Wingtip vortex in a NACA0012 airfoil and its active control

Contribución mediante sesión pósterWe conduct experiments in a towing-tank to analyse the flow patterns of wingtip vortices in a NACA 0012 airfoil. In this experimental research, we provide PIV measurements and flow visualisations. Without active control, several parameters are given experimentally as function of the Reynolds number, so we compare these data with the theoretical models of Batchelor, and Moore and Saffman together with DNS. Secondly, we analyse the effect of a continuous injection in the spanwise direction. The continuous jet has a strong influence on the wing-tip vortex formation. We explore this effect at low chord based Reynolds number ranging from 7000 up to 20000. We change the aspect ratio of the injection, R, defined as the ratio of the velocities between the jet (Uj) and free-stream (U). For R=1, we find that the jet strongly affects the wingtip vortex formation with a sudden decrement of the axial vorticity and the azimuthal velocity. This technique is a challenge and a promising tool to reduce the intensity of the vortex core.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Effect of the axial jet on the optimal response in Batchelor vortex

En este póster se estudia la respuesta óptima del torbellino de Batchelor para distintos números de onda. Se demuestra que incluso teniendo la velocidad axial, un torbellino es capaz de tener grandes amplificaciones de energía.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Estudio experimental y numérico del comportamiento de un modelo de difusor de aire por desplazamiento acoplado a un suelo frío

En la última década se han realizado muchos trabajos sobre sistemas de refrigeración para grandes superficies usando ventilación por desplazamiento con suelos radiantes (por ejemplo en aeropuertos y estaciones). De especial interés tiene el conocimiento de los campos de velocidad y de temperatura. De forma simplificada, en este estudio se presentan los resultados de un difusor a escala que utiliza ventilación por desplazamiento con suelo radiante frío. Tres son los parámetros que se modifican: el caudal (Q), la diferencia entre la temperatura ambiente y el aire de impulsión (dT1) y la diferencia entre la temperatura del suelo y el aire de impulsión (dT2). Las visualizaciones y mediciones del campo de velocidad del flujo se han realizado para un régimen laminar en estado estacionario. Además, las simulaciones numéricas del campo de temperatura representado en la figura muestran buena concordancia con los datos experimentales. Las zonas de mayor interés en este estudio son: la salida del difusor, la zona cercana al suelo y la zona lejos del difusor sobre el suelo, donde las condiciones de contorno se discuten con detalle. La distancia radial (r) para la que cada difusor afecta a su alrededor en los términos de gradiente de temperatura y de velocidad es un parámetro importante para el diseño de la distribución espacial de estos difusores. Los principales resultados de este trabajo se basan en la relación r = f (Q, dT1, dT2).AIRZON

Higher Order Dynamic Mode Decomposition of an experimental trailing vortex

The decay of trailing vortices is a fundamental problem in fluid mechanics and constitutes the basis of control applications that intend to alleviate the wake hazard. In order to progress, we use the recently developed modal-decomposition technique to identify the governing dynamics in an experimental trailing vortex. A particular emphasis is on the difficulty and usefulness of applying such tools to noisy experimental data. We conducted a water-tunnel experiment at a chord-based Reynolds number Re = 4 x 10^4 using stereoscopic particle image velocimetry measurements over a downstream range of 36 chords. The downstream evolution of the maximum of vorticity suggests that the whole wake can be partitioned into three consecutive regimes. A higher-order dynamic mode decomposition of the streamwise vorticity in each such part of the wake shows that the decay is well approximated by at most three modes. Additionally, our study provides evidence for the existence of several instabilities after the vortex roll up beyond about 6.5 chords

Association of Candidate Gene Polymorphisms With Chronic Kidney Disease: Results of a Case-Control Analysis in the Nefrona Cohort

Chronic kidney disease (CKD) is a major risk factor for end-stage renal disease, cardiovascular disease and premature death. Despite classical clinical risk factors for CKD and some genetic risk factors have been identified, the residual risk observed in prediction models is still high. Therefore, new risk factors need to be identified in order to better predict the risk of CKD in the population. Here, we analyzed the genetic association of 79 SNPs of proteins associated with mineral metabolism disturbances with CKD in a cohort that includes 2, 445 CKD cases and 559 controls. Genotyping was performed with matrix assisted laser desorption ionizationtime of flight mass spectrometry. We used logistic regression models considering different genetic inheritance models to assess the association of the SNPs with the prevalence of CKD, adjusting for known risk factors. Eight SNPs (rs1126616, rs35068180, rs2238135, rs1800247, rs385564, rs4236, rs2248359, and rs1564858) were associated with CKD even after adjusting by sex, age and race. A model containing five of these SNPs (rs1126616, rs35068180, rs1800247, rs4236, and rs2248359), diabetes and hypertension showed better performance than models considering only clinical risk factors, significantly increasing the area under the curve of the model without polymorphisms. Furthermore, one of the SNPs (the rs2248359) showed an interaction with hypertension, being the risk genotype affecting only hypertensive patients. We conclude that 5 SNPs related to proteins implicated in mineral metabolism disturbances (Osteopontin, osteocalcin, matrix gla protein, matrix metalloprotease 3 and 24 hydroxylase) are associated to an increased risk of suffering CKD

Genome-wide association study of inhaled corticosteroid response in admixed children with asthma

Background Inhaled corticosteroids (ICS) are the most widely prescribed and effective medication to control asthma symptoms and exacerbations. However, many children still have asthma exacerbations despite treatment, particularly in admixed populations, such as Puerto Ricans and African Americans. A few genome‐wide association studies (GWAS) have been performed in European and Asian populations, and they have demonstrated the importance of the genetic component in ICS response. Objective We aimed to identify genetic variants associated with asthma exacerbations in admixed children treated with ICS and to validate previous GWAS findings. Methods A meta‐analysis of two GWAS of asthma exacerbations was performed in 1347 admixed children treated with ICS (Hispanics/Latinos and African Americans), analysing 8.7 million genetic variants. Those with P ≤ 5 × 10−6 were followed up for replication in 1697 asthmatic patients from six European studies. Associations of ICS response described in published GWAS were followed up for replication in the admixed populations. Results A total of 15 independent variants were suggestively associated with asthma exacerbations in admixed populations (P ≤ 5 × 10−6). One of them, located in the intergenic region of APOBEC3B and APOBEC3C, showed evidence of replication in Europeans (rs5995653, P = 7.52 × 10−3) and was also associated with change in lung function after treatment with ICS (P = 4.91 × 10−3). Additionally, the reported association of the L3MBTL4‐ARHGAP28 genomic region was confirmed in admixed populations, although a different variant was identified. Conclusions and clinical relevance This study revealed the novel association of APOBEC3B and APOBEC3C with asthma exacerbations in children treated with ICS and replicated previously identified genomic regions. This contributes to the current knowledge about the multiple genetic markers determining responsiveness to ICS which could lead in the future the clinical identification of those asthma patients who are not able to respond to such treatment

Predictive Power of the "Trigger Tool" for the detection of adverse events in general surgery: a multicenter observational validation study

Background In spite of the global implementation of standardized surgical safety checklists and evidence-based practices, general surgery remains associated with a high residual risk of preventable perioperative complications and adverse events. This study was designed to validate the hypothesis that a new “Trigger Tool” represents a sensitive predictor of adverse events in general surgery. Methods An observational multicenter validation study was performed among 31 hospitals in Spain. The previously described “Trigger Tool” based on 40 specific triggers was applied to validate the predictive power of predicting adverse events in the perioperative care of surgical patients. A prediction model was used by means of a binary logistic regression analysis. Results The prevalence of adverse events among a total of 1,132 surgical cases included in this study was 31.53%. The “Trigger Tool” had a sensitivity and specificity of 86.27% and 79.55% respectively for predicting these adverse events. A total of 12 selected triggers of overall 40 triggers were identified for optimizing the predictive power of the “Trigger Tool”. Conclusions The “Trigger Tool” has a high predictive capacity for predicting adverse events in surgical procedures. We recommend a revision of the original 40 triggers to 12 selected triggers to optimize the predictive power of this tool, which will have to be validated in future studies

CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

Terrestrial Very-Long-Baseline Atom Interferometry:Workshop Summary

This document presents a summary of the 2023 Terrestrial Very-Long-Baseline Atom Interferometry Workshop hosted by CERN. The workshop brought together experts from around the world to discuss the exciting developments in large-scale atom interferometer (AI) prototypes and their potential for detecting ultralight dark matter and gravitational waves. The primary objective of the workshop was to lay the groundwork for an international TVLBAI proto-collaboration. This collaboration aims to unite researchers from different institutions to strategize and secure funding for terrestrial large-scale AI projects. The ultimate goal is to create a roadmap detailing the design and technology choices for one or more km-scale detectors, which will be operational in the mid-2030s. The key sections of this report present the physics case and technical challenges, together with a comprehensive overview of the discussions at the workshop together with the main conclusions