Correlations between acoustic and electrochemical measurements for metallic corrosion on steel strings used in guitars

The corrosion state of steel guitar strings and their morphology were evaluated according to exposure time to artificial human sweat solution. The instantaneous corrosion rate was evaluated using polarization resistance. Electrochemical impedance spectroscopy was used to measure the strings' state due to corrosion in artificial human sweat solution. Modification of vibroacoustic parameters was analyzed: changes in harmonic content of sound were studied by means of the Fast Fourier Transform and spectrograms. The correlation between corrosion and acoustic measurements was established in the successive stages of corrosion. Thus, the strings' acoustic properties could be modified by means of controlled corrosion processes. (C) 2015 Elsevier Ltd. All rights reserved.The authors wish to thank to the Spanish Ministerio de Ciencia e Innovacion (contract CTM2011-23583) for the financial support.López Muelas, JL.; Bonastre Cano, JA.; Segura Alcaraz, JG.; Gadea Borrell, JM.; Juliá Sanchis, E.; Cases Iborra, FJ. (2015). Correlations between acoustic and electrochemical measurements for metallic corrosion on steel strings used in guitars. Engineering Failure Analysis. 57:270-281. https://doi.org/10.1016/j.engfailanal.2015.07.014S2702815

A functional variant of TLR10 modifies the activity of NFkB and may help predict a worse prognosis in patients with rheumatoid arthritis

Background: Toll-like receptor (TLR) family members are key players in inflammation. TLR10 has been poorly studied in chronic inflammatory disorders, and its clinical relevance in rheumatoid arthritis (RA) is as yet unknown. We aimed at identifying TLR10 variants within all coding regions of the gene in patients with RA as well as studying their functional and clinical significance. Methods: TLR10 gene variants were studied by performing sequencing of 66 patients with RA and 30 control subjects. A selected variant, I473T, was then analyzed in 1654 patients and 1702 healthy control subjects. The capacity of this TLR10 variant to modify the transcriptional activity of nuclear factor kappa-light-chain-enhancer of activated B cells (NFkB) was determined by using a luciferase reporter assay and analyzing the expression of NFkB target genes by quantitative polymerase chain reaction. Differences between groups were analyzed by using the Mann-Whitney U test and the unpaired two-tailed Student’s t test. Results: We detected ten missense variants in the TLR10 gene and focused on the I473T substitution based on allele frequencies and the predicted functional impact. I473T variant is not associated with susceptibility to RA, but it significantly correlates with erosive disease in patients seropositive for antibodies to citrullinated protein antigens (p = 0.017 in the total cohort and p = 0.0049 in female patients) and with a lower response to infliximab treatment as measured by the change in Disease Activity Score in 28 joints (p = 0.012) and by the European League Against Rheumatism criteria (p = 0.049). Functional studies showed that TLR10 reduced activation of the NFkB inflammatory pathway in hematopoietic cells, whereas the I473T variant lacked this inhibitory capacity. Consistently, after exposure to infliximab, cells expressing the I437T variant showed higher NFkB activity than cells carrying wild-type TLR10. Conclusions: A TLR10 allelic variant, I473T, has impaired NFkB inhibitory activity and is highly associated with disease severity and low response to infliximab in patients with RA

Association of Functional Polymorphisms of KIR3DL1/DS1 With Behçet's Disease

Behçet's disease (BD) is an immune-mediated vasculitis related to imbalances between the innate and adaptive immune response. Infectious agents or environmental factors may trigger the disease in genetically predisposed individuals. HLA-B51 is the genetic factor stronger associated with the disease, although the bases of this association remain elusive. NK cells have also been implicated in the etiopathogenesis of BD. A family of NK receptors, Killer-cell Immunoglobulin-like Receptor (KIR), with a very complex organization, is very important in the education and control of the NK cells by the union to their ligands, most of them, HLA class I molecules. This study aimed to investigate the contribution of certain KIR functional polymorphisms to the susceptibility to BD. A total of 466 BD patients and 444 healthy individuals were genotyped in HLA class I (A, B, and C). The set of KIR genes and the functional variants of KIR3DL1/DS1 and KIR2DS4 were also determined. Frequency of KIR3DL1004 was lower in patients than in controls (0.15 vs. 0.20, P = 0.005, Pc = 0.015; OR = 0.70; 95% CI 0.54-0.90) in both B51 positive and negative individuals. KIR3DL1004, which encodes a misfolded protein, is included in a common telomeric haplotype with only one functional KIR gene, KIR3DL2. Both, KIR3DL1 and KIR3DL2 sense pathogen-associated molecular patterns but they have different capacities to eliminate them. The education of the NK cells depending on the HLA, the balance of KIR3DL1/KIR3DL2 licensed NK cells and the different capacities of these receptors to eliminate pathogens could be involved in the etiopathogenesis of BD

All-cause mortality in the cohorts of the Spanish AIDS Research Network (RIS) compared with the general population: 1997Ł2010

Abstract Background: Combination antiretroviral therapy (cART) has produced significant changes in mortality of HIVinfected persons. Our objective was to estimate mortality rates, standardized mortality ratios and excess mortality rates of cohorts of the AIDS Research Network (RIS) (CoRIS-MD and CoRIS) compared to the general population. Methods: We analysed data of CoRIS-MD and CoRIS cohorts from 1997 to 2010. We calculated: (i) all-cause mortality rates, (ii) standardized mortality ratio (SMR) and (iii) excess mortality rates for both cohort for 100 personyears (py) of follow-up, comparing all-cause mortality with that of the general population of similar age and gender. Results: Between 1997 and 2010, 8,214 HIV positive subjects were included, 2,453 (29.9%) in CoRIS-MD and 5,761 (70.1%) in CoRIS and 294 deaths were registered. All-cause mortality rate was 1.02 (95% CI 0.91-1.15) per 100 py, SMR was 6.8 (95% CI 5.9-7.9) and excess mortality rate was 0.8 (95% CI 0.7-0.9) per 100 py. Mortality was higher in patients with AIDS, hepatitis C virus (HCV) co-infection, and those from CoRIS-MD cohort (1997. Conclusion: Mortality among HIV-positive persons remains higher than that of the general population of similar age and sex, with significant differences depending on the history of AIDS or HCV coinfection

Spatiotemporal Characteristics of the Largest HIV-1 CRF02_AG Outbreak in Spain: Evidence for Onward Transmissions

Background and Aim: The circulating recombinant form 02_AG (CRF02_AG) is the predominant clade among the human immunodeficiency virus type-1 (HIV-1) non-Bs with a prevalence of 5.97% (95% Confidence Interval-CI: 5.41–6.57%) across Spain. Our aim was to estimate the levels of regional clustering for CRF02_AG and the spatiotemporal characteristics of the largest CRF02_AG subepidemic in Spain.Methods: We studied 396 CRF02_AG sequences obtained from HIV-1 diagnosed patients during 2000–2014 from 10 autonomous communities of Spain. Phylogenetic analysis was performed on the 391 CRF02_AG sequences along with all globally sampled CRF02_AG sequences (N = 3,302) as references. Phylodynamic and phylogeographic analysis was performed to the largest CRF02_AG monophyletic cluster by a Bayesian method in BEAST v1.8.0 and by reconstructing ancestral states using the criterion of parsimony in Mesquite v3.4, respectively.Results: The HIV-1 CRF02_AG prevalence differed across Spanish autonomous communities we sampled from (p < 0.001). Phylogenetic analysis revealed that 52.7% of the CRF02_AG sequences formed 56 monophyletic clusters, with a range of 2–79 sequences. The CRF02_AG regional dispersal differed across Spain (p = 0.003), as suggested by monophyletic clustering. For the largest monophyletic cluster (subepidemic) (N = 79), 49.4% of the clustered sequences originated from Madrid, while most sequences (51.9%) had been obtained from men having sex with men (MSM). Molecular clock analysis suggested that the origin (tMRCA) of the CRF02_AG subepidemic was in 2002 (median estimate; 95% Highest Posterior Density-HPD interval: 1999–2004). Additionally, we found significant clustering within the CRF02_AG subepidemic according to the ethnic origin.Conclusion: CRF02_AG has been introduced as a result of multiple introductions in Spain, following regional dispersal in several cases. We showed that CRF02_AG transmissions were mostly due to regional dispersal in Spain. The hot-spot for the largest CRF02_AG regional subepidemic in Spain was in Madrid associated with MSM transmission risk group. The existence of subepidemics suggest that several spillovers occurred from Madrid to other areas. CRF02_AG sequences from Hispanics were clustered in a separate subclade suggesting no linkage between the local and Hispanic subepidemics

Factors Related to the Intra-Partner Postnatal Sense of Security in a Spanish Sample

Background: The fathers' sense of security and their related factors during the process of parenthood remains largely unexplored. The objectives were to analyse: the psychometric properties of the Spanish version of the Parent's Postnatal Sense of Security scale used for fathers, and the factors related to fathers' sense of security during the postpartum period. Methods: A total of 583 fathers participated. The fathers' version of the questionnaire was adapted for Spanish speakers. The psychometric properties of the instrument and its relationship with the mother's sense of security were considered. Findings: The results showed that the data fit well with the original model (TLI = 0.98, CFI = 0.98, and RMSEA = 0.05). The fathers' sense of security was associated with previously having become a father (t = −2.39, p = .02), the level of state anxiety (r = −0.34; p < .01) and trait anxiety (r = −0.24; p < .01), as well as the sense of security of their partners (r = 0.55, p < .001). In the regression analysis, the mothers' sense of security construct provided the greatest explanation of the model. Discussion: The results of this study highlight the importance of considering the family unit in pre-, intra-, and postnatal education in order to increase the sense of security of both parents and reduce their anxiety levels. Application to practice: This study provides Spanish healthcare professionals with access to a scale for assessing fathers' sense of security in the immediate postpartum period and allows them to identify needs in the process of becoming parents, emphasising the inclusion of both parents in any intervention.This present study received funding from the Institute of Health Carlos III, ISCIII and the European Regional Development Fund (FEDER; grant № PI14/01549)

The Spanish version of the Mothers' Postnatal Sense of Security Scale: Psychometric properties and predictive utility

Postnatal sense of security is a relevant construct related to several variables of motherhood. However, it has not yet been studied in the Spanish context. The aims were: (a) To analyze the psychometric properties of a Spanish version of the Mothers' Postnatal Sense of Security Scale (PPSS‐S); (b) analyze the factors related to mothers' sense of security during the first 2 weeks following childbirth (sociodemographic variables and factors related to maternity); and (c) examine the predictive utility that mothers' sense of security has on symptoms of postpartum depression 6–11 months after childbirth. This was a prospective longitudinal study performed in the first 6–11 months post‐partum in four regions of Spain. A total of 928 mothers whose mean age was 33.67 years (standard deviation = 4.54) participated. The confirmatory factor analysis showed adequate adjustment to the original structure (χ2 = 17,272.79, df = 153, p < .001; Tucker–Lewis index = 0.98; comparative fit index = 0.98; root mean square error of approximation = 0.058 [0.053‐0.063])and the overall internal consistency was 0.89. Direct relationships were shown between women' sense of security and already having had a child, the absence of postpartum health complications (either in the mother or the newborn) and receiving consistent information from healthcare professionals. Our results showed adequate evidence for the reliability and validity of the Spanish version of the PPSS‐S. Understanding mothers' sense of security during the early months of motherhood, as well as related factors in the postpartum period, will allow health professionals to implement preventive measures to promote mental health and could help reduce symptoms of postpartum depression.The present study was granted by Institute of Health Carlos III, ISCIII and the European Regional Development Fund (FEDER) (No. PI14/01549)

Evaluation of the acoustic performance of a novelty cathodic protection system against guitar steel strings corrosion [Dataset]

This work was conducted to establish the efficiency of an impressed current cathodic protection system for musical instruments’ steel strings in protecting them from corrosion caused by human sweat. To conduct this research, the harmonic content degradation of a guitar string subjected to different corrosion stages by artificial human sweat, with and without cathodic protection by an impressed current, was studied. String corrosion is characterised by not only the electrochemical technique of polarisation resistance, but also by weight loss by gravimetric measurements and FESEM microscopy. From the correlation between the acoustic and electrochemical results, it can be concluded that harmonic content degradation of guitar strings increases corrosion but is less significant in the strings protected by impressed current.Funding for Open Access charge: CRUE-Universitat Politècnica de València is acknowledged.Segura Alcaraz, JG.; Bonastre Cano, JA.; Juliá Sanchis, E.; Gadea Borrell, JM.; Cases Iborra, FJ. (2024). Evaluation of the acoustic performance of a novelty cathodic protection system against guitar steel strings corrosion [Dataset]. Universitat Politècnica de València. https://doi.org/10.4995/Dataset/10251/20442

Método para predecir la respuesta clínica a un tratamiento con agentes antiinflamatorios

ABSTRACT: The present invention relates to the use of allelic variants of human TLR10, including the allelic variant of human TLR10, I473T, as biomarkers for predicting gravity or prognosis in inflammatory diseases, including rheumatoid arthritis, and/or for predicting the response to a treatment using anti-inflammatory agents such as anti-TNFα agents.RESUMEN: La presente invención se refiere al uso de variantes alélicas de TLR10 humano, incluyendo a la variante alélica de TLR10 humano I473T: como biomarcador para predecir la gravedad o el pronóstico en enfermedades inflamatorias, incluyendo la artritis reumatoide y/o para predecir la respuesta a un tratamiento con agentes antiinflamatorios, tales como agentes anti-TNFα.Solicitud: PCT/ES2017/000089 (07.07.2017)Nº de Publicación: WO2018/020060A1 (01.02.2018

The complex HLA-E-nonapeptide in Behçet disease

Introduction: The knowledge of the aetiology of Behçet disease (BD), an immune-mediated vasculitis, is limited. HLA-B, mainly HLA-B51, and HLA-A molecules are associated with disease, but the ultimate cause of this association remains obscure. There is evidence that NK cells participate in the etiopathology of BD. NK cells have activator and inhibitor surface receptors, like the KIR and the NKG2 families. Classical HLA-class I molecules (A, B and C) are keys in the activity control of the NK because they are KIR ligands. Most NKG2 receptors bind HLA-E, which presents only nonapeptides derived from the signal peptide of other class-I molecules. Objective: This study investigates the contribution of the pair HLA-E and ligand, nonapeptide derived from the 3-11 sequence of the signal peptides of class I classical molecules, to the susceptibility to BD. Methods: We analyzed the frequency of the HLA-derivated nonapeptide forms in 466 BD patients and 444 controls and an HLA-E functional dimorphism in a subgroup of patients and controls. Results: In B51 negative patients, the frequency of VMAPRTLLL was lower (70.4% versus 80.0% in controls; P=0.006, Pc=0.04, OR=0.60, 95%CI 0.41-0.86), and the frequency of VMAPRTLVL was higher (81.6% versus 71.4% in controls; P=0.004, Pc=0.03, OR=1.78, 95%CI 1.20-2.63). In homozygosity, VMAPRTLLL is protective, and VMAPRTLVL confers risk. The heterozygous condition is neutral. There were no significant differences in the distribution of the HLA-E dimorphism. Discussion: Our results explain the association of BD with diverse HLA-A molecules, reinforce the hypothesis of the involvement of the NK cells in the disease and do not suggest a significant contribution of the HLA-E polymorphism to disease susceptibility.Funding. This work was supported by Fondo de Investigaciones Sanitarias, Instituto de Salud Carlos III (ISCIII PI16/01373 and PI19/00605), Fondos FEDER and Plan Andaluz de Investigación (CTS-0197).The datasets presented in this study can be found in the online repository NCBI https://www.ncbi.nlm.nih.gov/bioproject?term= %20PRJNA100100