Applying probabilistic temporal and multi-site data quality control methods to a public health mortality registry in Spain: A systematic approach to quality control of repositories

OBJECTIVE: To assess the variability in data distributions among data sources and over time through a case study of a large multisite repository as a systematic approach to data quality (DQ). MATERIALS AND METHODS: Novel probabilistic DQ control methods based on information theory and geometry are applied to the Public Health Mortality Registry of the Region of Valencia, Spain, with 512 143 entries from 2000 to 2012, disaggregated into 24 health departments. The methods provide DQ metrics and exploratory visualizations for (1) assessing the variability among multiple sources and (2) monitoring and exploring changes with time. The methods are suited to big data and multitype, multivariate, and multimodal data. RESULTS: The repository was partitioned into 2 probabilistically separated temporal subgroups following a change in the Spanish National Death Certificate in 2009. Punctual temporal anomalies were noticed due to a punctual increment in the missing data, along with outlying and clustered health departments due to differences in populations or in practices. DISCUSSION: Changes in protocols, differences in populations, biased practices, or other systematic DQ problems affected data variability. Even if semantic and integration aspects are addressed in data sharing infrastructures, probabilistic variability may still be present. Solutions include fixing or excluding data and analyzing different sites or time periods separately. A systematic approach to assessing temporal and multisite variability is proposed. CONCLUSION: Multisite and temporal variability in data distributions affects DQ, hindering data reuse, and an assessment of such variability should be a part of systematic DQ procedures.This work was supported by the Spanish Ministry of Economy and Competitiveness grant numbers RTC-2014-1530-1 and TIN-2013-43457-R, and by the Universitat Politecnica de Valencia grant number SP20141432.Sáez Silvestre, C.; Zurriaga, O.; Pérez-Panadés, J.; Melchor, I.; Robles Viejo, M.; García Gómez, JM. (2016). Applying probabilistic temporal and multi-site data quality control methods to a public health mortality registry in Spain: A systematic approach to quality control of repositories. Journal of the American Medical Informatics Association. 23(6):1085-1095. https://doi.org/10.1093/jamia/ocw010S1085109523

An Energy-Reduced Mediterranean Diet, Physical Activity, and Body Composition

[ENG]Importance Strategies targeting body composition may help prevent chronic diseases in persons with excess weight, but randomized clinical trials evaluating lifestyle interventions have rarely reported effects on directly quantified body composition. OBJECTIVE To evaluate the effects of a lifestyle weight-loss intervention on changes in overall and regional body composition. DESIGN, SETTING, AND PARTICIPANTS The ongoing Prevención con Dieta Mediterránea-Plus (PREDIMED-Plus) randomized clinical trial is designed to test the effect of the intervention on cardiovascular disease prevention after 8 years of follow-up. The trial is being conducted in 23 Spanish research centers and includes men and women (age 55-75 years) with body mass index between 27 and 40 and metabolic syndrome. The trial reported herein is an interim subgroup analysis of the intermediate outcome body composition after 3-year follow-up, and data analysis was conducted from February 1 to November 30, 2022. Of 6874 total PREDIMED-Plus participants, a subsample of 1521 individuals, coming from centers with access to a dual energy x-ray absorptiometry device, underwent body composition measurements at 3 time points. INTERVENTION Participants were randomly allocated to a multifactorial intervention based on an energy-reduced Mediterranean diet (MedDiet) and increased physical activity (PA) or to a control group based on usual care, with advice to follow an ad libitum MedDiet, but no physical activity promotion. MAIN OUTCOMES AND MEASURES The outcomes (continuous) were 3-year changes in total fat and lean mass (expressed as percentages of body mass) and visceral fat (in grams), tested using multivariable linear mixed-effects models. Clinical relevance of changes in body components (dichotomous) was assessed based on 5% or more improvements in baseline values, using logistic regression. Main analyses were performed in the evaluable population (completers only) and in sensitivity analyses, multiple imputation was performed to include data of participants lost to follow-up (intention-to-treat analyses). RESULTS A total of 1521 individuals were included (mean [SD] age, 65.3 [5.0] years; 52.1% men). In comparison with the control group (n=761), participants in the intervention arm (n=760) showed greater reductions in the percentage of total fat (between group differences after 1-year, −0.94% [95% CI, −1.19 to −0.69]; 3 years, −0.38% [95% CI, −0.64 to −0.12] and visceral fat storage after 1 year, -126 g [95% CI, −179 to −73.3 g]; 3 years, −70.4 g [95% CI, −126 to −15.2 g] and greater increases in the percentage of total lean mass at 1 year, 0.88% [95% CI, 0.63%-1.12%]; 3-years 0.34% [95%CI, 0.09%-0.60%]). The intervention group was more likely to show improvements of 5% or more in baseline body components (absolute risk reduction after 1 year, 13% for total fat mass, 11% for total lean mass, and 14% for visceral fat mass; after 3-years: 6% for total fat mass, 6% for total lean mass, and 8% for visceral fat mass). The number of participants needed to treat was between 12 and 17 to attain at least 1 individual with possibly clinically meaningful improvements in body composition. CONCLUSIONS AND RELEVANCE The findings of this trial suggest a weight-loss lifestyle intervention based on an energy-reduced MedDiet and physical activity significantly reduced total and visceral fat and attenuated age-related losses of lean mass in older adults with overweight or obesity and metabolic syndrome. Continued follow-up is warranted to confirm the long-term consequences of these changes on cardiovascular clinical end points.S

The Effect of Physical Activity and High Body Mass Index on Health-Related Quality of Life in Individuals with Metabolic Syndrome

[EN] The main objective of this study was to examine the relationship between the level of physical activity (PA) and the degree of obesity with health-related quality of life (HRQoL) in individuals with metabolic syndrome (MetS) who participated in the Predimed-Plus study. A total of 6875 subjects between 55 and 75 years of age with MetS were selected and randomized in 23 Spanish centers. Subjects were classified according to categories of body mass index (BMI). PA was measured with the validated Registre Gironi del Cor (REGICOR) questionnaire and subjects were classified according to their PA level (light, moderate, vigorous) and the HRQoL was measured with the validated short-form 36 (SF-36) questionnaire. By using the ANOVA model, we found a positive and statistically significant association between the level of PA and the HRQoL (aggregated physical and mental dimensions p < 0.001), but a negative association with higher BMI in aggregated physical dimensions p < 0.001. Furthermore, women obtained lower scores compared with men, more five points in all fields of SF-36. Therefore, it is essential to promote PA and body weight control from primary care consultations to improve HRQoL, paying special attention to the differences that sex incurs.SIThe Predimed-Plus trial was supported by the Spanish government’s official funding agency for biomedical research, ISCIII, through the Fondo de Investigación para la Salud (FIS), which is co-funded by the European Regional Development Fund (three coordinated FIS projects led by Jordi Salas-Salvadó and Josep Vidal, including the following projects: PI13/00673, PI13/00492, PI13/00272, PI13/01123, PI13/00462, PI13/00233, PI13/02184, PI13/00728, PI13/01090, PI13/01056, PI14/01722, PI14/0147, PI14/00636, PI14/00972, PI14/00618, PI14/00696, PI14/01206, PI14/01919, PI14/00853, PI14/01374, PI16/00473, PI16/00662, PI16/01873, PI16/01094, PI16/00501, PI16/00533, PI16/00381, PI16/00366, PI16/01522, PI16/01120, PI17/00764, PI17/01183, PI17/00855, PI17/01347, PI17/00525, PI17/01827, PI17/00532, PI17/00215, PI17/01441, PI17/00508, PI17/01732, PI17/00926, PI19/00957, PI19/00386, PI19/00309, PI19/01032, PI19/00576, PI19/00017, PI19/01226, PI19/00781, PI19/01560, PI19/01,332), the Special Action Project entitled: Implementación y evaluación de una intervención intensiva sobre la actividad física Cohorte PREDIMED-PLUS grant to Jordi Salas-Salvadó, the European Research Council (Advanced Research Grant 2013–2018; 340918) grant to Miguel Ángel Martínez-Gonzalez, the Recercaixa grant to Jordi Salas-Salvadó (2013ACUP00194), grants from the Consejería de Salud de la Junta de Andalucía (PI0458/2013; PS0358/2016; PI0137/2018), the PROMETEO/2017/017 grant from the Generalitat Valenciana, the SEMERGEN grant and FEDER funds (CB06/03 and CB12/03), Olga Castaner is funded by the JR17/00,022 grant, ISCIII. Christopher Papandreou is supported by a postdoctoral fellowship granted by the Autonomous Government of Catalonia (PERIS 2016–2020 Incorporació de Científics i Tecnòlegs, SLT002/0016/00,428). María Rosa Bernal-Lopez was supported by “Miguel Servet Type I” program (CP15/00028) from the ISCIII-Madrid (Spain), cofinanced by the Fondo Europeo de Desarrollo Regional-FEDER, Ignacio M.Giménez-Alba is supported by a FPU predoctoral contract (reference FPU18/01703) from the Ministerio de Ciencia, Innovación y Universidades, Spain

Understanding Primary Ciliary Dyskinesia: Experience From a Mediterranean Diagnostic Reference Centre

Background: Due to the lack of a gold standard diagnostic test, reference centres with experienced personnel and costly procedures are needed for primary ciliary dyskinesia (PCD) diagnostics. Diagnostic flowcharts always start with clinical symptoms. Therefore, the aim of this work is to define differential clinical criteria so that only patients clinically compatible with PCD are referred to reference centres. Materials and methods: 18 variables from 476 Mediterranean patients with clinically suspicious PCD were collected. After analysing cilia function and ultrastructure, 89 individuals were diagnosed with PCD and 387 had a negative diagnosis. Simple logistic regression analysis, considering PCD as a dependent variable and the others as independent variables, was done. In order to define the variables that best explain PCD, a step-wise logistic regression model was defined. Aiming to classify individuals as PCD or PCD-like patients, based on variables included in the study, a classification and regression tree (CART) was designed. Results and conclusions: Simple logistic regression analysis shows statistically significant association between age at the beginning of their symptomatology, periodicity, fertility, situs inversus, recurrent otitis, atelectasis, bronchiectasis, chronic productive cough, rhinorrea, rhinusinusitis and recurrent pneumonias, and PCD. The step-wise logistic regression model selected situs inversus, atelectasis, rhinorrea, chronic productive cough, bronchiectasis, recurrent pneumonias, and otitis as PCD predictive variables (82% sensitivity, 88% specificity, and 0.92 Area Under the Curve (AUC)). A decision tree was designed in order to classify new individuals based on pansinusitis, situs inversus, periodicity, rhinorrea, bronchiectasis, and chronic wet cough

Quantitative detection of Citrus tristeza virus in plant tissues and single aphids by real time RT-PCR

12 páginas, ilustraciones y tablas estadísticasTaqMan real-time reverse transcriptase (RT)-polymerase chain reaction (PCR) using purified RNA targets or coupled to tissue-print and squash procedures was developed to detect and quantify Citrus tristeza virus (CTV) RNA-targets in plant tissues and in single aphids. With this method all CTV isolates tested from different hosts and origins were detected. The sensitivity of conventional realtime RT-PCR was 1,000 times higher than immunocapture (IC)-RT-nested PCR and 106 times higher than enzyme linked immunosorbent assay (ELISA). The quantitation limit ranged from 1.7×102 to 1.7× 109 transcript copies. The estimated number of CTV RNA-targets detected in different organs of a CTVinfected tree ranged from 4.5×105 to 6.5×108 copies when purified RNA was used as template and from 1.9×104 to 3.7×106 when tissue-printed material was used. In single squashed aphids the number of copies ranged from 4.73×103 to 1.23×105. Reliable quantitation of CTV targets present in infected plant material or acquired by single aphid species, was achieved with tissue-print and squash procedures combined with real-time RT-PCR, both of which do not require extraction procedures or nucleic acid purification.RTA2005-00190 (IVIA 1606)Peer reviewe

Inadequate visits to the emergency department by pregnant women

Inadequate emergency visits, which could be resolved in primary care, are an unnecessary expense for the healthcare service. We did a review of all gynaecology and obstetrics emergency visits by pregnant or postpartum women during 2010 and 2011 in order to describe the adequacy of the visits by pregnant women to the emergency service. We defined three levels of adequacy: adequate, moderately adequate, and inadequate. One thousand seven hundred and forty-three visits to the emergency room of gynaecology and obstetrics were studied. These consultation motivations were adequate in 38.9%, moderately adequate in 46.7% and inadequate in 14.4%. This shows that the amount of inadequate and moderately adequate visits to the emergency department could be reduced by 61% by implementing different interventions, and also reducing health spending for emergencies.Impact statement What is already known on this subject: Visits to the emergency room constitute a basic pillar in the hospital structure, and it generates great health expense. Other authors have reported high rates of inadequacy of these visits to the emergency services. They find inadequate visits are associated with young age and female gender among other factors. What the results of this study add: Knowing the adequacy of the visits generated by pregnant young women is a starting point for implementing health policies that could reduce these inadequate visits and consequently health expenditure could be reduced. What the implications are of these findings for clinical practice and/or further research: These health policies could consequently reduce health expenditure

Understanding Primary Ciliary Dyskinesia : Experience From a Mediterranean Diagnostic Reference Centre

Background: Due to the lack of a gold standard diagnostic test, reference centres with experienced personnel and costly procedures are needed for primary ciliary dyskinesia (PCD) diagnostics. Diagnostic flowcharts always start with clinical symptoms. Therefore, the aim of this work is to define di ff erential clinical criteria so that only patients clinically compatible with PCD are referred to reference centres. Materials and methods: 18 variables from 476 Mediterranean patients with clinically suspicious PCD were collected. After analysing cilia function and ultrastructure, 89 individuals were diagnosed with PCD and 387 had a negative diagnosis. Simple logistic regression analysis, considering PCD as a dependent variable and the others as independent variables, was done. In order to define the variables that best explain PCD, a step-wise logistic regression model was defined. Aiming to classify individuals as PCD or PCD-like patients, based on variables included in the study, a classification and regression tree (CART) was designed. Results and conclusions: Simple logistic regression analysis shows statistically significant association between age at the beginning of their symptomatology, periodicity, fertility, situs inversus, recurrent otitis, atelectasis, bronchiectasis, chronic productive cough, rhinorrea, rhinusinusitis and recurrent pneumonias, and PCD. The step-wise logistic regression model selected situs inversus, atelectasis, rhinorrea, chronic productive cough, bronchiectasis, recurrent pneumonias, and otitis as PCD predictive variables (82% sensitivity, 88% specificity, and 0.92 Area Under the Curve (AUC)). A decision tree was designed in order to classify new individuals based on pansinusitis, situs inversus, periodicity, rhinorrea, bronchiectasis, and chronic wet cough. Keywords: standard diagnosis; reference centres; clinical presentation; cilia; primary ciliary dyskinesi

Inequalities in Perinatal Mortality Rates Among Immigrant and Native Population in Spain, 2005–2008

We compared perinatal mortality rates (PMRs) and the risk from certain causes among immigrant and native population in the Valencian Community (Spain). Using data from the Perinatal Mortality Registry, crude and age standardized mortality ratios were obtained in the different groups of mothers. Mortality rate ratios were calculated to compare the causes of death resulting from prematurity, congenital anomalies, infectious diseases and Sudden Infant Death Syndrome between Spanish and foreign women. PMRs were higher among all the immigrant groups compared with the native population, with a statistical significance in Eastern European and sub-Saharan mothers. Neonatal mortality rates in North African and Latin American mothers were similar to those of native women. Babies of immigrant mothers were at a significant higher risk of dying from late infectious diseases and from causes resulting from being premature. More research is needed on the risk factors which contribute to generating differences in our setting

Interacción entre los pulgones de los cítricos (Hemiptera, Aphididae) y el minador de las hojas de los cítricos Phyllocnistis citrella Stainton (Lepidoptera, Gracillariidae)

Para estudiar en cítricos la interacción entre los pulgones (Aphis spiraecola Aphis gossypii) y el minador de las hojas Phyllocnistis cirella, se realizaron dos tipos de experimentos, unos en campo y otros en laboratorio, En campo se comparó la evolución anual de los pulgones y del minador en dos parcelas de cítricos localizadas en Moncada (Valencia) y Elche (Alicante). En laboratorio se estudió la evolución de P. citrella y A. spiraecola sobre plantones de naranjo amargo cuando los dos fitófagos infestaban las plantas al mismo tiempo, cuando A. spiraecola infestaba primero las hojas de las plantas, y cuando el pulgón infestaba hojas que ya tenían larvas (bien jóvenes o bien desarrolladas) del minador. En todos los casos se comparó la supervivencia de cada insecto con la de los controles correspondientes. Los resultados indican que hay poca convivencia entre el minador y los pulgones en campo, aunque sí que coincidieron en junio y en otoño. Cuando se da esta convivencia, tal y como se demostró en laboratorio, no parece afectar a A. spiraecola (que evoluciona como si no estuviera el minador), pero sí al minador, que evoluciona peor en hojas donde encuentra ya instalado al pulgón que en hojas donde no lo estáTo study the interaction among the citrus aphids (Aphis spiraecola and Aphis gossypii) and the citrus leafminer Phyllocnistis citrella, two sets of experiments were conducted, under field and laboratory contitons. In field, the dynamics of the citrus aphids and citrus leafminer were obtained in two citrus orchards located in Moncada (Valencia) and Elche (Alicante). Under laboratory conditions, the development of P. Citrella and A. spiraecola on sour orange seedlings was studied when both infested plants simultaneously, when A. spiraecola was first installed, and when it was intalled on leaves infested previously with P. citrella larvae (young or late instars). In all cases, survival of each insect was compared whith the corresponding controls. Field results showed a limited period of co-existence among P. citrella and the citrus aphids: June and autumn. When this occurs, as laboratory results showed, A. spiraecola is not affected (because develops in the same way that when the citrus leafminer is not present). Nevertheless, the survival of the citrus leafminer is lower when infests leaves with the presence of citrus aphid

Magnitude and factors associated with the solitary death phenomenon of the elderly in the Valencian Community.

[ES] En la Comunidad Valenciana un 23% de los ancianos viven solos, representando la muer-te solitaria del anciano un efecto indeseado del envejeci-miento. Nuestro objetivo fue determinar la magnitud de este fenómeno y sus factores de riesgo en la población mayor de 64 años de la CV durante el período 2015-2017. Estudio observacional, transversal. Se ana-lizaron las defunciones domiciliarias de residentes mayo-res de 64 años de la CV durante el período 2015-2017, con datos de los certificados médicos y judiciales de defun-ción. Se describieron las tasas de incidencia ajustadas, ca-racterísticas sociodemográficas y causas de muerte. Para el análisis de factores de riesgo se realizó una regresión logística multivariante tomando como medida de asocia-ción la Razón de Odds (OR) ajustada. Se usó un nivel de significación α=0,05 y unos IC del 95%. Se encontraron 417 casos. Las tasas ajustadas fueron: en 2015, 17,3 (IC95%: 14,7-20,2); en 2016, 14,5 (IC95%: 12,1-17,2); y en 2017, 13,2 (IC95%: 11,0-15,8). Las causas más frecuentes fueron circulatorias (52,5%) y externas (19,2%). Los factores asociados a la MSA fueron el sexo (OR M/H: 2,40; IC95%: 1,87-3,06), edad (OR ≥76/<76: 4,56; IC95%: 3,53-5,90), discapaci-dad (OR No/Sí: 0,51; IC95%: 0,31-0,85), estación (ref: primavera; OR verano: 2,34; IC95%: 1,63-3,37) y núcleo de población (OR rural/urbano: 2,20; IC95%1,58-3,08). La magnitud de la muerte en solitario en la Comunidad Valenciana es relevante, existiendo un mayor riesgo en hombres y a edades más tempranas, así como en verano y áreas urbanas. Presentar discapacidad representa una cierta protección. [EN] In the Valencian Community 23% of the elderly people live alone, representing the solitary death among aged persons an unwanted effect of aging. Our aim was to determine the magnitude of this phenomenon and its risk factors in the population over 64 years of the CV during the period 2015-2017. Cross-sectional study was carried out. Household deaths of residents over 64 years of the CV during the 2015-2017 period were analyzed, with records on medical and judicial death certificates. Adjusted incidence rates, sociodemographic characteristics and causes of death were described. For the analysis of risk factors, a multivariate logistic regression was performed, taking the adjusted Odds Ratio (OR) as an association measure. A significance level α=0.05 and 95% confidence intervals (CI) were used. 417 cases were found. The adjusted rates were: in 2015, 17.3 (95% CI: 14.7-20.2); in 2016, 14.5 (95% CI: 12.1-17.2); and in 2017, 13.2 (95% CI: 11,0-15.8). The most frequent causes were circulatory (52.5%) and external (19.2%). After adjustment, gender (OR M / H: 2.40; 95% CI: 1.87-3.06), age (OR ≥76 / <76: 4.56; 95% CI: 3.53 -5.90), disability (OR No / Yes: 0.51; 95% CI: 0.31-0.85), season (ref: spring; summer OR: 2.34; 95% CI: 1.63-3 , 37) and population nucleus (rural / urban OR: 2.20; 95% CI 1.58-3.08), remained associated whit the MSA. The solitary death among aged persons is a phenomenon scarcely studied in our environment from public health. The magnitude in the CV is relevant, with a greater risk in men and at younger ages, as well as in summer and urban areas. Presenting disability represents a certain protection.S