Restrain On Social Networks From Conjecture Attacks

These Social networks allow their members to connect by means of various web linkes  in which the We study the problem of privacy-preservation in social networks. Now-a-days the use of social networks among the people has become more popular. With the impact of social networks on society, the people become more sensitive regarding privacy issues in the common networks. Anonymization of the social networks (MySpace, Facebook, Twitter and Orkut) is essential to preserve privacy of informations gathered by the social networks. Collection of techniques that use node attributes and the link structure to refine classifications.Uses local classifiers to establish a set of priors for each nodeUses traditional relational classifiers as the iterative step in classification

Neuroprotective effect of secretin in chronic hypoxia induced neurodegeneration in rats

Background: Hypoxia is a condition in any stage in the delivery of oxygen to cells which include decreased partial pressures of oxygen, less diffusion of oxygen in the lungs, insufficient hemoglobin, inefficient blood flow to the end tissue, and breathing rhythm. Secretin is an amino acid which plays proper functioning of gastro intestinal system.Methods: The current study was conducted to evaluvate the effect of exogenously administrated secretin on chronic hypoxic damage of brain in rat model. Experimental design consists of control animals, Control animals + secretin hypoxia exposed animals; hypoxia exposed animals +secretin (20ng/kg.bw).Results: The results of this study point to a possible role of Secretin as neuroprotectant.Conclusions: Further research on secretin needs to be conducted in order to confirm the deductions made by this study

Facts and Treatment of Bullous Pemphigoid: A Review

Bullous pemphigoid (a type of pemphigoid) is an autoimmune pruritic skin disease that typically occurs in people aged over 60, that may involve the formation of blisters (bullae) in the space between the epidermal and dermal skin layers. It is classified as a type II hypersensitivity reaction, which involves formation of anti-hemidesmosome antibodies, causing a loss of keratinocytes to basement membrane adhesion. Pemphigus and bullous pemphigoid are autoantibody-mediated blistering skin diseases. In pemphigus, keratinocytes in epidermis and mucous membranes lose cell-cell adhesion, and in pemphigoid, the basal keratinocytes lose adhesion to the basement membrane. Pemphigus lesions are mediated directly by the autoantibodies, whereas the autoantibodies in pemphigoid fix complement and mediate inflammation. In both diseases, the autoantigens have been cloned and characterized; pemphigus antigens are desmogleins (cell adhesion molecules in desmosomes), and pemphigoid antigens are found in hemidesmosomes (which mediate adhesion to the basement membrane). This knowledge has enabled diagnostic testing for these diseases by enzyme-linked immunosorbent assays and dissection of various pathophysiological mechanisms, including direct inhibition of cell adhesion, antibody-induced internalization of antigen, and cell signaling. Understanding these mechanisms of disease has led to rational targeted therapeutic strategies

Contributions of the international plant science community to the fight against infectious diseases in humans-part 2: Affordable drugs in edible plants for endemic and re-emerging diseases.

The fight against infectious diseases often focuses on epidemics and pandemics, which demand urgent resources and command attention from the health authorities and media. However, the vast majority of deaths caused by infectious diseases occur in endemic zones, particularly in developing countries, placing a disproportionate burden on underfunded health systems and often requiring international interventions. The provision of vaccines and other biologics is hampered not only by the high cost and limited scalability of traditional manufacturing platforms based on microbial and animal cells, but also by challenges caused by distribution and storage, particularly in regions without a complete cold chain. In this review article, we consider the potential of molecular farming to address the challenges of endemic and re-emerging diseases, focusing on edible plants for the development of oral drugs. Key recent developments in this field include successful clinical trials based on orally delivered dried leaves of Artemisia annua against malarial parasite strains resistant to artemisinin combination therapy, the ability to produce clinical-grade protein drugs in leaves to treat infectious diseases and the long-term storage of protein drugs in dried leaves at ambient temperatures. Recent FDA approval of the first orally delivered protein drug encapsulated in plant cells to treat peanut allergy has opened the door for the development of affordable oral drugs that can be manufactured and distributed in remote areas without cold storage infrastructure and that eliminate the need for expensive purification steps and sterile delivery by injection

Contributions of the international plant science community to the fight against human infectious diseases - part 1: epidemic and pandemic diseases.

Infectious diseases, also known as transmissible or communicable diseases, are caused by pathogens or parasites that spread in communities by direct contact with infected individuals or contaminated materials, through droplets and aerosols, or via vectors such as insects. Such diseases cause ~17% of all human deaths and their management and control places an immense burden on healthcare systems worldwide. Traditional approaches for the prevention and control of infectious diseases include vaccination programmes, hygiene measures and drugs that suppress the pathogen, treat the disease symptoms or attenuate aggressive reactions of the host immune system. The provision of vaccines and biologic drugs such as antibodies is hampered by the high cost and limited scalability of traditional manufacturing platforms based on microbial and animal cells, particularly in developing countries where infectious diseases are prevalent and poorly controlled. Molecular farming, which uses plants for protein expression, is a promising strategy to address the drawbacks of current manufacturing platforms. In this review article, we consider the potential of molecular farming to address healthcare demands for the most prevalent and important epidemic and pandemic diseases, focussing on recent outbreaks of high-mortality coronavirus infections and diseases that disproportionately affect the developing world

Revolutionizing Plastic Waste Management: Fuel Production from Discarded Plastics

The startling acceleration in the amount of pollution caused by plastic rubbish has created a significant ecological issue on a scale that encompasses the entire planet. This study presents a comprehensive analysis of the process of reverse engineering, which is utilized in the conversion of unwanted plastic waste into beneficial fuel products. Pyrolysis and catalytic conversion are two examples of modern technologies for thermally degrading waste plastic, and both of these processes result in the production of fuels generated from hydrocarbons as well as other valuable byproducts. This study aims to increase the generation of fuel in terms of both quantity and quality. To accomplish this, it will investigate ways in which operational parameters, catalysts, and feedstock sources can be adjusted. In addition, the economic and environmental effects of the novel method are analyzed, with a particular focus on lowering the amount of pollution caused by plastic and increasing the production of renewable energy. The findings of the study emphasize the practicability and potential of changing plastic trash into viable fuels. This is a sustainable resolution to global energy and environmental challenges, and the findings also highlight the promise of this solution. We want to emphasize how important it is to conduct continual research and development in this field in order to support the extension of these processes for general acceptance and to contribute in the construction of a future that is environmentally conscientious and sustainable. To summarize, the findings of this study indicate the possibility of employing waste plastic in the production of valuable fuel commodities. This would both address environmental concerns and provide a solution that is both practical and effective to the problem of waste plastic. This is a great resource for policymakers, scientists, and businesses that are looking for long-term answers to the problems of managing plastic trash and producing energy

Hemostatic interference of Indian king cobra (Ophiophagus hannah) venom. Comparison with three other snake venoms of the subcontinent

Unlike Naja naja, Bungarus caeruleus, Echis carinatus, and Daboia/Vipera russellii venoms, Ophiophagus hannah venom is medically ignored in the Indian subcontinent. Being the biggest poisonous snake, O. hannah has been presumed to inject several lethal doses of venom in a single bite. Lack of therapeutic antivenom to O. hannah bite in India makes any attempt to save the victim a difficult exercise. This study was initiated to compare O. hannah venom with the above said venoms for possible interference in hemostasis. Ophiophagus hannah venom was found to actively interfere in hemostatic stages such as fibrin clot formation, platelet activation/aggregation, and fibrin clot dissolution. It decreased partial thromboplastin time (aPTT), prothrombin time (PT), and thrombin clotting time (TCT). These activities are similar to that shown by E. carinatus and D. russellii venoms, and thus O. hannah venom was found to exert procoagulant activity through the common pathway of blood coagulation, while N. naja venom increased aPTT and TCT but not PT, and hence it was found to exert anticoagulant activity through the intrinsic pathway. Venoms of O. hannah, E. carinatus, and D. russellii lack plasminogen activation property as they do not hydrolyze azocasein, while they all show plasmin-like activity by degrading the fibrin clot. Although N. naja venom did not degrade azocasein, unlike other venoms, it showed feeble plasmin-like activity on fibrin clot. Venom of E. carinatus induced clotting of human platelet rich plasma (PRP), while the other three venoms interfered in agonist-induced platelet aggregation in PRP. Venom of O. hannah least inhibited the ADP induced platelet aggregation as compared to D. russellii and N. naja venoms. All these three venoms showed complete inhibition of epinephrine-induced aggregation at varied doses. However, O. hannah venom was unique in inhibiting thrombin induced aggregation

Home Appliances Controlling Using Windows Phone 7

ABSTRACT: In modern days, we must use various high-tech machineries and equipments to get our jobs done and make the life easier. These machineries should be controlled by the house owner from any location as the house owner might be away from house at workplace or travelling in a different place in the weekend. Thus a system of remote monitoring and controlling are very much necessary. Smart home is one of these types of system equipped with home appliances which we wish to control home appliances smartly from anywhere. Some products are commercially available which allow remote home appliance controlling through internet which is undoubtedly emerging. But it lacks the true sense of real mobility and security, making the remote home appliance controlling a limited term than it is supposed to be. In search of a true remote and adequately secure solution to be really effective and practicable, mobile telephony is better than any other solutions. Mobile phones have become almost an inseparable part of civil lives today. In this work we introduce a new mechanism so that the ordinary services of the mobile phones can be leveraged to communicate with and control the home appliances and make our homes a really smart one

The polyphenol 3, 4, 5-tri-hydroxy benzoic acid inhibits indian daboia russelli venom and its hemorrhagic complex induced local toxicity

Despite a long history on treatment and management of snakebite, as of now, no satisfactory cure exists to treat local toxicity, including anti-venom therapy. Several natural compounds from plants and their synthetic analogs have shown to be protective. In this study 3, 4, 5-tri-hydroxy benzoic acid, the gallic acid (GA) was tested against the local toxicity of Daboia russelli (DR) venom and its purified hemorrhagic complex (HC). GA inhibited in vitro proteolytic activity of both DR venom and HC but, it did not inhibit phospholipase activity of DR venom. GA inhibited hemorrhage, edema forming, dermo- and myonecrotic activities of both HC and DR venom in in vivo experiments. GA was particularly effective against hemorrhagic activity but, GA inhibition had a greater effect on HC when compared to DR venom. The inhibition was likely due to GA induced structural changes in HC as revealed by alterations in fluorescence emission and CD spectral properties. However, the inhibition was not due to chelating property of GA as suggested by UV-visible spectral studies. Inhibition of collagen type IV, laminin and fibronectin degradation essentially provided the biochemical basis for GA which inhibited local effects of HC as well as DR venom. Thus, the study appears highly promising to explore GA and its generics against ruthless local effects and perhaps systemic hemorrhage of DR and other snake bites as well. Further, these agents will possibly find an immense value in the regulation of matrix metalloproteases (MMPs) in processes such as wound healing, inflammation and in the treatment of cancer

Projected Changes in Climate Over Cauvery Delta Zone of Tamil Nadu in Southern India

Climate change, as well as an increase in extreme weather, are posing a serious threat to socioeconomic and livelihood security. For this study, the Cauvery delta zone (CDZ) was chosen to examine current and anticipated climate variability and trend. The four largest districts of Tamil Nadu's Cauvery delta region are Thanjavur, Thiruvarur, Mayiladuthurai, and Nagapattinam. The Indian meteorological agency provided the baseline data sets (IMD). Using IPCC AR5 RCP4.5 and RCP8.5 scenarios, the maximum and minimum temperatures, as well as precipitation, were investigated. The maximum temperature could rise to 1.1oC to 3.6oC, while the minimum temperature could rise to 2.8 to 4.5oC, according to the findings. It was also concluded that there will be 15-16% rise in the rainfall during end of the century