577 research outputs found
Thermomagnetic history effects in SmMnGe
The intermetallic compound SmMnGe, displaying multiple magnetic phase
transitions, is being investigated in detail for its magnetization behavior
near the 145 K first order ferromagnetic to antiferromagnetic transition
occuring on cooling, in particular for thermomagnetic history effects in the
magnetization data. The most unusual finding is that the thermomagnetic
irreversibility, [= M(T)-M(T)] at 135 K is higher in
intermediate magnetic field strengths. By studying the response of the sample
(i.e., thermomagnetic irreversibility and thermal hysteresis) to different
histories of application of magnetic field and temperature, we demonstrate how
the supercooling and superheating of the metastable magnetic phases across the
first order transition at 145 K contribute to overall thermomagnetic
irreversibility.Comment: 15 pages, 5 figures, to appear in Physical Review
WISP genes are members of the connective tissue growth factor family that are up-regulated in Wnt-1-transformed cells and aberrantly expressed in human colon tumors
Wnt family members are critical to many developmental processes, and components of the Wnt signaling pathway have been linked to tumorigenesis in familial and sporadic colon carcinomas. Here we report the identification of two genes, WISP-1 and WISP-2, that are up-regulated in the mouse mammary epithelial cell line C57MG transformed by Wnt-1, but not by Wnt-4. Together with a third related gene, WISP-3, these proteins define a subfamily of the connective tissue growth factor family. Two distinct systems demonstrated WISP induction to be associated with the expression of Wnt-1. These included (i) C57MG cells infected with a Wnt-1 retroviral vector or expressing Wnt-1 under the control of a tetracyline repressible promoter, and (ii) Wnt-1 transgenic mice. The WISP-1 gene was localized to human chromosome 8q24.1-8q24.3. WISP-1 genomic DNA was amplified in colon cancer cell lines and in human colon tumors and its RNA overexpressed (2- to >30-fold) in 84% of the tumors examined compared with patient-matched normal mucosa. WISP-3 mapped to chromosome 6q22-6q23 and also was overexpressed (4- to >40-fold) in 63% of the colon tumors analyzed. In contrast, WISP-2 mapped to human chromosome 20q12-20q13 and its DNA was amplified, but RNA expression was reduced (2- to >30-fold) in 79% of the tumors. These results suggest that the WISP genes may be downstream of Wnt-1 signaling and that aberrant levels of WISP expression in colon cancer may play a role in colon tumorigenesis
Percolation model for structural phase transitions in LiHIO mixed crystals
A percolation model is proposed to explain the structural phase transitions
found in LiHIO mixed crystals as a function of the
concentration parameter . The percolation thresholds are obtained from Monte
Carlo simulations on the specific lattices occupied by lithium atoms and
hydrogen bonds. The theoretical results strongly suggest that percolating
lithium vacancies and hydrogen bonds are indeed responsible for the solid
solution observed in the experimental range .Comment: 4 pages, 2 figure
Exact solutions of the radial Schrodinger equation for some physical potentials
By using an ansatz for the eigenfunction, we have obtained the exact
analytical solutions of the radial Schrodinger equation for the pseudoharmonic
and Kratzer potentials in two dimensions. The energy levels of all the bound
states are easily calculated from this eigenfunction ansatz. The normalized
wavefunctions are also obtained.Comment: 13 page
Discovery of sultam-containing small-molecule disruptors of the huntingtin–calmodulin protein–protein interaction
The aberrant protein–protein interaction between calmodulin and mutant huntingtin protein in Huntington’s disease patients has been found to contribute to Huntington’s disease progression. A high-throughput screen for small molecules capable of disrupting this interaction revealed a sultam series as potent small-molecule disruptors. Diversification of the sultam scaffold afforded a set of 24 analogs or further evaluation. Several structure–activity trends within the analog set were found, most notably a negligible effect of absolute stereochemistry and a strong beneficial correlation with electron-withdrawing aromatic substituents. The most promising analogs were profiled for off-target effects at relevant kinases and, ultimately, one candidate molecule was evaluated for neuroprotection in a neuronal cell model of Huntington’s disease
The use of National Plant Monitoring Scheme data for making inferences concerning air pollution impacts
Shadowing in photo-production : role of in-medium hadrons
We study the effects of in-medium hadronic properties on shadowing in
photon-nucleus interactions in Glauber model as well as in the multiple
scattering approach. A reasonable agreement with the experimental data is
obtained in a scenario of downward spectral shift of the hadrons. Shadowing is
found to be insensitive to the broadening of the spectral functions. An impact
parameter dependent analysis of shadowing might shed more light on the role of
in-medium properties of hadrons.Comment: Title modified; version to appear in PRC, Rapid Communication
Photospheric Magnetic Field: Relationship Between North-South Asymmetry and Flux Imbalance
Photospheric magnetic fields were studied using the Kitt Peak synoptic maps
for 1976-2003. Only strong magnetic fields (B>100 G) of the equatorial region
were taken into account. The north-south asymmetry of the magnetic fluxes was
considered as well as the imbalance between positive and negative fluxes. The
north-south asymmetry displays a regular alternation of the dominant hemisphere
during the solar cycle: the northern hemisphere dominated in the ascending
phase, the southern one in the descending phase during Solar Cycles 21-23. The
sign of the imbalance did not change during the 11 years from one polar-field
reversal to the next and always coincided with the sign of the Sun's polar
magnetic field in the northern hemisphere. The dominant sign of leading
sunspots in one of the hemispheres determines the sign of the magnetic-flux
imbalance. The sign of the north-south asymmetry of the magnetic fluxes and the
sign of the imbalance of the positive and the negative fluxes are related to
the quarter of the 22-year magnetic cycle where the magnetic configuration of
the Sun remains constant (from the minimum where the sunspot sign changes
according to Hale's law to the magnetic-field reversal and from the reversal to
the minimum). The sign of the north-south asymmetry for the time interval
considered was determined by the phase of the 11-year cycle (before or after
the reversal); the sign of the imbalance of the positive and the negative
fluxes depends on both the phase of the 11-year cycle and on the parity of the
solar cycle. The results obtained demonstrate the connection of the magnetic
fields in active regions with the Sun's polar magnetic field in the northern
hemisphere.Comment: 24 pages, 12 figures, 2 table
An Institutional Theory perspective on sustainable practices across the dairy supply chain
AbstractThe need for sustainable practices in the food supply chain, particularly in the area of energy reduction, is becoming acute. The food industry currently has to contend with multiple competing pressures alongside the new challenges of sustainable production. We applied Institutional Theory to explore the role of supermarkets in the development of legitimate sustainable practices across the dairy supply chains. The paper focuses on dairy supply chain organizations and their consumption of energy. We conducted 70 semi-structured telephone interviews with various stakeholders across the supply chain. Findings revealed that the majority of actors in the supply chain identified supermarkets as the dominant player, and that the supermarkets exert pressure on other smaller organizations across the supply chain. Although some organizations wished to pursue a sustainable agenda through integrating new rules and legitimate practices within their own organization, the dominant logic appeared to be one of cost reduction and profit maximization. There was also evidence that supermarkets and other large organizations attempt to replicate publicly available information on green successes for image purposes. We conclude that the dominant logic of cost reduction is so well established that challenging the dominant logic may prove difficult. The challenge is therefore to complement the dominant logic with sustainable practices across the whole supply chain, a role Government needs to play. This will require a broader more systemic approach to encouraging sustainable practices including investment and financing practices, so that all members of the dairy supply chain can co-operate and contribute to energy reduction
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