Between Juan de Ávila and Teresa de Jesús: Philological notes about his correspondence

En este artículo se analizan varias versiones de la segunda carta enviada por Juan de Ávila a Teresa de Jesús en el año 1568, en la que se encuentra una aprobación del Libro de la vida de la carmelita. Con el fin de realizar una aproximación a su relación epistolar, se ofrecen algunos textos coetáneos que permiten comprender mejor su contenido y sus circunstancias. Finalmente, las variantes localizadas en las dos tradiciones textuales propuestas testifican la necesidad del análisis crítico y filológico de los textos de nuestra tradición literariaThis article discusses several versions of the second letter sent in the year 1568 by John of Ávila to Teresa de Jesús, which contains an approval of The book of the life of the Carmelite nun. In order to make an approach to his epistolary relationship, some contemporary texts that can provide meaning into its content and its circumstances are offered. Finally, the variants located in the two textual traditions proposed attest to the need for the critical and philological analysis of the texts of our literary traditio

Eficacia del diclofenaco tópico vs. nepafenaco tópico en la reducción del dolor durante la fotocoagulación panretiniana

ResumenPropósitoComparar la eficacia del diclofenaco tópico 0.1% vs. nepafenaco tópico en reducir el dolor asociado a la fotocoagulación panretiniana con láser argón.Material y métodosEnsayo clínico aleatorizado doble enmascarado, 132 pacientes (183 ojos) con diagnóstico de retinopatía diabética proliferativa tratados con fotocoagulación panretiniana. Aleatorización en 2 grupos: diclofenaco y nepafenaco tópicos. Se aplicaron 2 dosis de los analgésicos tópicos previas a la fotocoagulación panretiniana, se evaluó el dolor inmediatamente y 15min después. Se analizó nivel de dolor, efectos adversos y síntomas asociados al finalizar la fotocoagulación retiniana.ResultadosLa mediana de la edad para ambos grupos fue de 55 años, relación H:M de 1:1.4. El nivel de dolor inmediato fue de 35.5 (RIC 14-72) para el nepafenaco y de 45 (RIC 14-70) para el diclofenaco (p=0.48). A los 15min fue de 30 (RIC 4-50) para el nepafenaco y de 20 (RIC 2-50) para el diclofenaco (p=0.48). No hubo diferencias significativas en síntomas asociados entre los grupos ni efectos adversos en la superficie ocular.ConclusionesEl tratamiento previo con nepafenaco y diclofenaco tópicos es igualmente eficaz y seguro para reducir el dolor asociado a la fotocoagulación panretiniana en pacientes con retinopatía diabética proliferativa.AbstractPurposeTo compare the efficacy of topical diclofenac 0.1% vs topical nepafenac in reducing pain associated to argon laser retinal photocoagulationMaterial and methodsDouble blinded, randomized clinical trial. One hundred thirty two patients with diagnosis of proliferative diabetic retinopathy treated with retinal photocoagulation. Randomization in to 2 groups: topical diclofenac and nepafenac. Before retinal photocoagulation 2 doses of topical non-steroidal anti-inflammatory drugs were applied, pain was assessed immediately and 15minutes after. Level of pain, adverse effects and associated symptoms at the end of retinal photocoagulation were analyzed.ResultsThe median for age in both groups was 55 years, M:F ratio of 1:1.4. The immediate level of pain was 35.5 (ICR 14-72) for nepafenac and 45 (ICR 14-70) for diclofenac (P=.48). At 15minutes the pain level was 30 (ICR 4-50) for nepafenac and 20 (ICR 2-50) for diclofenac. There was no difference in associated symptoms or adverse effects among groups.ConclusionsThe preventive treatment with topical nepafenac and diclofenac is equally effective and safe for reducing the pain associated with retinal photocoagulation in patients with proliferative diabetic retinopathy

Drought influence over radial growth of Mexican conifers inhabiting mesic and xeric sites

Drought is a major constraint of forest productivity and tree growth across diverse habitat types. In this study, we investigated the drought responses of four conifer species growing within two locations of differing elevation and climatic conditions in northern Mexico. Two species were selected at a mesic site (Cupressus lusitanica Mill., Abies durangensis Martínez) and the other two species were sampled at a xeric site (Pinus engelmannii Carr., Pinus cembroides Zucc.). Using a dendrochronological approach, we correlated the radial-growth series of each species and the climatic variables. All study species positively responded to wet-cool conditions during winter and spring. Despite the close proximity of species at a mesic site, A. durangensis had high responsiveness to hydroclimatic variability, but C. lusitanica was not responsive. At the xeric site, P. engelmannii and P. cembroides were very responsive to drought severity, differentiated only by the longer time scale of the response to accumulated drought of P. engelmannii. The responsiveness to hydroclimate and drought of these tree species seems to be modulated by site conditions, or by the functional features of each species that are still little explored. These findings indicate that differentiating between mesic and xeric habitats is a too coarse approach in diverse forests with a high topographic heterogeneity.Fil: Pompa García, Marín. Universidad Juárez; MéxicoFil: González Cásares, Marcos. Universidad Juárez; MéxicoFil: Acosta Hernández, Andrea C.. Universidad Juárez; MéxicoFil: Camarero, Jesús Julio. Instituto Pirenaico de Ecología; EspañaFil: Rodriguez Catón, Milagros Rocío. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Provincia de Mendoza. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales. Universidad Nacional de Cuyo. Instituto Argentino de Nivología, Glaciología y Ciencias Ambientales; Argentin

Farmacoeconomía de la terapia biológica de las espondiloartropatías

Las espondiloartropatías (EAS) son un grupo de enfermedades reumatológicas crónicas e inflamatorias. El diagnóstico de estas patologías frecuentemente es tardío; su curso evolutivo es progresivo, con el consecuente deterioro funcional y discapacidad, con compromiso articular que conlleva a la disminución en la calidad de vida con un alto impacto socioeconómico. La mayoría de los estudios farmacoeconómicos se enfocan en los aspectos de la sociedad o del proveedor de los servicios de salud, y sólo una minoría toma en cuenta la perspectiva del paciente, de donde se pueden estimar los recursos médicos directos e indirectos que el paciente y su familia destinan al tratamiento de la enfermedad. La terapia biológica ha demostrado control de todos los aspectos de la actividad de la enfermedad, incluyendo reactantes de fase aguda, dolor y rigidez, capacidad funcional, movilidad espinal, artritis periférica y entesitis

An Implemented of a Real-Time Experimental Setup for Robotic Teleoperation System

The development of this work presents the implementation of an experimental platform, which will permit to investigate on a methodology for the design and analysis of a teleoperated system, considering the delay in the communication channel. The project has been developed in partnership with the laboratory of Automatic and Robotics of the Universidad Politécnica de Madrid and the Laboratory at the Centro de Tecnologías Avanzadas de Manufactura at the Pontificia Universidad Católica del Perú. The mechanical structure of the arm that is located in the remote side has been built and the electric servomechanism has been mounted to control their movement. The experimental test of the Teleoperation system has been developed. The PC104 card commands the power interface and sensors of the DC motor of each articulation of the arm. Has developed the drives for the management of the operations of the master and the slave: send/reception of position, speed, acceleration and current data through a CAN network. The programs for the interconnection through a LAN network, between the Windows Operating System and the Real-time Operating System (QNX), has been developed. The utility of the developed platform (hardware and software) has been demonstrated

Large solutions to an anisotropic quasilinear elliptic problem

In this paper we consider existence, asymptotic behavior near the boundary and uniqueness of positive solutions to the problem: divx(|∇xu| p−2∇xu)(x, y) + divy(|∇yu| q−2∇yu)(x, y) = u r (x, y) in a bounded domain Ω⊂RN×RMΩ⊂RN×RM together with the boundary condition u (x, y) = ∞ on ∂Ω. We prove that the necessary and sufficient condition for the existence of a solution u∈W1,p,qloc(Ω)u∈Wloc1,p,q(Ω) to this problem is r > max{p−1, q−1}. Assuming that r > q−1 ≥ p−1 > 0 we will show that the exponent q controls the blow-up rates near the boundary in the sense that all points of ∂Ω share the same profile, that depends on q and r but not on p, with the sole exception of the vertical points (where the exponent p plays a role).Fil: García Melián, Jorge. Universidad de la Laguna; EspañaFil: Rossi, Julio Daniel. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Matemática; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Sabina de Lis, José C.. Universidad de la Laguna; Españ

EPICOG-SCH: A brief battery to screen cognitive impact of schizophrenia in stable outpatients

Brief batteries in schizophrenia, are needed to screen for the cognitive impact of schizophrenia. We aimed to validate and co-norm the Epidemiological Study of Cognitive Impairment in Schizophrenia (EPICOG-SCH) derived brief cognitive battery. A cross-sectional outpatient evaluation was conducted of six-hundred-seventy-two patients recruited from 234 centers. The brief battery included well-known subtests available worldwide that cover cognitive domains related to functional outcomes: WAIS-III-Letter-Number-Sequencing-LNS, Category Fluency Test-CFT, Logical-Memory Immediate Recall-LM, and Digit-Symbol-Coding-DSC. CGI-SCH Severity and WHO-DAS-S were used to assess clinical severity and functional impairment, respectively. Unit Composite Score (UCS) and functional regression-weighted Composite Scores (FWCS) were obtained; discriminant properties of FWCS to identify patients with different levels of functional disability were analyzed using receiver-operating characteristic (ROC) technique. The battery showed good internal consistency, Cronbach's alpha = 0.78. The differences between cognitive performance across CGI-SCH severity level subscales ranged from 0.5 to 1 SD. Discriminant capacity of the battery in identifying patients with up to moderate disability levels showed fair discriminant accuracy with areas under the curve (AUC) > 0.70, p < 0.0001. An FWCS mean cut-off score ≥ 100 showed likelihood ratios (LR) up to 4.7, with an LR+ of 2.3 and a LR− of 0.5. An FWCS cut-off ≥ 96 provided the best balance between sensitivity (0.74) and specificity (0.62). The EPICOG-SCH proved to be a useful brief tool to screen for the cognitive impact of schizophrenia, and its regression-weighted Composite Score was an efficient complement to clinical interviews for confirming patients' potential functional outcomes and can be useful for monitoring cognition during routine outpatient follow-up visits

Robust Timing Synchronization for Multicarrier Systems Based on RST Invariance

In this paper, a blind robust timing synchronization method, based on invariance properties and cyclostationarity, for multicarrier systems such as Orthogonal Frequency Division Multiplexing (OFDM) is proposed and evaluated. Its results outperform the state-of-the-art for blind methods, specially in hard wireless channels where our proposal is highly superior. It even surpasses the performance of most of non-blind (pilot-aided) methods, while at the same time, it gets the advantages of energy and bandwidth saving of blind proposals. Moreover, since this technique does not require the use of pilots, it can be easily applied to either packet-based or broadcasting systems.This work has been partly funded by the Spanish national projects GRE3N-SYST (TEC2011-29006-C03-03) and COMONSENS (CSD2008-00010).Publicad

Efecto de la crisis económica sobre el consumo de psicofármacos en Asturias

ResumenObjetivoEvaluar si la crisis económica de 2008ha comportado cambios en la evolución del consumo de ansiolíticos, hipnótico-sedantes y antidepresivos en Asturias.MétodoEstudio descriptivo y de utilización de medicamentos durante 2003-2013. Se calcularon las dosis diarias definidas por 1000 habitantes/día (DHD) de ansiolíticos, hipnótico-sedantes y antidepresivos. Se obtuvieron coeficientes de regresión lineal (b) de las DHD de la etapa precrisis (2003-2008) y de la etapa de crisis (2009-2013).ResultadosEl consumo de ansiolíticos creció un 40,25%, el de hipnóticos un 88,11% y el de antidepresivos un 80,93%. Para los ansiolíticos: b-(2003-2008)=4,38 DHD/año y b-(2009-2013)=1,08 DHD/año. Para los hipnótico-sedantes: b-(2003-2008)=2,30 DHD/año y b-(2009-2013)=0,40 DHD/año. Para los antidepresivos: b-(2003-2008)=5,79 DHD/año y b-(2009-2013)=2,83 DHD/año.ConclusionesEl incremento del consumo para los tres subgrupos en la época de crisis fue menor que en la época precrisis. No se confirma que la crisis económica haya influido aumentando el consumo de estos medicamentos.AbstractObjectiveTo assess whether the economic crisis of 2008 has changed the consumption of anxiolytics, hypnotics-sedatives and antidepressants in Asturias (Spain).MethodWe conducted a descriptive study of drug use from 2003 -2013. The defined daily doses of 1000 inhabitants per day (DHD) were calculated for anxiolytics, hypnotics-sedatives and antidepressants. Linear regression coefficients (b) of the DHD were obtained for the pre-crisis period (2003-2008) and the crisis period (2009-2013).ResultsThe consumption of anxiolytics increased by 40.25%, that of hypnotics by 88.11% and that of antidepressants by 80.93%. For anxiolytics: b-(2003-2008)=4.38 DDI/year and b-(2009-2013)=1.08 DDI/year. For hypnotics-sedatives: b-(2003-2008)=2.30 DDI/year and b-(2009-2013)=0.40 DDI/year. For antidepressants: b-(2003-2008)=5.79 DDI/year and b-(2009-2013)=2.83 DDI/year.ConclusionsThe rise in consumption of the three subgroups during the crisis period was lower than that of the pre-crisis period. This study does not confirm the influence of the economic crisis on the rise in consumption of these drugs