Microfluidic-based Split-Ring-Resonator Sensor for Real-time and Label-free Biosensing

AbstractIn this report, a split ring resonator (SRR), the most important building block of metamaterial, is fabricated and integrated with a microfluidic chamber for biosensing. The SRR is produced on a microwave printed circuit board while the microfluidic chamber is fabricated by casting of polydimethylsiloxane (PDMS). SRR was immobilized with Anti- Immunoglobulin G (IgG) for IgG detection by a standard covalent immobilization using Cystamine. The PDMS chamber was aligned and clamped on the circuit board and the electromagnetic response of the SRR sensor was continuously monitored when IgG analytes was flowed through the chamber. The reaction of Immunoglobulin G (IgG) and Anti-IgG results in a shift of resonance frequency. It was found that the response of the resonance frequency is sensitive to the IgG concentrations. Therefore, the SRR microfluidic scheme can be effectively used as an advanced bio-sensing device

Ultrasonic diffraction tomography: the experimental result

Diffraction tomography is a technique for imaging with acoustic fields. It takes advantage of the linearization process of the non-linear wave equation describing wave propagation in heterogeneous media. When the scattering effect is weak, one can invoke the Born or Rytov approximation and thus derive the generalized Fourier Slice Theorem to reconstruct the cross-section of the insonified object. Although diffraction tomography is a promising technology for medical application as it provides a quantitative ultrasonic image, its realization toward medical use is still far-to-go, this may be due to the complexity of the hardware involved. In this research we investigate a potential use of diffraction tomography for medical application by using a delicate-designed ultrasonic computerized tomographic system. The result of experiment investigation of diffraction tomography is very promising

Metamaterial-inspired microfluidic-based sensor for chemical discrimination

This work proposes a metamaterial-inspired microfluidic-based chemical sensor. The sensor comprises a microwave split-ring resonator (SRR), an important building block of metamaterials, integrated with a disposable flow-channel made of a transparency film. The electromagnetic response of the sensor is observed in the presence of various analytes including glycerol, ethanol, and phosphate buffered saline. It is found that the resonance frequency in the transmission amplitude and the zero crossing in the reflection phase of the sensor are good features for discrimination of these analytes and for determining their concentrations. The developed metamaterial-inspired microfluidic-based chemical sensor has a potential for advanced chemical sensing applications.Kata Jaruwongrungsee, Withawat Withayachumnankul, Anurat Wisitsoraat, Derek Abbott, Christophe Fumeaux, and Adisorn Tuantranon