Digital twin control of multi-axis wood CNC machining center based on LinuxCNC

Abstrack: This paper presents an application of an open architecture control system implemented on a multi-axis wood computer numerical control milling machining center, as a digital twin control. The development of the digital twin control system was motivated by research and educational requirements, especially in the field of configuring a new control system by “virtual commissioning”, enabling the validation of the developed controls, program verification, and analysis of the machining process and monitoring. The considered wood computer numerical control (CNC) machining system is supported by an equivalent virtual machine in a computer-aided design and computer-aided manufacturing (CAD/CAM) environment, as well as in the control system, as a digital twin. The configured virtual machines are used for the verification of the machining program and programming system via machining simulation, which is extremely important in multi-axis machining. Several test wood workpieces were machined to validate the effectiveness of the developed control system based on LinuxCNC

The challenge of return to work in workers with cancer : employer priorities despite variation in social policies related to work and health

This study explored employer's perspectives on (1) their experience of good practice related to workers diagnosed with cancer and their return to work (RTW), and (2) their perceived needs necessary to achieve good practice as reported by employers from nine separate countries. Twenty-five semi-structured interviews were held in eight European countries and Israel with two to three employers typically including HR managers or line managers from both profit and non-profit organisations of different sizes and sectors. Interviews were recorded and transcribed verbatim. A grounded theory/thematic analysis approach was completed. Employers' experience with RTW assistance for workers with cancer appears to be a dynamic process. Results indicate that good practice includes six phases: (1) reacting to disclosure, (2) collecting information, (3) decision-making related to initial actions, (4) remaining in touch, (5) decision-making on RTW, and (6) follow-up. The exact details of the process are shaped by country, employer type, and worker characteristics; however, there was consistency related to the need for (1) structured procedures, (2) collaboration, (3) communication skills training, (4) information on cancer, and (5) financial resources for realizing RTW support measures. Notwithstanding variations at country, employer, and worker levels, the employers from all nine countries reported that good practice regarding RTW assistance in workers with a history of cancer consists of the six phases above. Employers indicate that they would benefit from shared collaboration and resources that support good practice for this human resource matter. Further research and development based on the six phases of employer support as a framework for a tool or strategy to support workers with a history of cancer across countries and organisations is warranted

Empirijski kinetički model hidrolize proteina belanceta pretretiranih ultrazvučnim talasima visoke frekvencije

The subject of this paper was the examination of the influence of enzyme and substrate concentrations and temperature on the initial reaction rate of hydrolysis of the egg white catalyzed with Alcalase 2.4 L (Protease from Bacillus licheniformis). The main objective of this paper was investigating the effect of the ultrasound on the reaction rate of hydrolysis and modeling of enzymatic process of hydrolysis of the egg white protein in order to develop the process and design the enzyme reactor. The substrate in this reaction was 10 % w/w solution of egg white pretreated with ultrasound waves the frequency of 35 kHz during 30 min. Proper kinetic model with substrate inhibition and the enzyme inactivation were applied to the results and good congruence between model and experimental data was achieved. The calculated kinetic constants indicate that the ultrasonic pretreatment causes an increase in the degree of hydrolysis of the enzyme reaction.U ovom radu ispitivan je uticaj koncentacije enzima, supstrata i temperature na početnu brzinu reakcije hidrolize proteina belanceta katalizovane Alkalazom 2,4 L (proteaza iz Bacillus licheniformis). Glavni cilj ovog istraživanja bio je ispitivanje uticaja ultrazvučnih talasa na brzinu reakcije hidrolize, kao i modelovanje enzimskog procesa hidrolize proteina belanceta u cilju dobijanja projektnih jednačina neophodnih za projektovanje i dizajn enzimskog reaktora. Kao supstrat korišćen je 10 % w/w rastvor belanceta prethodno tretiran ultrazvučnim talasima frekvencije 35 kHz u toku 30 minuta. Dobijeni eksperimentalni rezultati modelovani su kinetičkim modelom koji uzima u obzir inhibiciju supstratom i deaktivaciju enzima. Predloženi kinetički model dao je dobro slaganje sa dobijenim eksperimentalnim rezultatima. Izračunate kinetičke konstante ukazuju da pretretman ultrazvučnim talasima dovodi do povećanja stepena hidrolize

Antioksidativna aktivnost hidrolizata belanceta i njegovih frakcija dobijenih membranskom ultrafiltraciom

Bioactive peptides with different biological properties can be obtained by egg white proteins hydrolysis. In this study we used the high intensity ultrasound pretreatment of the egg white proteins that were then hydrolyzed by different types of proteases in the one-step and two-step procedure. Membrane ultrafiltration into molecular size of 1 kDa, 10 kDa and 30 kDa was used to separated the obtained hydrolzyates and antioxidative activities of obtain fractions were studied. Between fractions less than 1 kDa, containing bioactive peptides, the ultrasound pretreated hydrolyzate obtained by using alcalaseflevorzyme in a two-stage procedure has shown the highest antioxidant activity.Hidrolizom proteina belanceta dobijaju se bioaktivni peptidi koji imaju različita biološka svojstva. U ovom radu korišćena je tehnologija ultrazvuka visokog intenziteta kao pretretman pripreme proteina belanceta koji su zatim hidrolizovani različitim vrstama proteaza u jednostepenom i dvostepenom postupku. Dobijeni hidrolizati su razdvojeni korišćenjem ultrafiltracionih membrana promera 1, 10 i 30 kDa i dobijenim frakcijama je ispitana antioksidativna aktivnost. Među frakcijama veličine manje od 1 kDa koje sadrže bioaktivne peptide, najveću antioksidativnu aktivnost je pokazao ultrazvučno pretretiran hidrolizat nastao delovanjem alkalaza-flevorzima u dvostepenom enzimskom postupku

Organic Fertilizer Abrasive Grits Increase Soil Available Nitrogen, Plant Height, and Biomass

In organic cropping systems, air‐propelled abrasive grits can be used to control in‐row weeds. If the applied abrasive grit is an approved organic fertilizer, these applications may serve a dual purpose of weed control and crop fertility. Laboratory soil incubations examined the N mineralization rates of several grit types with differing C/N ratios (Agra Grit [crushed walnut shells, 170:1], corncob grit [91:1], Sustane [composted turkey litter, 5.0:1], Phytaboost Plant Food [crushed and pelletized soybean meal, 5.0:1]). A greenhouse study determined plant wheat (Triticum aestivum L.), kale (Brassica napus pabluaria DC), and velvetleaf (Abutilon theophrasti Medik.) growth response in soils amended with these grits. The N mineralization rates varied by grit type, soil, and application rate. The N mineralized from Phytaboost within 56 d was similar among the amounts of N a whereas the amount of N mineralized from Sustane was inversely related to the amount of N applied. Agra Grit and corncob grit immobilized soil N due to their high C/N ratios. In soils amended with Sustane, plant height and biomass were 15–43% and 34–83% greater than for plants grown in soils with Agra Grit, corncob grit, and the nontreated soil. Applications of organic fertilizer as air‐propelled grit may improve crop growth; however, if weed control is imperfect, these grits may increase weed growth. Grits with high C/N ratios may immobilize soil available N but not affect plant growth

EURADOS Working Group-12 Studies in Interventional Radiology for Medical Staff Dosimetry

EURADOS (European Radiation Dosimetry Group) Working Group 12 (dosimetry in medical imaging) established a subtask devoted to the dosimetry of the medical staff employed in interventional radiology practices. As it is widely known, such practices are characterized by high doses, with respect the other medical procedures, both for the patient and the radiologist. For interventional cardiology there are several publications concerning medical staff dosimetry, on the contrary, for interventional radiology, data are more limited. For that reason WG-12 decided to study the irradiation scenario, employing simplified anthropomorphic models (MIRD type) with Monte Carlo simulations, reconstructing some specific interventional radiology practices (PTC and TIPS). In these procedures, where the X-ray C-arm is mainly fixed in PA projection and the beam directed to the patient abdomen, the radiologist is next to the patient right side, in correspondence to the liver region. The usage of the ceiling shielding is not very frequent, due to the difficulties in positioning it between the radiation source (the X-ray and the patient as the scattering source) and the operator. The aim of the simulations program is: to evaluate the dose received by the radiologist, in a region simulating the presence of the dosemeter fixed on the lead apron at the breast level ; to estimate the corresponding effective dose ; to make a sensitivity analysis on different parameters affecting the calculated results (as the reciprocal position between the two operators, the beam quality and the X-ray field dimension). Indeed a particular attention is devoted to the eye lens dosimetry, that has become a “critical issue” for personnel dosimetry, after ICRP has reconsidered the radiation sensitivity of the lens of the eye. In the present work the general scheme, the assumptions and the followed methodology are presented with some very preliminary results of the simulations and the measurements

Self-affirmation improves music performance among performers high on the impulsivity dimension of sensation seeking

In the light of evidence that self-affirmation can mitigate the negative effects of stress on outcomes, this study tested whether a self-affirmation manipulation could improve undergraduate students’ achievement in a formal musical performance examination. The study also investigated the association between impulsivity and music performance and explored whether impulsivity moderated any impact of self-affirmation on exam performance. Methods: At baseline, participants provided demographic information and completed the UPPS-P Impulsive Behaviour Scale (short-form), which assesses five dimensions of impulsivity (negative and positive urgency, lack of premeditation, lack of perseverance, and sensation seeking). In the subsequent 14 days, participants (N = 65) completed either a self-affirmation manipulation or a control task, before reading a message about the impact of practice on music performance. Music performance was formally assessed 14 days later. Findings: Sensation seeking was the only dimension of impulsivity associated with exam performance, with participants high in sensation seeking receiving lower grades. Critically, self-affirmation promoted better music performance among those high in sensation seeking. Discussion: Self-affirmation may provide a useful intervention to augment the performance of musicians who would otherwise perform worse than their counterparts under formal evaluative circumstances, such as those high in sensation seeking

Integrative Genomics Identifies the Molecular Basis of Resistance to Azacitidine Therapy in Myelodysplastic Syndromes

© 2017 The Author(s) Myelodysplastic syndromes and chronic myelomonocytic leukemia are blood disorders characterized by ineffective hematopoiesis and progressive marrow failure that can transform into acute leukemia. The DNA methyltransferase inhibitor 5-azacytidine (AZA) is the most effective pharmacological option, but only ∼50% of patients respond. A response only manifests after many months of treatment and is transient. The reasons underlying AZA resistance are unknown, and few alternatives exist for non-responders. Here, we show that AZA responders have more hematopoietic progenitor cells (HPCs) in the cell cycle. Non-responder HPC quiescence is mediated by integrin α5 (ITGA5) signaling and their hematopoietic potential improved by combining AZA with an ITGA5 inhibitor. AZA response is associated with the induction of an inflammatory response in HPCs in vivo. By molecular bar coding and tracking individual clones, we found that, although AZA alters the sub-clonal contribution to different lineages, founder clones are not eliminated and continue to drive hematopoiesis even in complete responders