218 research outputs found

    Residential construction cost estimating

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    "File: Housing, 1/80/3M""Several methods are currently being used to determine the cost of building a new home and even in determining the cost of remodeling an older home. Currently the two most used methods for estimating construction costs are: 1. Estimating cost per square foot. 2. Itemizing building costs."--First paragraph.Joe D. Logan (Instructor, Housing and Interior Design Dept.

    La Baguette Case Study

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    La Baguette is a bakery/deli/coffee shop with two company-owned stores and one franchise. Starting as a retail bakery, it expanded into coffee, deli sandwiches, catering services and custom orders. The owners are considering several expansion options

    Algorithms for 2-connected network design and flexible Steiner trees with a constant number of terminals

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    The k-Steiner-2NCS problem is as follows: Given a constant (positive integer) k, and an undirected connected graph G = (V, E), non-negative costs c on the edges, and a partition (T, V \ T) of V into a set of terminals, T, and a set of non-terminals (or, Steiner nodes), where |T| = k, find a min-cost two-node connected subgraph that contains the terminals. The k-Steiner-2ECS problem has the same inputs; the algorithmic goal is to find a min-cost two-edge connected subgraph that contains the terminals. We present a randomized polynomial-time algorithm for the unweighted k-Steiner-2NCS problem, and a randomized FPTAS for the weighted k-Steiner-2NCS problem. We obtain similar results for a capacitated generalization of the k-Steiner-2ECS problem. Our methods build on results by Björklund, Husfeldt, and Taslaman (SODA 2012) that give a randomized polynomial-time algorithm for the unweighted k-Steiner-cycle problem; this problem has the same inputs as the unweighted k-Steiner-2NCS problem, and the algorithmic goal is to find a min-cost simple cycle C that contains the terminals (C may contain any number of Steiner nodes)

    X-ray structures of 3-acetyloxazolidin-2-one, 3-acetyloxazolin-2-one and oxazolin-2(3H)-one

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    The X-ray structures of three simple heterocyclic compounds have been obtained for the first time. Structures of both 3-acetyloxazolidin-2-one 1 and its unsaturated analogue 3-acetyloxazolin-2-one 3 show a planar imide nitrogen with the exocyclic C=O oriented anti to the ring N–C(=O) bond and negligible intermolecular interactions, a pattern consistent with previously reported analogues. In contrast the parent NH heterocycle, oxazolin-2(3H)-one 4 , exists as hydrogen bonded dimers of two closely similar independent molecules but an unusual type of disorder involving exchange of the ring O and NH positions results in a very high R factor.Publisher PDFPeer reviewe

    N-Benzyl-N-(2-hydroxyethyl)-2-(oxazolidin-2-on-3-yl)-2-phenylacetamide

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    The title compound, obtained by base-induced dimerization of 3-benzyloxazolidin-2-one has been prepared and fully characterised. Its X-ray structure features hydrogen bonded dimers involving the hydroxyl OH and amide carbonyl forming a 14-membered ring.Publisher PDFPeer reviewe

    Prospectus, September 17, 1980

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    CATCHY SLOGAN BRINGS OUT RECORD NUMBER OF VOTES; Parkland People; Parkland English teacher speaks to PCF\u27ers on Self-Image ; Head of Placement Counseling will help employment seekers; PACT offers program; Blood drive to be at PC; Attention Accounting students; Classifieds; PC Datebook; Record number of voters turn out to elect new Student Senators; Letters to the editor: Student disappointed; Long distance marriage works-- Susan Kelley sets an example; Women\u27s Program offers self-series; Jackson Browne performance: unforgettable; Molly Hatchet\u27s cuts are consistently impressive and original; Bowen: Radio won\u27t roll over and die; Two kinds of clouds cause false tornado reports; Team shirts or fan shirts-- T-shirts make us all more human; P.C. Women\u27s Program offers workshops; Sign up for insurance this week; PACT offers program; Science You Can See: Cosmos Is Coming!!; Parkland College Cross Country Schedule 1980; 100 cash awards offered young people; Local members attend convention; Golf team disappointing in PC Invitational; Fast Freddy won\u27t contend Jimmy The Greek this week; Volleyball team opens season; Fast Freddy Contest; Bench Warmer: Faculty out to upset softball teamhttps://spark.parkland.edu/prospectus_1980/1021/thumbnail.jp

    Rare germline copy number variants (CNVs) and breast cancer risk

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    Germline copy number variants (CNVs) are pervasive in the human genome but potential disease associations with rare CNVs have not been comprehensively assessed in large datasets. We analysed rare CNVs in genes and non-coding regions for 86,788 breast cancer cases and 76,122 controls of European ancestry with genome-wide array data. Gene burden tests detected the strongest association for deletions in BRCA1 (P = 3.7E-18). Nine other genes were associated with a p-value < 0.01 including known susceptibility genes CHEK2 (P = 0.0008), ATM (P = 0.002) and BRCA2 (P = 0.008). Outside the known genes we detected associations with p-values < 0.001 for either overall or subtype-specific breast cancer at nine deletion regions and four duplication regions. Three of the deletion regions were in established common susceptibility loci. To the best of our knowledge, this is the first genome-wide analysis of rare CNVs in a large breast cancer case-control dataset. We detected associations with exonic deletions in established breast cancer susceptibility genes. We also detected suggestive associations with non-coding CNVs in known and novel loci with large effects sizes. Larger sample sizes will be required to reach robust levels of statistical significance. Dennis et al. investigate potential breast cancer associations with rare germline copy number variants (CNVs) by conducting a genome-wide analysis in a large breast cancer case-control dataset. The authors detected associations with exonic deletions in established breast cancer susceptibility genes and suggestive associations for a number of non-coding CNVs.Peer reviewe
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