27 research outputs found
Phasemeter core for intersatellite laser heterodyne interferometry: modelling, simulations and experiments
Inter satellite laser interferometry is a central component of future
space-borne gravity instruments like LISA, eLISA, NGO and future geodesy
missions. The inherently small laser wavelength allows to measure distance
variations with extremely high precision by interfering a reference beam with a
measurement beam. The readout of such interferometers is often based on
tracking phasemeters, able to measure the phase of an incoming beatnote with
high precision over a wide range of frequencies. The implementation of such
phasemeters is based on all digital phase-locked loops, hosted in FPGAs. Here
we present a precise model of an all digital phase locked loop that allows to
design such a readout algorithm and we support our analysis by numerical
performance measurements and experiments with analog signals.Comment: 17 pages, 6 figures, accepted for publication in CQ
Breadboard model of the LISA phasemeter
An elegant breadboard model of the LISA phasemeter is currently under
development by a Danish-German consortium. The breadboard is build in the frame
of an ESA technology development activity to demonstrate the feasibility and
readiness of the LISA metrology baseline architecture. This article gives an
overview about the breadboard design and its components, including the
distribution of key functionalities.Comment: 5 pages, 3 figures, published in ASP Conference Series, Vol. 467, 9th
LISA Symposium (2012), pp 271-27
Deep phase modulation interferometry
We have developed a method to equip homodyne interferometers with the
capability to operate with constant high sensitivity over many fringes for
continuous real-time tracking. The method can be considered as an extension of
the "J_1...J_4" methods, and its enhancement to deliver very sensitive angular
measurements through Differential Wavefront Sensing is straightforward. Beam
generation requires a sinusoidal phase modulation of several radians in one
interferometer arm. On a stable optical bench, we have demonstrated a long-term
sensitivity over thousands of seconds of 0.1 mrad/sqrt[Hz] that correspond to
20 pm/sqrt[Hz] in length, and 10 nrad/sqrt[Hz] in angle at millihertz
frequencies
Readout for intersatellite laser interferometry: Measuring low frequency phase fluctuations of HF signals with microradian precision
Precision phase readout of optical beat note signals is one of the core
techniques required for intersatellite laser interferometry. Future space based
gravitational wave detectors like eLISA require such a readout over a wide
range of MHz frequencies, due to orbit induced Doppler shifts, with a precision
in the order of at frequencies between
and . In this paper, we present phase
readout systems, so-called phasemeters, that are able to achieve such
precisions and we discuss various means that have been employed to reduce noise
in the analogue circuit domain and during digitisation. We also discuss the
influence of some non-linear noise sources in the analogue domain of such
phasemeters. And finally, we present the performance that was achieved during
testing of the elegant breadboard model of the LISA phasemeter, that was
developed in the scope of an ESA technology development activity.Comment: submitted to Review of Scientific Instruments on April 30th 201
a randomized, placebo-controlled phase II AIO trial with serum biomarker program
Background As a multi-targeted anti-angiogenic receptor tyrosine kinase (RTK)
inhibitor sunitinib (SUN) has been established for renal cancer and
gastrointestinal stromal tumors. In advanced refractory esophagogastric cancer
patients, monotherapy with SUN was associated with good tolerability but
limited tumor response. Methods This double-blind, placebo-controlled,
multicenter, phase II clinical trial was conducted to evaluate the efficacy,
safety and tolerability of SUN as an adjunct to second and third-line FOLFIRI
(NCT01020630). Patients were randomized to receive 6-week cycles including
FOLFIRI plus sodium folinate (Na-FOLFIRI) once every two weeks and SUN or
placebo (PL) continuously for four weeks followed by a 2-week rest period. The
primary study endpoint was progression-free survival (PFS). Preplanned serum
analyses of VEGF-A, VEGF-D, VEGFR2 and SDF-1α were performed retrospectively.
Results Overall, 91 patients were randomized, 45 in each group (one patient
withdrew). The main grade ≥3 AEs were neutropenia and leucopenia, observed in
56 %/20 % and 27 %/16 % for FOLFIRI + SUN/FOLFIRI + PL, respectively. Median
PFS was similar, 3.5 vs. 3.3 months (hazard ratio (HR) 1.11, 95 % CI
0.70–1.74, P = 0.66) for FOLFIRI + SUN vs. FOLFIRI + PL, respectively. For
FOLFIRI + SUN, a trend towards longer median overall survival (OS) compared
with placebo was observed (10.4 vs. 8.9 months, HR 0.82, 95 % CI 0.50–1.34,
one-sided P = 0.21). In subgroup serum analyses, significant changes in VEGF-A
(P = 0.017), VEGFR2 (P = 0.012) and VEGF-D (P < 0.001) serum levels were
observed. Conclusions Although sunitinib combined with FOLFIRI did not improve
PFS and response in chemotherapy-resistant gastric cancer, a trend towards
better OS was observed. Further biomarker-driven studies with other anti-
angiogenic RTK inhibitors are warranted. Trial registration This study was
registered prospectively in the NCT Clinical Trials Registry
(ClinicalTrials.gov) under NCT01020630 on November 23, 2009 after approval by
the leading ethics committee of the Medical Association of Rhineland-
Palatinate, Mainz, in coordination with the participating ethics committees
(see Additional file 2) on September 16, 2009
Six sequence variants on chromosome 9p21.3 are associated with a positive family history of myocardial infarction: a multicenter registry
<p>Abstract</p> <p>Background</p> <p>Recent genome-wide association studies have identified several genetic loci linked to coronary artery disease (CAD) and myocardial infarction (MI). The 9p21.3 locus was verified by numerous replication studies to be the first common locus for CAD and MI. In the present study, we investigated whether six single nucleotide polymorphisms (SNP) rs1333049, rs1333040, rs10757274, rs2383206, rs10757278, and rs2383207 representing the 9p21.3 locus were associated with the incidence of an acute MI in patients with the main focus on the familial aggregation of the disease.</p> <p>Methods</p> <p>The overall cohort consisted of 976 unrelated male patients presenting with an acute coronary syndrome (ACS) with ST-elevated (STEMI) as well as non-ST-elevated myocardial infarction (NSTEMI). Genotyping data of the investigated SNPs were generated and statistically analyzed in comparison to previously published findings of matchable control cohorts.</p> <p>Results</p> <p>Statistical evaluation confirmed a highly significant association of all analyzed SNP's with the occurrence of MI (p < 0.0001; OR: 1.621-2.039). When only MI patients with a positive family disposition were comprised in the analysis a much stronger association of the accordant risk alleles with incident disease was found with odds ratios up to 2.769.</p> <p>Conclusions</p> <p>The findings in the present study confirmed a strong association of the 9p21.3 locus with MI particularly in patients with a positive family history thereby, emphasizing the pathogenic relevance of this locus as a common genetic cardiovascular risk factor.</p
The German National Registry of Primary Immunodeficiencies (2012-2017)
Introduction: The German PID-NET registry was founded in 2009, serving as the first national registry of patients with primary immunodeficiencies (PID) in Germany. It is part of the European Society for Immunodeficiencies (ESID) registry. The primary purpose of the registry is to gather data on the epidemiology, diagnostic delay, diagnosis, and treatment of PIDs.
Methods: Clinical and laboratory data was collected from 2,453 patients from 36 German PID centres in an online registry. Data was analysed with the software Stata® and Excel.
Results: The minimum prevalence of PID in Germany is 2.72 per 100,000 inhabitants. Among patients aged 1–25, there was a clear predominance of males. The median age of living patients ranged between 7 and 40 years, depending on the respective PID. Predominantly antibody disorders were the most prevalent group with 57% of all 2,453 PID patients (including 728 CVID patients). A gene defect was identified in 36% of patients. Familial cases were observed in 21% of patients. The age of onset for presenting symptoms ranged from birth to late adulthood (range 0–88 years). Presenting symptoms comprised infections (74%) and immune dysregulation (22%). Ninety-three patients were diagnosed without prior clinical symptoms. Regarding the general and clinical diagnostic delay, no PID had undergone a slight decrease within the last decade. However, both, SCID and hyper IgE- syndrome showed a substantial improvement in shortening the time between onset of symptoms and genetic diagnosis. Regarding treatment, 49% of all patients received immunoglobulin G (IgG) substitution (70%—subcutaneous; 29%—intravenous; 1%—unknown). Three-hundred patients underwent at least one hematopoietic stem cell transplantation (HSCT). Five patients had gene therapy.
Conclusion: The German PID-NET registry is a precious tool for physicians, researchers, the pharmaceutical industry, politicians, and ultimately the patients, for whom the outcomes will eventually lead to a more timely diagnosis and better treatment
Works by Rosy Geiger-Kullmann.
List of Geiger-Kullmann's compositions, with notes on the title, source
text, arrangement, time signature, key, and instrumentation of the compositions, as well
as short remarks on the physical state and form of the composition text. Also included
are also 2 obituaries for Geiger-Kullmann which contain some biographical
information.Ruth Geiger-EngelJoachim MartiniComposer, born 1886 in Frankfurt. Wife of Rudolf Geiger, former
vice-president of Congregation Habonim. Died 1964 in Monterey (California).The original German-language inventory is available in the
folder.Frankfurt am MainProcessed for digitizationRe-integrated clippingsSent for digitizationReturned from digitizationLinked to online manifestationdigitize