The Real Estate Investment Trust: State Law Problems

We present a map of the three-dimensional (3D) distribution of dust in the Orion complex. Orion is the closest site of high-mass star formation, making it an excellent laboratory for studying the interstellar medium and star formation. We used data from the Gaia-TGAS catalogue combined with photometry from 2MASS and WISE to get the distances and extinctions of individual stars in the vicinity of the Orion complex. We use a Gaussian process and adopt a non-parametric method to infer the probability distribution function of the dust densities at arbitrary points throughout the region. We map the dust distribution towards different parts of the Orion complex. We find that the distance and depth of the cloud are compatible with other recent works, which show that the method can be applicable to local molecular clouds to map their 3D dust distribution. We also demonstrate the danger of only using colours of stars to derive their extinctions without considering further physical constraints, such as the colour-magnitude diagram (CMD)

Further examinations of attitudes toward discrete emotions, with a focus on attitudes toward anger

The present research aimed to better understand individual differences in attitudes towards emotions with a focus on anger. We report findings of four studies conducted with American and Polish individuals. Results showed that individuals who have more positive attitudes toward anger are higher in trait anger (Studies 1–4), are more likely to think about getting revenge (Study 1), and expect that getting revenge will make them feel good (Studies 1–2). In addition, these individuals are lower in agreeableness and lower in the tendency to engage in avoidance when angered (Studies 1–4). They score lower in humility (Studies 3–4), lower in secure romantic attachment but higher in anxious and avoidance attachment (Study 3). Finally, they are more likely to believe a wide range of conspiracies (Studies 2–4). Discussion focuses on the implications of these results

Evidence and future potential of mobile phone data for disease disaster management

This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record.Global health threats such as the recent Ebola and Zika virus outbreaks require rapid and robust responses to prevent, reduce and recover from disease dispersion. As part of broader big data and digital humanitarianism discourses, there is an emerging interest in data produced through mobile phone communications for enhancing the data environment in such circumstances. This paper assembles user perspectives and critically examines existing evidence and future potential of mobile phone data derived from call detail records (CDRs) and two-way short message service (SMS) platforms, for managing and responding to humanitarian disasters caused by communicable disease outbreaks. We undertake a scoping review of relevant literature and in-depth interviews with key informants to ascertain the: (i) information that can be gathered from CDRs or SMS data; (ii) phase(s) in the disease disaster management cycle when mobile data may be useful; (iii) value added over conventional approaches to data collection and transfer; (iv) barriers and enablers to use of mobile data in disaster contexts; and (v) the social and ethical challenges. Based on this evidence we develop a typology of mobile phone data sources, types, and end-uses, and a decision-tree for mobile data use, designed to enable effective use of mobile data for disease disaster management. We show that mobile data holds great potential for improving the quality, quantity and timing of selected information required for disaster management, but that testing and evaluation of the benefits, constraints and limitations of mobile data use in a wider range of mobile-user and disaster contexts is needed to fully understand its utility, validity, and limitations.A portion of this research was funded as part of the Science for Humanitarian Emergencies and Resilience (SHEAR) programme, by the UK Department for International Development (DFID), the Natural Environment Research Council (NERC) and the Economic and Social Research Council (ESRC)

Is there evidence of shifting baseline syndrome in environmental managers? An assessment using perceptions of bird population targets in UK nature reserves

Shifting baseline syndrome (SBS) describes changing perceptions of biological conditions due to a loss of historical knowledge. Perceptions of ‘normal’ environmental conditions are continually updated, leading to underestimation of the true magnitude of long-term ecological change and potential setting of unambitious management targets. There has been speculation as to the presence and impacts of SBS within conservation management since Daniel Pauly's seminal paper in 1995, which outlined the potential effects of SBS on target-setting in fisheries management. Previous case studies have suggested that SBS may not occur in management, despite empirical evidence of SBS in other systems. In this study, 44 professionals and volunteers involved in bird species management, monitoring and target-setting across England were interviewed. Interviews asked for personal perceptions of current, maximum and target abundance, long-term trends, and perceived conservation priority for six bird species. Using paired tests, this study found no significant effect of experience on perceptions of current, maximum or target abundance of all species, despite differences in national abundance and trends, and differences in participant experience. Further power analysis indicated that even if SBS was statistically detectible with a larger sample, the practical implications of the syndrome would be minimal due to small effect sizes. Finally, the effect of experience on individual perceptions of species conservation priority varied between species, with generational amnesia in the form of ‘lifting baselines’ suggested for only one of the six species. This study suggests that shifting baseline syndrome may not be as significant a threat in conservation management as first thought

Is good memory always a good thing? An early offset of infantile amnesia predicts anxiety-like behavior throughout development in rats

Infants tend to forget experiences much more rapidly than older individuals, a phenomenon referred to as infantile amnesia. This robust, cross-species phenomenon is commonly used to examine memory development. However, in this set of experiments, we examined the novel hypothesis that the expression of infantile amnesia is related to resilience/vulnerability. We conditioned infant rats to associate a white noise with shock. Animals were tested for memory of the association ~1 week later. We found that infants that expressed better memory of the aversive association emitted more vocalizations (indicative of higher levels of distress) when separated from their mother earlier in infancy (Experiment 1). Better expression of memory in infancy also predicted higher levels of conditioned fear (Experiment 2) and anxiety-like behavior (in a light-dark box; Experiment 3) in adulthood. Furthermore, probiotic-treatment administered early in development reduced anxiety-like behavior in animals that exhibited good expression of memory for an aversive association learnt in infancy (Experiment 4). However, the same treatment was ineffective if administered in adulthood. Taken together, these results suggest that individual differences in infants’ memory for an aversive association predict anxiety-like behavior throughout development, and that early administration of probiotics can reduce anxiety-like behavior in “at-risk” animals

Towards understanding the gliotoxin detoxification mechanism: in vivo thiomethylation protects yeast from gliotoxin cytotoxicity

Gliotoxin (GT) is a mycotoxin produced by some species of ascomycete fungi including the opportunistic human pathogen Aspergillus fumigatus . In order to produce GT the host organism needs to have evolved a selfprotection mechanism. GT contains a redox-cycling disulfide bridge that is important in mediating toxicity. Recently is has been demonstrated that A. fumigatus possesses a novel thiomethyltransferase protein called GtmA that has the ability to thiomethylate GT in vivo , which aids the organism in regulating GT biosynthesis. It has been suggested that thiomethylation of GT and similar sulfur-containing toxins may play a role in providing self-protection in host organisms. In this work we have engineered Saccharomyces cerevisiae , a GT-naïve organism, to express A. fumigatus GtmA. We demonstrate that GtmA can readily thiomethylate GT in yeast, which results in protection of the organism from exogenous GT. Our work has implications for understanding the evolution of GT self-protection mechanisms in organisms that are GT producers and non-producers

A prospective observational study of the impact of an electronic questionnaire (ePAQ-PO) on the duration of nurse-led pre-operative assessment and patient satisfaction.

OBJECTIVE: Standard pre-operative assessment at our institution involves a comprehensive history and examination by a nurse practitioner. An electronic pre-operative assessment questionnaire, ePAQ-PO® (ePAQ, Sheffield, UK) has previously been developed and validated. This study aimed to determine the impact of ePAQ-PO on nurse consultation times and patient satisfaction in low-risk patients. METHODS: The duration of pre-operative assessment consultation was recorded for American Society of Anesthesiology physical classification 1 and 2 patients undergoing pre-operative assessment by an electronic questionnaire (ePAQ-PO group) and standard face-to-face assessment by a nurse practitioner (standard group). Patients were also asked to complete an eight-item satisfaction questionnaire. Eighty-six patients were included (43 in each group). RESULTS: After adjusting for the duration of physical examination, median (IQR [min-max]) consultation time was longer in the standard compared to the ePAQ-PO group (25 (18-33 [10-49]) min vs. 12 (8-17 [4-45]) min, respectively; p <0.001). Response rate for the satisfaction questionnaire was 93%. There was no significant difference in patient satisfaction scores (38/39 in standard group vs. 39/41 in ePAQ-PO group were fully satisfied with their pre-operative assessment; p = 0.494). CONCLUSION: Pre-operative assessment using ePAQ-PO is associated with a significant reduction of over 50% in the duration of the assessment without impacting on patient satisfaction

Simulated projections for summer monsoon climate over India by a high-resolution regional climate model (PRECIS)

Impact of global warming on the Indian monsoon climate is examined using Hadley Centre's highresolution regional climate model, PRECIS (Providing REgional Climates for Impact Studies). Three simulations from a 17-member Perturbed Physics Ensemble generated using Hadley Center Coupled Model (HadCM3) for the Quantifying Uncertainty in Model Predictions (QUMP) project, are used to drive PRECIS. The PRECIS simulations corresponding to the IPCCSRES A1B emission scenario are carried out for a continuous period of 1961-2098. The model shows reasonable skill in simulating the monsoon climate over India. The climate projections are examined over three time slices, viz. short (2020s, i.e. 2011-2040), medium (2050s, i.e. 2041-2070) and long (2080s, i.e. 2071-2098). The model projections indicate significant warming over India towards the end of the 21st century. The summer monsoon precipitation over India is expected to be 9-16 more in 2080s compared to the baseline (1970s, i.e. 1961-1990) under global warming conditions. Also, the rainy days are projected to be less frequent and more intense over central India

Structural, mechanistic and functional insight into gliotoxin bis-thiomethylation in Aspergillus fumigatus.

Gliotoxin is an epipolythiodioxopiperazine (ETP) class toxin, contains a disulfide bridge that mediates its toxic effects via redox cycling and is produced by the opportunistic fungal pathogen Aspergillus fumigatus Self-resistance against gliotoxin is effected by the gliotoxin oxidase GliT, and attenuation of gliotoxin biosynthesis is catalysed by gliotoxin S-methyltransferase GtmA. Here we describe the X-ray crystal structures of GtmA-apo (1.66 Å), GtmA complexed to S-adenosylhomocysteine (1.33 Å) and GtmA complexed to S-adenosylmethionine (2.28 Å), providing mechanistic insights into this important biotransformation. We further reveal that simultaneous elimination of the ability of A. fumigatus to dissipate highly reactive dithiol gliotoxin, via deletion of GliT and GtmA, results in the most significant hypersensitivity to exogenous gliotoxin observed to date. Indeed, quantitative proteomic analysis of ΔgliT::ΔgtmA reveals an uncontrolled over-activation of the gli-cluster upon gliotoxin exposure. The data presented herein reveal, for the first time, the extreme risk associated with intracellular dithiol gliotoxin biosynthesis-in the absence of an efficient dismutation capacity. Significantly, a previously concealed protective role for GtmA and functionality of ETP bis-thiomethylation as an ancestral protection strategy against dithiol compounds is now evident