112 research outputs found
SOFIA/FORCAST and Spitzer/IRAC Imaging of the Ultra Compact H II Region W3(OH) and Associated Protostars in W3
We present infrared observations of the ultra-compact H II region W3(OH) made
by the FORCAST instrument aboard SOFIA and by Spitzer/IRAC. We contribute new
wavelength data to the spectral energy distribution, which constrains the
optical depth, grain size distribution, and temperature gradient of the dusty
shell surrounding the H II region. We model the dust component as a spherical
shell containing an inner cavity with radius ~ 600 AU, irradiated by a central
star of type O9 and temperature ~ 31,000 K. The total luminosity of this system
is 71,000 L_solar. An observed excess of 2.2 - 4.5 microns emission in the SED
can be explained by our viewing a cavity opening or clumpiness in the shell
structure whereby radiation from the warm interior of the shell can escape. We
claim to detect the nearby water maser source W3 (H2O) at 31.4 and 37.1 microns
using beam deconvolution of the FORCAST images. We constrain the flux densities
of this object at 19.7 - 37.1 microns. Additionally, we present in situ
observations of four young stellar and protostellar objects in the SOFIA field,
presumably associated with the W3 molecular cloud. Results from the model SED
fitting tool of Robitaille et al. (2006, 2007} suggest that two objects (2MASS
J02270352+6152357 and 2MASS J02270824+6152281) are intermediate-luminosity (~
236 - 432 L_solar) protostars; one object (2MASS J02270887+6152344) is either a
high-mass protostar with luminosity 3000 L_solar or a less massive young star
with a substantial circumstellar disk but depleted envelope; and one object
(2MASS J02270743+6152281) is an intermediate-luminosity (~ 768 L_solar)
protostar nearing the end of its envelope accretion phase or a young star
surrounded by a circumstellar disk with no appreciable circumstellar envelope.Comment: 12 pages, 8 figures, 2 tables, accepted by Ap
First Science Observations with SOFIA/FORCAST: Properties of Intermediate-Luminosity Protostars and Circumstellar Disks in OMC-2
We examine eight young stellar objects in the OMC-2 star forming region based
on observations from the SOFIA/FORCAST early science phase, the Spitzer Space
Telescope, the Herschel Space Observatory, 2MASS, APEX, and other results in
the literature. We show the spectral energy distributions of these objects from
near-infrared to millimeter wavelengths, and compare the SEDs with those of
sheet collapse models of protostars and circumstellar disks. Four of the
objects can be modelled as protostars with infalling envelopes, two as young
stars surrounded by disks, and the remaining two objects have double-peaked
SEDs. We model the double-peaked sources as binaries containing a young star
with a disk and a protostar. The six most luminous sources are found in a dense
group within a 0.15 x 0.25 pc region; these sources have luminosities ranging
from 300 L_sun to 20 L_sun. The most embedded source (OMC-2 FIR 4) can be fit
by a class 0 protostar model having a luminosity of ~50 L_sun and mass infall
rate of ~10^-4 solar masses per year.Comment: Accepted by ApJ Letter
Obscured Activity: AGN, Quasars, Starbursts and ULIGs observed by the Infrared Space Observatory
Some of the most active galaxies in the Universe are obscured by large
quantities of dust and emit a substantial fraction of their bolometric
luminosity in the infrared. Observations of these infrared luminous galaxies
with the Infrared Space Observatory (ISO) have provided a relatively unabsorbed
view to the sources fuelling this active emission. The improved sensitivity,
spatial resolution and spectroscopic capability of ISO over its predecessor
Infrared Astronomical Satellite (IRAS), has enabled significant advances in the
understanding of the infrared properties of active galaxies. ISO surveyed a
wide range of active galaxies which, in the context of this review, includes
those powered by intense bursts of star-formation as well as those containing a
dominant active galactic nucleus (AGN). Mid infrared imaging resolved for the
first time the dust enshrouded nuclei in many nearby galaxies, while a new era
in infrared spectroscopy was opened by probing a wealth of atomic, ionic and
molecular lines as well as broad band features in the mid and far infrared.
This was particularly useful since it resulted in the understanding of the
power production, excitation and fuelling mechanisms in the nuclei of active
galaxies including the intriguing but so far elusive ultraluminous infrared
galaxies. Detailed studies of various classes of AGN and quasars greatly
improved our understanding of the unification scenario. Far-infrared imaging
and photometry also revealed the presence of a new very cold dust component in
galaxies and furthered our knowledge of the far-infrared properties of faint
starbursts, ULIGs and quasars. We summarise almost nine years of key results
based upon ISO data spanning the full range of luminosity and type of active
galaxies.Comment: Accepted for publication in 'ISO science legacy - a compact review of
ISO major achievements', Space Science Reviews - dedicated ISO issue. To be
published by Springer in 2005. 62 pages (low resolution figures version).
Higher resolution PDFs available from
http://users.physics.uoc.gr/~vassilis/papers/VermaA.pdf or
http://www.iso.vilspa.esa.es/science/SSR/Verma.pd
Expression of Aquaporin 5 (AQP5) Promotes Tumor Invasion in Human Non Small Cell Lung Cancer
The aquaporins (AQP) are water channel proteins playing a major role in transcellular and transepithelial water movement. Recently, the role of AQPs in human carcinogenesis has become an area of great interest. Here, by immunohistochemistry (IHC), we have found an expression of AQP5 protein in 35.3% (IHC-score: ≥1, 144/408) of the resected NSCLC tissue samples. Cases with AQP5-positive status (IHC-score: ≥2) displayed a higher rate of tumor recurrence than negative ones in NSCLC (54.7% vs. 35.1%, p = 0.005) and worse disease-free survival (p = 0.033; OR = 1.52; 95%CI:1.04−2.23). Further in vitro invasion assay using BEAS-2B and NIH3T3 cells stably transfected with overexpression constructs for full length wild-type AQP5 (AQP5) and its two mutants, N185D which blocks membrane trafficking and S156A which blocks phosphorylation on Ser156, showed that AQP5 induced cell invasions while both mutants did not. In BEAS-2B cells, the expression of AQP5 caused a spindle-like and fibroblastic morphologic change and losses of cell-cell contacts and cell polarity. Only cells with AQP5, not either of two mutants, exhibited a loss of epithelial cell markers and a gain of mesenchymal cell markers. In a human SH3-domains protein array, cellular extracts from BEAS-2B with AQP5 showed a robust binding activity to SH3-domains of the c-Src, Lyn, and Grap2 C-terminal. Furthermore, in immunoprecipitation assay, activated c-Src, phosphorylated on Tyr416, showed a stronger binding activity to cellular extracts from BEAS-2B with AQP5 compared with N185D or S156A mutant. Fluorescence in situ hybridization (FISH) analysis failed to show evidence of genomic amplification, suggesting AQP5 expression as a secondary event. Based on these clinical and molecular observations, we conclude that AQP5, through its phosphorylation on Ser156 and subsequent interaction with c-Src, plays an important role in NSCLC invasion and, therefore, may provide a unique opportunity for developing a novel therapeutic target as well as a prognostic marker in NSCLC
Re-Arrest Among Juvenile Justice-Involved Youth: An Examination Of The Static And Dynamic Risk Factors
The purpose of this study is to investigate the static and dynamic risk factors for re-arrest among detained youth by examining gender, race/ethnicity, age, special education and mental health variables (i.e., anger/irritability, depression/anxiety, somatic complaints, suicide ideation, thought disturbances, and traumatic experiences). The demographic profiles of detained youth with one admit were also compared with those with multiple admits to the juvenile detention center. With regards to static risk factors, older, white, and special education were significantly at risk of re-arrest. Concerning dynamic risk factors, only anger/irritability predicted re-arrest. Practice implications are also discussed
The Prevalence of Sexually Transmitted Infections in Papua New Guinea: A Systematic Review and Meta-Analysis
Patellofemoral osteoarthritis (PF OA) is more prevalent than previously thought and contributes to patient's suffering from knee OA. Synthesis of prevalence data can provide estimates of the burden of PF OA
Progressive skin fibrosis is associated with a decline in lung function and worse survival in patients with diffuse cutaneous systemic sclerosis in the European Scleroderma Trials and Research (EUSTAR) cohort.
Objectives To determine whether progressive skin fibrosis is associated with visceral organ progression and mortality during follow-up in patients with diffuse cutaneous systemic sclerosis (dcSSc). Methods We evaluated patients from the European Scleroderma Trials and Research database with dcSSc, baseline modified Rodnan skin score (mRSS) ≥7, valid mRSS at 12±3 months after baseline and ≥1 annual follow-up visit. Progressive skin fibrosis was defined as an increase in mRSS >5 and ≥25% from baseline to 12±3 months. Outcomes were pulmonary, cardiovascular and renal progression, and all-cause death. Associations between skin progression and outcomes were evaluated by Kaplan-Meier survival analysis and multivariable Cox regression. Results Of 1021 included patients, 78 (7.6%) had progressive skin fibrosis (skin progressors). Median follow-up was 3.4 years. Survival analyses indicated that skin progressors had a significantly higher probability of FVC decline ≥10% (53.6% vs 34.4%; p<0.001) and all-cause death (15.4% vs 7.3%; p=0.003) than non-progressors. These significant associations were also found in subgroup analyses of patients with either low baseline mRSS (≤22/51) or short disease duration (≤15 months). In multivariable analyses, skin progression within 1 year was independently associated with FVC decline ≥10% (HR 1.79, 95% CI 1.20 to 2.65) and all-cause death (HR 2.58, 95% CI 1.31 to 5.09). Conclusions Progressive skin fibrosis within 1 year is associated with decline in lung function and worse survival in dcSSc during follow-up. These results confirm mRSS as a surrogate marker in dcSSc, which will be helpful for cohort enrichment in future trials and risk stratification in clinical practice
Les droits disciplinaires des fonctions publiques : « unification », « harmonisation » ou « distanciation ». A propos de la loi du 26 avril 2016 relative à la déontologie et aux droits et obligations des fonctionnaires
The production of tt‾ , W+bb‾ and W+cc‾ is studied in the forward region of proton–proton collisions collected at a centre-of-mass energy of 8 TeV by the LHCb experiment, corresponding to an integrated luminosity of 1.98±0.02 fb−1 . The W bosons are reconstructed in the decays W→ℓν , where ℓ denotes muon or electron, while the b and c quarks are reconstructed as jets. All measured cross-sections are in agreement with next-to-leading-order Standard Model predictions.The production of , and is studied in the forward region of proton-proton collisions collected at a centre-of-mass energy of 8 TeV by the LHCb experiment, corresponding to an integrated luminosity of 1.98 0.02 \mbox{fb}^{-1}. The bosons are reconstructed in the decays , where denotes muon or electron, while the and quarks are reconstructed as jets. All measured cross-sections are in agreement with next-to-leading-order Standard Model predictions
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