Políticas de comunicación y medios comunitarios en Europa. Análisis de la situación en Reino Unido, Francia y Países Bajos

El objeto de estudio que se considera en este artículo es de una extraordinaria complejidad tipológica y conceptual. Por este motivo, realizamos en primer lugar una introducción para aclarar qué entendemos por medios comunitarios , término que se va imponiendo en el contexto europeo junto al de tercer sector de la comunicación. Haremos también un análisis de las políticas que en relación a este ámbito se están llevando a cabo en Reino Unido, Francia y Países Bajos. Realizamos así una aproximación histórica, para pasar después a estudiar la situación legal y real de los medios comunitarios en cada uno de ellos. Los estudios de caso se contextualizan con las políticas de la Unión Europea, cuya Comisión se muestra tibia y poco decidida a regular al respecto.The subject matter of this article is very complex from a typological and conceptual standpoint. For this reason, we will conduct an introduction to clarify what we mean by community media , one of the names adopted in the European context. We will also conduct an analysis of policies relating to community media that are being carried out in three states: United Kingdom, France and The Netherlands. In each of them, we make an historical approach and study the actual and legal situation of the sector. Previously we reviewed the policy sector of the European Union to understand the unenthusiastic position of the Commission to regulate the matter

Relaxation time for the alignment between quark spin and angular velocity in a rotating QCD medium

We compute the relaxation times for massive quarks and anti-quarks to align their spins with the angular velocity in a rigidly rotating medium at finite temperature and baryon density. The rotation effects are implemented using a fermion propagator immersed in a cylindrical rotating environment. The relaxation time is computed as the inverse of the interaction rate to produce an asymmetry between the quark (anti-quark) spin components along and opposite to the angular velocity. For conditions resembling heavy-ion collisions, the relaxation times for quarks are smaller than for anti-quarks. For semi-central collisions the relaxation time is within the possible life-time of the QGP for all collision energies. However, for anti-quarks this happens only for collision energies $\sqrt{s_{NN}}\gtrsim 50$ GeV. The results are quantified in terms of the intrinsic quark and anti-quark polarizations, namely, the probability to build the spin asymmetry as a function of time. Our results show that these intrinsic polarizations tend to 1 with time at different rates given by the relaxation times with quarks reaching a sizable asymmetry at a faster pace. These are key results to further elucidate the mechanisms of hyperon polarization in relativistic heavy-ion collisions.Comment: 9 pages, 10 figure

Toward a clinical practice guide in pharmacogenomics testing for functional polymorphisms of drug-metabolizing enzymes. Gene/drug pairs and barriers perceived in Spain

The development of clinica lpractice recommendations or guidelines for the clinical use of biomarkers is an issue of great importance withr regard to adverse drug reactions.The poten-tial of pharmacogenomicbiomarkers has been extensively investigated in recent years.However,several barriers to implementing the use of pharmacogenomics testing exist.We conducted a survey among members of the Spanish Societies of Pharmacology and Clinical Pharmacology to obtain information about the perception of such barriers and to compare the perceptions of participants about the relative importance of majorgene/drug pairs.Of 11 potential barriers,the highest importance was attributed to lack of institutional support for pharmacogenomic stesting,and to the issues related to the lack of guidelines.Of the proposed gene/drug pairs the highest importance was assigned to HLA-B/abacavir, UGT1A1/irinotecan, and CYP2D6/tamoxifen.In this perspective article,we compare the relative importance of 29 gene/drugpairs in the Spanish study with that of the same pairs in the American Society for Clinical Pharmacology and Therapeutic sstudy,and we provide suggestions and areas of focus to develop a guide for clinical practice in pharmacogenomics testingThe work in the author’s laboratory is financed by Grants PS09/00943, PS09/00469, RETICS RIRAAF RD07/0064/0016, and CIBERehd from Instituto de Salud CarlosIII,Madrid, Spain, and by Grants GR10068 from Junta de Extremadura, Spain. Financed in part with FEDER funds from the European Unio

Propuesta de programa de promoción de la salud en ciudadores informales de enfermos de Alzheimer y prevención del síndrome del cuidador "evitando que el cuidador se convierta en paciente"

RESUMEN: Según el World Alzheimer Report de 2014 en España existen 1.000.000 personas que padecen esta enfermedad, sin embargo, ésta afecta de manera indirecta a 3,5 millones de personas. En el presente artículo se desarrolla, desde la perspectiva de la promoción de la salud y con un modelo participativo, una propuesta de programa dedicado a los cuidadores informales de enfermos de Alzheimer. El objetivo es mejorar tanto la calidad del cuidado como la calidad de su salud y prevenir el desarrollo del Síndrome del Cuidador, definido por Zarit como el “conjunto de problemas físicos, psíquicos, emocionales, sociales y económicos que pueden experimentar los cuidadores de adultos incapacitados” (citado en Montorio, I. et al., 1998).ABSTRACT: According to World Alzheimer’s Report from 2014, there are 1,000,000 people suffering from Alzheimer’s in Spain. However, this disease affects indirectly more than 3.5 million people. This study develops a programme devoted to informal Alzheimer’s carers from the perspective of health promotion and within a participative model. The main objective is to improve care’s quality as well as his/ her health quality preventing the so called “Care’s Syndrome” defined by Zarit as the combination of physical, mental, emotional, social and economical problems that adult untrained cares may suffer

Ergonomía y discapacidad : Ergowork una alianza estratégica para la innovación

RESUMEN: Las Alianzas para el conocimiento tienen por objeto consolidar la capacidad innovadora del nuevo espacio europeo potenciando procesos de innovación en la educación superior, el sector empresarial y los principales agentes del contexto social donde se implementa la estrategia. Con este objeto la Asociación Internacional de Psicología Evolutiva y Educativa, INFAD junto con Universidades y Organizaciones empresariales procedentes de Bélgica, Italia, Reino Unido, Eslovenia y Polonia impulsaron el proyecto ERGOWORK, aprobado por la Comisión Europea en el marco del “Lifelong Learning Programme. Erasmus”, dirigido a desarrollar enfoques nuevos, multidisciplinarios e innovadores entorno a la ERGONOMIA como disciplina. ERGOWORK plantea soluciones concretas a necesidades educativas y empresariales. Mediante una cooperación triangulada ofrece diseños curriculares específicos en el ámbito de la Ergonomía, cuyo objetivo no sólo es contribuir a innovar y homogeneizar la oferta en el actual espacio europeo, sino además ofrecer una formación de calidad que dote de altas competencias a los estudiantes posibilitando su acceso al mercado laboral y contribuyendo a resolver las propias demandas de los empleadores.ABSTRACT: Knowledge partnerships are created to strengthen the innovative capacity of the new European context through enhancing innovation processes in higher education, business and key actors of the social context. With this aim, the International Association of Developmental and Educational Psychology, "INFAD Association" along with Universities, Business and Social organizations from Belgium, Italy, United Kingdom, Slovenia and Poland boosted ERGO WORK project, approved by the European Commission, and conducted under the Lifelong Learning Programme (Erasmus). A project which aims at developing multidisciplinary and innovative approaches to the ERGONOMICS as a discipline, as well as seeking to improve the design of jobs and workplaces for people with disabilities. ERGOWORK project raises to provide concrete solutions to these educational and business needs. The "Knowledge Triangle" (Higher Educational Institutions, Companies and VET and Social organizations), created within the project, offers specific curricula in the field of ergonomics, which aims to not only contribute to innovate and standardize supply in the current European context, but also help to provide quality training and high skills, allowing students access to the labor market and helping to meet the employers need

Immunological and genetic kinetics from diagnosis to clinical progression in chronic lymphocytic leukemia

Progressió clínica; Evasió immuneProgresión clínica; Evasión inmuneClinical progression; Immune evasionBackground Mechanisms driving the progression of chronic lymphocytic leukemia (CLL) from its early stages are not fully understood. The acquisition of molecular changes at the time of progression has been observed in a small fraction of patients, suggesting that CLL progression is not mainly driven by dynamic clonal evolution. In order to shed light on mechanisms that lead to CLL progression, we investigated longitudinal changes in both the genetic and immunological scenarios. Methods We performed genetic and immunological longitudinal analysis using paired primary samples from untreated CLL patients that underwent clinical progression (sampling at diagnosis and progression) and from patients with stable disease (sampling at diagnosis and at long-term asymptomatic follow-up). Results Molecular analysis showed limited and non-recurrent molecular changes at progression, indicating that clonal evolution is not the main driver of clinical progression. Our analysis of the immune kinetics found an increasingly dysfunctional CD8+ T cell compartment in progressing patients that was not observed in those patients that remained asymptomatic. Specifically, terminally exhausted effector CD8+ T cells (T-betdim/−EomeshiPD1hi) accumulated, while the the co-expression of inhibitory receptors (PD1, CD244 and CD160) increased, along with an altered gene expression profile in T cells only in those patients that progressed. In addition, malignant cells from patients at clinical progression showed enhanced capacity to induce exhaustion-related markers in CD8+ T cells ex vivo mainly through a mechanism dependent on soluble factors including IL-10. Conclusions Altogether, we demonstrate that the interaction with the immune microenvironment plays a key role in clinical progression in CLL, thereby providing a rationale for the use of early immunotherapeutic intervention.This work was supported by the Instituto de Salud Carlos III, Fondo de Investigaciones Sanitarias (PI17/00950, M.C., PI18/01392, P.A. and PI17/00943, F.B.) and co-financed by the European Regional Development Fund (ERDF) and Fundación Asociación Española Contra el Cáncer (M.C. and P.A.), Gilead Fellowships (GLD16/00144, GLD18/00047, F.B.) and Fundació la Marató de TV3 (201905–30-31 F.B). S.B. is the recipient of a postdoctoral fellowship from Fundación Alfonso Martin Escudero. R.V-M. is supported by a Torres Quevedo fellowship from the Spanish Ministry of Science and Innovation (PTQ-16-08623). A.E-C. is funded by ISCIII/MINECO (PT17/0009/0019) which is co-funded by FEDER. M.C. holds a contract from Ministerio de Ciencia, Innovación y Universidades (RYC-2012-2018)

Extracellular cysteine disulfide bond break at Cys122 disrupts PIP2-dependent Kir2.1 channel function and leads to arrhythmias in Andersen-Tawil Syndrome

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Extracellular Kir2.1C122Y Mutant Upsets Kir2.1-PIP2 Bonds and Is Arrhythmogenic in Andersen-Tawil Syndrome.

BACKGROUND Andersen-Tawil syndrome type 1 is a rare heritable disease caused by mutations in the gene coding the strong inwardly rectifying K+ channel Kir2.1. The extracellular Cys (cysteine)122-to-Cys154 disulfide bond in the channel structure is crucial for proper folding but has not been associated with correct channel function at the membrane. We evaluated whether a human mutation at the Cys122-to-Cys154 disulfide bridge leads to Kir2.1 channel dysfunction and arrhythmias by reorganizing the overall Kir2.1 channel structure and destabilizing its open state. METHODS We identified a Kir2.1 loss-of-function mutation (c.366 A>T; p.Cys122Tyr) in an ATS1 family. To investigate its pathophysiological implications, we generated an AAV9-mediated cardiac-specific mouse model expressing the Kir2.1C122Y variant. We employed a multidisciplinary approach, integrating patch clamping and intracardiac stimulation, molecular biology techniques, molecular dynamics, and bioluminescence resonance energy transfer experiments. RESULTS Kir2.1C122Y mice recapitulated the ECG features of ATS1 independently of sex, including corrected QT prolongation, conduction defects, and increased arrhythmia susceptibility. Isolated Kir2.1C122Y cardiomyocytes showed significantly reduced inwardly rectifier K+ (IK1) and inward Na+ (INa) current densities independently of normal trafficking. Molecular dynamics predicted that the C122Y mutation provoked a conformational change over the 2000-ns simulation, characterized by a greater loss of hydrogen bonds between Kir2.1 and phosphatidylinositol 4,5-bisphosphate than wild type (WT). Therefore, the phosphatidylinositol 4,5-bisphosphate-binding pocket was destabilized, resulting in a lower conductance state compared with WT. Accordingly, on inside-out patch clamping, the C122Y mutation significantly blunted Kir2.1 sensitivity to increasing phosphatidylinositol 4,5-bisphosphate concentrations. In addition, the Kir2.1C122Y mutation resulted in channelosome degradation, demonstrating temporal instability of both Kir2.1 and NaV1.5 proteins. CONCLUSIONS The extracellular Cys122-to-Cys154 disulfide bond in the tridimensional Kir2.1 channel structure is essential for the channel function. We demonstrate that breaking disulfide bonds in the extracellular domain disrupts phosphatidylinositol 4,5-bisphosphate-dependent regulation, leading to channel dysfunction and defects in Kir2.1 energetic stability. The mutation also alters functional expression of the NaV1.5 channel and ultimately leads to conduction disturbances and life-threatening arrhythmia characteristic of Andersen-Tawil syndrome type 1.The authors thank the Centro Nacional de Investigaciones Cardiovasculares (CNIC) Viral Vectors Unit for producing the adeno-associated virus serotype 9. Confocal experiments were conducted at the CNIC Microscopy and Dynamic Imaging Unit. The authors thank the CNIC Bioinformatics Unit for generating the in silico homology modeling simulations, F-function analysis, and helpful discussions. The authors also thank the Centro de Supercomputación de Galicia for the use of the Finis Terrae III supercomputer to perform molecular dynamics studies. The CNIC was supported by the Instituto de Salud Carlos III, the Ministerio de Ciencia, Innovación y Universidades, and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (grant CEX2020-001041-S funded by MICIU/AEI/10.13039/501100011033). This work was supported by the National heart, Lung and Blood Institute under National Institutes of Health (NIH) grant R01HL163943; the La Caixa Banking Foundation project code HR18-00304 (grant LCF/PR/HR19/52160013); grants PI-FIS-2020, PI20/01220, PI-FIS-2023, and PI23/01039 from the Instituto de Salud Carlos III and cofunded by the Fondo Europeo de Desarrollo Regional (FEDER) and the European Union, respectively; grants PID2020-116935RB-I00 and BFU2016-75144-R funded by MICIU/AEI/10.13039/501100011033; the Fundación La Marató de TV3 (736/C/2020) amb el suport de la Fundació La Marató de TV3; the CIBER (Centro de Investigación Biomédica en Red) de Enfermedades Cardiovasculares (grant CB16/11/00458); the European Union’s Horizon 2020 grant agreement GA-965286; and the Program S2022/BMD7229-CM ARCADIACM funded by the Comunidad de Madrid to J. Jalife; grant PID2021-126423OB-C22 (to M. Martín-Martínez) funded by MICIU/AEI/10.13039/501100011033; and European Regional Development Fund (ERDF) grant PID2022-137214OB-C22 (to M. Gutierrez-Rodríguez) funded by MICIU/AEI/10.13039/501100011033. The imaging studies were performed in the TRIMA@CNIC (Infraestructura de Imagen Traslacional Avanzada del CNIC) node of the ICTS ReDIB (Infraestructuras Científicas y Técnicas Singulares: Red Distribuida de Imagen Biomédica) grant ICTS-2018- 04-CNIC-16 funded by MICIU/AEI/10.13039/501100011033 and ERDF, and project EQC2018-005070-P funded by MICIU/AEI/10.13039/501100011033 and FEDER. A.I. Moreno-Manuel holds an formación profesional universitaria (FPU) contract (FPU20/01569) from the Ministerio de Universidades. J.M. Ruiz Robles holds an FPU contract (FPU22/03253) from the Ministerio de Universidades. L.K. Gutiérrez holds an FPI contract (PRE2018-083530) from the Ministerio de Economía y Competitividad de España cofunded by the Fondo Social Europeo, attached to project SEV-2015-0505-18-2. I. Martínez-Carrascoso holds a PFIS (Contratos predoctorales de formación en investigación en salud) contract (FI21/00243) funded by Instituto de Salud Carlos III and the Fondo Social Europeo Plus cofunded by the European Union. M.L. Vera-Pedrosa held contract PEJD-2019-PRE/BMD15982 funded by the Consejería de Educación e Investigación de la Comunidad de Madrid y Fondo Social Europeo.S

Towards a Digital Twin of the Earth System: Geo-Soft-CoRe, a Geoscientific Software & Code Repository

[Abstract] The immense advances in computer power achieved in the last decades have had a significant impact in Earth science, providing valuable research outputs that allow the simulation of complex natural processes and systems, and generating improved forecasts. The development and implementation of innovative geoscientific software is currently evolving towards a sustainable and efficient development by integrating models of different aspects of the Earth system. This will set the foundation for a future digital twin of the Earth. The codification and update of this software require great effort from research groups and therefore, it needs to be preserved for its reuse by future generations of geoscientists. Here, we report on Geo-Soft-CoRe, a Geoscientific Software & Code Repository, hosted at the archive DIGITAL.CSIC. This is an open source, multidisciplinary and multiscale collection of software and code developed to analyze different aspects of the Earth system, encompassing tools to: 1) analyze climate variability; 2) assess hazards, and 3) characterize the structure and dynamics of the solid Earth. Due to the broad range of applications of these software packages, this collection is useful not only for basic research in Earth science, but also for applied research and educational purposes, reducing the gap between the geosciences and the society. By providing each software and code with a permanent identifier (DOI), we ensure its self-sustainability and accomplish the FAIR (Findable, Accessible, Interoperable and Reusable) principles. Therefore, we aim for a more transparent science, transferring knowledge in an easier way to the geoscience community, and encouraging an integrated use of computational infrastructure.This research has been funded by the Projects EPOS IP 676564, EPOS SP 871121, SERA 730900, GeoCAM (PGC2018-095154-B-I00, Spanish Government) and the Center of Excellence for Exascale in Solid Earth (ChEESE) under the Grant Agreement 823844. IDF was funded by a FEDER-Junta de Castilla y León Postdoctoral contract (SA0084P20). JA and M-GL are funded by the Spanish Ministry of Science and Innovation through the Juan de la Cierva fellowship (IJC 2018-036074-I and IJC 2018-036826-I, respectively), funded by MCIN/AEI /10.13039/501100011033. AH is grateful for his Ramón y Cajal contract (RYC 2020-029253-I). Additional funding was provided by the Spanish Ministry of Science and Innovation (RTI 2018-095594-B-I00, PGC 2018-095154-B-100) and the Generalitat de Catalunya (AGAUR, 2017SGR1022). AP’s work was supported by: a Science Foundation Ireland Career Development Award (17/CDA/4695); an investigator award (16/IA/4520); a Marine Research Programme funded by the Irish Government, co-financed by the European Regional Development Fund (Grant-Aid Agreement No. PBA/CC/18/01); European Union’s Horizon 2020 research and innovation programme InnoVar under grant agreement No 818144; SFI Centre for Research Training in Foundations of Data Science 18/CRT/6049, and SFI Research Centre awards I-Form 16/RC/3872 and Insight 12/RC/2289_P2. AH and SG thank the Spanish research project PaleoModes (CGL2016-75281-C2-1-R) which provided some of their financial support. JF is supported by an Atracción de Talento senior fellowship (2018-T1/AMB/11493) funded by Comunidad Autonoma de Madrid (Spain), and a project funded by the Spanish Ministry of Science and Innovation (PID2020-114854GB-C22)Junta de Castilla y León; SA0084P20Generalitat de Catalunya; 2017SGR1022Science Foundation Ireland; 17/CDA/4695Science Foundation Ireland; 16/IA/4520Ireland. Marine Institute; PBA/CC/18/01Science Foundation Ireland; 18/CRT/6049Science Foundation Ireland; 16/RC/3872Science Foundation Ireland; 12/RC/2289_P2Comunidad Autonoma de Madrid; 2018-T1/AMB/1149

Brain Functional Connectivity Is Modified By A Hypocaloric Mediterranean Diet And Physical Activity In Obese Women

Functional magnetic resonance imaging (fMRI) in the resting state has shown altered brain connectivity networks in obese individuals. However, the impact of a Mediterranean diet on cerebral connectivity in obese patients when losing weight has not been previously explored. The aim of this study was to examine the connectivity between brain structures before and six months after following a hypocaloric Mediterranean diet and physical activity program in a group of sixteen obese women aged 46.31 +/- 4.07 years. Before and after the intervention program, the body mass index (BMI) (kg/m(2)) was 38.15 +/- 4.7 vs. 34.18 +/- 4.5 (p < 0.02), and body weight (kg) was 98.5 +/- 13.1 vs. 88.28 +/- 12.2 (p < 0.03). All subjects underwent a pre- and post-intervention fMRI under fasting conditions. Functional connectivity was assessed using seed-based correlations. After the intervention, we found decreased connectivity between the left inferior parietal cortex and the right temporal cortex (p < 0.001), left posterior cingulate (p < 0.001), and right posterior cingulate (p < 0.03); decreased connectivity between the left superior frontal gyrus and the right temporal cortex (p < 0.01); decreased connectivity between the prefrontal cortex and the somatosensory cortex (p < 0.025); and decreased connectivity between the left and right posterior cingulate (p < 0.04). Results were considered significant at a voxel-wise threshold of p <= 0.05, and a cluster-level family-wise error correction for multiple comparisons of p <= 0.05. In conclusion, functional connectivity between brain structures involved in the pathophysiology of obesity ( the inferior parietal lobe, posterior cingulate, temporo-insular cortex, prefrontal cortex) may be modified by a weight loss program including a Mediterranean diet and physical exercise