Low molecular weight ϵ-caprolactone-pcoumaric acid copolymers as potential biomaterials for skin regeneration applications

ϵ-caprolactone-p-coumaric acid copolymers at different mole ratios (ϵ-caprolactone:p-coumaric acid 1:0, 10:1, 8:1, 6:1, 4:1, and 2:1) were synthesized by melt-polycondensation and using 4-dodecylbenzene sulfonic acid as catalyst. Chemical analysis by NMR and GPC showed that copolyesters were formed with decreasing molecular weight as p-coumaric acid content was increased. Physical characteristics, such as thermal and mechanical properties, as well as water uptake and water permeability, depended on the mole fraction of pcoumaric acid. The p-coumarate repetitive units increased the antioxidant capacity of the copolymers, showing antibacterial activity against the common pathogen Escherichia coli. In addition, all the synthesized copolyesters, except the one with the highest concentration of the phenolic acid, were cytocompatible and hemocompatible, thus becoming potentially useful for skin regeneration applications

In vitro characterization of solute transport in the spinal canal

This paper presents results of an experimental investigation of solute transport in a simplified model of the spinal canal. The work aims to provide increased understanding of the mechanisms responsible for drug dispersion in intrathecal drug delivery (ITDD) procedures. The model consists of an annular channel bounded externally by a rigid transparent tube of circular section, representing the dura mater, and internally by an eccentric cylindrical compliant insert, representing the spinal cord. The tube, closed at one end, is connected to a rigid acrylic reservoir, representing the cranial cavity. The system is filled with water, whose properties are almost identical to those of the cerebrospinal fluid. A programmable peristaltic pump is employed to generate oscillatory motion at frequencies that are representative of those induced by the cardiac and respiratory cycles. Laser induced fluorescence is used to characterize the dispersion of fluorescent dye along the canal and into the cranial cavity for different values of the relevant Womersley number and different eccentricities of the annular section. The present work corroborates experimentally, for the first time, the existence of a steady bulk flow, associated with the mean Lagrangian motion, which plays a key role in the transport of the solute along the spinal canal. The measurements of solute dispersion are found to be in excellent agreement with theoretical predictions obtained using a simplified transport equation derived earlier on the basis of a two-timescale asymptotic analysis. The experimental results underscore the importance of the eccentricity and its variations along the canal and identifies changes in the flow topology associated with differences in the Womersley number, with potential implications in guiding future designs of ITDD protocols.This work was supported by the coordinated project, PID2020-115961RB-C31, PID2020-115961RB-C32, and PID2020-115961RA-C33, financed by MCIN/AEI/10.13039/501100011033, and by the Junta de Andalucia and European Funds, Project No. P18-FR-4619. F. Moral-Pulido wants to thank the Spanish Ministry of Universities for the financial support provided by the Fellowship FPU18/05694. The work of A. L. Sánchez was supported by the U.S. National Science Foundation through Grant No. 1853954

Pérdida de suelo por erosión hídrica superficial en caña de azúcar para producción de panela

Soil loss due to surface water erosion is one of the degradation processes that most affects the physical quality of the soil and produces the largest area of degradation worldwide. This study compared soil loss in two methods of harvesting sugarcane for panela production, considering factors such as rainfall intensity, slope of the land, and time of plant growth. It was observed that the moment just after harvesting is when the greatest differences between cutting methods occur, the loss of soil being greater when harvesting by "parejo" than when harvesting by "entresaque". As the crop develops, this difference decreases, and soil loss is more influenced by the intensity of precipitation. Finally, the measurements made after cutting were compared with a soil condition without vegetation cover, where it was observed that soil losses in crops already established with sugarcane were notably lower concerning this condition. This study establishes the importance of leaf mulch as a soil protection factor in sugarcane crops for panela.La pérdida de suelo por erosión hídrica superficial es uno de los procesos de degradación que más afecta la calidad física del suelo, y produce más área de degradación a nivel mundial. En este estudio se comparó la pérdida de suelo presente en dos métodos de cosecha de caña de azúcar para la producción de panela, donde se consideraron factores como la intensidad de la precipitación, la pendiente del terreno y el tiempo de crecimiento de la planta. Se observó que el momento justo después de la cosecha es cuando se presentan mayores diferencias entre los métodos de corte, donde la pérdida de suelo es mayor al cosechar por “parejo” que al cosechar por “entresaque”. A medida que se desarrolla el cultivo, esta diferencia disminuye, y la pérdida de suelo se ve más influenciada por la intensidad de la precipitación. Finalmente, se compararon las mediciones realizadas después del corte, con una condición de suelo sin cobertura vegetal, donde se observó que las pérdidas de suelo en cultivos ya establecidos con caña eran notablemente menores con respecto a esta condición. Este estudio establece la importancia del mantillo de hojas como factor protector de suelos en cultivos de caña de azúcar para panela

Analytical tools for the multiplex rapid detection of SARS-CoV-2

There is a high demand for analytical tools that can readily be applied to effectively diagnose the Covid-19 but also to carry out screening and surveillance detection with enough frequency to get the transmission rates under control and thus help to timely tackling the disease. On the one hand, high throughput analytical benchtop approaches are still highly demanding for accelerating diagnostics. Such platforms are required to show multiplexed capabilities while in turn reducing the turnaround times of currently applied techniques such as the RT-PCR gold standard. On the other hand, massive screening and surveillance protocols still require for effective tools at the point of need that could reliably detect the virus in individuals after being exposed or the likelihood of being immunized after suffering from the disease. The rapid detection of coronavirus biomarkers, including RNA as well as spike and nucleocapsid proteins in nasopharyngeal and oropharyngeal samples, together with host biomarkers such as immunoglobulins and cytokines in serum has been addressed in this work. We aim to produce tools that provided with a global response to the diagnosis, prognosis and follow-up of the disease (Figure 1). All the biocomponents and corresponding bioassay protocols required for measuring these biomarkers have been tailored made and implemented in three different platforms. A calorimetric device based on a lateral flow assay format [1, 2] and a multiplex electrochemical platform comprising an electrochemical transducer array and a paper microfluidic component [3] have been adapted to produce tools to be used at the point of care. Likewise, a fluorescence microarray platform has been set up with the potential for high-throughput screening by recording molecular signatures thanks to the its multiplexing and miniaturization capabilities. REFERENCES [1] E. Polo et al. PCT, ES2013/070549 [2] E. Polo et al. Chem. Commun., 49 (2013) 3676 [3] C. Fernández-Sánchez et al. Application no. EP20382721.

Biología reproductiva del olivo (BRO-EEZ-CSIC)

Trabajo presentado a las III Jornadas Nacionales del grupo de Horticultura de la SECH, celebradas en Sevilla el 6 y 7 de octubre de 2011.Peer reviewe

Development and analysis of the Soil Water Infiltration Global database

In this paper, we present and analyze a novel global database of soil infiltration measurements, the Soil Water Infiltration Global (SWIG) database. In total, 5023 infiltration curves were collected across all continents in the SWIG database. These data were either provided and quality checked by the scientists who performed the experiments or they were digitized from published articles. Data from 54 different countries were included in the database with major contributions from Iran, China, and the USA. In addition to its extensive geographical coverage, the collected infiltration curves cover research from 1976 to late 2017. Basic information on measurement location and method, soil properties, and land use was gathered along with the infiltration data, making the database valuable for the development of pedotransfer functions (PTFs) for estimating soil hydraulic properties, for the evaluation of infiltration measurement methods, and for developing and validating infiltration models. Soil textural information (clay, silt, and sand content) is available for 3842 out of 5023 infiltration measurements ( ∼ 76%) covering nearly all soil USDA textural classes except for the sandy clay and silt classes. Information on land use is available for 76% of the experimental sites with agricultural land use as the dominant type ( ∼ 40%). We are convinced that the SWIG database will allow for a better parameterization of the infiltration process in land surface models and for testing infiltration models. All collected data and related soil characteristics are provided online in *.xlsx and *.csv formats for reference, and we add a disclaimer that the database is for public domain use only and can be copied freely by referencing it. Supplementary data are available at https://doi.org/10.1594/PANGAEA.885492 (Rahmati et al., 2018). Data quality assessment is strongly advised prior to any use of this database. Finally, we would like to encourage scientists to extend and update the SWIG database by uploading new data to it

Colombian consensus recommendations for diagnosis, management and treatment of the infection by SARS-COV-2/ COVID-19 in health care facilities - Recommendations from expert´s group based and informed on evidence

La Asociación Colombiana de Infectología (ACIN) y el Instituto de Evaluación de Nuevas Tecnologías de la Salud (IETS) conformó un grupo de trabajo para desarrollar recomendaciones informadas y basadas en evidencia, por consenso de expertos para la atención, diagnóstico y manejo de casos de Covid 19. Estas guías son dirigidas al personal de salud y buscar dar recomendaciones en los ámbitos de la atención en salud de los casos de Covid-19, en el contexto nacional de Colombia

La educación intercultural a través del cine

Resumen basado en el de la publicaciónSe persigue fomentar el conocimiento, la tolerancia y la convivencia entre alumnos españoles y alumnos inmigrantes en los centros escolares, a través del estudio, la reflexión y el análisis de películas como 'Bailando con lobos', 'El Río' y 'Lawrence de Arabia', entre otras. Se proponen numerosas actividades y ejercicios didácticos en torno a las secuencias más significativas desarrolladas en cada película, y que inciden transversalmente en materias como Filosofía, Historia, Ética, Literatura, Educación Plástica y Visual, Sociedad, Cultura, Religión y Educación para la Ciudadanía.AndalucíaBiblioteca de Educación del Ministerio de Educación, Cultura y Deporte; Calle San Agustín 5 -3 Planta; 28014 Madrid; Tel. +34917748000; [email protected]

Revista del CAP Ciudad Lineal

Presenta una experiencia pedagógica denominada 'Ciclo de Cineforum sobre Antropología' que se desarrolla un día a la semana en el CAP de Ciudad Lineal. En ella, a través del visionado de películas se analizan conflictos y dificultades de la convivencia entre pueblos, razas y culturas diferentes en el mundo, con el fin de ofrecer una educación intercultural al alumnado. Para relatar esta experiencia se toma como ejemplo la película 'Los dientes del diablo', se proporciona la ficha técnica, el análisis de la estructura narrativa, el análisis de la estructura valorativa, el análisis de la estructura formal y los rasgos del animismo esquimal.MadridES