Global urban environmental change drives adaptation in white clover

Urbanization transforms environments in ways that alter biological evolution. We examined whether urban environmental change drives parallel evolution by sampling 110,019 white clover plants from 6169 populations in 160 cities globally. Plants were assayed for a Mendelian antiherbivore defense that also affects tolerance to abiotic stressors. Urban-rural gradients were associated with the evolution of clines in defense in 47% of cities throughout the world. Variation in the strength of clines was explained by environmental changes in drought stress and vegetation cover that varied among cities. Sequencing 2074 genomes from 26 cities revealed that the evolution of urban-rural clines was best explained by adaptive evolution, but the degree of parallel adaptation varied among cities. Our results demonstrate that urbanization leads to adaptation at a global scale

ALTERACIONES MORFOLÓGICAS E INMUNOHISTOQUIMCIAS EN HIPERTENSIÓN ARTERIAL PULMONAR EN AUTOPSIAS DE PACIENTES CON LUPUS ERITEMATOSO SISTÉMICO

Facultad de Medicin

Cohesión y adaptabilidad familiar en mujeres con epilepsia: estudio transversal analítico

Objetivo: Probar la hipótesis de que las mujeres con epilepsia pertenecen a familias con deficiencias en la cohesión y adaptabilidad a la enfermedad, en comparación con mujeres sanas. Diseño: Estudio transversal analítico. Emplazamiento: Se incluyó de forma retrospectiva a 263 mujeres de la consulta externa del servicio de neurología y una unidad de medicina familiar del Instituto Mexicano del Seguro Social en Sonora (México), entre 2010 y 2011. Participantes: Ochenta y dos mujeres epilépticas (casos) y 181 mujeres sanas (grupo control). Muestra apareada por edad y zona de residencia (1:2,2). Mediciones principales: Se realizó un análisis univariado para variables sociodemográficas, tipología familiar, nivel socioeconómico y nivel de cohesión-adaptabilidad familiar con el cuestionario FACES III. Un análisis con regresión logística se realizó para aquellas variables asociadas a disfunción familiar en mujeres con y sin epilepsia. Resultados: Se encontró disfunción familiar en el 22% de las mujeres epilépticas (RM = 2,91 [2,17-3,89]; p = 0,0001). El análisis univariado sugirió asociación para presencia de epilepsia, edad, evolución mayor a 15 años con epilepsia, tipología familiar (rural, urbana y tradicional) contra la presencia de disfunción familiar. El modelo de regresión logística confirmó asociación solo para la presencia de epilepsia (RM = 7,30 [4,00-13,33]; p = 0,0001). Conclusión: El estudio responde la hipótesis de que mujeres con epilepsia viven con familias con mayor deterioro psicosocial, manifestado por deficiencias en la cohesión y adaptabilidad a la enfermedad, en comparación con mujeres sanas

Chitosan treatment for skin ulcers associated with diabetes

Infections, ulcerations, gangrene and, in severe cases, extremity amputation, are common complications among diabetic subjects. Various biomaterials have been utilized for the treatment of these lesions. Chitosan is an amino sugar with a low risk of toxicity and immune response. In this study, we evaluated chitosan topical gel and film treatments for subjects with diabetic ulcerations and wounds associated with diabetes mellitus. In a pre-experimental design, we described the result of chitosan gel and film treatment for wounds and skin ulcers among patients with long-standing diabetes mellitus. We studied 8 diabetic patients with wounds and skin ulcers (long duration and Wagner degree 1–2). Initially, most lesions had some degree of infection, tissue damage and ulceration. At the end of the treatment (topical chitosan) period, the infections were cured. All patients experienced a significant improvement in the initial injury and developed granulation tissue and a healthy skin cover. This report represents one of the few published clinical experience regarding the chitosan for the treatment of skin lesions among diabetic subjects. These results are relevant and promising for the treatment of this disease

Risk factors for three-vessel coronary artery disease in patients of Northwest Mexico

Introduction: Three-vessel coronary artery disease is an advanced manifestation of atherosclerosis, with high prevalence in Mexico. Objective: The aim of this study was to describe coronary risk factors in a group of patients with three-vessel coronary artery disease in Northwest Mexico. Methods: A cross sectional study was conducted on a population with three-vessel coronary artery disease from May 2015 to February 2016. The disease was defined when ≥70% stenosis was present in each major epicardial coronary artery. Anthropometric and biochemical parameters were measured in each patient. Ankle-Brachial Index was measured with vascular ultrasound, and Syntax score calculation with an on-line application. Statistical analysis for qualitative differences was performed using Pearson X2 test, with p < 0.05 being considered as significant. Results: The study included 100 patients, of whom 75 were male (mean age 63 ± 9 years) and 25 female (mean age 69 ± 9 years). The coronary risk factors observed were diabetes (58%), hypertension (86%), smoking (68%), dyslipidaemia (100%), metabolic syndrome (71%), and obesity/overweight (75%). Diabetes and metabolic syndrome prevalence was higher in women (p = 0.03), but smoking was higher in men (76%, p = 0.003). Ankle-Brachial Index was abnormal in 58% of patients, the mean Syntax score was in 36.9 ± 11.5, and the prevalence of left main coronary heart disease was 36%. Conclusions: This group of patients with complex coronary lesions has a high prevalence of coronary risk factors, which could represent a worse prognosis. Resumen: Introducción: La enfermedad coronaria de tres vasos (ECTV) es una manifestación avanzada de aterosclerosis, con alta prevalencia en el noroeste de México. Objetivo: Describir los factores de riesgo coronario (FRC) en un grupo de enfermos con ECTV en el noroeste de México. Métodos: De mayo de 2015 a febrero de 2016 se realizó un estudio transversal en una población del noroeste de México diagnosticada con ECTV. Se definió ECTV cuando existía estenosis ≥70% en cada una de las arterias coronarias epicárdicas mayores. Se midieron parámetros antropométricos y bioquímicos en cada paciente. Los parámetros para el índice tobillo-brazo (ITB) se obtuvieron con ultrasonido vascular (Edan SonoTrax 8 Hz) y un cálculo de puntaje Syntax con una aplicación en línea. Análisis estadístico con χ2 de Pearson para diferencias cualitativas Se consideró significativo cuando p ≤ 0.05. Resultados: Se estudiaron 25 mujeres (edad 69 ± 9 años) y 75 varones (edad 63 ± 9 años). Los FRC observados fueron diabetes (58%), hipertensión (86%), antecedente de tabaquismo (68%), dislipidemia (100%), síndrome metabólico (71%) y sobrepeso/obesidad (75%). En las mujeres la prevalencia de diabetes y síndrome metabólico fue mayor que en los varones (p = 0.03), pero el tabaquismo fue más prevalente en los varones (76%, p = 0.003). El ITB se encontró anormal en el 58% de los pacientes, el puntaje Syntax promedio fue de 36.9 ± 11.5 y la prevalencia de la enfermedad del tronco de la arteria coronaria izquierda fue del 36%. Conclusión: En este grupo de estudio con lesiones coronarias complejas existe alta prevalencia de FRC que se refleja en y posiblemente un peor pronóstico. Keywords: Coronary artery disease, Atherosclerosis, Risk factors, Syntax score, Ankle-Brachial Index, Mexico, Palabras clave: Enfermedad arterial coronaria, Aterosclerosis, Factores de riesgo, Puntaje Syntax, Índice tobillo-brazo, Méxic

Global urban environmental change drives adaptation in white clover

Urbanization transforms environments in ways that alter biological evolution. We examined whether urban environmental change drives parallel evolution by sampling 110,019 white clover plants from 6169 populations in 160 cities globally. Plants were assayed for a Mendelian antiherbivore defense that also affects tolerance to abiotic stressors. Urban-rural gradients were associated with the evolution of clines in defense in 47% of cities throughout the world. Variation in the strength of clines was explained by environmental changes in drought stress and vegetation cover that varied among cities. Sequencing 2074 genomes from 26 cities revealed that the evolution of urban-rural clines was best explained by adaptive evolution, but the degree of parallel adaptation varied among cities. Our results demonstrate that urbanization leads to adaptation at a global scale