Plant community ecology of a major subtropical riverine floodplain

This project described the vegetation of a stretch of the Parana River and investigated which natural or human-imposed factors might be controlling its characteristics, its capacity for biodiversity support and its potential to provide an economic resource. This information is of value in the planning of management strategies aiming to conserve biodiversity and develop sustainable ways in which the floodplain resources can be utilised. Central to this study were the surveys of vegetation and environmental characteristics of aquatic, terrestrial and transitional habitats of the Parana floodplain near Porto Rico. These produced extensive data sets which helped to reveal the types of vegetation-environment relationships structuring the floodplain plant communities. To complement this investigative approach, three aspects of the functioning of floodplain vegetation were chosen for closer study. These were the impacts of livestock grazing on wetland and island vegetation, competitive interactions between pairs of free-floating aquatic plant species and the role of aquatic macrophytes in contributing carbon to aquatic food webs. Three major community types were identified in the aquatic habitats of the floodplain, one which included Eichhornia azurea in mixture with several free-floating and emergent species, a second in which E. azurea was strongly dominant and a third comprised purely of submerged species. Two strongly contrasting broad vegetation communities were identified at bank and shore environments. Polygonum and Ludwigia species were important in one group and Poaceae, creepers, woody plants and ferns in the other group. Sub-groups of these communities could also be suggested, but these are less distinct. Most of the floodplain sites supported a Poaceae-creeper community type with the remaining sites supporting a community indicated by Polygonum species. The Poaceae group was comprised of a number of sub-communities in which the importance of Poaceae relative to other species varied. The aquatic vegetation communities differed structurally with contrasting community biomass, canopy height, canopy cover, species richness and stem density. They were associated with waterbodies with different water depth and pH and different sediment nitrogen and phosphorus contents. Water flow rate category and underwent light availability also differed between the sites that tended to support the different vegetation types. The two major bank and shore vegetation communities differed in canopy cover, in the soil nitrogen, phosphorus and calcium levels with which they were associated and in the steepness of the bank on which they tended to grow. Floodplain vegetation communities contrasted in species richness and differed in the soil nitrogen and calcium levels and river systems with which they were associated

Plant community ecology of a major subtropical riverine floodplain

This project described the vegetation of a stretch of the Parana River and investigated which natural or human-imposed factors might be controlling its characteristics, its capacity for biodiversity support and its potential to provide an economic resource. This information is of value in the planning of management strategies aiming to conserve biodiversity and develop sustainable ways in which the floodplain resources can be utilised. Central to this study were the surveys of vegetation and environmental characteristics of aquatic, terrestrial and transitional habitats of the Parana floodplain near Porto Rico. These produced extensive data sets which helped to reveal the types of vegetation-environment relationships structuring the floodplain plant communities. To complement this investigative approach, three aspects of the functioning of floodplain vegetation were chosen for closer study. These were the impacts of livestock grazing on wetland and island vegetation, competitive interactions between pairs of free-floating aquatic plant species and the role of aquatic macrophytes in contributing carbon to aquatic food webs. Three major community types were identified in the aquatic habitats of the floodplain, one which included Eichhornia azurea in mixture with several free-floating and emergent species, a second in which E. azurea was strongly dominant and a third comprised purely of submerged species. Two strongly contrasting broad vegetation communities were identified at bank and shore environments. Polygonum and Ludwigia species were important in one group and Poaceae, creepers, woody plants and ferns in the other group. Sub-groups of these communities could also be suggested, but these are less distinct. Most of the floodplain sites supported a Poaceae-creeper community type with the remaining sites supporting a community indicated by Polygonum species. The Poaceae group was comprised of a number of sub-communities in which the importance of Poaceae relative to other species varied. The aquatic vegetation communities differed structurally with contrasting community biomass, canopy height, canopy cover, species richness and stem density. They were associated with waterbodies with different water depth and pH and different sediment nitrogen and phosphorus contents. Water flow rate category and underwent light availability also differed between the sites that tended to support the different vegetation types. The two major bank and shore vegetation communities differed in canopy cover, in the soil nitrogen, phosphorus and calcium levels with which they were associated and in the steepness of the bank on which they tended to grow. Floodplain vegetation communities contrasted in species richness and differed in the soil nitrogen and calcium levels and river systems with which they were associated

Urinary eicosanoid metabolites in HIV-infected women with central obesity switching to raltegravir: an analysis from the women, integrase, and fat accumulation trial.

Chronic inflammation is a hallmark of HIV infection. Eicosanoids reflect inflammation, oxidant stress, and vascular health and vary by sex and metabolic parameters. Raltegravir (RAL) is an HIV-1 integrase inhibitor that may have limited metabolic effects. We assessed urinary F2-isoprostanes (F2-IsoPs), prostaglandin E2 (PGE-M), prostacyclin (PGI-M), and thromboxane B2 (TxB2) in HIV-infected women switching to RAL-containing antiretroviral therapy (ART). Thirty-seven women (RAL = 17; PI/NNRTI = 20) with a median age of 43 years and BMI 32 kg/m(2) completed week 24. TxB2 increased in the RAL versus PI/NNRTI arm (+0.09 versus -0.02; P = 0.06). Baseline PGI-M was lower in the RAL arm (P = 0.005); no other between-arm cross-sectional differences were observed. In the PI/NNRTI arm, 24-week visceral adipose tissue change correlated with PGI-M (rho = 0.45; P = 0.04) and TxB2 (rho = 0.44; P = 0.005) changes, with a trend seen for PGE-M (rho = 0.41; P = 0.07). In an adjusted model, age ≥ 50 years (N = 8) was associated with increased PGE-M (P = 0.04). In this randomized trial, a switch to RAL did not significantly affect urinary eicosanoids over 24 weeks. In women continuing PI/NNRTI, increased visceral adipose tissue correlated with increased PGI-M and PGE-M. Older age (≥ 50) was associated with increased PGE-M. Relationships between aging, adiposity, ART, and eicosanoids during HIV-infection require further study

Islands of linkage in an ocean of pervasive recombination reveals two-speed evolution of human cytomegalovirus genomes

Human cytomegalovirus (HCMV) infects most of the population worldwide, persisting throughout the host's life in a latent state with periodic episodes of reactivation. While typically asymptomatic, HCMV can cause fatal disease among congenitally infected infants and immunocompromised patients. These clinical issues are compounded by the emergence of antiviral resistance and the absence of an effective vaccine, the development of which is likely complicated by the numerous immune evasins encoded by HCMV to counter the host's adaptive immune responses, a feature that facilitates frequent super-infections. Understanding the evolutionary dynamics of HCMV is essential for the development of effective new drugs and vaccines. By comparing viral genomes from uncultivated or low-passaged clinical samples of diverse origins, we observe evidence of frequent homologous recombination events, both recent and ancient, and no structure of HCMV genetic diversity at the whole-genome scale. Analysis of individual gene-scale loci reveals a striking dichotomy: while most of the genome is highly conserved, recombines essentially freely and has evolved under purifying selection, 21 genes display extreme diversity, structured into distinct genotypes that do not recombine with each other. Most of these hyper-variable genes encode glycoproteins involved in cell entry or escape of host immunity. Evidence that half of them have diverged through episodes of intense positive selection suggests that rapid evolution of hyper-variable loci is likely driven by interactions with host immunity. It appears that this process is enabled by recombination unlinking hyper-variable loci from strongly constrained neighboring sites. It is conceivable that viral mechanisms facilitating super-infection have evolved to promote recombination between diverged genotypes, allowing the virus to continuously diversify at key loci to escape immune detection, while maintaining a genome optimally adapted to its asymptomatic infectious lifecycle

Social Work Research in the UK: A View through the Lens of REF2021

The Research Assessment Exercise was introduced in 1986 to measure research quality and to determine the allocation of higher education funding. The renamed Research Excellence Framework (REF) has become an important barometer of research capacity and calibre across academic disciplines in UK universities. Based on the expert insights of REF sub-panel members for Unit of Assessment 20 (UOA20), Social Work and Social Policy, this article contributes to understanding of the current state of UK social work research. It documents the process of research quality assessment and reports on the current social work research landscape, including impact. Given its growing vigour, increased engagement with theory and conceptual frameworks, policy and practice and its methodological diversity, it is evident that social work research has achieved considerable consolidation and growth in its activity and knowledge base. Whilst Russell Group and older universities cluster at the top of the REF rankings, this cannot be taken for granted as some newer institutions performed well in REF2021. The article argues that the discipline’s embeddedness in interdisciplinary research, its quest for social justice and its applied nature align well with the REF framework where interdisciplinarity, equality, diversity and inclusion and impact constitute core principles

Urinary Eicosanoid Metabolites in HIV-Infected Women with Central Obesity Switching to Raltegravir: An Analysis from the Women, Integrase, and Fat Accumulation Trial

Chronic inflammation is a hallmark of HIV infection. Eicosanoids reflect inflammation, oxidant stress, and vascular health and vary by sex and metabolic parameters. Raltegravir (RAL) is an HIV-1 integrase inhibitor that may have limited metabolic effects. We assessed urinary F2-isoprostanes (F2-IsoPs), prostaglandin E2 (PGE-M), prostacyclin (PGI-M), and thromboxane B2 (TxB2) in HIV-infected women switching to RAL-containing antiretroviral therapy (ART). Thirty-seven women (RAL = 17; PI/NNRTI = 20) with a median age of 43 years and BMI 32 kg/m2 completed week 24. TxB2 increased in the RAL versus PI/NNRTI arm (+0.09 versus −0.02; P=0.06). Baseline PGI-M was lower in the RAL arm (P=0.005); no other between-arm cross-sectional differences were observed. In the PI/NNRTI arm, 24-week visceral adipose tissue change correlated with PGI-M (rho=0.45; P=0.04) and TxB2 (rho=0.44; P=0.005) changes, with a trend seen for PGE-M (rho=0.41; P=0.07). In an adjusted model, age ≥ 50 years (N=8) was associated with increased PGE-M (P=0.04). In this randomized trial, a switch to RAL did not significantly affect urinary eicosanoids over 24 weeks. In women continuing PI/NNRTI, increased visceral adipose tissue correlated with increased PGI-M and PGE-M. Older age (≥50) was associated with increased PGE-M. Relationships between aging, adiposity, ART, and eicosanoids during HIV-infection require further study

High Viral Diversity and Mixed Infections in Cerebral Spinal Fluid From Cases of Varicella Zoster Virus Encephalitis.

BACKGROUND: Varicella zoster virus (VZV) may cause encephalitis, both with and without rash. Here we investigate whether viruses recovered from the central nervous system (CNS; encephalitis or meningitis) differ genetically from those recovered from non-CNS samples. METHODS: Enrichment-based deep sequencing of 45 VZV genomes from cerebral spinal fluid (CSF), plasma, bronchoalveolar lavage (BAL), and vesicles was carried out with samples collected from 34 patients with and without VZV infection of the CNS. RESULTS: Viral sequences from multiple sites in the same patient were identical at the consensus level. Virus from vesicle fluid and CSF in cases of meningitis showed low-level diversity. By contrast, plasma, BAL, and encephalitis had higher numbers of variant alleles. Two CSF-encephalitis samples had high genetic diversity, with variant frequency patterns typical of mixed infections with different clades. CONCLUSIONS: Low viral genetic diversity in vesicle fluid is compatible with previous observations that VZV skin lesions arise from single or low numbers of virions. A similar result was observed in VZV from cases of VZV meningitis, a generally self-limiting infection. CSF from cases of encephalitis had higher diversity with evidence for mixed clade infections in 2 cases. We hypothesize that reactivation from multiple neurons may contribute to the pathogenesis of VZV encephalitis.Action Medical research GN2424 This work was supported by a UK MRC New Investigator Award to D. P. D; UCL/UCLH BRC (J. B.); Action Medical Research (grant number GN2424 to C. J. H); Swedish Research Council (P. N. and T. B.). The work was also support by an NIHR Fellowship (grant number DRF-2013-06-168 to F. M.), the Meningitis Research Foundation (grant number 0904.0), an NIHR Programme Grant in Applied Research (grant number RP-PG-0108-10048 to T. S.), and the NIHR Health Protection Research Unit in Emerging and Zoonotic Infections, University of Liverpool

Solution-processed thin film transistors incorporating YSZ gate dielectrics processed at 400 °C

This work investigates a solution process for yttria-stabilized zirconia (YSZ) thin film deposition involving the addition of yttria nanoparticles, at 400 ○C, in air. Different yttrium doping levels in the YSZ were studied and a wide range of optical, structural, surface, dielectric, and electronic transport properties were also investigated. An optimum yttrium doping level of 5% mol. resulted in the smoothest films (RRMS ∼ 0.5 nm), a wide bandgap (∼5.96 eV), a dielectric constant in excess of 26, and a leakage current of ∼0.3 nA cm−2 at 2 MV/cm. The solution-processed YSZ films were incorporated as gate dielectrics in thin films transistors with solution-processed In2O3 semiconducting channels. Excellent operational characteristics, such as negligible hysteresis, low operational voltages (5 V), electron mobility in excess of 36 cm2 V−1 s−1, high on/off current modulation ratio on the order of 107, and low interfacial trap density states (<1012 cm−2), were demonstrated. In addition, excellent film homogeneity was achieved over a large area (16 × 16 cm2), with both film thickness and capacitance deviation of <1.2%

The Rapidly Flaring Afterglow of the Very Bright and Energetic GRB 070125

We report on multi-wavelength observations, ranging from the X-ray to radio wave bands, of the IPN-localized gamma-ray burst GRB 070125. Spectroscopic observations reveal the presence of absorption lines due to O I, Si II, and C IV, implying a likely redshift of z = 1.547. The well-sampled light curves, in particular from 0.5 to 4 days after the burst, suggest a jet break at 3.7 days, corresponding to a jet opening angle of ~7.0 degrees, and implying an intrinsic GRB energy in the 1 - 10,000 keV band of around E = (6.3 - 6.9)x 10^(51) erg (based on the fluences measured by the gamma-ray detectors of the IPN network). GRB 070125 is among the brightest afterglows observed to date. The spectral energy distribution implies a host extinction of Av < 0.9 mag. Two rebrightening episodes are observed, one with excellent time coverage, showing an increase in flux of 56% in ~8000 seconds. The evolution of the afterglow light curve is achromatic at all times. Late-time observations of the afterglow do not show evidence for emission from an underlying host galaxy or supernova. Any host galaxy would be subluminous, consistent with current GRB host-galaxy samples. Evidence for strong Mg II absorption features is not found, which is perhaps surprising in view of the relatively high redshift of this burst and the high likelihood for such features along GRB-selected lines of sight.Comment: 50 pages, 9 figures, 5 tables Accepted to the Astrophysical Journa

A comprehensive evaluation of interaction between genetic variants and use of menopausal hormone therapy on mammographic density.

INTRODUCTION: Mammographic density is an established breast cancer risk factor with a strong genetic component and can be increased in women using menopausal hormone therapy (MHT). Here, we aimed to identify genetic variants that may modify the association between MHT use and mammographic density. METHODS: The study comprised 6,298 postmenopausal women from the Mayo Mammography Health Study and nine studies included in the Breast Cancer Association Consortium. We selected for evaluation 1327 single nucleotide polymorphisms (SNPs) showing the lowest P-values for interaction (P int) in a meta-analysis of genome-wide gene-environment interaction studies with MHT use on risk of breast cancer, 2541 SNPs in candidate genes (AKR1C4, CYP1A1-CYP1A2, CYP1B1, ESR2, PPARG, PRL, SULT1A1-SULT1A2 and TNF) and ten SNPs (AREG-rs10034692, PRDM6-rs186749, ESR1-rs12665607, ZNF365-rs10995190, 8p11.23-rs7816345, LSP1-rs3817198, IGF1-rs703556, 12q24-rs1265507, TMEM184B-rs7289126, and SGSM3-rs17001868) associated with mammographic density in genome-wide studies. We used multiple linear regression models adjusted for potential confounders to evaluate interactions between SNPs and current use of MHT on mammographic density. RESULTS: No significant interactions were identified after adjustment for multiple testing. The strongest SNP-MHT interaction (unadjusted P int <0.0004) was observed with rs9358531 6.5kb 5' of PRL. Furthermore, three SNPs in PLCG2 that had previously been shown to modify the association of MHT use with breast cancer risk were found to modify also the association of MHT use with mammographic density (unadjusted P int <0.002), but solely among cases (unadjusted P int SNP×MHT×case-status <0.02). CONCLUSIONS: The study identified potential interactions on mammographic density between current use of MHT and SNPs near PRL and in PLCG2, which require confirmation. Given the moderate size of the interactions observed, larger studies are needed to identify genetic modifiers of the association of MHT use with mammographic density.This is the final version of the article. It first appeared from BioMed Central via http://dx.doi.org/10.1186/s13058-015-0625-