The Journal of Comorbidity affiliates with the Society for Academic Primary Care

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The homeodomain protein PAL-1 specifies a lineage-specific regulatory network in the C. elegans embryo

Maternal and zygotic activities of the homeodomain protein PAL-1 specify the identity and maintain the development of the multipotent C blastomere lineage in the C. elegans embryo. To identify PAL-1 regulatory target genes, we used microarrays to compare transcript abundance in wild-type embryos with mutant embryos lacking a C blastomere and to mutant embryos with extra C blastomeres. pal-1-dependent C-lineage expression was verified for select candidate target genes by reporter gene analysis, though many of the target genes are expressed in additional lineages as well. The set of validated target genes includes 12 transcription factors, an uncharacterized wingless ligand and five uncharacterized genes. Phenotypic analysis demonstrates that the identified PAL-1 target genes affect specification, differentiation and morphogenesis of C-lineage cells. In particular, we show that cell fate-specific genes (or tissue identity genes) and a posterior HOX gene are activated in lineage-specific fashion. Transcription of targets is initiated in four temporal phases, which together with their spatial expression patterns leads to a model of the regulatory network specified by PAL-1

The sober rave project: investigating the acceptability and personal experiences of alcohol-free dance events

Our research is an innovative, European-wide collaborative investigation into the benefits of alcohol-free events, otherwise known as ‘sober raves’. Much of the existing behaviour work which focuses on preventing and regulating maladaptive alcohol misuse suggests individuals act rationally in choosing to consume alcohol. However, intentions and other cognitive mediators often fail to map onto actual behaviour and do not explain why individuals continue to carry out risky health-risk behaviours, despite being aware of the associated risks. Substance use is also often driven by the pursuit of pleasure, rather than by the avoidance of harms. For example, many young people get social pleasures from drinking alcohol, but due to limited alcohol-free socialising opportunities non-drinkers can feel stigmatised. Our research is focusing on the perceived acceptability, attitudes and perceptions of a range of alcohol-free events for young people across Europe. Following the first stage of this research project, we hope to explore how these types of events could be used as a means of reducing alcohol consumption in young people

Psychometric Properties of the Driving Behaviour Scale (DBS) among Polish Drivers

© 2020 Elsevier Ltd. All rights reserved. This manuscript is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/).Anxiety can negatively affect an individual’s psychological wellbeing and lead to mild-to-moderate functional impairment in various areas of their lives. Despite this, the relationship between anxiety and driving performance has received very little empirical attention. The Driving Behaviour Scale (Clapp, Olsen, Beck, et al., 2011, Clapp, Olsen, Danoff-Burg, et al., 2011) was developed as a measure of anxious driving behaviours to support research in this area. The current study details adaptation and validation of the Driving Behaviour Scale (DBS; Clapp, Olsen, Beck, et al., 2011, Clapp, Olsen, Danoff-Burg, et al., 2011) in 310 university students in Poland. The overall internal consistency for the DBS was 0.76, while the two subscales demonstrated acceptable internal consistency (safety/cautious = 0.75 and hostile/aggressive behaviours = 0.85). The reliability estimates for performance deficit returned a lower coefficient of 0.65. Factor analysis produced a three-factor solution that supported the original structure of the DBS. The DBS may be utilised as a measure of driving anxiety in samples drawn from the general population.Peer reviewe

Beyond ‘witnessing’: children’s experiences of coercive control in domestic violence and abuse

Children’s experiences and voices are underrepresented in academic literature and professional practice around domestic violence and abuse. The project ‘Understanding Agency and Resistance Strategies’ addresses this absence, through direct engagement with children. We present an analysis from interviews with 21 children in the United Kingdom (12 girls and 9 boys, aged 8-18 years), about their experiences of domestic violence and abuse, and their responses to this violence. These interviews were analysed using interpretive interactionism. Three themes from this analysis are presented: a) ‘Children’s experiences of abusive control’, which explores children’s awareness of controlling behaviour by the adult perpetrator, their experience of that control, and its impact on them; b) ‘Constraint’, which explores how children experience the constraint associated with coercive control in situations of domestic violence, and c) ‘Children as agents’ which explores children’s strategies for managing controlling behaviour in their home and in family relationships. The paper argues that, in situations where violence and abuse occurs between adult intimate partners, children are significantly impacted, and can be reasonably described as victims of abusive control. Recognising children as direct victims of domestic violence and abuse would produce significant changes in the way professionals respond to them, by 1) recognising children’s experience of the impact of domestic violence and abuse; 2) recognising children’s agency, undermining the perception of them as passive ‘witnesses’ or ‘collateral damage’ in adult abusive encounters; and 3) strengthening professional responses to them as direct victims, not as passive witnesses to violence

A burst chasing x-ray polarimeter

Gamma-ray bursts are one of the most powerful explosions in the universe and have been detected out to distances of almost 13 billion light years. The exact origin of these energetic explosions is still unknown but the resulting huge release of energy is thought to create a highly relativistic jet of material and a power-law distribution of electrons. There are several theories describing the origin of the prompt GRB emission that currently cannot be distinguished. Measurements of the linear polarization would provide unique and important constraints on the mechanisms thought to drive these powerful explosions. We present the design of a sensitive, and extremely versatile gamma-ray burst polarimeter. The instrument is a photoelectric polarimeter based on a time-projection chamber. The photoelectric time-projection technique combines high sensitivity with broad band-pass and is potentially the most powerful method between 2 and 100 keV where the photoelectric effect is the dominant interaction process. We present measurements of polarized and unpolarized X-rays obtained with a prototype detector and describe the two mission concepts; the Gamma-Ray Burst Polarimeter (GRBP) for the U.S. Naval Academy satellite MidSTAR-2, and the Low Energy Polarimeter (LEP) onboard POET, a broadband polarimetry concept for a small explorer mission

\u3ci\u3eCritical Social Justice Issues for School Practitioners\u3c/i\u3e

Editors: Sandra Harris and Stacey Edmonson Chapter 5: From Ice Raids to Equity: Hispanic Students\u27 Progress through High School in an Immigrant Responsive City, co-authored by John Hill, UNO faculty member. Chapter 9: Focusing School Leadership on Poverty and Ethnicity for K-12 Student Success, co-authored by Jeanne L. Surface, Kay A. Keiser, Peter J. Smith, and Karen L. Hayes. This project was borne of a desire to support these scholar-practitioner leaders. We invited educational leaders to share recent studies which brought issues of social justice to the fore. Certainly, the 20 papers that were accepted as chapters for this book do not address all of the problems with which educators are faced. Nor do the 20 chapters provide definitive answers to these difficult issues. However, they do provide valuable information and ensure that thoughtful, reflective dialogue is occurring regarding critical social justice understandings or misunderstandings.https://digitalcommons.unomaha.edu/facultybooks/1173/thumbnail.jp

The narcissism epidemic is dead; long live the narcissism epidemic

Are recent cohorts of college students more narcissistic than their predecessors? To address debates about the so-called “narcissism epidemic,” we used data from three cohorts of students (N1990s = 1,166; N2000s = 33,647; N2010s = 25,412) to test whether narcissism levels (overall and specific facets) have increased across generations. We also tested whether our measure, the Narcissistic Personality Inventory (NPI), showed measurement equivalence across the three cohorts, a critical analysis that had been overlooked in prior research. We found that several NPI items were not equivalent across cohorts. Models accounting for nonequivalence of these items indicated a small decline in overall narcissism levels from the 1990s to the 2010s (d = ?0.27). At the facet-level, leadership (d = ?0.20), vanity (d = –0.16), and entitlement (d = –0.28) all showed decreases. Our results contradict the claim that recent cohorts of college students are more narcissistic than earlier generations of college students

LHC Predictions from a Tevatron Anomaly in the Top Quark Forward-Backward Asymmetry

We examine the implications of the recent CDF measurement of the top-quark forward-backward asymmetry, focusing on a scenario with a new color octet vector boson at 1-3 TeV. We study several models, as well as a general effective field theory, and determine the parameter space which provides the best simultaneous fit to the CDF asymmetry, the Tevatron top pair production cross section, and the exclusion regions from LHC dijet resonance and contact interaction searches. Flavor constraints on these models are more subtle and less severe than the literature indicates. We find a large region of allowed parameter space at high axigluon mass and a smaller region at low mass; we match the latter to an SU(3)xSU(3)/SU(3) coset model with a heavy vector-like fermion. Our scenario produces discoverable effects at the LHC with only 1-2 inverse femtobarns of luminosity at 7-8 TeV. Lastly, we point out that a Tevatron measurement of the b-quark forward-backward asymmetry would be very helpful in characterizing the physics underlying the top-quark asymmetry.Comment: 35 pages, 10 figures, 4 table