Impact of Asthma on Plantar Pressures in a Sample of Adult Patients: A Case-Control Study

Based on the high prevalence of asthma in the population, and its relationship with various musculoskeletal and postural disorders, the aim of this study was to evaluate the plantar pressures in asthmatic patients compared to a control group. A case-control study involving 90 participants was conducted, consisting of 45 asthma patients and 45 healthy paired controls. Static plantar pressure data were recorded using a portable pressure sensor platform. Statistically significant differences were shown in the body weight on the left heel (p = 0.031), and the right forefoot maximum peak pressure was lower in the case group (p = 0.042). The findings of this study show alterations in static plantar pressures in asthmatic patients compared to healthy individuals. Specifically, the subjects with asthma showed less maximum pressure in the right forefoot and less weight on the left heel, which appear to be associated with the asthma disease

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

The evolution of the ventilatory ratio is a prognostic factor in mechanically ventilated COVID-19 ARDS patients

Background: Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission. Methods: Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days. We collected demographic and clinical data prior to admission; information about clinical evolution at days 1 and 3 of mechanical ventilation; and outcomes. Results: Of the 2,095 patients with COVID-19 admitted to the ICU, 1,118 (53.3%) were intubated at day 1 and remained under mechanical ventilation at day three. From days 1 to 3, PaO2/FiO2 increased from 115.6 [80.0-171.2] to 180.0 [135.4-227.9] mmHg and the ventilatory ratio from 1.73 [1.33-2.25] to 1.96 [1.61-2.40]. In-hospital mortality was 38.7%. A higher increase between ICU admission and day 3 in the ventilatory ratio (OR 1.04 [CI 1.01-1.07], p = 0.030) and creatinine levels (OR 1.05 [CI 1.01-1.09], p = 0.005) and a lower increase in platelet counts (OR 0.96 [CI 0.93-1.00], p = 0.037) were independently associated with a higher risk of death. No association between mortality and the PaO2/FiO2 variation was observed (OR 0.99 [CI 0.95 to 1.02], p = 0.47). Conclusions: Higher ventilatory ratio and its increase at day 3 is associated with mortality in patients with COVID-19 receiving mechanical ventilation at ICU admission. No association was found in the PaO2/FiO2 variation

Escalera a la luna

El trabajo no ha sido publicado. Resumen basado en ficha elaborada por los autoresEl proyecto tiene lugar en el CP José María de Pereda, por parte de los 28 profesores que componen su claustro. El objetivo principal es mejorar la competencia en escritura del alumnado, esto se logra a través de formar al profesorado en temas relacionados con dicha materia, de actualizar la metodología de aprendizaje de la escritura y de proporcionar estrategias para abordar diferentes actividades de composición escrita. Se han realizado diversas actividades relacionadas con la escritura (test de lecto-escritura, ponencias y un curso virtual para el profesorado, elaboración de ejercicios, etc.)El grupo de trabajo considera que se ha contribuido a que los alumnos lleguen a ser conscientes del proceso de escritura (lo que hacen y por qué lo hacen).Consejería de Educación y Juventud de CantabriaCantabriaES

Proyecto PARTIC : tiza + ratón

El proyecto no ha sido publicado. Se adjunta un volumen anexo con las actas de asistencia, etc. El resumen está basado en una ficha elaborada por los autores o el responsableEl proyecto se desarrolla en el CP José María de Pereda de Los Corrales de Buelna, al que pertenecen los 28 profesores del claustro que participaron en él. Como objetivos se plantearon: la aplicación de las TIC en la organización de los procesos de enseñanza y aprendizaje que se desarrollan en el aula; la selección, utilización diseño y producción de materiales didácticos con las TIC (multimedia, paginas web, etc.), que promueven la adquisición de aprendizajes significativos; integrar las TIC en la planificación y desarrollo del currículo, como recurso mediador en las capacidades del alumno, fomento de hábitos de indagación, observación y reflexión que permitan profundizar en el conocimiento y 'aprender a aprender'; promover en los alumnos el uso de las TIC como fuente de información y vehículo de expresiones creativas; continuar y profundizar la formación del profesorado en las TIC para la mejora de la práctica docente; abrir nuevos cauces para la transmisión de información entre familia y colegio, fuera del horario y del entorno escolar; diseñar estrategias de utilización de los recursos digitales del aula; usar las TIC como un medio más de integración de los ACNEES. Para lograrlo se realizó un análisis previo de los programas candidatos a ser usados con los alumnos, usándolos después en clases prácticas con ellos, tanto sin conexión a Internet, como con ella. La evaluación realizada por los profesores y los alumnos es bastante positiva, entre los beneficios cabe destacar que el proyecto les permite acceder a la información dentro del aula en el momento en que se necesita. Los materiales empleados engloban todo tipo de material informático (programas, ordenadores, sistemas para red WI-FI, conexión a Internet) así como una aula de TIC.Consejería de Educación y Juventud de CantabriaCantabriaES