Cord blood cardiovascular biomarkers in left-sided congenital heart disease.

Fetal echocardiography has limited prognostic ability in the evaluation of left-sided congenital heart defects (left heart defects). Cord blood cardiovascular biomarkers could improve the prognostic evaluation of left heart defects. A multicenter prospective cohort (2013-2019) including fetuses with left heart defects (aortic coarctation, aortic stenosis, hypoplastic left heart, and multilevel obstruction (complex left heart defects) subdivided according to their outcome (favorable vs. poor), and control fetuses were evaluated in the third trimester of pregnancy at three referral centers in Spain. Poor outcome was defined as univentricular palliation, heart transplant, or death. Cord blood concentrations of N-terminal precursor of B-type natriuretic peptide, Troponin I, transforming growth factor β, placental growth factor, and soluble fms-like tyrosine kinase-1 were determined. A total of 45 fetuses with left heart defects (29 favorable and 16 poor outcomes) and 35 normal fetuses were included, with a median follow-up of 3.1 years (interquartile range 1.4-3.9). Left heart defects with favorable outcome showed markedly increased cord blood transforming growth factor β (normal heart median 15.5 ng/mL (6.8-21.4) vs. favorable outcome 51.7 ng/mL (13.8-73.9) vs. poor outcome 25.1 ng/mL (6.9-39.0), p = 0.001) and decreased placental growth factor concentrations (normal heart 17.9 pg/mL (13.8-23.9) vs. favorable outcome 12.8 pg/mL (11.7-13.6) vs. poor outcome 11.0 pg/mL (8.8-15.4), p < 0.001). Poor outcome left heart defects had higher N-terminal precursor of B-type natriuretic peptide (normal heart 508.0 pg/mL (287.5-776.3) vs. favorable outcome 617.0 pg/mL (389.8-1087.8) vs. poor outcome 1450.0 pg/mL (919.0-1645.0), p = 0.001) and drastically reduced soluble fms-like tyrosine kinase-1 concentrations (normal heart 1929.7 pg/mL (1364.3-2715.8) vs. favorable outcome (1848.3 pg/mL (646.9-2313.6) vs. poor outcome 259.0 pg/mL (182.0-606.0), p < 0.001). Results showed that fetuses with left heart defects present a distinct cord blood biomarker profile according to their outcome

Millora del nivell de formació realitzan pràctiques en Serveis de Suport a la Recerca. Un cas pràctic real

La motivació del present projecte és intentar aprofitar els recursos de que disposa el SAQ per a que alumnes de diferents titulacions (Químiques, Ciències Ambientals i Enginyeria Química) puguin fer pràctiques d'anàlisi instrumental amb aparells de característiques similars als que es trobaran quan surtin de la Universitat i tractant els problemes analítics amb una perspectiva globa

Total knee replacement from the patient's perspective. A qualitative study

Total knee replacement (TKR) is effective in relieving pain and improving function in patients with severe osteoarthritis (OA) However, studies report that 14-30% of patients are dissatisfied with the result and do not achieve the expected benefits, especially in function. Objectives: To examine the factors influencing decision-making before TKR. Methods: We made a phenomenological study of the determinants that lead patients to accept, delay or reject TKR (this study is part of a larger study). Demographic and clinical data were collected and pain intensity measured by the WOMAC scale. Focus groups were conducted and the results transcribed and analysed using the 4-stage analysis of qualitative data according to Ritchie, Spencer and O'Connor (2003). Results: 12 patients (9 female, mean age 71.58 + 6.02 years, BMI 37.43 + 5.32, mean comorbidities 6.73 + 2.19 and mean WOMAC pain 14.9 + 8.89, function 15.77 + 8.6, total 15. 71 + 8. 22) were included: 6 had received, 4 were waiting for and 2 had rejected TKR. Focus groups identified widespread pain (pain intensity functional limitations), causal beliefs and perceptions (OA a natural process associated with age, obesity, physical work, sport) mood (importance of optimism), professional-user relationship (communication, experience of OA) expectations (need for surgery conditioned by pain, lost function, surgical risks), and social support (promotion of healthy habits and adherence conditioned by family and social support) as factors influencing attitudes to undergoing TKR. Conclusions: The process of deciding to undergo TKR is complex and influenced by multiple factors. TKR improves a small proportion of an aging painful body. Our results suggest the need of care before and after TKR, psychosocial support and preventive and educational programmes. References: Ritchie J, Spencer L, O'Connor W. Carrying out qualitative analysis. In Ritchie J. and Lewis J. (eds.) guide for social science students and researchers Oaks; New Delhi. Qualitative research practice: A. Sage: London; Thousand; 2003 Disclosure of Interest: None declare

Genome-wide pathway analysis identifies VEGF pathway association with oral ulceration in systemic lupus erythematosus

Background: Systemic lupus erythematosus (SLE) is a genetically complex rheumatic disease characterized by heterogeneous clinical manifestations of unknown etiology. Recent studies have suggested the existence of a genetic basis for SLE heterogeneity. The objective of the present study was to identify new genetic variation associated with the clinically relevant phenotypes in SLE. Methods: A two-stage pathway-based approach was used to identify the genetic variation associated with the main clinical phenotypes in SLE. In the discovery stage, 482 SLE patients were genotyped using Illumina Human Quad610 microarrays. Association between 798 reference genetic pathways from the Molecular Signatures Database and 11 SLE phenotypes was tested using the set-based method implemented in PLINK software. Pathways significantly associated after multiple test correction were subsequently tested for replication in an independent cohort of 425 SLE patients. Using an in silico approach, we analyzed the functional effects of common SLE therapies on the replicated genetic pathways. The association of known SLE risk variants with the development of the clinical phenotypes was also analyzed. Results: In the discovery stage, we found a significant association between the vascular endothelial growth factor (VEGF) pathway and oral ulceration (P value for false discovery rate (P FDR) < 0.05), and between the negative regulation signaling pathway of retinoic acid inducible gene-I/melanoma differentiation associated gene 5 and the production of antinuclear antibodies (P FDR < 0.05). In the replication stage, we validated the association between the VEGF pathway and oral ulceration. Therapies commonly used to treat mucocutaneous phenotypes in SLE were found to strongly influence VEGF pathway gene expression (P = 4.60e-4 to 5.38e-14). Analysis of known SLE risk loci identified a strong association between PTPN22 and the risk of hematologic disorder and with the development of antinuclear antibodies. Conclusions: The present study has identified VEGF genetic pathway association with the risk of oral ulceration in SLE. New therapies targeting the VEGF pathway could be more effective in reducing the severity of this phenotype. These findings represent a first step towards the understanding of the genetic basis of phenotype heterogeneity in SLE

La movilidad en áreas metropolitanas. Un desafío permanente

Una de las actividades principales del Think Tank Movilidad es elaborar y proponer ideas sobre la movilidad y su entorno, a través de trabajos de investigación. El presente trabajo, “La movilidad en áreas metropolitanas. Un desafío permanente”, es el primero de una serie de trabajos de investigación, los cuales pretenden reflexionar en torno a varios aspectos de un tema tan importante como es la movilidad en las áreas metropolitana, a la vista de su importancia capital en la calidad de vida de las personas que las habitan y sus importantes repercusiones en aspectos tan esenciales y dispares como la salud o la competitividad económica.Think Tank Movilidad - Fundación CorellNo data 2019UE

Papers impresos. Núm. 7

Núm. 7 (Primavera 1985)La villa reale di Marlia / Federico Correa. Amb l'excusa del jardí / Francesc Parcerisas. Amb el paisatge i contra el paisatge / Llorenç Torrado. Umbráculos: aquellos fragmentos del paraíso / María del Mar Arnús. L'escultura com a paisatge. Una natura morta / Xavier Olivé, Josep Bag

Reportatge: Cobi, escola bressol pública municipal al Poblenou de Barcelona

La llar d’infants Cobi es troba en una emplaçament que és bastant freqüent al Poblenou de Barcelona: en la mateixa illa, limita amb l’escola dels nens més grans, i per la banda del carrer dóna a un xamfrà en el que hi ha un edifici industrial i els habitatges que ocupen l’illa dels carrers Turró/Àvila/Alava i Llull, projectats per l’arquitecte Carlos Ferrater a la Vila Olímpica, tots aquests força alts. En definitiva, un teixit urbà una mica caòtic i desigual. Potser per això, la llar d’infants es tanca sobre si mateixa sense que s’apreciï gairebé cap obertura a l’exterior. Malgrat això no dóna la sensació de búnquer –que es el que cabria esperar d’una actitud arquitectònica com aquesta, i més si pensem que l’acabat exterior és de formigó vist– sinó que, ben al contrari, el seu aspecte exterior és amable i agradable. Aquest darrer aspecte té la seva causa en diversos factors.Tres artículos sobre Cobi, escola bressol pública municipal al Poblenou de Barcelona: - Un edifici amable / Josep Olivé Saperas - Solucions innovadores i subjecció al programa / Jordi Olivés Salvadó - Joc de volums / María Isabel Bennasar Félix; Xavier Badia Armengo

Total knee replacement from the patient's perspective. A qualitative study

Total knee replacement (TKR) is effective in relieving pain and improving function in patients with severe osteoarthritis (OA) However, studies report that 14-30% of patients are dissatisfied with the result and do not achieve the expected benefits, especially in function. Objectives: To examine the factors influencing decision-making before TKR. Methods: We made a phenomenological study of the determinants that lead patients to accept, delay or reject TKR (this study is part of a larger study). Demographic and clinical data were collected and pain intensity measured by the WOMAC scale. Focus groups were conducted and the results transcribed and analysed using the 4-stage analysis of qualitative data according to Ritchie, Spencer and O'Connor (2003). Results: 12 patients (9 female, mean age 71.58 + 6.02 years, BMI 37.43 + 5.32, mean comorbidities 6.73 + 2.19 and mean WOMAC pain 14.9 + 8.89, function 15.77 + 8.6, total 15. 71 + 8. 22) were included: 6 had received, 4 were waiting for and 2 had rejected TKR. Focus groups identified widespread pain (pain intensity functional limitations), causal beliefs and perceptions (OA a natural process associated with age, obesity, physical work, sport) mood (importance of optimism), professional-user relationship (communication, experience of OA) expectations (need for surgery conditioned by pain, lost function, surgical risks), and social support (promotion of healthy habits and adherence conditioned by family and social support) as factors influencing attitudes to undergoing TKR. Conclusions: The process of deciding to undergo TKR is complex and influenced by multiple factors. TKR improves a small proportion of an aging painful body. Our results suggest the need of care before and after TKR, psychosocial support and preventive and educational programmes. References: Ritchie J, Spencer L, O'Connor W. Carrying out qualitative analysis. In Ritchie J. and Lewis J. (eds.) guide for social science students and researchers Oaks; New Delhi. Qualitative research practice: A. Sage: London; Thousand; 2003 Disclosure of Interest: None declare