Dynamical generation of wormholes with charged fluids in quadratic Palatini gravity

The dynamical generation of wormholes within an extension of General Relativity (GR) containing (Planck's scale-suppressed) Ricci-squared terms is considered. The theory is formulated assuming the metric and connection to be independent (Palatini formalism) and is probed using a charged null fluid as a matter source. This has the following effect: starting from Minkowski space, when the flux is active the metric becomes a charged Vaidya-type one, and once the flux is switched off the metric settles down into a static configuration such that far from the Planck scale the geometry is virtually indistinguishable from that of the standard Reissner-Nordstr\"om solution of GR. However, the innermost region undergoes significant changes, as the GR singularity is generically replaced by a wormhole structure. Such a structure becomes completely regular for a certain charge-to-mass ratio. Moreover, the nontrivial topology of the wormhole allows to define a charge in terms of lines of force trapped in the topology such that the density of lines flowing across the wormhole throat becomes a universal constant. To the light of our results we comment on the physical significance of curvature divergences in this theory and the topology change issue, which support the view that space-time could have a foam-like microstructure pervaded by wormholes generated by quantum gravitational effects.Comment: 14 pages, 3 figures, revtex4-1 style. New content added on section VI. Other minor corrections introduced. Final version to appear in Phys. Rev.

Non-linear classifiers applied to EEG analysis for epilepsy seizure detection

This work presents a novel approach for automatic epilepsy seizure detection based on EEG analysis that exploits the underlying non-linear nature of EEG data. In this paper, two main contributions are presented and validated: the use of non-linear classifiers through the so-called kernel trick and the proposal of a Bag-of-Words model for extracting a non-linear feature representation of the input data in an unsupervised manner. The performance of the resulting system is validated with public datasets, previously processed to remove artifacts or external disturbances, but also with private datasets recorded under realistic and non-ideal operating conditions. The use of public datasets caters for comparison purposes whereas the private one shows the performance of the system under realistic circumstances of noise, artifacts, and signals of different amplitudes. Moreover, the proposed solution has been compared to state-of-the-art works not only for pre-processed and public datasets but also with the private datasets. The mean F1-measure shows a 10% improvement over the second-best ranked method including cross-dataset experiments. The obtained results prove the robustness of the proposed solution to more realistic and variable conditions. (C) 2017 Elsevier Ltd. All rights reserved

Log canonical thresholds of Del Pezzo Surfaces in characteristic p

The global log canonical threshold of each non-singular complex del Pezzo surface was computed by Cheltsov. The proof used Koll\'ar-Shokurov's connectedness principle and other results relying on vanishing theorems of Kodaira type, not known to be true in finite characteristic. We compute the global log canonical threshold of non-singular del Pezzo surfaces over an algebraically closed field. We give algebraic proofs of results previously known only in characteristic $0$. Instead of using of the connectedness principle we introduce a new technique based on a classification of curves of low degree. As an application we conclude that non-singular del Pezzo surfaces in finite characteristic of degree lower or equal than $4$ are K-semistable.Comment: 21 pages. Thorough rewrite following referee's suggestions. To be published in Manuscripta Mathematic

The CORTEX Cognitive Robotics Architecture: use cases

CORTEX is a cognitive robotics architecture inspired by three key ideas: modularity, internal modelling and graph representations. CORTEX is also a computational framework designed to support early forms of intelligence in real world, human interacting robots, by selecting an a priori functional decomposition of the capabilities of the robot. This set of abilities was then translated to computational modules or agents, each one built as a network of software interconnected components. The nature of these agents can range from pure reactive modules connected to sensors and/or actuators, to pure deliberative ones, but they can only communicate with each other through a graph structure called Deep State Representation (DSR). DSR is a short-term dynamic representation of the space surrounding the robot, the objects and the humans in it, and the robot itself. All these entities are perceived and transformed into different levels of abstraction, ranging from geometric data to high-level symbolic relations such as "the person is talking and gazing at me". The combination of symbolic and geometric information endows the architecture with the potential to simulate and anticipate the outcome of the actions executed by the robot. In this paper we present recent advances in the CORTEX architecture and several real-world human-robot interaction scenarios in which they have been tested. We describe our interpretation of the ideas inspiring the architecture and the reasons why this specific computational framework is a promising architecture for the social robots of tomorrow

Use of Pleurotus pulmonarius to change the nutritional quality of wheat straw. I. effect on chemical composition

The effect of Pleurotus pulmonarius on the chemical composition of wheat straw was evaluated. Wheat straw, treated and untreated with P. pulmonarius, was obtained from a commercial facility. Ten samples plastic bags of wheat straw used previously as substrate to culture edible fungus were collected at random. The negative control group consisted of the pasteurized wheat straw untreated with P. pulmonarius. All samples were analyzed to determine dry matter, organic matter, crude protein, neutral detergent fiber, acid detergent fiber, cellulose and hemicellulose of each wheat straw. Data were analyzed by mean comparison using a t-Student test. No differences (P>0.05) between treatments were found for dry matter, crude protein and hemicellulose; however, straw treated with P. pulmonarius showed higher percentages (P<0.05) of organic matter, neutral and acid detergent fiber. It is concluded that growing P. pulmonarius in wheat straw improves the chemical composition of the straw by increasing its organic matter content and modifies the fiber structure, which increases the soluble carbohydrates content

CSA06 Computing, Software and Analysis challenge at the Spanish Tier-1 and Tier-2 sites

This note describes the participation of the Spanish centres PIC, CIEMAT and IFCA as Tier-1 and Tier-2 sites in the CMS CSA06 Computing, Software and Analysis challenge. A number of the facilities, services and workflows have been demonstrated at the 2008 25% scale. Very valuable experience has been gained running the complex computing system under realistic conditions at a significant scale. The focus of this note is on presenting achieved results, operational experience and lessons learnt during the challenge

Novel purine chemotypes with activity against Plasmodium 2 falciparum and Trypanosoma cruzi

Malaria and Chagas disease, caused by Plasmodium spp. and Trypanosoma cruzi parasites, remain important global health problems. Available treatments for those diseases present several limitations, such as lack of efficacy, toxic side effects, and drug resistance. Thus, new drugs are urgently needed. The discovery of new drugs may be benefited by considering the significant biological differences between hosts and parasites. One of the most striking differences is found in the purine metabolism, because most of the parasites are incapable of de novo purine biosynthesis. Herein, we have analyzed the in vitro anti-P. falciparum and anti-T. cruzi activity of a collection of 81 purine derivatives and pyrimidine analogs. We firstly used a primary screening at three fixed concentrations (100, 10, and 1 µM) and progressed those compounds that kept the growth of the parasites < 30% at 100 µM to dose–response assays. Then, we performed two different cytotoxicity assays on Vero cells and human HepG2 cells. Finally, compounds specifically active against T. cruzi were tested against intracellular amastigote forms. Purines 33 (IC50 = 19.19 µM) and 76 (IC50 = 18.27 µM) were the most potent against P. falciparum. On the other hand, 6D (IC50 = 3.78 µM) and 34 (IC50 = 4.24 µM) were identified as hit purines against T. cruzi amastigotes. Moreover, an in silico docking study revealed that P. falciparum and T. cruzi hypoxanthine guanine phosphoribosyltransferase enzymes could be the potential targets of those compounds. Our study identified two novel, purine-based chemotypes that could be further optimized to generate potent and diversified anti-parasitic drugs against both parasites.SAF2016-76080-R (Spanish Ministry of Economy (AEI/FEDER, UE))PID2019-110810RB-I00 (Spanish Ministry of Science and Innovation)Generalitat of Catalonia Universities and Research Department, Spain (AGAUR; 2017SGR00924)Carlos III Health Institute (ISCIII)RICET Network for Cooperative Research in Tropical Diseases (ISCIII; RD12/0018/0010)Generalitat of Catalonia Department of Health (PERIS 2016–2010 SLT008/18/00132)Spanish Ministry of Education, Culture, and Sports (FPU grant ref. 14/00818)Spanish Ministry of Science, Innovation, and Universities through the “Centro de Excelencia Severo Ochoa 2019–2023” Program (CEX2018-000806-S)CERCA Progra

Energy-dispersive X-ray absorption spectroscopy at LNLS: Investigation on strongly correlated metal oxides

An energy-dispersive X-ray absorption spectroscopy beamline mainly dedicated to X-ray magnetic circular dichroism (XMCD) and material science under extreme conditions has been implemented in a bending-magnet port at the Brazilian Synchrotron Light Laboratory. Here the beamline technical characteristics are described, including the most important aspects of the mechanics, optical elements and detection set-up. The beamline performance is then illustrated through two case studies on strongly correlated transition metal oxides: an XMCD insight into the modifications of the magnetic properties of Cr-doped manganites and the structural deformation in nickel perovskites under high applied pressure. © 2010 International Union of Crystallography. Printed in Singapore - all rights reserved.Fil: Cezar, Julio C.. Laboratorio Nacional de Luz Síncrotron; BrasilFil: Souza Neto, Narcizo M.. Laboratorio Nacional de Luz Síncrotron; BrasilFil: Piamonteze, Cínthia. Laboratorio Nacional de Luz Síncrotron; BrasilFil: Tamura, Edilson. Laboratorio Nacional de Luz Síncrotron; BrasilFil: Garcia, Flávio. Laboratorio Nacional de Luz Síncrotron; BrasilFil: Carvalho, Edson J.. Laboratorio Nacional de Luz Síncrotron; BrasilFil: Neueschwander, Régis T.. Laboratorio Nacional de Luz Síncrotron; BrasilFil: Ramos, Aline Y.. Centre National de la Recherche Scientifique; FranciaFil: Tolentino, Hélio C. N.. Centre National de la Recherche Scientifique; FranciaFil: Caneiro, Alberto. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina. Comisión Nacional de Energía Atómica. Gerencia del Área de Energía Nuclear. Instituto Balseiro; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Massa, Nestor Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaFil: Martinez Lope, Maria Jesus. Instituto de Ciencia de Materiales de Madrid; España. Consejo Superior de Investigaciones Científicas; EspañaFil: Alonso, José Antonio. Instituto de Ciencia de Materiales de Madrid; España. Consejo Superior de Investigaciones Científicas; EspañaFil: Itié, Jean Paul. L'Orme des Merisiers. Synchrotron SOLEIL; Franci

A protective personal factor against disability and dependence in the elderly: an ordinal regression analysis with nine geographically-defined samples from Spain

Background Sense of Coherence (SOC) is defined as a tendency to perceive life experiences as comprehensible, manageable and meaningful. The construct is split in three major domains: Comprehensibility, Manageability, and Meaningfulness. SOC has been associated with successful coping strategies in the face of illness and traumatic events and is a predictor of self-reported and objective health in a variety of contexts. In the present study we aim to evaluate the association of SOC with disability and dependence in Spanish elders. Methods A total of 377 participants aged 75 years or over from nine locations across Spain participated in the study (Mean age: 80.9 years; 65.3% women). SOC levels were considered independent variables in two ordinal logistic models on disability and dependence, respectively. Disability was established with the World health Organization-Disability Assessment Schedule 2.0 (36-item version), while dependence was measured with the Extended Katz Index on personal and instrumental activities of daily living. The models included personal (sex, age, social contacts, availability of an intimate confidant), environmental (municipality size, access to social resources) and health-related covariates (morbidity). Results High Meaningfulness was a strong protective factor against both disability (Odds Ratio [OR] = 0.50; 95% Confidence Interval [CI] = 0.29–0.87) and dependence (OR = 0.33; 95% CI = 0.19–0.58) while moderate and high Comprehensibility was protective for disability (OR = 0.40; 95% CI = 0.22–0.70 and OR = 0.39; 95%CI = 0.21–0.74), but not for dependence. Easy access to social and health resources was also highly protective against both disability and dependence. Conclusions Our results are consistent with the view that high levels of SOC are protective against disability and dependence in the elderly. Elderly individuals with limited access to social and health resources and with low SOC may be a group at risk for dependence and disability in Spain.This project was partially funded by a research contract in support of the project “Epidemiological Study of Dementia in Spain” signed by the Pfizer Foundation and Carlos III Institute of HealthS

The OTELO survey: A case study of [O III] lambda 4959,5007 emitters at z=0.83

Context. The OSIRIS Tunable Filter Emission Line Object (OTELO) survey is a very deep, blind exploration of a selected region of the Extended Groth Strip and is designed for finding emission-line sources (ELSs). The survey design, observations, data reduction, astrometry, and photometry, as well as the correlation with ancillary data used to obtain a final catalogue, including photo-z estimates and a preliminary selection of ELS, were described in a previous contribution. Aims. Here, we aim to determine the main properties and luminosity function (LF) of the [O III] ELS sample of OTELO as a scientific demonstration of its capabilities, advantages, and complementarity with respect to other surveys. Methods. The selection and analysis procedures of ELS candidates obtained using tunable filter pseudo-spectra are described. We performed simulations in the parameter space of the survey to obtain emission-line detection probabilities. Relevant characteristics of [O III] emitters and the LF ([O III]), including the main selection biases and uncertainties, are presented. Results. From 541 preliminary emission-line source candidates selected around z = 0.8, a total of 184 sources were confirmed as [O III] emitters. Consistent with simulations, the minimum detectable line flux and equivalent width in this ELS sample are ∼5 × 10−19 erg s−1 cm2 and ∼6 Å, respectively. We are able to constrain the faint-end slope (α = −1.03 ± 0.08) of the observed LF ([O III]) at a mean redshift of z = 0.83. This LF reaches values that are approximately ten times lower than those from other surveys. The vast majority (84%) of the morphologically classified [O III] ELSs are disc-like sources, and 87% of this sample is comprised of galaxies with stellar masses of M⋆ <  1010 M⊙