Supporting self-evaluation for children with mental disabilities through Augmented Reality

Proceedings of the 18th ACM International Conference on Interaction Design and Children, Boise© Association for Computing Machinery 2019. This is the author's version of the work. It is posted here for your personal use. Not for redistribution. The definitive Version of Record was published in {SourcePublication}, https://doi.org/10.1145/3311927.3325307Self-evaluation is the ability to assess one's work, and is a key element in the psycho-pedagogical development of children with special needs in their path towards autonomy and self-determination. Acquiring this skill requires explicit training and materials, and it is often cumbersome and time-consuming. In this paper we present a study to ascertain to what extent systems based on Augmented Reality (AR) are a suitable and less expensive alternative to help children with cognitive disabilities to train self-evaluation skills in special education schools. For this purpose, we have developed tablet application (BART) that offers assistance to children with special needs to self-evaluate basic arithmetic operations. The system was designed through the involvement of 2 educators, 2 experts on psycho-pedagogy, and 2 software designers. The contribution of this paper is the description of BART, an innovative system for children with special needs and a concrete plan for an empirical study that is to be carried out on a short-term basis. Here we describe the methodology that is to be applied to the proposed study and outline the main expectations about the results and their implications in the issue of self-evaluation skills acquisition for children in special education

Towards more supportive ICT for children with autism spectrum disorders:lessons learned from COVID-19 pandemic

COVID-19 pandemic has disrupted daily routines, causing isolation and quarantine. Technologyhas emerged as a crucial tool for sustaining essential activities, but children with autismspectrum disorders have faced distinct challenges due to their intricate interaction with it. Weemployed an online survey to analyse the impact of technology use in online learning, remoteassistance and daily life of children with autism along COVID-19, and we have identifiedbenefits and challenges with assistive technology exposed by the pandemic. Findings aredivided in (1) seven themes where COVID-19 impacted this population the most and theirrelationship with technology (remote communication, learning, emotional management,entertainment management, executive functions, activities of daily living, and physical activityand motor skills), and (2) a mapping of technological categories that define the working areasspecifically aimed to cover the special needs of children with autism whenever face-to-faceinteractions are not possible (attention, authoring tools, calculation, e-learning, emotions,entertainment, experience of self, language and communication, memory, planning and timemanagement, social networking, and social skills). These results help provide a more well-rounded knowledge of how to improve technology to make it accessible to autistic children, tohandle and avoid services interruption in similar scenarios.This work was co-funded by the Project Indigo! (Ministry ofScience and Innovation with reference number PID2019-105951RB-I00/AEI/10.13039/501100011033) and by theMadrid Regional Government through the e-Madrid-CMProject under Grant S2018/TCS-4307, co-funded by the Euro-pean Structural Funds (FSE and FEDER).BEHAVIOUR & INFORMATION TECHNOLOGY1

Developing Software for Motivating Individuals with Intellectual Disabilities to do Outdoor Physical Activity

Proceedings of International Conference on Software Engineering: Software Engineering in Society, Seoul, Republic of KoreaPeople with intellectual disabilities (IDs) often have a sedentary lifestyle that can lead to long-term issues like cardiovascular diseases, diabetes, obesity and depression. Few games and apps promoting physical activity for people with IDs exist, and they do not have a focus on the motivational aspect. This paper aims to find how to develop software that can motivate people with IDs to do physical activity outdoors. For this purpose, we have followed a design and creation research strategy using several qualitative methods such as semi-structured interviews with health care workers, special education experts and software engineers; a focus group with occupational therapists, physical therapists and software engineers; and a preliminary pilot user test with 3 users and 2 caregivers aiming to a test of the software on the field and at the refinement of its specifications. Having social interaction during the physical activity turned out to be a major motivational aspect of the system, whereas rewards systems did not attract much of the users' attention. Regarding the adapted navigational assistance, easy-to-read text, visual communication and street-level pictures were the key features to achieve successful and understandable guidance outdoors for people with intellectual disabilities

First Records for Spawning of Caribbean Acropora Species in Colombian MPAs

Estimates of Colombian Caribbean coral percent cover in the Southern Caribbean are consistent with those throughout the Caribbean Sea, which has declined to about 10% of historical levels in the last few decades. Human activities like destructive fishing techniques in the marine parks have degraded the reefs over the last few decades. Colombia’s Marine Protected Areas (MPAs) have thousands of square kilometers to map and patrol and few resources to devote to scientific and restoration efforts. Efforts to implement sexual reproduction techniques for restoration are starting to successfully propagate and settle corals on ceramic plates for reef deployment in the area but require more natural history information for large-scale implementation in restoration. Past observations of captive endangered coral Acropora cervicornis in the nursery of the Oceanario Islas del Rosario indicate spawning 6 days after the August full moon for the previous 3 years. Coral spawn collection from the wild reef was completed each night from 2 to 7 days after the full moon in August 2019, and resulted in the first observation of A. cervicornis spawning on natural reefs in Parque Nacional Natural Los Corales del Rosario y de San Bernardo, a 1,200 km2 underwater national park and MPA established in 1977. Additionally, coral spawn collection from the nursery reefs in August 2019 provide the first reported observations of spawning for endangered coral Acropora palmata in Colombia

Oral particle uptake and organ targeting drives the activity of amphotericin B nanoparticles

There are very few drug delivery systems that target key organs via the oral route, as oral delivery advances normally address gastrointestinal drug dissolution, permeation, and stability. Here we introduce a nanomedicine in which nanoparticles, while also protecting the drug from gastric degradation, are taken up by the gastrointestinal epithelia and transported to the lung, liver, and spleen, thus selectively enhancing drug bioavailability in these target organs and diminishing kidney exposure (relevant to nephrotoxic drugs). Our work demonstrates, for the first time, that oral particle uptake and translocation to specific organs may be used to achieve a beneficial therapeutic response. We have illustrated this using amphotericin B, a nephrotoxic drug encapsulated within <i>N</i>-palmitoyl-<i>N</i>-methyl-<i>N</i>,<i>N</i>-dimethyl-<i>N</i>,<i>N</i>,<i>N</i>-trimethyl-6-<i>O</i>-glycol chitosan (GCPQ) nanoparticles, and have evidenced our approach in three separate disease states (visceral leishmaniasis, candidiasis, and aspergillosis) using industry standard models of the disease in small animals. The oral bioavailability of AmB-GCPQ nanoparticles is 24%. In all disease models, AmB-GCPQ nanoparticles show comparable efficacy to parenteral liposomal AmB (AmBisome). Our work thus paves the way for others to use nanoparticles to achieve a specific targeted delivery of drug to key organs via the oral route. This is especially important for drugs with a narrow therapeutic index

The 2021 eruption of the Cumbre Vieja volcanic ridge on La Palma, Canary Islands

Almost exactly half a century after the eruption of the Teneguía Volcano on La Palma (26 October to 28 November 1971), a new eruption occurred on the island and lasted for 85 days from 19 September until 13 December 2021. This new eruption opened a volcanic vent complex on the western flank of the Cumbre Vieja rift zone, the N-S elongated polygenetic volcanic ridge that has developed on La Palma over the last c. 125 ka. The Cumbre Vieja ridge is the volcanically active region of the island and the most active one of the Canary Islands, hosting half of all the historically recorded eruptive events in the archipelago. The 2021 La Palma eruption has seen no direct loss of human life, thanks to efficient early detection and sensible management of the volcanic crisis by the authorities, but more than 2800 buildings and almost 1000 hectares of plantations and farmland were affected by lava flows and pyroclastic deposits. Satellite surveillance enabled accurate mapping of the progressive buildup of the extensive and complex basaltic lava field, which together with monitoring of gas emissions informed the timely evacuation of local populations from affected areas. Lava flows that reached the sea constructed an extensive system of lava deltas and platforms, similar to events during earlier historical eruptions such as in 1712, 1949 and 1971. Long-term challenges in the aftermath of the eruption include protection of drainage systems from potential redistribution of tephra during high rainfall events, the use of the large surplus quantities of ash in reconstruction of buildings and in agriculture, and the crucial concerns of where and how rebuilding should and could occur in the aftermath of the eruption. Finally, there remain strong financial concerns over insurance for properties consumed or damaged by the eruption in the light of future volcanic hazards from the Cumbre Vieja volcanic ridge.Peer reviewe

Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs

Flavonoids represent a potential source of new antitrypanosomatidic leads. Starting from a library of natural products, we combined target-based screening on pteridine reductase 1 with phenotypic screening on Trypanosoma brucei for hit identification. Flavonols were identified as hits, and a library of 16 derivatives was synthesized. Twelve compounds showed EC50 values against T. brucei below 10 \u3bcM. Four X-ray crystal structures and docking studies explained the observed structure-activity relationships. Compound 2 (3,6-dihydroxy-2-(3-hydroxyphenyl)-4H-chromen-4-one) was selected for pharmacokinetic studies. Encapsulation of compound 2 in PLGA nanoparticles or cyclodextrins resulted in lower in vitro toxicity when compared to the free compound. Combination studies with methotrexate revealed that compound 13 (3-hydroxy-6-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one) has the highest synergistic effect at concentration of 1.3 \u3bcM, 11.7-fold dose reduction index and no toxicity toward host cells. Our results provide the basis for further chemical modifications aimed at identifying novel antitrypanosomatidic agents showing higher potency toward PTR1 and increased metabolic stability

Improving girls’ perception of computer science as a viable career option through game playing and design: Lessons from a systematic literature review

The objective of exposing girls to Computer Science as a career option has led to research directed towards gaming activities for girls. These activities include both game play and game design. Research about gaming activities for increasing girls’ interest in computer science has gained much attention over the past few years and has resulted in a number of contributions. We follow up with an overview of the status of research through a Systematic Literature Review. We investigate the relation between the various game playing or designing activities and their impact on girls’ perception of Computer Science as a career choice. We further present the design consideration for the games and related activities to potentially improve the perception of girls towards a Computer Science career. The applied method is a Systematic Literature Review through which we investigate which contributions were made, which knowledge areas were most explored, and which research facets have been used. We identify 25 papers to distill a common understanding of the state-of-the-art. Specifically, we investigate the effects that the game play/design activities had on girls’ perception about Computer Science; and what are the key design factors to be kept in mind while designing a serious game to improve girls’ perception about Computer Science. The results of this systematic literature review show that game playing or designing could indeed improve how girls perceive having a career in CS. The key aspects that such activities require are personalizing, opportunity for collaboration and the presence of a female lead characterThis work has been done during the tenure of an ERCIM Alain Bensoussan fellowshi

Composición química IGF para el tratamiento y prevención de enfermedades neurodegenerativas

Traducción de Patente Europea E03744388 (fecha de solicitud, 21/02/2003).-- Prioridad: ES20020228200200491.-- Titulares: Consejo Superior de Investigaciones Científicas (CSIC), Universidad Complutense de Madrid (UCM).La invención se refiere a nuevas composiciones terapéuticas de administración lenta de IGF-I, a un procedimiento de preparación y obtención de las mismas y a su empleo para la elaboración de medicamentos para el tratamiento y prevención de enfermedades neurodegenerativas como, entre otras, la enfermedad de Alzheimer o la ataxia cerebelar.Estas composiciones se corresponden con microesferas de tamaño menor de 5 micrometros, entre otras características, y con cápsulas de implantación subcutánea.Peer reviewe

Microspheres containing insulin-like growth factor I for treatment of chronic neurodegeneration

The therapeutic potential of peptide growth factors as insulin-like growth factor I (IGF-I) is currently under intense scrutiny in a wide variety of diseases, including neurodegenerative illnesses. A new poly(lactic-co-glycolide) -based microsphere IGF-I controlled release formulation for subcutaneous (SC) delivery has been developed by a triple emulsion method. The resulting microspheres displayed a mean diameter of 1.5μm, with an encapsulation efficiency of 74.3%. The protein retained integrity after the microencapsulation process as evaluated by circular dichroism and SDS-PAGE. The administration of IGF-I in microspheres caused at least a 30-fold increase in IGF-I mean residence time in rats and mice when compared with the conventional SC solution. Therefore, dosing can be changed from the conventional twice a day to once every 2 weeks. Therapeutic efficacy of this new formulation has been studied in mutant mice with inherited Purkinje cell degeneration (PCD). These mice show a chronic limb discoordination that is resolved after continuous systemic delivery of IGF-I. Normal motor coordination was maintained as long as IGF-I microsphere therapy is continued. Moreover, severely affected PCD mice, with marked ataxia, muscle wasting and shortened life-span showed a significant improvement after continuous IGF-I microsphere therapy as determined by enhanced motor coordination, marked weight gain and extended survival. This new formulation can be considered of great therapeutic promise for some chronic brain diseases. © 2003 Elsevier Ltd. All rights reserved.Peer Reviewe