Active Amplification of the Terrestrial Albedo to Mitigate Climate Change: An Exploratory Study

This study explores the potential to enhance the reflectance of solar insolation by the human settlement and grassland components of the Earth's terrestrial surface as a climate change mitigation measure. Preliminary estimates derived using a static radiative transfer model indicate that such efforts could amplify the planetary albedo enough to offset the current global annual average level of radiative forcing caused by anthropogenic greenhouse gases by as much as 30 percent or 0.76 W/m2. Terrestrial albedo amplification may thus extend, by about 25 years, the time available to advance the development and use of low-emission energy conversion technologies which ultimately remain essential to mitigate long-term climate change. However, additional study is needed to confirm the estimates reported here and to assess the economic and environmental impacts of active land-surface albedo amplification as a climate change mitigation measure.Comment: 21 pages, 3 figures. In press with Mitigation and Adaptation Strategies for Global Change, Springer, N

Interpersonal dynamics in baseline rallies in tennis

In tennis, the relative positioning of players on court constrains their opportunities to perform successful actions. In this study we proposed and validated an empirical function that captures the spatial-temporal relationship between tennis players during competitive performance. This parameter, termed goal-directed displacement index (GDD Index), is defined over time by the product of both players' distances to the central line of the court and to the centre of the net. Results showed that the GDD index successfully described tennis players' patterns of interaction, as well as identified breaks in patterns of play during competitive performance, due to changes in relative positioning on court. Our analysis revealed two different patterns of interpersonal interactions, cross and down-the-line rallies, and two ways for a break to emerge in game dynamics, parallel variation (transition from a cross court rally to a down-the-line rally) and angle opening (lateral displacement). Data suggest that the elaboration of specific individual profiles of performance for different players, using the GDD index, could improve performance analysis in tennis

Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms

Type 2 diabetes (T2D) affects Latinos at twice the rate seen in populations of European descent. We recently identified a risk haplotype spanning SLC16A11 that explains ∼20% of the increased T2D prevalence in Mexico. Here, through genetic fine-mapping, we define a set of tightly linked variants likely to contain the causal allele(s). We show that variants on the T2D-associated haplotype have two distinct effects: (1) decreasing SLC16A11 expression in liver and (2) disrupting a key interaction with basigin, thereby reducing cell-surface localization. Both independent mechanisms reduce SLC16A11 function and suggest SLC16A11 is the causal gene at this locus. To gain insight into how SLC16A11 disruption impacts T2D risk, we demonstrate that SLC16A11 is a proton-coupled monocarboxylate transporter and that genetic perturbation of SLC16A11 induces changes in fatty acid and lipid metabolism that are associated with increased T2D risk. Our findings suggest that increasing SLC16A11 function could be therapeutically beneficial for T2D. Video Abstract [Figure presented] Keywords: type 2 diabetes (T2D); genetics; disease mechanism; SLC16A11; MCT11; solute carrier (SLC); monocarboxylates; fatty acid metabolism; lipid metabolism; precision medicin

Narrow-band search for gravitational waves from known pulsars using the second LIGO observing run

Isolated spinning neutron stars, asymmetric with respect to their rotation axis, are expected to be sources of continuous gravitational waves. The most sensitive searches for these sources are based on accurate matched filtering techniques that assume the continuous wave to be phase locked with the pulsar beamed emission. While matched filtering maximizes the search sensitivity, a significant signal-to-noise ratio loss will happen in the case of a mismatch between the assumed and the true signal phase evolution. Narrow-band algorithms allow for a small mismatch in the frequency and spin-down values of the pulsar while coherently integrating the entire dataset. In this paper, we describe a narrow-band search using LIGO O2 data for the continuous wave emission of 33 pulsars. No evidence of a continuous wave signal is found, and upper limits on the gravitational wave amplitude over the analyzed frequency and spin-down ranges are computed for each of the targets. In this search, we surpass the spin-down limit, namely, the maximum rotational energy loss due to gravitational waves emission for some of the pulsars already present in the LIGO O1 narrow-band search, such as J1400-6325, J1813-1246, J1833-1034, J1952+3252, and for new targets such as J0940-5428 and J1747-2809. For J1400-6325, J1833-1034, and J1747-2809, this is the first time the spin-down limit is surpassed. © 2019 American Physical Society

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Recombinant human interleukin-11 prevents hypotension in LPS-treated anesthetized rabbits

Recombinant human interleukin-11 (rhlL-11) was evaluated in a New Zealand White rabbit model of endotoxemia. Animals received Escherichia coli LPS (150 μg/kg i.v.) via a femoral venous catheter. 30 min later, animals were treated with rhlL-11 (100 μg/kg i.v., n = 7), or rhlL-11 formulation buffer (n = 6). Arterial pressures were monitored for 6 h following rhlL-11. Approximately 5 h after LPS treatment, mean arterial pressure in vehicle-treated control animals was 46.7 mmHg, or 55% of group mean baseline, while that of rhlL-11-treated animals was 74.8 mmHg, or 94% of group mean baseline (P &lt; 0.0005). Histologic evaluation of ileum, cecum and colon from rhlL-11-treated rabbits showed decreased hemorrhage, edema, and mucosal damage (P &lt; 0.02), compared to the vehicle-treated controls. Intravenous LPS evokes hypotension mediated by the induction of inducible nitric oxide synthase (iNOS) and subsequent production of NO. Maintenance of blood pressure by rhIL-11 in LPS-treated rabbits in addition to the concurrent significant decrease in NO levels compared to vehicle-treated animals ( P &lt; 0.04) suggests that rhlL-11 interferes with the production of NO by iNOS and or the physiologic effects of NO on vascular smooth muscle. </jats:p