Structural properties of Pb3Mn7O15 determined from high-resolution synchrotron powder diffraction

We report on the crystallographic structure of the layered compound Pb3Mn7O15. Previous analysis based on laboratory X-ray data at room temperature gave contradictory results in terms of the description of the unit cell. Motivated by recent magnetic bulk measurements of this system, we re-investigated the chemical structure with high-resolution synchrotron powder diffraction at temperatures between 15 K and 295 K. Our results show that the crystal structure of stoichiometric Pb3Mn7O15 has a pronounced 2-dimensional character and can be described in the orthorhombic space group Pnma.Comment: 6 pages, 4 figures, 2 table

Non-Invasive Mouse Models of Post-Traumatic Osteoarthritis

SummaryAnimal models of osteoarthritis (OA) are essential tools for investigating the development of the disease on a more rapid timeline than human OA. Mice are particularly useful due to the plethora of genetically modified or inbred mouse strains available. The majority of available mouse models of OA use a joint injury or other acute insult to initiate joint degeneration, representing post-traumatic osteoarthritis (PTOA). However, no consensus exists on which injury methods are most translatable to human OA. Currently, surgical injury methods are most commonly used for studies of OA in mice; however, these methods may have confounding effects due to the surgical/invasive injury procedure itself, rather than the targeted joint injury. Non-invasive injury methods avoid this complication by mechanically inducing a joint injury externally, without breaking the skin or disrupting the joint. In this regard, non-invasive injury models may be crucial for investigating early adaptive processes initiated at the time of injury, and may be more representative of human OA in which injury is induced mechanically. A small number of non-invasive mouse models of PTOA have been described within the last few years, including intra-articular fracture of tibial subchondral bone, cyclic tibial compression loading of articular cartilage, and anterior cruciate ligament (ACL) rupture via tibial compression overload. This review describes the methods used to induce joint injury in each of these non-invasive models, and presents the findings of studies utilizing these models. Altogether, these non-invasive mouse models represent a unique and important spectrum of animal models for studying different aspects of PTOA

EVR-CB-004: An Inflated Hot Subdwarf O Star + Unseen WD Companion in a Compact Binary Discovered with the Evryscope

We present the discovery of EVR-CB-004, a close binary with a remnant stellar core and an unseen white dwarf (WD) companion. The analysis in this work reveals that the primary is potentially an inflated hot subdwarf (sdO) and more likely is a rarer post-blue horizontal branch (post-BHB) star. Post-BHBs are the short-lived shell-burning final stage of a blue horizontal star or hot subdwarf before transitioning to a WD. This object was discovered using Evryscope photometric data in a southern all-sky hot subdwarf variability survey. The photometric light curve for EVR-CB-004 shows multicomponent variability from ellipsoidal deformation of the primary and Doppler boosting, as well as gravitational limb darkening. The binary EVR-CB-004 is one of just a handful of known systems and has a long period (6.08426 hr) and large-amplitude ellipsoidal modulation (16.0% change in brightness from maximum to minimum) for these extremely close binary systems, while the properties of the primary make it a truly unique system. It also shows a peculiar low-amplitude (less than 1%) sinusoidal light-curve variation with a period that is a 1/3 resonance of the binary period. We tentatively identify this additional variation source as a tidally induced resonant pulsation, and we suggest follow-up observations that could verify this interpretation. From the evolutionary state of the system, its components, and its mass fraction, EVR-CB-004 is a strong merger candidate to form a single high-mass (1.2 M o˙) WD. It offers a glimpse into a brief phase of remnant core evolution and secondary variation not seen before in a compact binary

Dynamics of charged dust particles in protoplanetary discs

We study the effect of an imposed magnetic field on the motion of charged dust particles in magnetically active regions of a protoplanetary disc. Assuming a power law structure for the vertical and the toroidal components of the magnetic field for the regions beyond magnetically dead region of the disc, the radial and the vertical velocities of the charged particles, in the asymptotic case of small particles, are calculated analytically. While grains with radii smaller than a critical radius significantly are affected by the magnetic force, motion of the particles with larger radii is independent of the magnetic field. The critical radius depends on the magnetic geometry and the charge of the grains. Assuming that a grain particle has one elementary charge and the physical properties of the disc correspond to a minimum-mass solar nebula, we show that only micron-sized grains are affected by the magnetic force. Also, charge polarity determines direction of the radial velocity. For such small particles, both the radial and the vertical velocities increase due to the magnetic force.Comment: Accepted for publication in Astrophysics & Space Scienc

Insights into malaria susceptibility using genome-wide data on 17,000 individuals from Africa, Asia and Oceania

The human genetic factors that affect resistance to infectious disease are poorly understood. Here we report a genome-wide association study in 17,000 severe malaria cases and population controls from 11 countries, informed by sequencing of family trios and by direct typing of candidate loci in an additional 15,000 samples. We identify five replicable associations with genome-wide levels of evidence including a newly implicated variant on chromosome 6. Jointly, these variants account for around one-tenth of the heritability of severe malaria, which we estimate as -23% using genome-wide genotypes. We interrogate available functional data and discover an erythroid-specific transcription start site underlying the known association in ATP2B4, but are unable to identify a likely causal mechanism at the chromosome 6 locus. Previously reported HLA associations do not replicate in these samples. This large dataset will provide a foundation for further research on thegenetic determinants of malaria resistance in diverse populations.Peer reviewe

Some Consequences of Thermosolutal Convection: The Grain Structure of Castings

The essential principles of thermosolutal convection are outlined, and how convection provides a transport mechanism between the mushy region of a casting and the open bulk liquid is illustrated. The convective flow patterns which develop assist in heat exchange and macroscopic solute segregation during solidification; they also provide a mechanism for the transport of dendritic fragments from the mushy region into the bulk liquid. Surviving fragments become nuclei for equiaxed grains and so lead to blocking of the parental columnar, dendritic growth front from which they originated. The physical steps in such a sequence are considered and some experimental data are provided to support the argument

Scaling of Energy Gain with Plasma Parameters in a Plasma Wakefield Accelerator

We have recently demonstrating the doubling of the energy of particles of the ultra-short, ultra-relativistic electron bunches of the Stanford Linear Accelerator Center [1]. This energy doubling occurred in a plasma only 85 cm-long with a density of {approx} 2.6 x 10{sup 17} e{sup -}/cm{sup -3}. This milestone is the result of systematic measurements that show the scaling of the energy gain with plasma length and density, and show the reproducibility and the stability of the acceleration process. We show that the energy gain increases linearly with plasma length from 13 to 31 cm. These are key steps toward the application of beam-driven plasma accelerators or plasma wakefield accelerators (PWFA) to doubling the energy of a future linear collider without doubling its length