Articles with short titles describing the results are cited more often

OBJECTIVE: The aim of this study was to evaluate some features of article titles from open access journals and to assess the possible impact of these titles on predicting the number of article views and citations. METHODS: Research articles (n = 423, published in October 2008) from all Public Library of Science (PLoS) journals and from 12 Biomed Central (BMC) journals were evaluated. Publication metrics (views and citations) were analyzed in December 2011. The titles were classified according to their contents, namely methods-describing titles and results-describing titles. The number of title characters, title typology, the use of a question mark, reference to a specific geographical region, and the use of a colon or a hyphen separating different ideas within a sentence were analyzed to identify predictors of views and citations. A logistic regression model was used to identify independent title characteristics that could predict citation rates. RESULTS: Short-titled articles had higher viewing and citation rates than those with longer titles. Titles containing a question mark, containing a reference to a specific geographical region, and that used a colon or a hyphen were associated with a lower number of citations. Articles with results-describing titles were cited more often than those with methods-describing titles. After multivariate analysis, only a low number of characters and title typology remained as predictors of the number of citations. CONCLUSIONS: Some features of article titles can help predict the number of article views and citation counts. Short titles presenting results or conclusions were independently associated with higher citation counts. The findings presented here could be used by authors, reviewers, and editors to maximize the impact of articles in the scientific community

Perspectivas epidemiológicas, clínicas e terapêuticas do transtorno bipolar em comorbidade com o uso de drogas: revisão de sistemática: Epidemiological, clinical and therapeutic perspectives of bipolar disorder in comorbidity with drug use: a systematic review

Conhecida como transtorno maníaco-depressivo, atualmente possui um novo nome: Transtorno Afetivo Bipolar, visto que com o passar do tempo foi se percebendo que esse transtorno não se tratava de uma alteração psicótica, e mais de um prejuízo afetivo. O transtorno bipolar possui alguns tipos, não se caracterizando em apenas uma forma, sua manifestação varia conforme o indivíduo e suas tendências, disforia e/ou euforia porém independente da forma expressa o paciente bipolar pode ter sua vida social comprometida, se não tratada, visto a irregularidade no estado de humor; bem como pode fazer uso de substâncias psicoativas, o que prejudica a sua condição clínica. Objetivo central da pesquisa é de apresentar a correlação do transtorno bipolar com o uso de drogas, mediante uma revisão de literatura integrativa realizada entre os meses de março de 2022 a julho de 2022, através da busca de artigos científicos nos bancos de dados online PubMed, Scielo e Google Acadêmico, utilizando como critério de refinamento de pesquisa artigos de todas as línguas publicados entre os anos 2000 e 2022

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio

Repercussão da terapia de suplementação de proteína em detrimento das alterações na composição muscular de idosos: uma revisão: Repercussion of protein supplementation therapy to the detriment of changes in muscle composition in the elderly: a review

INTRODUÇÃO: O ato de envelhecer traz consigo inúmeras mudanças fisiológicas, dentre elas, destaca-se a sarcopenia, que por vezes pode levar a perda da capacidade funcional, podendo prejudicar a mobilidade e por fim acarretar em acidentes graves ou mortes. A atual concentração diária recomendada de proteína por quilograma não foi projetada para uma população em fase de envelhecimento, o que pode levar a uma concentração de proteína insuficiente. A suplementação proteica surgiu como forma alternativa de preservar a manutenção muscular. OBJETIVO: Analisar os efeitos da suplementação proteica na manutenção da capacidade funcional muscular na população idosa. METODOLOGIA: Para tanto, foi realizada uma revisão integrativa da literatura de aspecto qualitativo, no qual, a partir de uma pesquisa em bases de dados selecionadas, baseou-se em estudos que apresentaram efeitos da suplementação proteica na manutenção da capacidade funcional muscular de idosos. Ao final foram selecionados seis estudos que contemplavam o tema em questão. RESULTADOS E DISCUSSÃO: A melhora do estado nutricional está relacionada ao desempenho muscular, com base nisso, foram analisados nos estudos os seguintes aspectos: ganho de massa muscular, exercício físico em jejum, membros inferiores, velocidade da marcha e outros parâmetros funcionais e 25-hidroxivitamina D, todos colocando-se em comparação com a suplementação proteica como forma intervencionista e de manutenção da capacidade funcional muscular. Ainda, foi realizada uma análise da suplementação dietética com aminoácidos de cadeia ramificada (BCAAs) em relação a desnutrição. CONCLUSÃO: A análise dos dados supracitados revelou a relevância da busca pela melhoria na qualidade de vida e bem-estar da população senil, de maneira que o consumo diário recomendado de proteína seja preconizado como principal medida para manutenção da massa muscular nesta parcela populacional. Deve-se estimular o consumo diário de alimentos ricos em proteínas, tais como carnes, ovos, leite e derivados e suplementos alimentares, quando sua prescrição se faz necessária. Diante da corroboração da sarcopenia no aumento da incidência de quedas em idosos, se faz necessário orientar e estimular a população senil para a prática regular de exercício físico resistido, além do acompanhamento de equipe multidisciplinar

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear understanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5,6,7 vast areas of the tropics remain understudied.8,9,10,11 In the American tropics, Amazonia stands out as the world's most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepresented in biodiversity databases.13,14,15 To worsen this situation, human-induced modifications16,17 may eliminate pieces of the Amazon's biodiversity puzzle before we can use them to understand how ecological communities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple organism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region's vulnerability to environmental change. 15%–18% of the most neglected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lost

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear understanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5,6,7 vast areas of the tropics remain understudied.8,9,10,11 In the American tropics, Amazonia stands out as the world's most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepresented in biodiversity databases.13,14,15 To worsen this situation, human-induced modifications16,17 may eliminate pieces of the Amazon's biodiversity puzzle before we can use them to understand how ecological communities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple organism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region's vulnerability to environmental change. 15%–18% of the most neglected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lost

Catálogo Taxonômico da Fauna do Brasil: setting the baseline knowledge on the animal diversity in Brazil

The limited temporal completeness and taxonomic accuracy of species lists, made available in a traditional manner in scientific publications, has always represented a problem. These lists are invariably limited to a few taxonomic groups and do not represent up-to-date knowledge of all species and classifications. In this context, the Brazilian megadiverse fauna is no exception, and the Catálogo Taxonômico da Fauna do Brasil (CTFB) (http://fauna.jbrj.gov.br/), made public in 2015, represents a database on biodiversity anchored on a list of valid and expertly recognized scientific names of animals in Brazil. The CTFB is updated in near real time by a team of more than 800 specialists. By January 1, 2024, the CTFB compiled 133,691 nominal species, with 125,138 that were considered valid. Most of the valid species were arthropods (82.3%, with more than 102,000 species) and chordates (7.69%, with over 11,000 species). These taxa were followed by a cluster composed of Mollusca (3,567 species), Platyhelminthes (2,292 species), Annelida (1,833 species), and Nematoda (1,447 species). All remaining groups had less than 1,000 species reported in Brazil, with Cnidaria (831 species), Porifera (628 species), Rotifera (606 species), and Bryozoa (520 species) representing those with more than 500 species. Analysis of the CTFB database can facilitate and direct efforts towards the discovery of new species in Brazil, but it is also fundamental in providing the best available list of valid nominal species to users, including those in science, health, conservation efforts, and any initiative involving animals. The importance of the CTFB is evidenced by the elevated number of citations in the scientific literature in diverse areas of biology, law, anthropology, education, forensic science, and veterinary science, among others

Platinum analog associated to camptothecin versus platinum analog associated to etoposide as first-line chemotherapy for small cell lung cancer extensive disease : systematic review and meta-analysis

Orientadores: André Deeke Sasse, Carmen Silvia Passos LimaTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências MédicasResumo: Introdução: a superioridade de regimes baseados em camptotecinas sobre os regimes baseados em etoposidio para câncer de pulmão de células pequenas, doença extensa, (CPCP-DE) e assunto amplamente debatido com achados contraditórios nos estudos randomizados que compararam estas combinações. Variações farmacogenomicas entre etnias surgiram como hipótese para justificar estas diferenças. Com objetivo de elucidar esta duvida e mensurar a extensão de um eventual beneficio, realizamos uma revisão sistemática e metalize. Métodos: Revisão sistemática da literatura com metanalise. Foram elegíveis estudos randomizados controlados que comparassem o uso de análogo de platina associado ou a camptotecina (irinotecano ou topotecana) ou ao etoposidio como tratamento de primeira linha para CPCP-DE. Buscamos estes estudos nas bases PubMed, EMBASE, CENTRAL, LILACS e nos sítios eletrônicos dos congressos da ASCO, ESMO, ECCO e IASLC. As avaliações de sobrevida global (SG) e sobrevida livre de progressão mediana (SLP) foram apresentadas como hazard ratio (HR) enquanto a taxa de resposta tumoral (RT), toxicidades graves e sobrevida global em um e dois anos foram expressas através de odds ratio (OR). Os intervalos de confiança de 95% foram calculados para cada desfecho. A metalize utilizou método de efeitos randomicos, sendo a heterogeneidade entre estudos expressa através do índice de heterogeneidade I². Avaliação de subgrupos conforme origem geográfica dos estudos foi realizada e o teste de interação foi utilizado para identificar eventuais diferenças. Irinotecano-platina (IP) e topotecana-platina (TP) foram avaliados separadamente. Resultados: 615 referencias foram avaliadas, sendo selecionados nove estudos (3527 pacientes). Dois estudos compararam TP versus EP enquanto sete compararam IP versus EP. A metanalise demonstrou que IP e capaz de aumentar a sobrevida global (1965 pacientes, HR = 0,87; 95% CI 0,80-0,95; P=0,002; I²=0%) e sobrevida global em um ano (HR = 0,74; IC95% 0,60-0,91; P = 0,004; I² = 14%), sem contudo, aumentar claramente a sobrevida livre de progressão, ou resposta tumoral. IP levou a maior incidência de toxicidades gastrointestinais e menos hematológicas. A avaliação de subgrupos conforme origem geográfica não identificou diferença na extensão de beneficio em sobrevida global e em um ano (interação ocidente versus oriente P = 0,34 e P = 0,08 respectivamente) com IP. Na analise de sobrevida global em dois anos, IP e superior a EP em pacientes europeus e asiáticos, sem contudo trazer ganho para pacientes da América do Norte (OR 1,05; IC95% 0,65-1,69; P = 0,85; interação América do Norte versus Europa, P = 0,009; interação América do Norte versus Ásia, P = 0,02). IP aumenta a sobrevida livre de progressão para pacientes orientais (HR = 0,61; IC95% 0,45 - 0,84; P = 0,01) sem ter impacto nos pacientes ocidentais (HR = 0,96; IC95% 0,82 - 1,13; P = 0,65%) com diferença estatisticamente significativa entre estes dois grupos (interação ocidente versus oriente, P = 0,03). O teste de interação não identificou impacto em taxa de resposta tumoral ao esquema IP conforme a origem geográfica (interação ocidente versus oriente P = 0,07). Nas diversas toxicidades avaliadas, não houve diferença entre pacientes ocidentais e orientais. A metanalise de TP versus EP não foi possível devido a heterogeneidade em todos os desfechos avaliados. Conclusão: O presente estudo confirma que IP aumenta sobrevida global tanto para pacientes ocidentais quanto orientais. A sobrevida livre de progressão sob o regime IP e a sobrevida global em dois anos parecem diferir conforme a origem geográfica, enquanto a taxa de resposta e tolerância não. IP pode ser considerado um novo padrão terapêutico para CPCP-DE em todo o globo, com diferenças regionais que merecem avaliação mais profundaAbstract: Background: Superiority of camptothecin regimens over etoposide - both combined with platinum analogs - in extensive disease small cell lung cancer (ED-SCLC) has been extensively debated, with contradictory results in randomized trials worldwide. Ethnic and pharmacogenomical issues were hypothesized as major causes for these divergent findings. A systematic review was sought to elucidate this confounding scenario. Methods: Randomized controlled trials comparing first-line camptothecin (either irinotecan or topotecan)-platinum doublets (CP) versus etoposide-platinum doublets (EP) in ED-SCLC patients were searched in PubMed, EMBASE, and CENTRAL databases, ESMO, ASCO, and IASLC meeting proceedings. Meta-analyses were performed using random-effects model. Overall survival (OS) and Progression Free survival (PFS) were pooled as hazard ratio (HR), whereas response rate and toxicity were computed as odds ratio (OR). Pertinent 95% confidence intervals (CI) were calculated for all outcomes. Heterogeneity was measured by I². Subgroup analyses were undertaken comparing the geographical area of study and interaction tests were used to evaluate any existing differences found among subgroups. Irinotecanplatinum (IP) and topotecan-platinum (TP) trials were evaluated separately. Results: Nine studies (3527 patients) were included. IP improved median OS (1965 patients; HR = 0.87; 95% CI 0.80- 0.95; P=0.002; I²=0%) and one year OS (HR = 0.74; IC95% 0.60-0.91; P = 0.004; I² = 14%). PFS meta-analysis of IP versus EP was not feasible due to impending heterogeneity (I²=80%), as response rate meta-analysis (I²=56%; absolute response rates: IP = 52%, EP = 50%). There was more severe gastrointestinal toxicity with IP than EP, but less hematological toxicity. The median, and the one year OS analyses according to geographical area demonstrated that eastern and western patients experienced similar benefit from IP (interaction test Western trials versus Eastern trial, P=0.34 and P=0.08 respectively); however the two year OS analysis according to continental origin stated that European and Asian patients derived benefit from IP, whereas North Americans did not (interaction North America versus Europe, P = 0.009; North America versus Asia, P = 0.02). IP improved progression free survival in the Eastern trial (HR = 0.61; CI95% 0.45 - 0.84; P = 0.01), while it had no impact in Western trials (HR = 0.90; CI95% 0.78 - 1.03; P = 0.13; I² = 24%) with difference according to geographical origin (interaction test Western versus Eastern trials, P = 0.03). There was no identifiable difference in response rate to IP due to trial origin (interaction test, P = 0.07). In all toxicity sought, there was no suggestion of different toxicity according to trial origin. The metaanalysis of TP was not reliable due to impending heterogeneity in all outcomes. Conclusion: The present meta-analysis demonstrated that IP improved median and one year OS for both Western and Eastern patients. The activity of IP in terms of PFS and two year OS may be subject of geographical origin of patients ,while IP tolerance seemed to be stable. The present findings corroborate the role of IP as a new standard of care for SCLC-ED worldwide, with regional differences that merit further appraisalDoutoradoClinica MedicaDoutor em Clínica Médic