Interplay between function and structure in complex networks

We show that abrupt structural transitions can arise in functionally optimal networks, driven by small changes in the level of transport congestion. Our results offer an explanation as to why so many diverse species of network structure arise in Nature (e.g. fungal systems) under essentially the same environmental conditions. Our findings are based on an exactly solvable model system which mimics a variety of biological and social networks. We then extend our analysis by introducing a novel renormalization scheme involving cost motifs, to describe analytically the average shortest path across multiple-ring-and-hub networks. As a consequence, we uncover a 'skin effect' whereby the structure of the inner multi-ring core can cease to play any role in terms of determining the average shortest path across the network.Comment: Expanded version of physics/0508228 with additional new result

How does Europe Make Its Mind Up? Connections, cliques, and compatibility between countries in the Eurovision Song Contest

We investigate the complex relationships between countries in the Eurovision Song Contest, by recasting past voting data in terms of a dynamical network. Despite the British tendency to feel distant from Europe, our analysis shows that the U.K. is remarkably compatible, or 'in tune', with other European countries. Equally surprising is our finding that some other core countries, most notably France, are significantly 'out of tune' with the rest of Europe. In addition, our analysis enables us to confirm a widely-held belief that there are unofficial cliques of countries -- however these cliques are not always the expected ones, nor can their existence be explained solely on the grounds of geographical proximity. The complexity in this system emerges via the group 'self-assessment' process, and in the absence of any central controller. One might therefore speculate that such complexity is representative of many real-world situations in which groups of 'agents' establish their own inter-relationships and hence ultimately decide their own fate. Possible examples include groups of individuals, societies, political groups or even governments

Environmental Stressors and the PINE Network: Can Physical Environmental Stressors Drive Long-Term Physical and Mental Health Risks?

Both psychosocial and physical environmental stressors have been linked to chronic mental health and chronic medical conditions. The psycho-immune-neuroendocrine (PINE) network details metabolomic pathways which are responsive to varied stressors and link chronic medical conditions with mental disorders, such as major depressive disorder via a network of pathophysiological pathways. The primary objective of this review is to explore evidence of relationships between airborne particulate matter (PM, as a concrete example of a physical environmental stressor), the PINE network and chronic non-communicable diseases (NCDs), including mental health sequelae, with a view to supporting the assertion that physical environmental stressors (not only psychosocial stressors) disrupt the PINE network, leading to NCDs. Biological links have been established between PM exposure, key sub-networks of the PINE model and mental health sequelae, suggesting that in theory, long-term mental health impacts of PM exposure may exist, driven by the disruption of these biological networks. This disruption could trans-generationally influence health; however, long-term studies and information on chronic outcomes following acute exposure event are still lacking, limiting what is currently known beyond the acute exposure and all-cause mortality. More empirical evidence is needed, especially to link long-term mental health sequelae to PM exposure, arising from PINE pathophysiology. Relationships between physical and psychosocial stressors, and especially the concept of such stressors acting together to impact on PINE network function, leading to linked NCDs, evokes the concept of syndemics, and these are discussed in the context of the PINE network

Professional capacity and organizational change as measures of educational effectiveness: assessing the impact of postgraduate education in development policy and management

We tend to measure educational performance by students' attainment in coursework or examinations. In the case of professional education, the impact of the educational programme on the students' own capacities to enhance their work practices, and the wider organizational effects of the students' education and training, are also key 'products' of the educational process. This is particularly important with education for Development Policy and Management (DPAM), which is directly concerned with capacity-building. This article adopts a work-related approach to educational effectiveness and examines four professional programmes in DPAM--three in Southern Africa and one in the UK. Through the analysis of the results of surveys and case studies, the article demonstrates how a positive learning experience is related to the application of learning at work. However the conditions for applying learning also depend strongly on organizational context, as do the wider organizational impacts of learning. The article presents a broad approach to assessing educational effectiveness in professional programmes which incorporate these factors

Concert recording 2018-04-26

[Track 1]. Concerto no. 1 / Alexander Lebedev -- [Track 2]. Andante et allegro / Joseph Edouard Barat -- [Track 3]. Sonata for trombone and piano. III. Allegro ritmico e vigoroso / George McKay -- [Track 4]. Sonata in F minor, TWV 41:1. I. Andante cantabile [Track 5]. II. Allegro / Georg Philipp Telemann -- [Track 6]. Grand concerto / Friedebald Gräfe -- [Track 7]. Concerto for trombone. I. Andante maestoso - allegro molto - andante maestoso / Gordon Jacob -- [Track 8]. Concerto in one movement / Alexander Lebedev

New high-resolution radio observations of the SNR CTB 80

We report new high resolution and high sensitivity radio observations of the extended supernova remnant (SNR) CTB 80 (G69.0+2.7) at 240 MHz, 324 MHz, 618 MHz, and 1380 MHz. The imaging of CTB 80 at 240 MHz and 618 MHz was performed using the Giant Metrewave Radio Telescope (GMRT) in India. The observations at 324 MHz and 1380 MHz were obtained using the Very Large Array (VLA, NRAO) in its C and D configurations. The new radio images reveal faint extensions for the asymmetric arms of CTB 80. The arms are irregular with filaments and clumps of size 1' (or 0.6 pc at a distance of 2 kpc). The radio image at 1380 MHz is compared with IR and optical emission. The correspondence IR/radio is excellent along the N arm of CTB 80. Ionized gas observed in the [SII] line perfectly matches the W and N edges of CTB 80. The central nebula associated with the pulsar PSR B1951+32 was investigated with an angular resolution of 10" x 6". The new radio image obtained at 618 MHz shows with superb detail structures in the 8' x 4' E-W ``plateau'' nebula that hosts the pulsar on its western extreme. A twisted filament, about 6' in extent (~3.5 pc), trails behind the pulsar in an approximate W-E direction. In the bright ``core'' nebula (size \~45"), located to the W of the plateau, the images show a distortion in the morphology towards the W; this feature corresponds to the direction in which the pulsar escapes from the SNR with a velocity of ~240 km/s. Based on the new observations, the energetics of the SNR and of the PWN are investigated.Comment: 11 pages, Latex, 6 eps figures, To appear in AJ Vol 126., No. 5, November 200

Downscaling Changing Coastlines in a Changing Climate: The Hybrid Approach

Shifts in the frequency of typical meteorological patterns in an ocean basin, over interannual to decadal time scales, cause shifts in the patterns of wave generation. Therefore, ocean basin-scale climate shifts produce shifts in the wave climates affecting the coastlines of the basin. We present a hybrid methodology for downscaling observed (or predicted) climate shifts into local nearshore wave climates and then into the associated coastline responses. A series of statistical analyses translate observed (or predicted) distributions of meteorological states into the deep water wave climate affecting a coastal region and dynamical modeling combined with statistical analyses transform the deep water wave climate into the nearshore wave climate affecting a particular coastline. Finally, dynamical modeling of coastline evolution hindcasts (or predicts) how coastline shapes respond to climate shifts. As a case study, we downscale from meteorological hindcast in the North Atlantic basin since 1870 to the responses of the shape of the coast of the Carolinas, USA. We test the hindcasts using shoreline change rates calculated from historical shorelines, because shifts in coastline shape equate to changes in the alongshore pattern of shoreline change rates from one historical period to another. Although limited by the availability of historical shorelines (and complicated by historical inlet openings), the observations are consistent with the predicted signal of ocean basin-scale climate change. The hybrid downscaling methodology, applied to the output of global climate models, can be used to help forecast future patterns of shoreline change related to future climate change scenarios.This work was partially funded by the “U.S. National Science Foundation, Coupled Natural Human Systems Program.” J. A. A. Antolínez is indebted to the MEC (Ministerio de Educación, Cultura y Deporte, Spain) for the funding provided in the FPU (Formación del Profesorado Universitario) studentship (BOE-A-2013-12235). J. A. A. Antolínez and F. J. Méndez acknowledge the support of the Spanish “Ministerio de Economia y Competitividad” under grant BIA2014-59643-R

Nerves and blood vessels in degenerated intervertebral discs are confined to physically disrupted tissue

Nerves and blood vessels are found in the peripheral annulus and endplates of healthy adult intervertebral discs. Degenerative changes can allow these vessels to grow inwards and become associated with discogenic pain, but it is not yet clear how far, and why, they grow in. Previously we have shown that physical disruption of the disc matrix, which is a defining feature of disc degeneration, creates free surfaces which lose proteoglycans and water, and so become physically and chemically conducive to cell migration. We now hypothesise that blood vessels and nerves in degenerated discs are confined to such disrupted tissue. Whole lumbar discs were obtained from 40 patients (aged 37–75 years) undergoing surgery for disc herniation, disc degeneration with spondylolisthesis or adolescent scoliosis (‘non‐degenerated’ controls). Thin (5‐μm) sections were stained with H&E and toluidine blue for semi‐quantitative assessment of blood vessels, fissures and proteoglycan loss. Ten thick (30‐μm) frozen sections from each disc were immunostained for CD31 (an endothelial cell marker), PGP 9.5 and Substance P (general and nociceptive nerve markers, respectively) and examined by confocal microscopy. Volocity image analysis software was used to calculate the cross‐sectional area of each labelled structure, and its distance from the nearest free surface (disc periphery or internal fissure). Results showed that nerves and blood vessels were confined to proteoglycan‐depleted regions of disrupted annulus. The maximum distance of any blood vessel or nerve from the nearest free surface was 888 and 247 μm, respectively. Blood vessels were greater in number, grew deeper, and occupied more area than nerves. The density of labelled blood vessels and nerves increased significantly with Pfirrmann grade of disc degeneration and with local proteoglycan loss. Analysing multiple thick sections with fluorescent markers on a confocal microscope allows reliable detection of thin filamentous structures, even within a dense matrix. We conclude that, in degenerated and herniated discs, blood vessels and nerves are confined to proteoglycan‐depleted regions of disrupted tissue, especially within annulus fissures