611 research outputs found
Inertial frame rotation induced by rotating gravitational waves
We calculate the rotation of the inertial frames within an almost flat
cylindrical region surrounded by a pulse of non-axially-symmetric gravitational
waves that rotate about the axis of our cylindrical polar coordinates. Our
spacetime has only one Killing vector. It is along the z-axis and hypersurface
orthogonal. We solve the Einstein equations to first order in the wave
amplitude and superpose such linearized solutions to form a wave pulse. We then
solve the relevant Einstein equation to second order in the amplitude to find
the rotation of inertial frames produced by the pulse. The rotation is without
time delay. The influence of gravitational wave angular momentum on the
inertial frame demonstrates that Mach's principle can not be expressed in terms
of the influence of the stress-energy-momentum tensor alone but must involve
also influences of gravitational wave energy and angular momentum.Comment: Scheduled to appear in Class. and Quantum Grav. July 2008, "inertial"
added in titl
Validation of Twelve Small Kepler Transiting Planets in the Habitable Zone
We present an investigation of twelve candidate transiting planets from
Kepler with orbital periods ranging from 34 to 207 days, selected from initial
indications that they are small and potentially in the habitable zone (HZ) of
their parent stars. Few of these objects are known. The expected Doppler
signals are too small to confirm them by demonstrating that their masses are in
the planetary regime. Here we verify their planetary nature by validating them
statistically using the BLENDER technique, which simulates large numbers of
false positives and compares the resulting light curves with the Kepler
photometry. This analysis was supplemented with new follow-up observations
(high-resolution optical and near-infrared spectroscopy, adaptive optics
imaging, and speckle interferometry), as well as an analysis of the flux
centroids. For eleven of them (KOI-0571.05, 1422.04, 1422.05, 2529.02, 3255.01,
3284.01, 4005.01, 4087.01, 4622.01, 4742.01, and 4745.01) we show that the
likelihood they are true planets is far greater than that of a false positive,
to a confidence level of 99.73% (3 sigma) or higher. For KOI-4427.01 the
confidence level is about 99.2% (2.6 sigma). With our accurate characterization
of the GKM host stars, the derived planetary radii range from 1.1 to 2.7
R_Earth. All twelve objects are confirmed to be in the HZ, and nine are small
enough to be rocky. Excluding three of them that have been previously validated
by others, our study doubles the number of known rocky planets in the HZ.
KOI-3284.01 (Kepler-438b) and KOI-4742.01 (Kepler-442b) are the planets most
similar to the Earth discovered to date when considering their size and
incident flux jointly.Comment: 27 pages in emulateapj format, including tables and figures. To
appear in The Astrophysical Journa
Climatic patterns in the establishment of wintering areas by North American migratory birds
Long-distance migration in birds is relatively well studied in nature; however, one aspect of this phenomenon that remains poorly understood is the pattern of distribution presented by species during arrival to and establishment of wintering areas. Some studies suggest that the selection of areas in winter is somehow determined by climate, given its influence on both the distribution of bird species and their resources. We analyzed whether different migrant passerine species of North America present climatic preferences during arrival to and departure from their wintering areas. We used ecological niche modeling to generate monthly potential climatic distributions for 13 migratory bird species during the winter season by combining the locations recorded per month with four environmental layers. We calculated monthly coefficients of climate variation and then compared two GLM (generalized linear models), evaluated with the AIC (Akaike information criterion), to describe how these coefficients varied over the course of the season, as a measure of the patterns of establishment in the wintering areas. For 11 species, the sites show nonlinear patterns of variation in climatic preferences, with low coefficients of variation at the beginning and end of the season and higher values found in the intermediate months. The remaining two species analyzed showed a different climatic pattern of selective establishment of wintering areas, probably due to taxonomic discrepancy, which would affect their modeled winter distribution. Patterns of establishment of wintering areas in the species showed a climatic preference at the macroscale, suggesting that individuals of several species actively select wintering areas that meet specific climatic conditions. This probably gives them an advantage over the winter and during the return to breeding areas. As these areas become full of migrants, alternative suboptimal sites are occupied. Nonrandom winter area selection may also have consequences for the conservation of migratory bird species, particularly under a scenario of climate change
Microbes as engines of ecosystem function : When does community structure enhance predictions of ecosystem processes?
FUNDING This work was supported by NSF grant DEB-1221215 to DN, as well as grants supporting the generation of our datasets as acknowledged in their original publications and in Supplementary Table S1. ACKNOWLEDGMENT We thank the USGS Powell Center ‘Next Generation Microbes’ working group, anonymous reviews, Brett Melbourne, and Alan Townsend for valuable feedback on this project.Peer reviewedPublisher PD
Functional Performance of an Enabling Atmosphere Revitalization Subsystem Architecture for Deep Space Exploration Missions
A subsystem architecture derived from the International Space Station's (ISS) Atmosphere Revitalization Subsystem (ARS) has been functionally demonstrated. This ISS-derived architecture features re-arranged unit operations for trace contaminant control and carbon dioxide removal functions, a methane purification component as a precursor to enhance resource recovery over ISS capability, operational modifications to a water electrolysis-based oxygen generation assembly, and an alternative major atmospheric constituent monitoring concept. Results from this functional demonstration are summarized and compared to the performance observed during ground-based testing conducted on an ISS-like subsystem architecture. Considerations for further subsystem architecture and process technology development are discussed
Evaluation of an Atmosphere Revitalization Subsystem for Deep Space Exploration Missions
An Atmosphere Revitalization Subsystem (ARS) suitable for deployment aboard deep space exploration mission vehicles has been developed and functionally demonstrated. This modified ARS process design architecture was derived from the International Space Station's (ISS) basic ARS. Primary functions considered in the architecture include trace contaminant control, carbon dioxide removal, carbon dioxide reduction, and oxygen generation. Candidate environmental monitoring instruments were also evaluated. The process architecture rearranges unit operations and employs equipment operational changes to reduce mass, simplify, and improve the functional performance for trace contaminant control, carbon dioxide removal, and oxygen generation. Results from integrated functional demonstration are summarized and compared to the performance observed during previous testing conducted on an ISS-like subsystem architecture and a similarly evolved process architecture. Considerations for further subsystem architecture and process technology development are discussed
Rotation of planet-harbouring stars
The rotation rate of a star has important implications for the detectability,
characterisation and stability of any planets that may be orbiting it. This
chapter gives a brief overview of stellar rotation before describing the
methods used to measure the rotation periods of planet host stars, the factors
affecting the evolution of a star's rotation rate, stellar age estimates based
on rotation, and an overview of the observed trends in the rotation properties
of stars with planets.Comment: 16 pages, 4 figures: Invited review to appear in 'Handbook of
Exoplanets', Springer Reference Works, edited by Hans J. Deeg and Juan
Antonio Belmont
Apoptosis induction in renal cell carcinoma by TRAIL and γ-radiation is impaired by deficient caspase-9 cleavage
Safety and Efficacy of Dihydroartemisinin-Piperaquine in Falciparum Malaria: A Prospective Multi-Centre Individual Patient Data Analysis
BACKGROUND: The fixed dose antimalarial combination of dihydroartemisinin-piperaquine (DP) is a promising new artemisinin-based combination therapy (ACT). We present an individual patient data analysis of efficacy and tolerability in acute uncomplicated falciparum malaria, from seven published randomized clinical trials conducted in Africa and South East Asia using a predefined in-vivo protocol. Comparator drugs were mefloquine-artesunate (MAS3) in Thailand, Myanmar, Laos and Cambodia; artemether-lumefantrine in Uganda; and amodiaquine+sulfadoxine-pyrimethamine and artesunate+amodiaquine in Rwanda. METHODS AND FINDINGS: In total 3,547 patients were enrolled: 1,814 patients (32% children under five years) received DP and 1,733 received a comparator antimalarial at 12 different sites and were followed for 28-63 days. There was no significant heterogeneity between trials. DP was well tolerated with 1.7% early vomiting. There were less adverse events with DP in children and adults compared to MAS3 except for diarrhea; ORs (95%CI) 2.74 (2.13 to 3.51) and 3.11 (2.31 to 4.18), respectively. DP treatment resulted in a rapid clearance of fever and parasitaemia. The PCR genotype corrected efficacy at Day 28 of DP assessed by survival analysis was 98.7% (95%CI 97.6-99.8). DP was superior to the comparator drugs in protecting against both P.falciparum recurrence and recrudescence (P = 0.001, weighted by site). There was no difference between DP and MAS3 in treating P. vivax co-infections and in suppressing the first relapse (median interval to P. vivax recurrence: 6 weeks). Children under 5 y were at higher risk of recurrence for both infections. The proportion of patients developing gametocytaemia (P = 0.002, weighted by site) and the subsequent gametocyte carriage rates were higher with DP (11/1000 person gametocyte week, PGW) than MAS3 (6/1000 PGW, P = 0.001, weighted by site). CONCLUSIONS: DP proved a safe, well tolerated, and highly effective treatment of P.falciparum malaria in Asia and Africa, but the effect on gametocyte carriage was inferior to that of MAS3
PDE-4 inhibition rescues aberrant synaptic plasticity in Drosophila and mouse models of fragile X syndrome.
Fragile X syndrome (FXS) is the leading cause of both intellectual disability and autism resulting from a single gene mutation. Previously, we characterized cognitive impairments and brain structural defects in a Drosophila model of FXS and demonstrated that these impairments were rescued by treatment with metabotropic glutamate receptor (mGluR) antagonists or lithium. A well-documented biochemical defect observed in fly and mouse FXS models and FXS patients is low cAMP levels. cAMP levels can be regulated by mGluR signaling. Herein, we demonstrate PDE-4 inhibition as a therapeutic strategy to ameliorate memory impairments and brain structural defects in the Drosophila model of fragile X. Furthermore, we examine the effects of PDE-4 inhibition by pharmacologic treatment in the fragile X mouse model. We demonstrate that acute inhibition of PDE-4 by pharmacologic treatment in hippocampal slices rescues the enhanced mGluR-dependent LTD phenotype observed in FXS mice. Additionally, we find that chronic treatment of FXS model mice, in adulthood, also restores the level of mGluR-dependent LTD to that observed in wild-type animals. Translating the findings of successful pharmacologic intervention from the Drosophila model into the mouse model of FXS is an important advance, in that this identifies and validates PDE-4 inhibition as potential therapeutic intervention for the treatment of individuals afflicted with FXS
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