Expressions 2020

https://openspace.dmacc.edu/expressions/1036/thumbnail.jp

Global Anomalies and Anyons in 1+1 Dimensions

We consider the analog in one spatial dimension of the Bose-Fermi transmutation for planar systems. A quantum mechanical system of a spin 1/2 particle coupled to an abelian gauge field, which is classically invariant under gauge transformations and charge conjugation is studied. It is found that unless the flux enclosed by the particle orbits is quantized, and the spin takes a value $n+ 1/2$, at least one of the two symmetries would be anomalous. Thus, charge conjugation invariance and the existence of abelian instantons simultaneously force the particles to be either bosons or fermions, but not anyons.Comment: Changed title. To be published in Physics Letters

The effect of lifestyle and risk factor modification on occlusive peripheral arterial disease outcomes: standard healthcare vs structured programme—for a randomised controlled trial protocol

© The Author(s) 2021. Background: Peripheral arterial disease (PAD) affects more than 200 million of the global population. PAD represents a marker for premature cardiovascular events. Patients with PAD, even in the absence of a history of myocardial infarction or ischemic stroke, have approximately the same relative risk of death from cardiovascular causes as patients with a history of coronary or cerebrovascular disease. Despite the high prevalence of PAD and the strong association with cardiovascular morbidity and mortality, patients with PAD are less likely to receive appropriate treatment for their atherosclerotic risk factors than those who are being treated for coronary artery disease. Atherosclerotic risk factor identification and modification play an important role in reducing the number of adverse outcomes among patients with atherosclerosis. Risk reduction therapy decreases the risk of cardiovascular mortality and morbidity in patients with PAD. In this study, we aim to evaluate the effectiveness of a lifestyle and risk factor modification intervention programme in achieving treatment goals for PAD risk factors. Methods: This is a randomised, parallel group, active-control trial to compare the effectiveness of the risk factor modification intervention programme to standard healthcare in a tertiary vascular care centre, in the reduction of modified risk factors in PAD patients. The primary outcome of this study is to evaluate the effectiveness of a lifestyle and risk factor modification intervention programme in achieving treatment goals for PAD risk factors at 3 and 12 months. The secondary outcomes are to compare the impact of the programme on clinical outcomes in PAD patients at 12 months. Secondary outcomes include amputation-free survival, clinical improvement, haemodynamic improvement, need for revascularisation procedures, outcomes of revascularisation procedures, changes in quality of life and the incidence of adverse events. Discussion: This study will provide clear evidence on the effectiveness of a lifestyle and risk factor modification intervention programme in achieving treatment goals for PAD risk factors, through a high-quality, well-powered clinical trial. Trial registration: This trial was registered (11/07/2017) on the European Clinical Trials Database (EudraCT number 2017-002964-41) and ClinicalTrials.gov (NCT03935776) which was registered on 02 May 2019.Ministry of Higher Education and Scientific Research, Libyan Embassy medical doctorate scholarshi

Synthesis and characterisation of a nucleotide based pro-drug formulated with a peptide into a nano-chemotherapy for colorectal cancer

Recent studies in colorectal cancer patients (CRC) have shown that increased resistance to thymidylate synthase (TS) inhibitors such as 5-fluorouracil (5-FU), reduce the efficacy of standard of care (SoC) treatment regimens. The nucleotide pool cleanser dUTPase is highly expressed in CRC and is an attractive target for potentiating anticancer activity of chemotherapy. The purpose of the current work was to investigate the activity of P1, P4-di(2',5'-dideoxy-5'-selenouridinyl)-tetraphosphate (P4-SedU2), a selenium-modified symmetrically capped dinucleoside with prodrug capabilities that is specifically activated by dUTPase. Using mechanochemistry, P4-SedU2 and the corresponding selenothymidine analogue P4-SeT2 were prepared with a yield of 19% and 30% respectively. The phosphate functionality facilitated complexation with the amphipathic cell-penetrating peptide RALA to produce nanoparticles (NPs). These NPs were designed to deliver P4-SedU2 intracellularly and thereby maximise in vivo activity. The NPs demonstrated effective anti-cancer activity and selectivity in the HCT116 CRC cell line, a cell line that overexpresses dUTPase; compared to HT29 CRC cells and NCTC-929 fibroblast cells which have reduced levels of dUTPase expression. In vivo studies in BALB/c SCID mice revealed no significant toxicity with respect to weight or organ histology. Pharmacokinetic analysis of blood serum showed that RALA facilitates effective delivery and rapid internalisation into surrounding tissues with NPs eliciting lower plasma Cmax than the equivalent injection of free P4-SedU2, translating the in vitro findings. Tumour growth delay studies have demonstrated significant inhibition of growth dynamics with the tumour doubling time extended by &gt;2weeks. These studies demonstrate the functionality and action of a new pro-drug nucleotide for CRC. </p

A Computational Approach for Designing Tiger Corridors in India

Wildlife corridors are components of landscapes, which facilitate the movement of organisms and processes between intact habitat areas, and thus provide connectivity between the habitats within the landscapes. Corridors are thus regions within a given landscape that connect fragmented habitat patches within the landscape. The major concern of designing corridors as a conservation strategy is primarily to counter, and to the extent possible, mitigate the effects of habitat fragmentation and loss on the biodiversity of the landscape, as well as support continuance of land use for essential local and global economic activities in the region of reference. In this paper, we use game theory, graph theory, membership functions and chain code algorithm to model and design a set of wildlife corridors with tiger (Panthera tigris tigris) as the focal species. We identify the parameters which would affect the tiger population in a landscape complex and using the presence of these identified parameters construct a graph using the habitat patches supporting tiger presence in the landscape complex as vertices and the possible paths between them as edges. The passage of tigers through the possible paths have been modelled as an Assurance game, with tigers as an individual player. The game is played recursively as the tiger passes through each grid considered for the model. The iteration causes the tiger to choose the most suitable path signifying the emergence of adaptability. As a formal explanation of the game, we model this interaction of tiger with the parameters as deterministic finite automata, whose transition function is obtained by the game payoff.Comment: 12 pages, 5 figures, 6 tables, NGCT conference 201

N budgets and aquatic uptake in the Ipswich River basin, northeastern Massachusetts

Author Posting. © American Geophysical Union, 2004. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Water Resources Research 40 (2004): W11201, doi:10.1029/2004WR003172.We calculated N budgets and conducted nutrient uptake experiments to evaluate the fate of N in the aquatic environment of the Ipswich River basin, northeastern Massachusetts. A mass balance indicates that the basin retains about 50% of gross N inputs, mostly in terrestrial components of the landscape, and the loss and retention of total nitrogen (TN) in the aquatic environment was about 9% of stream loading. Uptake lengths of PO4 and NH4 were measurable in headwater streams, but NO3 uptake was below detection (minimum detection limit = 0.05 μM). Retention or loss of NO3 was observed in a main stem reach bordered by wetland habitat. Nitrate removal in urban headwater tributaries was because of water withdrawals and denitrification during hypoxic events and in ponded wetlands with long water residence times. A mass balance using an entire river network indicates that basin-wide losses due to aquatic denitrification are considerably lower than estimates from several recent studies and range from 4 to 16% of TDN in stream loading. Withdrawals for domestic use restrict the runoff of headwater catchments from reaching the main stem during low base flow periods, thereby contributing to the spatial and temporal regulation of N export from headwater tributaries.This research was funded by grants DEB- 9726862 and OCE-9726921 (NSF)

Incidental nutrient transfers: Assessing critical times in agricultural catchments using high-resolution data

AbstractManaging incidental losses associated with liquid slurry applications during closed periods has significant cost and policy implications and the environmental data required to review such a measure are difficult to capture due to storm dependencies. Over four years (2010–2014) in five intensive agricultural catchments, this study used high-resolution total and total reactive phosphorus (TP and TRP), total oxidised nitrogen (TON) and suspended sediment (SS) concentrations with river discharge data to investigate the magnitude and timing of nutrient losses. A large dataset of storm events (defined as 90th percentile discharges), and associated flow-weighted mean (FWM) nutrient concentrations and TP/SS ratios, was used to indicate when losses were indicative of residual or incidental nutrient transfers. The beginning of the slurry closed period was reflective of incidental and residual transfers with high storm FWM P (TP and TRP) concentrations, with some catchments also showing elevated storm TP:SS ratios. This pattern diminished at the end of the closed period in all catchments. Total oxidised N behaved similarly to P during storms in the poorly drained catchments and revealed a long lag time in other catchments. Low storm FWM P concentrations and TP:SS ratios during the weeks following the closed period suggests that nutrients either weren't applied during this time (best times chosen) or that they were applied to less risky areas (best places chosen). For other periods such as late autumn and during wet summers, where storm FWM P concentrations and TP:SS ratios were high, it is recommended that an augmentation of farmer knowledge of soil drainage characteristics with local and detailed current and forecast soil moisture conditions will help to strengthen existing regulatory frameworks to avoid storm driven incidental nutrient transfers

Observed Reductions in Schistosoma mansoni Transmission from Large-Scale Administration of Praziquantel in Uganda: A Mathematical Modelling Study

To date schistosomiasis control programmes based on chemotherapy have largely aimed at controlling morbidity in treated individuals rather than at suppressing transmission. In this study, a mathematical modelling approach was used to estimate reductions in the rate of Schistosoma mansoni reinfection following annual mass drug administration (MDA) with praziquantel in Uganda over four years (2003-2006). In doing this we aim to elucidate the benefits of MDA in reducing community transmission.Age-structured models were fitted to a longitudinal cohort followed up across successive rounds of annual treatment for four years (Baseline: 2003, TREATMENT: 2004-2006; n = 1,764). Instead of modelling contamination, infection and immunity processes separately, these functions were combined in order to estimate a composite force of infection (FOI), i.e., the rate of parasite acquisition by hosts.MDA achieved substantial and statistically significant reductions in the FOI following one round of treatment in areas of low baseline infection intensity, and following two rounds in areas with high and medium intensities. In all areas, the FOI remained suppressed following a third round of treatment.This study represents one of the first attempts to monitor reductions in the FOI within a large-scale MDA schistosomiasis morbidity control programme in sub-Saharan Africa. The results indicate that the Schistosomiasis Control Initiative, as a model for other MDA programmes, is likely exerting a significant ancillary impact on reducing transmission within the community, and may provide health benefits to those who do not receive treatment. The results obtained will have implications for evaluating the cost-effectiveness of schistosomiasis control programmes and the design of monitoring and evaluation approaches in general

Discrete Determinants and the Gel'fand-Yaglom formula

I present a partly pedagogic discussion of the Gel'fand-Yaglom formula for the functional determinant of a one-dimensional, second order difference operator, in the simplest settings. The formula is a textbook one in discrete Sturm-Liouville theory and orthogonal polynomials. A two by two matrix approach is developed and applied to Robin boundary conditions. Euler-Rayleigh sums of eigenvalues are computed. A delta potential is introduced as a simple, non-trivial example and extended, in an appendix, to the general case. The continuum limit is considered in a non--rigorous way and a rough comparison with zeta regularised values is made. Vacuum energies are also considered in the free case. Chebyshev polynomials act as free propagators and their properties are developed using the two-matrix formulation, which has some advantages and appears to be novel. A trace formula, rather than a determinant one, is derived for the Gel'fand-Yaglom function.Comment: 29 pages. Submitted version. Typos corrected and adjustments made. Comments and references adde

Charting a perfect storm of water quality pressures

peer-reviewedThe agri-food economy can be a significant driver of water quality pressures but the role of hydro-meteorological patterns in a changing climate also requires consideration. For this purpose, an assessment was made of a ten-year synchronous high temporal resolution water quality and hydro-meteorological dataset in Irish agricultural catchments. Changes occurring to rainfall intensity and soil temperature patterns were found to be important drivers of nutrient mobility in soils. There were links between the intensity of the North Atlantic Oscillation over the decade and large shifts in baseline nutrient concentrations in catchments. The data also revealed extreme weather impacts to pollution patterns including short periods of rain induced nutrient flux, that exceeded average annual mass loads in these catchments, and drought influences on point source pollution. These influences need consideration, and may require different mitigation strategies, as links between water quality land use pressure and water quality state in regulatory reviews. In a decade of both increased land use source and hydro-meteorological transport pressures, water quality natural capital in Ireland has faced a perfect storm. Such conditions are difficult to model and only revealed in high temporal resolution datasets.Government of Ireland Department of Agriculture Food and the Marin