1,509 research outputs found
An algorithmic method for functionally defining regions of interest in the ventral visual pathway
In a widely used functional magnetic resonance imaging (fMRI) data analysis method, functional regions of interest (fROIs) are handpicked in each participant using macroanatomic landmarks as guides, and the response of these regions to new conditions is then measured. A key limitation of this standard handpicked fROI method is the subjectivity of decisions about which clusters of activated voxels should be treated as the particular fROI in question in each subject. Here we apply the Group-Constrained Subject-Specific (GSS) method for defining fROIs, recently developed for identifying language fROIs (Fedorenko et al., 2010), to algorithmically identify fourteen well-studied category-selective regions of the ventral visual pathway (Kanwisher, 2010). We show that this method retains the benefit of defining fROIs in individual subjects without the subjectivity inherent in the traditional handpicked fROI approach. The tools necessary for using this method are available on our website (http://web.mit.edu/bcs/nklab/GSS.shtml).Ellison Medical Foundatio
The occipital place area represents the local elements of scenes
Neuroimaging studies have identified three scene-selective regions in human cortex: parahippocampal place area (PPA), retrosplenial complex (RSC), and occipital place area (OPA). However, precisely what scene information each region represents is not clear, especially for the least studied, more posterior OPA. Here we hypothesized that OPA represents local elements of scenes within two independent, yet complementary scene descriptors: spatial boundary (i.e., the layout of external surfaces) and scene content (e.g., internal objects). If OPA processes the local elements of spatial boundary information, then it should respond to these local elements (e.g., walls) themselves, regardless of their spatial arrangement. Indeed, we found that OPA, but not PPA or RSC, responded similarly to images of intact rooms and these same rooms in which the surfaces were fractured and rearranged, disrupting the spatial boundary. Next, if OPA represents the local elements of scene content information, then it should respond more when more such local elements (e.g., furniture) are present. Indeed, we found that OPA, but not PPA or RSC, responded more to multiple than single pieces of furniture. Taken together, these findings reveal that OPA analyzes local scene elements - both in spatial boundary and scene content representation - while PPA and RSC represent global scene properties.National Institutes of Health (U.S.) (Grant EY013455
Addition of tabulated equation of state and neutrino leakage support to IllinoisGRMHD
We have added support for realistic, microphysical, finite-temperature
equations of state (EOS) and neutrino physics via a leakage scheme to
IllinoisGRMHD, an open-source GRMHD code for dynamical spacetimes in the
Einstein Toolkit. These new features are provided by two new, NRPy+-based
codes: NRPyEOS, which performs highly efficient EOS table lookups and
interpolations, and NRPyLeakage, which implements a new, AMR-capable neutrino
leakage scheme in the Einstein Toolkit. We have performed a series of strenuous
validation tests that demonstrate the robustness of these new codes,
particularly on the Cartesian AMR grids provided by Carpet. Furthermore, we
show results from fully dynamical GRMHD simulations of single unmagnetized
neutron stars, and magnetized binary neutron star mergers. This new version of
IllinoisGRMHD, as well as NRPyEOS and NRPyLeakage, is pedagogically documented
in Jupyter notebooks and fully open source. The codes will be proposed for
inclusion in an upcoming version of the Einstein Toolkit.Comment: 20 pages, 9 figures. v2 matches PRD versio
Ars2 Links the Nuclear Cap-Binding Complex to RNA Interference and Cell Proliferation
SummaryHere we identify a component of the nuclear RNA cap-binding complex (CBC), Ars2, that is important for miRNA biogenesis and critical for cell proliferation. Unlike other components of the CBC, Ars2 expression is linked to the proliferative state of the cell. Deletion of Ars2 is developmentally lethal, and deletion in adult mice led to bone marrow failure whereas parenchymal organs composed of nonproliferating cells were unaffected. Depletion of Ars2 or CBP80 from proliferating cells impaired miRNA-mediated repression and led to alterations in primary miRNA processing in the nucleus. Ars2 depletion also reduced the levels of several miRNAs, including miR-21, let-7, and miR-155, that are implicated in cellular transformation. These findings provide evidence for a role for Ars2 in RNA interference regulation during cell proliferation
The Palomar Transient Factory Orion Project: Eclipsing Binaries and Young Stellar Objects
The Palomar Transient Factory (PTF) Orion project is an experiment within the
broader PTF survey, a systematic automated exploration of the sky for optical
transients. Taking advantage of the wide field of view available using the PTF
camera at the Palomar 48" telescope, 40 nights were dedicated in December
2009-January 2010 to perform continuous high-cadence differential photometry on
a single field containing the young (7-10Myr) 25 Ori association. The primary
motivation for the project is to search for planets around young stars in this
region. The unique data set also provides for much ancillary science. In this
first paper we describe the survey and data reduction pipeline, and present
initial results from an inspection of the most clearly varying stars relating
to two of the ancillary science objectives: detection of eclipsing binaries and
young stellar objects. We find 82 new eclipsing binary systems, 9 of which we
are candidate 25 Ori- or Orion OB1a-association members. Of these, 2 are
potential young W UMa type systems. We report on the possible low-mass (M-dwarf
primary) eclipsing systems in the sample, which include 6 of the candidate
young systems. 45 of the binary systems are close (mainly contact) systems; one
shows an orbital period among the shortest known for W UMa binaries, at
0.2156509 \pm 0.0000071d, with flat-bottomed primary eclipses, and a derived
distance consistent with membership in the general Orion association. One of
the candidate young systems presents an unusual light curve, perhaps
representing a semi-detached binary system with an inflated low-mass primary or
a star with a warped disk, and may represent an additional young Orion member.
Finally, we identify 14 probable new classical T-Tauri stars in our data, along
with one previously known (CVSO 35) and one previously reported as a candidate
weak-line T-Tauri star (SDSS J052700.12+010136.8).Comment: 66 pages, 27 figures, accepted to Astronomical Journal. Minor
typographical corrections and update to author affiliation
The PTF Orion Project: a Possible Planet Transiting a T-Tauri Star
We report observations of a possible young transiting planet orbiting a
previously known weak-lined T-Tauri star in the 7-10 Myr old Orion-OB1a/25-Ori
region. The candidate was found as part of the Palomar Transient Factory (PTF)
Orion project. It has a photometric transit period of 0.448413 +- 0.000040
days, and appears in both 2009 and 2010 PTF data. Follow-up low-precision
radial velocity (RV) observations and adaptive optics imaging suggest that the
star is not an eclipsing binary, and that it is unlikely that a background
source is blended with the target and mimicking the observed transit. RV
observations with the Hobby-Eberly and Keck telescopes yield an RV that has the
same period as the photometric event, but is offset in phase from the transit
center by approximately -0.22 periods. The amplitude (half range) of the RV
variations is 2.4 km/s and is comparable with the expected RV amplitude that
stellar spots could induce. The RV curve is likely dominated by stellar spot
modulation and provides an upper limit to the projected companion mass of M_p
sin i_orb < 4.8 +- 1.2 M_Jup; when combined with the orbital inclination, i
orb, of the candidate planet from modeling of the transit light curve, we find
an upper limit on the mass of the planetary candidate of M_p < 5.5 +- 1.4
M_Jup. This limit implies that the planet is orbiting close to, if not inside,
its Roche limiting orbital radius, so that it may be undergoing active mass
loss and evaporation.Comment: Corrected typos, minor clarifications; minor updates/corrections to
affiliations and bibliography. 35 pages, 10 figures, 3 tables. Accepted to
Ap
Accretion of Planetary Material onto Host Stars
Accretion of planetary material onto host stars may occur throughout a star's
life. Especially prone to accretion, extrasolar planets in short-period orbits,
while relatively rare, constitute a significant fraction of the known
population, and these planets are subject to dynamical and atmospheric
influences that can drive significant mass loss. Theoretical models frame
expectations regarding the rates and extent of this planetary accretion. For
instance, tidal interactions between planets and stars may drive complete
orbital decay during the main sequence. Many planets that survive their stars'
main sequence lifetime will still be engulfed when the host stars become red
giant stars. There is some observational evidence supporting these predictions,
such as a dearth of close-in planets around fast stellar rotators, which is
consistent with tidal spin-up and planet accretion. There remains no clear
chemical evidence for pollution of the atmospheres of main sequence or red
giant stars by planetary materials, but a wealth of evidence points to active
accretion by white dwarfs. In this article, we review the current understanding
of accretion of planetary material, from the pre- to the post-main sequence and
beyond. The review begins with the astrophysical framework for that process and
then considers accretion during various phases of a host star's life, during
which the details of accretion vary, and the observational evidence for
accretion during these phases.Comment: 18 pages, 5 figures (with some redacted), invited revie
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