Serum inhibin B as a marker of spermatogenesis

Inhibin B is produced by Sertoli cells, provides negative feedback on FSH secretion, and may prove to be an important marker for the functioning of seminiferous tubules. The purpose of the present study was to examine the relationship between the spermatogenic function of the testis of subfertile men and the plasma concentrations of inhibin B and FSH. These parameters were estimated in a group of 218 subfertile men. Serum inhibin B levels were closely correlated with the serum FSH levels (r = -0.78, P < 0.001), confirming the role of inhibin B as feedback signal for FSH production. The spermatogenic function of the testis was evaluated by determining testicular volume and total sperm count. Inhibin B levels were significantly correlated with the total sperm count and testicular volume (r = 0.54 and r = 0.63, respectively; P < 0.001). Testicular biopsies were obtained in 22 of these men. Inhibin B was significantly correlated with the biopsy score (r = 0.76, P < 0.001). Receiver operating characteristic analysis revealed a diagnostic accuracy of 95% for differentiating competent from impaired spermatogenesis for inhibin B, whereas for FSH, a value of 80% was found. We conclude that inhibin B is the best available endocrine marker of spermatogenesis in subfertile men

Universality of Shot-Noise in Multiterminal Diffusive Conductors

We prove the universality of shot-noise in multiterminal diffusive conductors of arbitrary shape and dimension for purely elastic scattering as well as for hot electrons. Using a Boltzmann-Langevin approach we reduce the calculation of shot-noise correlators to the solution of a diffusion equation. We show that shot-noise in multiterminal conductors is a non-local quantity and that exchange effects can occur without quantum phase coherence even at zero electron temperature. Concrete numbers for shot-noise are given that can be tested experimentally.Comment: 4 double-column pages, REVTeX, 1 eps figure embedded with eps

Shot-noise suppression by Fermi and Coulomb correlations in ballistic conductors

We investigate the injection of degenerate Fermi-Dirac electrons into a multimode ballistic conductor under the space-charge limited regime. The nonequilibrium current fluctuations were found to be suppressed by both Coulomb and Fermi correlations. We show that the Fermi shot-noise suppression factor is limited below by the value 2kT/epsilon_F, where T is the temperature and epsilon_F the Fermi energy of the injected electrons. The Coulomb noise suppression factor may attain much lower values epsilon_F/2qU, because of its dependence on the applied bias U >> kT/q. The asymptotic behaviour of the overall shot-noise suppression factor in a high degenerate limit was found to be kT/qU, independently of the material parameters.Comment: 8 pages, 4 figures, minor changes, published versio

Quantum-Statistical Current Correlations in Multi-Lead Chaotic Cavities

Quantum mechanics requires that identical particles are treated as indistinguishable. This requirement leads to correlations in the fluctuating properties of a system. Theoretical predictions are made for an experiment on a multi-lead chaotic quantum dot which can identify exchange effects in electronic current-current correlations. Interestingly, we find that the ensemble averaged exchange effects are of the order of the channel number, and are insensitive to dephasing.Comment: 4 pages REVTEX, including two figure

Effects of Electron-Electron Scattering on Electron-Beam Propagation in a Two-Dimensional Electron-Gas

We have studied experimentally and theoretically the influence of electron-electron collisions on the propagation of electron beams in a two-dimensional electron gas for excess injection energies ranging from zero up to the Fermi energy. We find that the detector signal consists of quasiballistic electrons, which either have not undergone any electron-electron collisions or have only been scattered at small angles. Theoretically, the small-angle scattering exhibits distinct features that can be traced back to the reduced dimensionality of the electron system. A number of nonlinear effects, also related to the two-dimensional character of the system, are discussed. In the simplest situation, the heating of the electron gas by the high-energy part of the beam leads to a weakening of the signal of quasiballistic electrons and to the appearance of thermovoltage. This results in a nonmonotonic dependence of the detector signal on the intensity of the injected beam, as observed experimentally.Comment: 9 pages, 7 figure

Analysis of host responses to Mycobacterium tuberculosis antigens in a multi-site study of subjects with different TB and HIV infection states in sub-Saharan Africa.

BACKGROUND: Tuberculosis (TB) remains a global health threat with 9 million new cases and 1.4 million deaths per year. In order to develop a protective vaccine, we need to define the antigens expressed by Mycobacterium tuberculosis (Mtb), which are relevant to protective immunity in high-endemic areas. METHODS: We analysed responses to 23 Mtb antigens in a total of 1247 subjects with different HIV and TB status across 5 geographically diverse sites in Africa (South Africa, The Gambia, Ethiopia, Malawi and Uganda). We used a 7-day whole blood assay followed by IFN-γ ELISA on the supernatants. Antigens included PPD, ESAT-6 and Ag85B (dominant antigens) together with novel resuscitation-promoting factors (rpf), reactivation proteins, latency (Mtb DosR regulon-encoded) antigens, starvation-induced antigens and secreted antigens. RESULTS: There was variation between sites in responses to the antigens, presumably due to underlying genetic and environmental differences. When results from all sites were combined, HIV- subjects with active TB showed significantly lower responses compared to both TST(-) and TST(+) contacts to latency antigens (Rv0569, Rv1733, Rv1735, Rv1737) and the rpf Rv0867; whilst responses to ESAT-6/CFP-10 fusion protein (EC), PPD, Rv2029, TB10.3, and TB10.4 were significantly higher in TST(+) contacts (LTBI) compared to TB and TST(-) contacts fewer differences were seen in subjects with HIV co-infection, with responses to the mitogen PHA significantly lower in subjects with active TB compared to those with LTBI and no difference with any antigen. CONCLUSIONS: Our multi-site study design for testing novel Mtb antigens revealed promising antigens for future vaccine development. The IFN-γ ELISA is a cheap and useful tool for screening potential antigenicity in subjects with different ethnic backgrounds and across a spectrum of TB and HIV infection states. Analysis of cytokines other than IFN-γ is currently on-going to determine correlates of protection, which may be useful for vaccine efficacy trials

The astrometric data reduction software (ADRS) and error budget for PRIMA

The Astrometric Data-Reduction Software (ADRS) processes fringe, delay, environmental, and calibration data for PRIMA narrow-angle astrometry. It is automated software designed to provide fully-calibrated differential delays and separation angles. The ADRS is divided into on-line and off-line processing. The former deals with calibration and data compression, while the latter applies corrections and calculates science quantities. PRIMA is the first VLTI instrument that may require removal of long-term environmental trends. The trend identification and fitting routines are not part of the distributed on-line and off-line processing software. Instead, files containing fit parameters will be updated regularly. Coding is presently underway. The PRIMA error budget summarizes the principal sources of error in PRIMA astrometric observation

“SPLIT” Pancreaticojejunostomy in the Surgical Treatment of Chronic Pancreatitis

“Split” pancreaticojejunostomy is a procedure consisting of vertical transection of the pancreas and anastomosis of both sides of the cut pancreatic duct with an interposed, Roux-en-Y jejunal loop. In this paper we report the long term results of this procedure in the treatment of eight patients with chronic pancreatitis (CP)