The Longue Durée of Literary Prestige

A history of literary prestige needs to study both works that achieved distinction and the mass of volumes from which they were distinguished. To understand how those patterns of preference changed across a century, we gathered two samples of English-language poetry from the period 1820–1919: one drawn from volumes reviewed in prominent periodicals and one selected at random from a large digital library (in which the majority of authors are relatively obscure). The stylistic differences associated with literary prominence turn out to be quite stable: a statistical model trained to distinguish reviewed from random volumes in any quarter of this century can make predictions almost as accurate about the rest of the period. The “poetic revolutions” described by many histories are not visible in this model; instead, there is a steady tendency for new volumes of poetry to change by slightly exaggerating certain features that defined prestige in the recent past.Ope

The Ecology Of Elevational Positions In Plants: Drought Resistance In Five Montane Pine Species In Southeastern Arizona

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/141149/1/ajb213762.pd

Photosynthesis, carboxylation and leaf nitrogen responses of 16 species to elevated pCO 2 across four free-air CO 2 enrichment experiments in forest, grassland and desert

The magnitude of changes in carboxylation capacity in dominant plant species under long-term elevated CO 2 exposure (elevated pC a ) directly impacts ecosystem CO 2 assimilation from the atmosphere. We analyzed field CO 2 response curves of 16 C 3 species of different plant growth forms in favorable growth conditions in four free-air CO 2 enrichment (FACE) experiments in a pine and deciduous forest, a grassland and a desert. Among species and across herb, tree and shrub growth forms there were significant enhancements in CO 2 assimilation ( A ) by +40±5% in elevated pC a (49.5–57.1 Pa), although there were also significant reductions in photosynthetic capacity in elevated pC a in some species. Photosynthesis at a common pC a ( A a ) was significantly reduced in five species growing under elevated pC a , while leaf carboxylation capacity ( V cmax ) was significantly reduced by elevated pC a in seven species (change of −19±3% among these species) across different growth forms and FACE sites. Adjustments in V cmax with elevated pC a were associated with changes in leaf N among species, and occurred in species with the highest leaf N. Elevated pC a treatment did not affect the mass-based relationships between A or V cmax and N, which differed among herbs, trees and shrubs. Thus, effects of elevated pC a on leaf C assimilation and carboxylation capacity occurred largely through changes in leaf N, rather than through elevated pC a effects on the relationships themselves. Maintenance of leaf carboxylation capacity among species in elevated pC a at these sites depends on maintenance of canopy N stocks, with leaf N depletion associated with photosynthetic capacity adjustments. Since CO 2 responses can only be measured experimentally on a small number of species, understanding elevated CO 2 effects on canopy N m and N a will greatly contribute to an ability to model responses of leaf photosynthesis to atmospheric CO 2 in different species and plant growth forms.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72832/1/j.1365-2486.2004.00867.x.pd

One way or another? Criminal investigators' beliefs regarding the disclosure of evidence in interviews with suspects in England and Wales

The research base concerning interviews with suspects remains to be comprehensively developed. For example, the extant literature provides differing views regarding how best to undertake the important interview task of disclosing evidence. In the current study, using a self-report questionnaire, 224 investigators based in England and Wales were asked as to their own preferred methods. Most respondents advocated a gradual method of disclosing evidence, stating that this approach would better reveal inconsistencies and obtain a complete version of events (similar to the reasoning of those who preferred disclosing evidence later). Those who advocated revealing evidence early stated this approach would more likely elicit confessions. Several respondents would not commit to one single method, arguing that their chosen strategy was contextually dependent. The study’s findings suggest that it remains arguable as to whether there is one best approach to evidence disclosure and/or whether particular circumstances should influence interviewing strategies

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

Middle East respiratory syndrome coronavirus (MERS-CoV) is the causative agent of a severe respiratory disease associated with more than 2468 human infections and over 851 deaths in 27 countries since 2012. There are no approved treatments for MERS-CoV infection although a combination of lopinavir, ritonavir and interferon beta (LPV/RTV-IFNb) is currently being evaluated in humans in the Kingdom of Saudi Arabia. Here, we show that remdesivir (RDV) and IFNb have superior antiviral activity to LPV and RTV in vitro. In mice, both prophylactic and therapeutic RDV improve pulmonary function and reduce lung viral loads and severe lung pathology. In contrast, prophylactic LPV/RTV-IFNb slightly reduces viral loads without impacting other disease parameters. Therapeutic LPV/RTV-IFNb improves pulmonary function but does not reduce virus replication or severe lung pathology. Thus, we provide in vivo evidence of the potential for RDV to treat MERS-CoV infections

History, Commemoration, and Belief: Abraham Lincoln in American Memory, 1945-2001

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/91765/1/Schuman-History_Commemoration_Belief.pd

Allele-Specific HLA Loss and Immune Escape in Lung Cancer Evolution

Immune evasion is a hallmark of cancer. Losing the ability to present neoantigens through human leukocyte antigen (HLA) loss may facilitate immune evasion. However, the polymorphic nature of the locus has precluded accurate HLA copy-number analysis. Here, we present loss of heterozygosity in human leukocyte antigen (LOHHLA), a computational tool to determine HLA allele-specific copy number from sequencing data. Using LOHHLA, we find that HLA LOH occurs in 40% of non-small-cell lung cancers (NSCLCs) and is associated with a high subclonal neoantigen burden, APOBEC-mediated mutagenesis, upregulation of cytolytic activity, and PD-L1 positivity. The focal nature of HLA LOH alterations, their subclonal frequencies, enrichment in metastatic sites, and occurrence as parallel events suggests that HLA LOH is an immune escape mechanism that is subject to strong microenvironmental selection pressures later in tumor evolution. Characterizing HLA LOH with LOHHLA refines neoantigen prediction and may have implications for our understanding of resistance mechanisms and immunotherapeutic approaches targeting neoantigens. Video Abstract [Figure presented] Development of the bioinformatics tool LOHHLA allows precise measurement of allele-specific HLA copy number, improves the accuracy in neoantigen prediction, and uncovers insights into how immune escape contributes to tumor evolution in non-small-cell lung cancer