The contemporary framework on social media analytics as an emerging tool for behavior informatics, HR analytics and business process

Organizations can use social media analytics as an effective assessment tool from behavioral perspectives, HR as well as business process to collaboratively build competency framework. The present piece of work is an attempt to put forth social media as a contemporary model in the light of the existing literature. Providing literature reviews, this paper also highlights current practices of social media analytics as to how organizations are accessing vast amount of live data from social media in order to understand work-related behavioral aspects of the employees and their employability for both HR process and the business. The analyzed data on customers is also being taken into account to highlight patterns and customers’ sentiments related to the marketing efforts. Furthermore, on the basis of the above presented discussion this paper suggests the road map to how organizations can foster the social media practices. Finally, this paper raises some significant plausible research questions to be empirically researched in order to methodically validate or discard the presented framework on this rapidly emerging phenomenon

EFFECT OF MUSTAKADI VATI IN THE MANAGEMENT OF GRAHANI DOSHA IN CHILDREN – A CASE STUDY

BACKGROUND: Grahani is the Adhishthana of Agni and Agni Dushti is the main reason of the disease. The disease Grahani Dosha is very commonly seen in present pediatric practice and it aggravates to form a critical condition if the proper care is not taken. MATERIAL AND METHOD: A 8-years-old male patient of Grahani Dosha with complaints of defecation just after taking meal, Bowel frequency 3-4 times/day, irregular bowel habit, loss of appetite, generalized weakness, occasional pain in abdomen, slow weight gain for 5-6 months was treated by Mustakadi Vati in three divided doses of 10 Vati per day after meal for 8 weeks with SukhoshnaJala. RESULT: Marked improvement was found after 8 weeks of treatment i.e., bowel frequency reduced to 1 time/day, no weakness, abdominal pain relieved, 2 kg body weight gained. Hematological parameters along with routine and microscopic investigations of stool and urine were done before and after the treatment, all were found normal. Mala Parikshana was done before treatment which showed sinking of stool in water and foul smell and after 8 weeks of treatment again Mala Parikshana was done where floating of stool in water and no foul smell were found. CONCLUSION: This case study has shown that Mustakadi Vati is effective in improving the symptoms of Grahani Dosha. Marked improvements were found in all the symptoms of Grahani Dosha in Children

Search for Gravitational Waves Associated with Gamma-Ray Bursts Detected by Fermi and Swift during the LIGO-Virgo Run O3b

We search for gravitational-wave signals associated with gamma-ray bursts (GRBs) detected by the Fermi and Swift satellites during the second half of the third observing run of Advanced LIGO and Advanced Virgo (2019 November 1 15:00 UTC-2020 March 27 17:00 UTC). We conduct two independent searches: A generic gravitational-wave transients search to analyze 86 GRBs and an analysis to target binary mergers with at least one neutron star as short GRB progenitors for 17 events. We find no significant evidence for gravitational-wave signals associated with any of these GRBs. A weighted binomial test of the combined results finds no evidence for subthreshold gravitational-wave signals associated with this GRB ensemble either. We use several source types and signal morphologies during the searches, resulting in lower bounds on the estimated distance to each GRB. Finally, we constrain the population of low-luminosity short GRBs using results from the first to the third observing runs of Advanced LIGO and Advanced Virgo. The resulting population is in accordance with the local binary neutron star merger rate. © 2022. The Author(s). Published by the American Astronomical Society

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

Open data from the third observing run of LIGO, Virgo, KAGRA, and GEO

The global network of gravitational-wave observatories now includes five detectors, namely LIGO Hanford, LIGO Livingston, Virgo, KAGRA, and GEO 600. These detectors collected data during their third observing run, O3, composed of three phases: O3a starting in 2019 April and lasting six months, O3b starting in 2019 November and lasting five months, and O3GK starting in 2020 April and lasting two weeks. In this paper we describe these data and various other science products that can be freely accessed through the Gravitational Wave Open Science Center at https://gwosc.org. The main data set, consisting of the gravitational-wave strain time series that contains the astrophysical signals, is released together with supporting data useful for their analysis and documentation, tutorials, as well as analysis software packages

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Not AvailableA field experiment was conducted during 2003 to 2006 to study different machinery for the establishment of rice (Oryga satva L.) and the effect on subsequent crop growth, productivity and energy. The study was made for direct seeding (dry bed), d rum s eeding (wet b ed), mechanical transplanting (puddled and unpuddled) and manual transplanting (puddled) in subsequent crops of wheat. The mean yield of hybrid rice was higher (8.52 t/ha) with drum seeding (wet bed) that was at par with direct seeding (dry bed) and mechanical transplanting (puddled) as compared to manual transplanting (puddled) and mechanical transplanting (unpuddled). Direct seeding (dry bed) adopted in previous rice crops gave higher mean yield of wheat (5.70 t/ha) followed by drum seeding (wet bed), mechanical transplanting (unpuddled), manual transplanting (puddled) and mechanical transplanting (puddled). The net return energy of the system was high in drum seeded (170,926 MJ/ha) followed by direct seeded (169,070 MJ/ha) and lowest of 150,542 MJ/ha in manually transplanted (puddled). The drum seeded rice required 3.6 % less input energy and gave 8.9 % higher output energy, whereas, direct seeded required 2.6 % less input and gave 8.2 % higher output energy as compared to manually transplanted ( puddled). The direct seeded (dry bed) and drum-seeding (wet bed- unpuddled) saved irrigation water by 13 to 19 % when compared to manual transplanting (puddled).Not Availabl

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Not AvailableThe field investigations were carried out for energy use analysis in terms of different input requirements and outputs harvested under the diversified rice–wheat cropping systems at the research farm of Project Directorate for Cropping Systems Research, Modipuram, Meerut, India during the year 2000–2004. The experiments were conducted on rice (Oryza sativa L.)–wheat (Triticum aestivum L. emend. Fiori and Paol) system involving 8 sequences using diversification, furrow irrigated raised bed system (FIRB) of sowing wheat, use of summer period for deep ploughing or raising legume crops for seed or green manure to study the energy dynamics of different diversified cropping systems. Results revealed that total energy use was highest in rice–potato–wheat (i.e. 77,601 MJ/ha in flat bed & 75,697 MJ/ha in raised bed) followed by rice–wheat–sesbania (i.e. 48,770 MJ/ha in flat & 47,830 MJ/ha in raised bed) and rice–wheat– greengram (i.e. 48,414 MJ/ha in flat & 47,482 MJ/ha in raised bed). In overall, the raised bed sowing of wheat in the cropping system consumed 6–11% less fertilizer energy than flat bed while saved up to 4.2% energy through irrigation. The total output energy of the system was recorded significantly higher in rice–potato–wheat system (i.e. 222,836 MJ/ha in flat bed & 218,065 MJ/ha in raised bed) in comparison to rice–wheat–greengram (i.e. 177,477 MJ/ha in flat bed & 175,125 MJ/ha in raised bed), rice–wheat–sesbania (i.e. 172,000 MJ/ha in flat bed & 168,919 MJ/ha in raised bed) and rice–wheat system (i.e. 156,085 MJ/ha in flat bed & 151,862 MJ/ha in raised bed). The significantly higher net return of energy was obtained in rice–potato–wheat system as compared to other systems. This system required about 75% more input energy but provided about 42% more output energy compared to conventional rice– wheat system. About 10% higher output energy was obtained through growing greengram in summer for grain and foliage incorporation while 14% gain obtained by green manuring sesbania, when compared to deep summer ploughing after wheat harvest.Not Availabl

Studies on anti-inflammatory effect of aqueous extract of leaves of Holoptelea integrifolia, Planch. in rats

Objectives: The purpose of the present study was to investigate the anti-inflammatory properties of aqueous extract of the leaves of H. integrifolia, Planch. Materials and Methods: The hind paw edema was produced in rats by subplanter injection of carageenan. The aqueous extract of H. integrifolia, Planch. (AHI) at dose (250 and 500 mg/kg p.o) was given to observe % inhibition of paw edema which were comparable with indomethacin (10 mg/kg p.o) used as a reference drug. Results: The extract administered orally at doses of 250 and 500 mglkg p.o produced a significant (P < 0.05) dose dependent inhibition of edema formation Conclusions: A significant % inhibition of paw edema by the aqueous extract of leaves of H. integrifolia, Planch. and its almost nearby same % inhibition with indomethacin suggest its usefulness as an anti-inflammatory agent

Cytoplasmic induction and over-expression of cyclooxygenase-2 in human prostate cancer: implications for prevention and treatment

Objective To assess the level and morphological distribution of cyclooxygenase (COX)-1 and -2 in human prostates and to determine any association with the Gleason grade of prostate cancer. Materials and methods The study comprised 30 samples from patients with benign prostatic hyperplasia (BPH) and 82 with prostate cancer. Immunohistochemistry was used to assess the expression of COX-1 and -2, and 13 samples were also assessed using immunoblotting (six BPH and seven cancers). Results For both BPH and prostate cancer, COX-1 expression was primarily in the fibromuscular stroma, with variable weak cytoplasmic expression in glandular/neoplastic epithelial cells. In contrast, COX-2 expression differed markedly between BPH and cancer. In BPH there was membranous expression of COX-2 in luminal glandular cells and no stromal expression. In cancer the stromal expression of COX-2 was unaltered, but expression by tumour cells was significantly greater (P = 0.008), with a change in the staining pattern from membranous to cytoplasmic (P < 0.001). COX-2 expression was significantly higher in poorly differentiated than in well differentiated tumours (P < 0.001). These results were supported by immunoblotting, which showed similar levels of COX-1 in both BPH and cancer, but four times greater expression of COX-2 in cancer than in BPH. Conclusion This is the first study to assess the co-expression of COX-1 and COX-2 proteins in benign and malignant human prostates, and showed the induction and significantly greater expression of COX-2 in cancer, which was also associated with tumour grade. The regular use of nonsteroidal anti-inflammatory drugs is associated with a reduced incidence of cancers. The present results provide the basis for a potential role for COX-2 inhibitors in the prevention and treatment of prostate cancer

Cytoplasmic induction and over-expression of cyclooxygenase-2 in human prostate cancer: implications for prevention and treatment

Objective :To assess the level and morphological distribution of cyclooxygenase (COX)-1 and -2 in human prostates and to determine any association with the Gleason grade of prostate cancer.Materials and methods: The study comprised 30 samples from patients with benign prostatic hyperplasia (BPH) and 82 with prostate cancer. Immunohistochemistry was used to assess the expression of COX-1 and -2, and 13 samples were also assessed using immunoblotting (six BPH and seven cancers).Results: For both BPH and prostate cancer, COX-1 expression was primarily in the fibromuscular stroma, with variable weak cytoplasmic expression in glandular/neoplastic epithelial cells. In contrast, COX-2 expression differed markedly between BPH and cancer. In BPH there was membranous expression of COX-2 in luminal glandular cells and no stromal expression. In cancer the stromal expression of COX-2 was unaltered, but expression by tumour cells was significantly greater (P = 0.008), with a change in the staining pattern from membranous to cytoplasmic (P \u3c 0.001). COX-2 expression was significantly higher in poorly differentiated than in well differentiated tumours (P \u3c 0.001). These results were supported by immunoblotting, which showed similar levels of COX-1 in both BPH and cancer, but four times greater expression of COX-2 in cancer than in BPH.Conclusion:This is the first study to assess the co-expression of COX-1 and COX-2 proteins in benign and malignant human prostates, and showed the induction and significantly greater expression of COX-2 in cancer, which was also associated with tumour grade. The regular use of nonsteroidal anti-inflammatory drugs is associated with a reduced incidence of cancers. The present results provide the basis for a potential role for COX-2 inhibitors in the prevention and treatment of prostate cancer