Automated detection of block falls in the north polar region of Mars

We developed a change detection method for the identification of ice block falls using NASA's HiRISE images of the north polar scarps on Mars. Our method is based on a Support Vector Machine (SVM), trained using Histograms of Oriented Gradients (HOG), and on blob detection. The SVM detects potential new blocks between a set of images; the blob detection, then, confirms the identification of a block inside the area indicated by the SVM and derives the shape of the block. The results from the automatic analysis were compared with block statistics from visual inspection. We tested our method in 6 areas consisting of 1000x1000 pixels, where several hundreds of blocks were identified. The results for the given test areas produced a true positive rate of ~75% for blocks with sizes larger than 0.7 m (i.e., approx. 3 times the available ground pixel size) and a false discovery rate of ~8.5%. Using blob detection we also recover the size of each block within 3 pixels of their actual size

Morphology of the recently re-classified Tasman masked booby (Sula dactylatra tasmani) breeding on the Kermadec Islands

Once thought to be extinct, the Tasman Booby Sula tasmani has recently been re-classified as a subspecies of the Masked Booby S. dactylatra on the basis of genetic data. This re-classification raises the issue of whether this novel clade has a distinct morphology. Morphological differences in size, as well as coloration of integuments, bill and iris have been found in other subspecies of the Masked Booby but have not yet been reported for live Kermadec Islands breeding individuals. Museum specimens from this breeding location have been separated from other Pacific breeding subspecies by their longer wings. We sampled a total of 21 individuals from North Meyer Islet, Kermadec Group, New Zealand, and applied molecular sexing to obtain sex-specific morphometric measurements. We matched dimorphism in vocalization with genetic sexing results and photographic documentation of human-assessed bill, foot and eye coloration. While culmen measurements were consistent with reports from museum specimens, wing chords from living specimens of Tasman Masked Boobies were 3% and 4% larger in males and females, respectively. Females had larger culmens and wings than males, consistent with the low extent of sexual dimorphism reported from museum skins. Adult Tasman Masked Boobies had yellow to buff-yellow feet, while fledglings, as in most sulids, had grey to greyish-yellow feet. Our findings confirm the distinctively long wing and particular iris coloration previously reported for the taxon and provide the first description of integument coloration of live specimens. This study highlights the importance of including in situ assessment in taxon descriptions

The neural correlates of childhood maltreatment and the ability to understand mental states of others

$\textbf{Background}$: Emotional abuse and emotional neglect are related to impaired interpersonal functioning. One underlying mechanism could be a developmental delay in mentalizing, the ability to understand other people’s thoughts and emotions. $\textbf{Objective}$: This study investigates the neural correlates of mentalizing and the specific relationship with emotional abuse and neglect whilst taking into account the level of sexual abuse, physical abuse and physical neglect. $\textbf{Method}$: The RMET was performed in an fMRI scanner by 46 adolescents (Age: $\textit{M}$ = 18.70, $\textit{SD}$ = 1.46) who reported a large range of emotional abuse and/or emotional neglect. CM was measured using a self-report questionnaire (CTQ). $\textbf{Results}$: Neither severity of emotional abuse nor neglect related to RMET accuracy or reaction time. The severity of sexual abuse was related to an increased activation of the left IFG during mentalization even when controlled for psychopathology and other important covariates. This increased activation was only found in a group reporting both sexual abuse and emotional maltreatment and not when reporting isolated emotional abuse or neglect or no maltreatment. Functional connectivity analysis showed that activation in the left IFG was associated with increased activation in the right insula and right STG, indicating that the IFG activation occurs in a network relevant for mentalizing. $\textbf{Conclusions}$: Being sexually abused in the context of emotional abuse and neglect is related to an increase in activation of the left IFG, which may indicate a delayed development of mirroring other people’s thoughts and emotions. Even though thoughts and emotions were correctly decoded from faces, the heightened activity of the left IFG could be an underlying mechanism for impaired interpersonal functioning when social situations are more complex or more related to maltreatment experiences.This work was supported by The Netherlands Organisation for Scientific Research (NWO)-E.A.C., VICI-grant [453-14- 001], B.M.E., VIDI-grant [016-085-353], A.L.v.H., Rubicon grant [446-13-006] and by the Royal Society-A.L.v.H., Dorothy Hodgkin Fellowship [DH150176]

Dual mechanism of brain injury and novel treatment strategy in maple syrup urine disease

Maple syrup urine disease (MSUD) is an inherited disorder of branched-chain amino acid metabolism presenting with lifethreatening cerebral oedema and dysmyelination in affected individuals. Treatment requires life-long dietary restriction and monitoring of branched-chain amino acids to avoid brain injury. Despite careful management, children commonly suffer metabolic decompensation in the context of catabolic stress associated with non-specific illness. The mechanisms underlying this decompensation and brain injury are poorly understood. Using recently developed mouse models of classic and intermediate maple syrup urine disease, we assessed biochemical, behavioural and neuropathological changes that occurred during encephalopathy in these mice. Here, we show that rapid brain leucine accumulation displaces other essential amino acids resulting in neurotransmitter depletion and disruption of normal brain growth and development. A novel approach of administering norleucine to heterozygous mothers of classic maple syrup urine disease pups reduced branched-chain amino acid accumulation in milk as well as blood and brain of these pups to enhance survival. Similarly, norleucine substantially delayed encephalopathy in intermediate maple syrup urine disease mice placed on a high protein diet that mimics the catabolic stress shown to cause encephalopathy in human maple syrup urine disease. Current findings suggest two converging mechanisms of brain injury in maple syrup urine disease including: (i) neurotransmitter deficiencies and growth restriction associated with branchedchain amino acid accumulation and (ii) energy deprivation through Krebs cycle disruption associated with branched-chain ketoacid accumulation. Both classic and intermediate models appear to be useful to study the mechanism of brain injury and potential treatment strategies for maple syrup urine disease. Norleucine should be further tested as a potential treatment to prevent encephalopathy in children with maple syrup urine disease during catabolic stress

Targeted HIV-1 Latency Reversal Using CRISPR/Cas9-Derived Transcriptional Activator Systems

CRISPR/Cas9 technology is currently considered the most advanced tool for targeted genome engineering. Its sequence-dependent specificity has been explored for locus-directed transcriptional modulation. Such modulation, in particular transcriptional activation, has been proposed as key approach to overcome silencing of dormant HIV provirus in latently infected cellular reservoirs. Currently available agents for provirus activation, so-called latency reversing agents (LRAs), act indirectly through cellular pathways to induce viral transcription. However, their clinical performance remains suboptimal, possibly because reservoirs have diverse cellular identities and/or proviral DNA is intractable to the induced pathways. We have explored two CRISPR/Cas9-derived activator systems as targeted approaches to induce dormant HIV-1 proviral DNA. These systems recruit multiple transcriptional activation domains to the HIV 5'long terminal repeat (LTR), for which we have identified an optimal target region within the LTR U3 sequence. Using this target region, we demonstrate transcriptional activation of proviral genomes via the synergistic activation mediator complex in various in culture model systems for HIV latency. Observed levels of induction are comparable or indeed higher than treatment with established LRAs. Importantly, activation is complete, leading to production of infective viral particles. Our data demonstrate that CRISPR/Cas9-derived technologies can be applied to counteract HIV latency and may therefore represent promising novel approaches in the quest for HIV elimination

The neural correlates of childhood maltreatment and the ability to understand mental states of others

New methods for child psychiatric diagnosis and treatment outcome evaluatio

Evolution of cooperation without reciprocity

A long-standing problem in biological and social sciences is to understand the conditions required for the emergence and maintenance of cooperation in evolving populations. For many situations, kin selection(1) is an adequate explanation, although kin-recognition may still be a problem. Explanations of cooperation between non-kin include continuing interactions that provide a shadow of the future (that is, the expectation of an ongoing relationship) that can sustain reciprocity(2-4), possibly supported by mechanisms to bias interactions such as embedding the agents in a two-dimensional space(4-6) or other context-preserving networks(7). Another explanation, indirect reciprocity(8), applies when benevolence to one agent increases the chance of receiving help from others. Here we use computer simulations to show that cooperation can arise when agents donate to others who are sufficiently similar to themselves in some arbitrary characteristic. Such a characteristic, or 'tag', can be a marking, display, or other observable trait. Tag-based donation can lead to the emergence of cooperation among agents who have only rudimentary ability to detect environmental signals and, unlike models of direct(3,4) or indirect reciprocity(9,10), no memory of past encounters is required.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/62686/1/414441a0.pd

An Extremely Elongated Cloud over Arsia Mons Volcano on Mars: I. Life Cycle

We report a previously unnoticed annually repeating phenomenon consisting of the daily formation of an extremely elongated cloud extending as far as 1800 km westward from Arsia Mons. It takes place in the Solar Longitude (Ls) range of ~220-320, around the Southern solstice. We study this Arsia Mons Elongated Cloud (AMEC) using images from different orbiters, including ESA Mars Express, NASA MAVEN, Viking 2, MRO, and ISRO Mars Orbiter Mission (MOM). We study the AMEC in detail in Martian Year (MY) 34 in terms of Local Time and Ls and find that it exhibits a very rapid daily cycle: the cloud growth starts before sunrise on the western slope of the volcano, followed by a westward expansion that lasts 2.5 hours with a velocity of around 170 m/s in the mesosphere (~45 km over the areoid). The cloud formation then ceases, it detaches from its formation point, and continues moving westward until it evaporates before the afternoon, when most sun-synchronous orbiters observe. Moreover we comparatively study observations from different years (i.e. MYs 29-34) in search of interannual variations and find that in MY33 the cloud exhibits lower activity, whilst in MY34 the beginning of its formation was delayed compared to other years, most likely due to the Global Dust Storm. This phenomenon takes place in a season known for the general lack of clouds on Mars. In this paper we focus on observations, and a theoretical interpretation will be the subject of a separate paper

An Extremely Elongated Cloud Over Arsia Mons Volcano on Mars: I. Life Cycle

We report a previously unnoticed annually repeating phenomenon consisting of the daily formation of an extremely elongated cloud extending as far as 1,800 km westward from Arsia Mons. It takes place in the solar longitude (Ls) range of ∼220°–320°, around the Southern solstice. We study this Arsia Mons Elongated Cloud (AMEC) using images from different orbiters, including ESA Mars Express, NASA MAVEN, Viking 2, MRO, and ISRO Mars Orbiter Mission (MOM). We study the AMEC in detail in Martian year (MY) 34 in terms of local time and Ls and find that it exhibits a very rapid daily cycle: the cloud growth starts before sunrise on the western slope of the volcano, followed by a westward expansion that lasts 2.5 h with a velocity of around 170 m/s in the mesosphere (∼45 km over the areoid). The cloud formation then ceases, detaches from its formation point, and continues moving westward until it evaporates before the afternoon, when most sun-synchronous orbiters make observations. Moreover, we comparatively study observations from different years (i.e., MYs 29–34) in search of interannual variations and find that in MY33 the cloud exhibits lower activity, while in MY34 the beginning of its formation was delayed compared with other years, most likely due to the Global Dust Storm. This phenomenon takes place in a season known for the general lack of clouds on Mars. In this paper we focus on observations, and a theoretical interpretation will be the subject of a separate paper.This work has been supported by the Spanish project AYA2015-65041-P and PID2019-109467GB-I00 (MINECO/FEDER, UE) and Grupos Gobierno Vasco IT-1366-19. JHB was supported by ESA Contract No. 4000118461/16/ES/JD, Scientific Support for Mars Express Visual Monitoring Camera. The Aula EspaZio Gela is supported by a grant from the Diputación Foral de Bizkaia (BFA). We acknowledge support from the Faculty of the European Space Astronomy Center (ESAC). Special thanks are due to the Mars Express Science Ground Segment and Flight Control Team at ESAC and ESOC. The contributions by K.C and N.M.S were supported by NASA through the MAVEN project