumulative PN that appears near carrier is of relatively low importance compared to the white PN far from carrier. Our results also show that 1/f^3 noise is more predictable compared to 1/f^2 noise and in a fair comparison it affects the performance less.Comment: Accepted in IEEE Transactions on Circuits and Systems-I: Regular Paper

Invariant natural killer T cells act as an extravascular cytotoxic barrier for joint-invading Lyme Borrelia

SignificanceInvariant natural killer T cells (iNKT) have been found primarily patrolling inside blood vessels in the liver, where they respond to bacterial glycolipids presented by CD1d on liver macrophages. We show joint iNKT cells are localized outside of blood vessels and respond directly to the joint-homing pathogen, Borrelia burgdorferi, which causes Lyme borreliosis using multichannel spinning-disk intravital microscopy. These iNKT cells interacted with B. burgdorferi at the vessel wall and disrupted its dissemination attempts into joints. Successful penetrance of B. burgdorferi out of the vasculature and into the joint tissue was met by a lethal attack by extravascular iNKT cells through a granzyme-dependent pathway. These results suggest a critical extravascular iNKT cell immune surveillance in joints that functions as a cytotoxic barrier

Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells

Invariant natural killer T cells (iNKT cells) are innate-like T lymphocytes that act as critical regulators of the immune response. To better characterize this population, we profiled gene expression in iNKT cells during ontogeny and in peripheral subsets as part of the Immunological Genome Project. High-resolution comparative transcriptional analyses defined developmental and subset-specific programs of gene expression by iNKT cells. In addition, we found that iNKT cells shared an extensive transcriptional program with NK cells, similar in magnitude to that shared with major histocompatibility complex (MHC)-restricted T cells. Notably, the program shared by NK cells and iNKT cells also operated constitutively in γδ T cells and in adaptive T cells after activation. Together our findings highlight a core effector program regulated distinctly in innate and adaptive lymphocytes

Estimates of the global burden of ambient PM2.5, ozone, and NO2 on asthma incidence and emergency room visits

Abstract Background: Asthma is the most prevalent chronic respiratory disease worldwide, affecting 358 million people in 2015. Ambient air pollution exacerbates asthma among populations around the world and may also contribute to new-onset asthma. Objectives: We aimed to estimate the number of asthma emergency room visits and new onset asthma cases globally attributable to fine particulate matter (PM2.5), ozone, and nitrogen dioxide (NO2) concentrations. Methods: We used epidemiological health impact functions combined with data describing population, baseline asthma incidence and prevalence, and pollutant concentrations. We constructed a new dataset of national and regional emergency room visit rates among people with asthma using published survey data. Results: We estimated that 9–23 million and 5–10 million annual asthma emergency room visits globally in 2015 could be attributable to ozone and PM2.5, respectively, representing 8–20% and 4–9% of the annual number of global visits, respectively. The range reflects the application of central risk estimates from different epidemiological meta-analyses. Anthropogenic emissions were responsible for ∼37% and 73% of ozone and PM2.5 impacts, respectively. Remaining impacts were attributable to naturally occurring ozone precursor emissions (e.g., from vegetation, lightning) and PM2.5 (e.g., dust, sea salt), though several of these sources are also influenced by humans. The largest impacts were estimated in China and India. Conclusions: These findings estimate the magnitude of the global asthma burden that could be avoided by reducing ambient air pollution. We also identified key uncertainties and data limitations to be addressed to enable refined estimation. https://doi.org/10.1289/EHP376