Polarimetric Approaches for Persistent Scatterers Interferometry

In previous works, a general framework to exploit polarimetric diversity to optimize the results of persistent scatterers interferometry (PSI) was presented, but tested only with dual-pol data. In this paper, the performance of these algorithms is assessed using fully polarimetric data, acquired by the Radarsat-2 satellite over the urban area of Barcelona, Spain. In addition, two new highly efficient polarimetric optimization methods, mean intensity polarimetric optimization and joint diagonalization-based polarimetric optimization, are introduced and evaluated. Given the variety of dual-pol configurations provided by current polarimetric satellites, such as TerraSAR-X and Radarsat-2, and the upcoming launch of Sentinel-1, ALOS-2, and Radarsat Constellation Mission, a study has been also carried out to determine the best performing dual-pol configurations for polarimetric PSI. Subsidence maps of the area of study are computed for single-pol, dual-pol, and full-pol data, which show the increase in pixel density with valid deformation results as more polarimetric information is made available. In particular, for full-pol data we get an increase of up to 2.5 times more pixels for coherence-based PSI techniques (degraded resolution), and over four times more for amplitude-based approaches (full resolution), in comparison with single-pol data. Both higher density and quality of pixels yield better results in terms of coverage and accuracy.This work was supported in part by the Spanish Ministerio de Economía y Competitividad and European Union FEDER funds under Project TEC2011-28201-C02-02

Framing stakeholder considerations and business sustainability efforts : a construct, its dimensions and items

Purpose – The purpose of this paper is twofold: to determine the extent to which companies’™ efforts of sustainable business practices consider stakeholders within their organisations, business networks, the marketplace and society, and to develop and test a stakeholder construct in the context of companies’™ business sustainability efforts within their business networks, the marketplace and society by identifying underlying dimensions and items. Design/methodology/approach – A mixed-method approach was used. First, qualitative research involving a case study approach was followed so as to describe how companies in different industries in Norway implement and manage sustainable business practices. This was followed by a quantitative research phase to empirically measure and test a stakeholder construct in the context of business sustainability efforts, which is reported here. Findings – The results report both an initial factor solution as well as a refined factor solution. The factor analyses confirmed five stakeholder dimensions related to business sustainability in a cross-industry sample of organisations, their business networks, marketplace and society. These include: the focal company, downstream stakeholders, societal stakeholders, market stakeholders and upstream stakeholders. The results indicate satisfactory convergent, discriminant and nomological validity, as well as reliability of each dimension. Research limitations/implications – The study provides a stakeholder construct in the context of business sustainability efforts in focal companies and their business networks, the marketplace and society, based upon five common dimensions. The multi-dimensional framework may be used in both qualitative and quantitative research in future. It may also be used to assess stakeholders’™ business sustainability efforts. Practical implications – The multi-dimensional framework is useful for practitioners to obtain an indication of stakeholders’™ business sustainability efforts in relation to focal companies and their business networks, the marketplace and society. Originality/value – The study provides a general stakeholder construct in the context of business sustainability efforts in business networks, the marketplace and society. The proposed framework can be incorporated in further studies and could be used to assess the general status of stakeholders’™ sustainability efforts in their networks, the marketplace and society

On-Chip Solar Energy Harvester and PMU With Cold Start-Up and Regulated Output Voltage for Biomedical Applications

This paper presents experimental results from a system that comprises a fully autonomous energy harvester with a solar cell of 1 mm 2 as energy transducer and a Power Management Unit (PMU) on the same silicon substrate, and an output voltage regulator. Both chips are implemented in standard 0.18 μm CMOS technology with total layout areas of 1.575 mm 2 and 0.0126 mm 2 , respectively. The system also contains an off-the-shelf 3.2 mm × 2.5 mm × 0.9 mm supercapacitor working as an off-chip battery or energy reservoir between the PMU and the voltage regulator. Experimental results show that the fast energy recovery of the on-chip solar cell and PMU permits the system to replenish the supercapacitor with enough charge as to sustain Bluetooth Low Energy (BLE) communications even with input light powers of 510 nW. The whole system is able to self-start-up without external mechanisms at 340 nW. This work is the first step towards a self-supplied sensor node with processing and communication capabilities. The small form factor and ultra-low power consumption of the system components is in compliance with biomedical applications requirementsThis work was supported in part by the Spanish Government (Ministerio de Ciencia, Innovación y Universidades) under Project RTI2018-097088-B-C32 and Project RTI2018-095994-B-I00 (MICINN/FEDER), in part by the Xunta de Galicia, in part by the Consellería de Cultura, Educación e Ordenación Universitaria (accreditation 2016-2019, ED431G/08 and reference competitive group 2017-2020, ED431C 2017/69) and European Regional Development Fund (ERDF), and in part by the Junta de Extremadura and the ERDF, under Grant IB 18079S

A triple bottom line construct and reasons for implementing sustainable business practices in companies and their business networks

Purpose – The purpose of this study is to test a Triple Bottom Line (TBL)-construct as well as to describe the TBL-reasons for implementing sustainable business practices in companies and their business networks. This study explores how linking these seemingly disparate pillars of sustainability may be facilitated through a TBL construct. The notion of sustainable business practices has been evolving and is increasingly understood to encompass considerations of economic viability, as well as environmental sustainability and social responsibility. Design/methodology/approach – The research is quantitative in nature, exploring and analysing how companies in different Norwegian industries implement and manage sustainable business practices based on TBL. The survey results are reported here. Findings – The relevance of TBL to different aspects of sustainable business practices is outlined. The study generally supports the view that a heightened propensity for sustainable business practices ensures that organisations are better equipped for meeting the challenge of integrating TBL in companies and their business networks. Research limitations/implications – The study tested a construct of TBL in the context of sustainable business practices. It may be incorporated in further research in relation to other constructs. Suggestions for further research are proposed. Practical implications – Useful for practitioners to get insights into TBL-reasons for implementing business-sustainable practices in companies and their business networks. It may also be valuable to assess the general status of business-sustainable practices in a company and their business networks. Originality/value – Linking two traditionally separate and encapsulated areas of research, namely, the area of business sustainable practices and the area of TBL. The current study has contributed to a TBL-construct in relation to other constructs in measurement and structural models. It has also contributed to provide insights of priority into the main reasons to implement the elements of TBL within companies and their business networks

MODELACIÓN DE SISTEMAS DE RECOMENDACIÓN APLICANDO REDES NEURONALES ARTIFICIALES

Este artículo desarrolla y describe un modelo para un sistema recomendador de productos en empresas de alquiler de películas. Al aplicarlo sistemáticamente, caracteriza los clientes y permite conocer sus tendencias de manera oportuna, veraz y fiable. Para ello se utiliza la metodología de redes neuronales artificiales y la teoría de la resonancia adaptativa, ya que la flexibilidad implícita de adaptarse a las necesidades corporativas incrementa la eficiencia de las transacciones en el ámbito de las aplicaciones web. Se usa la base de datos de contenidos de alquiler electrónico de películas vía web The Netflix Prize. La validación y simulación del modelo se codifica en MatLab®

Modelacion de sistemas de recomendacion aplicando redes neuronales artificiales

This paper develops and describes a model for characterizing customers and product recommender system in movie rental companies, so that, when applied consistently, allows to know the trends of users in a timely, accurate and reliable. To do this, we use the methodology of artificial neural networks and adaptive resonance theory, because its implicit flexibility to adapt to business needs increases the efficiency of transactions in the field of web applications. Use the database The Netflix Prize, and the validation and simulation was coded in MatLab ®.Este artículo desarrolla y describe un modelo para un sistema recomendador de productos en empresas de alquiler de películas. Al aplicarlo sistemáticamente, caracteriza los clientes y permite conocer sus tendencias de manera oportuna, veraz y fiable. Para ello se utiliza la metodología de redes neuronales artificiales y la teoría de la resonancia adaptativa, ya que la flexibilidad implícita de adaptarse a las necesidades corporativas incrementa la eficiencia de las transacciones en el ámbito de las aplicaciones web. Se usa la base de datos de contenidos de alquiler electrónico de películas vía web The Netflix Prize. La validación y simulación del modelo se codifica en MatLab

Hereditary Cancer Program (ProCanHe): 21-years of experience at a referral registry in Argentina

Registries in South America were initiated in the early 90´s with thehelp of Henry T. Lynch. The Programa de Cancer Hereditario (Pro.Can.He), is a multidisciplinary program established in 1996 at theHospital Italiano, Argentina. The aim of the study is to update our 21-year experience to determine the applicability of genetic testshighlighting the most informative molecular findings in relation toLynch syndrome mostly.Materials and methods: Families undergoing genetic testing aftergenetic counselling between1996-2018 were included. Data were obtainedfrom a prospective IRB approved database. Clinicalepidemiologicaland molecular variables were analysed. Genetic testswere carried out after a genetic counselling session and obtainingthe informed consent of the patient.Molecular testingUntil 2015, the search for variants was carried out by PCR and Sangersequencing of exons and adjacent intronic regions of MLH1 andMSH2. Then, sequencing of MLH1/MSH2/MSH6/PMS2/EPCAM geneswas performed by NGS and large rearrangements were detected byMLPA. The variants were classified according to international databases.Variants with uncertain or unreported clinical significancewere analysed In-silico using the PolyPhen, SIFT and/or Human Splicingfinder 3.0 software.ResultsA total of 83 families (49 fulfilled Amsterdam Criteria [AC] and 34 BethesdaCriteria [BC]) were analysed. Pathogenic variants were foundin 26 out of 83 (31.3%) families, been 23 pathogenic and 3 likelypathogenic.Splice site and large rearrangements represented 19.2% (5/26) and11.5% (3/26) of the variants.23% (6/26) of them were originally describedin this series and 1 was a founding mutation from Piedmont,Italy. Affected genes include MSH2, MLH1, MSH6 and PMS2 (12, 11, 2and 1 cases respectively). Mutation detection rates in AC and BT familieswere 48.9% (N=24) and 5.9% (N=2), p<0.01. Among AC families,those with identified mutation had a lower median age of cancer onset and higher incidence of extra-CCR cancer than those withoutidentified mutations. Additionally, we have also studied other genesin patients with different clinical conditions included in the registry.We identified mutations in APC, MUTYH, BMPR1A, SMAD4, CDH1,BRCA1-2, CHEK2.ConclusionThe multidisciplinary approach and the international collaborationsallowed the correct implementation of the genetic tests. To ourknowledge, this study is the first Characterization of AC families accordingto genetic tests in South America. This allowed the identificationof AC families with different ages of onset and prevalence ofextra-CRC cancers, as well as several significant variant not previouslyreported in international databases.Fil: Piñero, Tamara Alejandra. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; ArgentinaFil: Herrando, Ignacio. Hospital Italiano; ArgentinaFil: Kalfayan, Pablo Germán. Hospital Italiano; ArgentinaFil: Gonzales, M.. Hospital Italiano; ArgentinaFil: Ferro, A.. Hospital Italiano; ArgentinaFil: Santino, Juan Pablo. Hospital Italiano; ArgentinaFil: Cajal, R.. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; ArgentinaFil: Falconi, D.. Hospital Italiano; ArgentinaFil: Guerrero, Gisella. Hospital Italiano; ArgentinaFil: Verzura, A.. Hospital Italiano; ArgentinaFil: Riggi, Maria. Hospital Italiano; ArgentinaFil: Church, James. No especifíca;Fil: Peltomäki, P.. No especifíca;Fil: Martins, Alexandra. No especifíca;Fil: Pavicic, Walter Hernan. Consejo Nacional de Investigaciones Cientificas y Tecnicas. Oficina de Coordinacion Administrativa Houssay. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Hospital Italiano. Instituto de Medicina Traslacional E Ingenieria Biomedica. - Instituto Universitario Hospital Italiano de Buenos Aires. Instituto de Medicina Traslacional E Ingenieria Biomedica.; ArgentinaFil: Dominguez, M.. University of Oslo; NoruegaFil: Vaccaro, C.. Hospital Italiano; ArgentinaThe 3rd European Hereditary Tumour Group MeetingNiceFranciaEuropean Hereditary Tumour Group Meetin

Truncating FLNC Mutations Are Associated With High-Risk Dilated and Arrhythmogenic Cardiomyopathies

BACKGROUND: Filamin C (encoded by the FLNC gene) is essential for sarcomere attachment to the plasmatic membrane. FLNC mutations have been associated with myofibrillar myopathies, and cardiac involvement has been reported in some carriers. Accordingly, since 2012, the authors have included FLNC in the genetic screening of patients with inherited cardiomyopathies and sudden death. OBJECTIVES: The aim of this study was to demonstrate the association between truncating mutations in FLNC and the development of high-risk dilated and arrhythmogenic cardiomyopathies. METHODS: FLNC was studied using next-generation sequencing in 2,877 patients with inherited cardiovascular diseases. A characteristic phenotype was identified in probands with truncating mutations in FLNC. Clinical and genetic evaluation of 28 affected families was performed. Localization of filamin C in cardiac tissue was analyzed in patients with truncating FLNC mutations using immunohistochemistry. RESULTS: Twenty-three truncating mutations were identified in 28 probands previously diagnosed with dilated, arrhythmogenic, or restrictive cardiomyopathies. Truncating FLNC mutations were absent in patients with other phenotypes, including 1,078 patients with hypertrophic cardiomyopathy. Fifty-four mutation carriers were identified among 121 screened relatives. The phenotype consisted of left ventricular dilation (68%), systolic dysfunction (46%), and myocardial fibrosis (67%); inferolateral negative T waves and low QRS voltages on electrocardiography (33%); ventricular arrhythmias (82%); and frequent sudden cardiac death (40 cases in 21 of 28 families). Clinical skeletal myopathy was not observed. Penetrance was >97% in carriers older than 40 years. Truncating mutations in FLNC cosegregated with this phenotype with a dominant inheritance pattern (combined logarithm of the odds score: 9.5). Immunohistochemical staining of myocardial tissue showed no abnormal filamin C aggregates in patients with truncating FLNC mutations. CONCLUSIONS: Truncating mutations in FLNC caused an overlapping phenotype of dilated and left-dominant arrhythmogenic cardiomyopathies complicated by frequent premature sudden death. Prompt implantation of a cardiac defibrillator should be considered in affected patients harboring truncating mutations in FLNC.Instituto de Salud Carlos III [PI11/0699, PI14/0967, PI14/01477, RD012/0042/0029, RD012/0042/0049, RD012/0042/0066, RD12/0042/0069]; Spanish Ministry of Economy and Competitiveness [SAF2015-71863-REDT]; Plan Nacional de I+D+I; Plan Estatalde I+D+I, European Regional Development Fund; Health in Code SLS

Clinical phenotypes and prognosis of dilated cardiomyopathy caused by truncating variants in the TTN Gene.

Background: Truncating variants in the TTN gene (TTNtv) are the commonest cause of heritable dilated cardiomyopathy. This study aimed to study the phenotypes and outcomes of TTNtv carriers. Methods: Five hundred thirty-seven individuals (61% men; 317 probands) with TTNtv were recruited in 14 centers (372 [69%] with baseline left ventricular systolic dysfunction [LVSD]). Baseline and longitudinal clinical data were obtained. The primary end point was a composite of malignant ventricular arrhythmia and end-stage heart failure. The secondary end point was left ventricular reverse remodeling (left ventricular ejection fraction increase by ≥10% or normalization to ≥50%). Results: Median follow-up was 49 (18–105) months. Men developed LVSD more frequently and earlier than women (45±14 versus 49±16 years, respectively; P=0.04). By final evaluation, 31%, 45%, and 56% had atrial fibrillation, frequent ventricular ectopy, and nonsustained ventricular tachycardia, respectively. Seventy-six (14.2%) individuals reached the primary end point (52 [68%] end-stage heart failure events, 24 [32%] malignant ventricular arrhythmia events). Malignant ventricular arrhythmia end points most commonly occurred in patients with severe LVSD. Male sex (hazard ratio, 1.89 [95% CI, 1.04–3.44]; P=0.04) and left ventricular ejection fraction (per 10% decrement from left ventricular ejection fraction, 50%; hazard ratio, 1.63 [95% CI, 1.30–2.04]; P<0.001) were independent predictors of the primary end point. Two hundred seven of 300 (69%) patients with LVSD had evidence of left ventricular reverse remodeling. In a subgroup of 29 of 74 (39%) patients with initial left ventricular reverse remodeling, there was a subsequent left ventricular ejection fraction decrement. TTNtv location was not associated with statistically significant differences in baseline clinical characteristics, left ventricular reverse remodeling, or outcomes on multivariable analysis (P=0.07). Conclusions: TTNtv is characterized by frequent arrhythmia, but malignant ventricular arrhythmias are most commonly associated with severe LVSD. Male sex and LVSD are independent predictors of outcomes. Mutation location does not impact clinical phenotype or outcomes.pre-print1,66 M