458 research outputs found
L’élection fédérale de 1993 : le comportement électoral des Québécois
L’article examine la dynamique de la campagne ainsi que les facteurs qui ont influencé le vote chez trois blocs d’électeurs : les non-francophones, les francophones souverainistes et les francophones non souverainistes. L’analyse se fonde sur les données recueillies dans le cadre de l’Étude sur l’élection canadienne de 1993. On montre que la raison première du succès du Bloc québécois réside dans l’appui indéfectible que lui ont accordé les souverainistes. Le Bloc a également réussi à obtenir l’appui d’une fraction des non souverainistes les plus nationalistes, des jeunes qui étaient insatisfaits des partis traditionnels et de ceux dont la situation économique s’était détériorée. Finalement, le Bloc a profité de la popularité personnelle de Lucien Bouchard.The paper examines the dynamics of the campaign as well as the factors that influenced voting behavior among three blocs of voters: non francophones, francophone sovereignists, and francophone non sovereignists. The analysis is based on survey date collected by the 1993 Canadian Election Study. We show that the primary reason for the success of the Bloc québécois lies in the overwhelming support of the sovereignists. The Bloc was also able to get the support of a fraction of the most nationalist non sovereignists, of younger voters who were dissatisfied with traditional parties, and of those whose personal economic situation had deteriorated. Finally, the Bloc was helped by the personal popularity of its leader, Lucien Bouchard
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Surfactants for heterogeneous processes in liquid or supercritical CO.sub.2
Heterogeneous polymer mixtures comprising a polymer in liquid or supercritical CO.sub.2 are stabilized by employing a poly(propylene oxide) or poly(butylene oxide) based surfactant. These surfactants are especially well suited for stabilizing heterogeneous polymer mixtures formed by micronizing techniques as well as by precipitation of a compressed fluid antisolvent applications.Board of Regents, University of Texas Syste
Drug resistance and viral tropism in HIV-1 subtype C-infected patients in KwaZulu-Natal, South Africa: implications for future treatment options
Article approval pendingDrug resistance poses a significant challenge for the successful application of highly active antiretroviral therapy (HAART) globally. Furthermore, emergence of HIV-1 isolates that preferentially use CXCR4 as a coreceptor for cell entry, either as a consequence of natural viral evolution or HAART use, may compromise the efficacy of CCR5 antagonists as alternative antiviral therapy
Perovskite-perovskite tandem photovoltaics with optimized bandgaps
We demonstrate four and two-terminal perovskite-perovskite tandem solar cells
with ideally matched bandgaps. We develop an infrared absorbing 1.2eV bandgap
perovskite, , that can deliver 14.8 %
efficiency. By combining this material with a wider bandgap
material, we reach monolithic two
terminal tandem efficiencies of 17.0 % with over 1.65 volts open-circuit
voltage. We also make mechanically stacked four terminal tandem cells and
obtain 20.3 % efficiency. Crucially, we find that our infrared absorbing
perovskite cells exhibit excellent thermal and atmospheric stability,
unprecedented for Sn based perovskites. This device architecture and materials
set will enable 'all perovskite' thin film solar cells to reach the highest
efficiencies in the long term at the lowest costs
Efficiency and safety of varying the frequency of whole blood donation (INTERVAL): a randomised trial of 45 000 donors
Background:
Limits on the frequency of whole blood donation exist primarily to safeguard donor health. However, there is substantial variation across blood services in the maximum frequency of donations allowed. We compared standard practice in the UK with shorter inter-donation intervals used in other countries.
Methods:
In this parallel group, pragmatic, randomised trial, we recruited whole blood donors aged 18 years or older from 25 centres across England, UK. By use of a computer-based algorithm, men were randomly assigned (1:1:1) to 12-week (standard) versus 10-week versus 8-week inter-donation intervals, and women were randomly assigned (1:1:1) to 16-week (standard) versus 14-week versus 12-week intervals. Participants were not masked to their allocated intervention group. The primary outcome was the number of donations over 2 years. Secondary outcomes related to safety were quality of life, symptoms potentially related to donation, physical activity, cognitive function, haemoglobin and ferritin concentrations, and deferrals because of low haemoglobin. This trial is registered with ISRCTN, number ISRCTN24760606, and is ongoing but no longer recruiting participants.
Findings:
45 263 whole blood donors (22 466 men, 22 797 women) were recruited between June 11, 2012, and June 15, 2014. Data were analysed for 45 042 (99·5%) participants. Men were randomly assigned to the 12-week (n=7452) versus 10-week (n=7449) versus 8-week (n=7456) groups; and women to the 16-week (n=7550) versus 14-week (n=7567) versus 12-week (n=7568) groups. In men, compared with the 12-week group, the mean amount of blood collected per donor over 2 years increased by 1·69 units (95% CI 1·59–1·80; approximately 795 mL) in the 8-week group and by 0·79 units (0·69–0·88; approximately 370 mL) in the 10-week group (p<0·0001 for both). In women, compared with the 16-week group, it increased by 0·84 units (95% CI 0·76–0·91; approximately 395 mL) in the 12-week group and by 0·46 units (0·39–0·53; approximately 215 mL) in the 14-week group (p<0·0001 for both). No significant differences were observed in quality of life, physical activity, or cognitive function across randomised groups. However, more frequent donation resulted in more donation-related symptoms (eg, tiredness, breathlessness, feeling faint, dizziness, and restless legs, especially among men [for all listed symptoms]), lower mean haemoglobin and ferritin concentrations, and more deferrals for low haemoglobin (p<0·0001 for each) than those observed in the standard frequency groups.
Interpretation:
Over 2 years, more frequent donation than is standard practice in the UK collected substantially more blood without having a major effect on donors' quality of life, physical activity, or cognitive function, but resulted in more donation-related symptoms, deferrals, and iron deficiency.
Funding:
NHS Blood and Transplant, National Institute for Health Research, UK Medical Research Council, and British Heart Foundation
Taking the Measure of the Universe: Precision Astrometry with SIM PlanetQuest
Precision astrometry at microarcsecond accuracy has application to a wide
range of astrophysical problems. This paper is a study of the science questions
that can be addressed using an instrument that delivers parallaxes at about 4
microarcsec on targets as faint as V = 20, differential accuracy of 0.6
microarcsec on bright targets, and with flexible scheduling. The science topics
are drawn primarily from the Team Key Projects, selected in 2000, for the Space
Interferometry Mission PlanetQuest (SIM PlanetQuest). We use the capabilities
of this mission to illustrate the importance of the next level of astrometric
precision in modern astrophysics. SIM PlanetQuest is currently in the detailed
design phase, having completed all of the enabling technologies needed for the
flight instrument in 2005. It will be the first space-based long baseline
Michelson interferometer designed for precision astrometry. SIM will contribute
strongly to many astronomical fields including stellar and galactic
astrophysics, planetary systems around nearby stars, and the study of quasar
and AGN nuclei. SIM will search for planets with masses as small as an Earth
orbiting in the `habitable zone' around the nearest stars using differential
astrometry, and could discover many dozen if Earth-like planets are common. It
will be the most capable instrument for detecting planets around young stars,
thereby providing insights into how planetary systems are born and how they
evolve with time. SIM will observe significant numbers of very high- and
low-mass stars, providing stellar masses to 1%, the accuracy needed to
challenge physical models. Using precision proper motion measurements, SIM will
probe the galactic mass distribution and the formation and evolution of the
Galactic halo. (abridged)Comment: 54 pages, 28 figures, uses emulateapj. Submitted to PAS
The Long-Baseline Neutrino Experiment: Exploring Fundamental Symmetries of the Universe
The preponderance of matter over antimatter in the early Universe, the
dynamics of the supernova bursts that produced the heavy elements necessary for
life and whether protons eventually decay --- these mysteries at the forefront
of particle physics and astrophysics are key to understanding the early
evolution of our Universe, its current state and its eventual fate. The
Long-Baseline Neutrino Experiment (LBNE) represents an extensively developed
plan for a world-class experiment dedicated to addressing these questions. LBNE
is conceived around three central components: (1) a new, high-intensity
neutrino source generated from a megawatt-class proton accelerator at Fermi
National Accelerator Laboratory, (2) a near neutrino detector just downstream
of the source, and (3) a massive liquid argon time-projection chamber deployed
as a far detector deep underground at the Sanford Underground Research
Facility. This facility, located at the site of the former Homestake Mine in
Lead, South Dakota, is approximately 1,300 km from the neutrino source at
Fermilab -- a distance (baseline) that delivers optimal sensitivity to neutrino
charge-parity symmetry violation and mass ordering effects. This ambitious yet
cost-effective design incorporates scalability and flexibility and can
accommodate a variety of upgrades and contributions. With its exceptional
combination of experimental configuration, technical capabilities, and
potential for transformative discoveries, LBNE promises to be a vital facility
for the field of particle physics worldwide, providing physicists from around
the globe with opportunities to collaborate in a twenty to thirty year program
of exciting science. In this document we provide a comprehensive overview of
LBNE's scientific objectives, its place in the landscape of neutrino physics
worldwide, the technologies it will incorporate and the capabilities it will
possess.Comment: Major update of previous version. This is the reference document for
LBNE science program and current status. Chapters 1, 3, and 9 provide a
comprehensive overview of LBNE's scientific objectives, its place in the
landscape of neutrino physics worldwide, the technologies it will incorporate
and the capabilities it will possess. 288 pages, 116 figure
LSST Science Book, Version 2.0
A survey that can cover the sky in optical bands over wide fields to faint
magnitudes with a fast cadence will enable many of the exciting science
opportunities of the next decade. The Large Synoptic Survey Telescope (LSST)
will have an effective aperture of 6.7 meters and an imaging camera with field
of view of 9.6 deg^2, and will be devoted to a ten-year imaging survey over
20,000 deg^2 south of +15 deg. Each pointing will be imaged 2000 times with
fifteen second exposures in six broad bands from 0.35 to 1.1 microns, to a
total point-source depth of r~27.5. The LSST Science Book describes the basic
parameters of the LSST hardware, software, and observing plans. The book
discusses educational and outreach opportunities, then goes on to describe a
broad range of science that LSST will revolutionize: mapping the inner and
outer Solar System, stellar populations in the Milky Way and nearby galaxies,
the structure of the Milky Way disk and halo and other objects in the Local
Volume, transient and variable objects both at low and high redshift, and the
properties of normal and active galaxies at low and high redshift. It then
turns to far-field cosmological topics, exploring properties of supernovae to
z~1, strong and weak lensing, the large-scale distribution of galaxies and
baryon oscillations, and how these different probes may be combined to
constrain cosmological models and the physics of dark energy.Comment: 596 pages. Also available at full resolution at
http://www.lsst.org/lsst/sciboo
The Atacama Cosmology Telescope: Relation Between Galaxy Cluster Optical Richness and Sunyaev-Zel'dovich Effect
We present the measured Sunyaev-Zel'dovich (SZ) flux from 474
optically-selected MaxBCG clusters that fall within the Atacama Cosmology
Telescope (ACT) Equatorial survey region. The ACT Equatorial region used in
this analysis covers 510 square degrees and overlaps Stripe 82 of the Sloan
Digital Sky Survey. We also present the measured SZ flux stacked on 52
X-ray-selected MCXC clusters that fall within the ACT Equatorial region and an
ACT Southern survey region covering 455 square degrees. We find that the
measured SZ flux from the X-ray-selected clusters is consistent with
expectations. However, we find that the measured SZ flux from the
optically-selected clusters is both significantly lower than expectations and
lower than the recovered SZ flux measured by the Planck satellite. Since we
find a lower recovered SZ signal than Planck, we investigate the possibility
that there is a significant offset between the optically-selected brightest
cluster galaxies (BCGs) and the SZ centers, to which ACT is more sensitive due
to its finer resolution. Such offsets can arise due to either an intrinsic
physical separation between the BCG and the center of the gas concentration or
from misidentification of the cluster BCG. We find that the entire discrepancy
for both ACT and Planck can be explained by assuming that the BCGs are offset
from the SZ maxima with a uniform random distribution between 0 and 1.5 Mpc.
Such large offsets between gas peaks and BCGs for optically-selected cluster
samples seem unlikely given that we find the physical separation between BCGs
and X-ray peaks for an X-ray-selected subsample of MaxBCG clusters to have a
much narrower distribution that peaks within 0.2 Mpc. It is possible that other
effects are lowering the ACT and Planck signals by the same amount, with
offsets between BCGs and SZ peaks explaining the remaining difference between
measurements. (Abridged)Comment: 10 pages; version matches that accepted by ApJ - minor additions to
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