Types of life strategy of people with disabilities in the perspective of labor employment

The article analyzes the concept of "life strategy", identifies the features and factors of life strategies of people with disabilities. Based on the results of the empirical research carried out by the authors, a typology of life strategies of disabled people – self-realization, adaptation, survival. Each of the selected strategies is characterized by a certain combination of components of the strategy, including the ability to solve life problems, social activity, self-esteem, value orientations of people with disabilities. The predominant strategies of working and non-working disabled people are shown.В статье проанализировано понятие «жизненная стратегия», выявлены особенности и факторы формирования жизненных стратегий людей с инвалидностью. На основе результатов эмпирического исследования, проведенного авторами, предложена типология жизненных стратегий инвалидов – самореализации, приспособления, выживания. Каждая из выделенных стратегий характеризуется определенным сочетанием компонентов стратегии, среди которых способ разрешения жизненных проблем, социальная активность, самооценка, ценностные ориентации людей с инвалидностью. Показаны преобладающие стратегии работающих и неработающих инвалидов

Comparison of Meat Composition from Offspring of Cloned and Conventionally Produced Boars

This study compares the meat composition of the offspring from boars produced by somatic cell nuclear transfer (n = 4) to that of the offspring from conventionally produced boars (n = 3). In total, 89 commercial gilts were artificially inseminated and 61 progressed to term and farrowed. All of the resulting piglets were housed and raised identically under standard commercial settings and slaughtered upon reaching market weight. Loin samples were taken from each slaughtered animal and shipped offsite for meat composition analysis. In total, loin samples from 404 animals (242 from offspring of clones and 162 from controls) were analyzed for 58 different parameters generating 14,036 and 9396 data points from offspring of clones and the controls, respectively. Values for controls were used to establish a range for each parameter. Ten percent was then added to the maximum and subtracted from the minimum of the control range, and all results within this range were considered clinically irrelevant. Of the 14,036 data points from the offspring of clones, only three points were found outside the clinically irrelevant range, two of which were within the range established by the USDA National Nutrient Database for Standard Reference, Release 18, 2005. The only outlier was the presence of Eicosadienoic acid (C20:2) in one sample which is typically present in minute quantities in pork; no reference data were found regarding this fatty acid in the USDA National Nutrient Database. In conclusion, these data indicated that meat from the offspring of clones was not chemically different than meat from controls and therefore supported the case for the safety of meat from the offspring of clones

Comparison of Meat Composition from Offspring of Cloned and Conventionally Produced Boars

This study compares the meat composition of the offspring from boars produced by somatic cell nuclear transfer (n = 4) to that of the offspring from conventionally produced boars (n = 3). In total, 89 commercial gilts were artificially inseminated and 61 progressed to term and farrowed. All of the resulting piglets were housed and raised identically under standard commercial settings and slaughtered upon reaching market weight. Loin samples were taken from each slaughtered animal and shipped offsite for meat composition analysis. In total, loin samples from 404 animals (242 from offspring of clones and 162 from controls) were analyzed for 58 different parameters generating 14,036 and 9396 data points from offspring of clones and the controls, respectively. Values for controls were used to establish a range for each parameter. Ten percent was then added to the maximum and subtracted from the minimum of the control range, and all results within this range were considered clinically irrelevant. Of the 14,036 data points from the offspring of clones, only three points were found outside the clinically irrelevant range, two of which were within the range established by the USDA National Nutrient Database for Standard Reference, Release 18, 2005. The only outlier was the presence of Eicosadienoic acid (C20:2) in one sample which is typically present in minute quantities in pork; no reference data were found regarding this fatty acid in the USDA National Nutrient Database. In conclusion, these data indicated that meat from the offspring of clones was not chemically different than meat from controls and therefore supported the case for the safety of meat from the offspring of clones

The DNDN, πΣc\pi \Sigma_c interaction in finite volume and the Λc(2595)\Lambda_c(2595) resonance

In this work the interaction of the coupled channels $DN$ and $\pi \Sigma_c$ in an SU(4) extrapolation of the chiral unitary theory, where the $\Lambda_c(2595)$ resonance appears as dynamically generated from that interaction, is extended to produce results in finite volume. Energy levels in the finite box are evaluated and, assuming that they would correspond to lattice results, the inverse problem of determining the phase shifts in the infinite volume from the lattice results is solved. We observe that it is possible to obtain accurate $\pi \Sigma_c$ phase shifts and the position of the $\Lambda_c(2595)$ resonance, but it requires the explicit consideration of the two coupled channels. We also observe that some of the energy levels in the box are attached to the closed $DN$ channel, such that their use to induce the $\pi \Sigma_c$ phase shifts via L\"uscher's formula leads to incorrect results.Comment: 10 pages, 13 figures, accepted for publication in Eur. Phys. J.

Matrix elements of unstable states

Using the language of non-relativistic effective Lagrangians, we formulate a systematic framework for the calculation of resonance matrix elements in lattice QCD. The generalization of the L\"uscher-Lellouch formula for these matrix elements is derived. We further discuss in detail the procedure of the analytic continuation of the resonance matrix elements into the complex energy plane and investigate the infinite-volume limit

Differential Differences in Methylation Status of Putative Imprinted Genes among Cloned Swine Genomes

DNA methylation is a major epigenetic modification in the mammalian genome that regulates crucial aspects of gene function. Mammalian cloning by somatic cell nuclear transfer (SCNT) often results in gestational or neonatal failure with only a small proportion of manipulated embryos producing live births. Many of the embryos that survive to term later succumb to a variety of abnormalities that are likely due to inappropriate epigenetic reprogramming. Aberrant methylation patterns of imprinted genes in cloned cattle and mice have been elucidated, but few reports have analyzed the cloned pig genome. Four surviving cloned sows that were created by ear fibroblast nuclear transfer, each with a different life span and multiple organ defects, such as heart defects and bone growth delay, were used as epigenetic study materials. First, we identified four putative differential methylation regions (DMR) of imprinted genes in the wild-type pig genome, including two maternally imprinted loci (INS and IGF2) and two paternally imprinted loci (H19 and IGF2R). Aberrant DNA methylation, either hypermethylation or hypomethylation, commonly appeared in H19 (45% of imprinted loci hypermethylated vs. 30% hypomethylated), IGF2 (40% vs. 0%), INS (50% vs. 5%), and IGF2R (15% vs. 45%) in multiple tissues from these four cloned sows compared with wild-type pigs. Our data suggest that aberrant epigenetic modifications occur frequently in the genome of cloned swine. Even with successful production of cloned swine that avoid prenatal or postnatal death, the perturbation of methylation in imprinted genes still exists, which may be one of reason for their adult pathologies and short life. Understanding the aberrant pattern of gene imprinting would permit improvements in future cloning techniques

Tissue engineering, stem cells, cloning, and parthenogenesis: new paradigms for therapy

Patients suffering from diseased and injured organs may be treated with transplanted organs. However, there is a severe shortage of donor organs which is worsening yearly due to the aging population. Scientists in the field of tissue engineering apply the principles of cell transplantation, materials science, and bioengineering to construct biological substitutes that will restore and maintain normal function in diseased and injured tissues. Both therapeutic cloning (nucleus from a donor cell is transferred into an enucleated oocyte), and parthenogenesis (oocyte is activated and stimulated to divide), permit extraction of pluripotent embryonic stem cells, and offer a potentially limitless source of cells for tissue engineering applications. The stem cell field is also advancing rapidly, opening new options for therapy. The present article reviews recent progress in tissue engineering and describes applications of these new technologies that may offer novel therapies for patients with end-stage organ failure

Quark-mass dependence in ω→3π\omega\to3\pi decays

We study the quark-mass dependence of $\omega\to3\pi$ decays, based on a dispersion-theoretical framework. We rely on the quark-mass-dependent scattering phase shift for the pion-pion $P$-wave extracted from unitarized chiral perturbation theory. The dispersive representation then takes into account the final-state rescattering among all three pions. The described formalism may be used as an extrapolation tool for lattice QCD calculations of three-pion decays, for which $\omega\to3\pi$ can serve as a paradigm case.Comment: 12 pages, 8 figures; v2: added two references, version published in EPJ