Collision of protons with carbon atoms of a graphene surface in the presence of adsorbed potassium

In this work we study the frontal collision of protons with the carbon atoms of a graphene surface with a low coverage of adsorbed potassium. It is aimed at the analysis of the effect of the adsorbates in both charge exchange and electron emission processes, when the binary collision occurs between the proton and a carbon atom of the surface. The frontal collision with the K adsorbate, already analyzed and discussed in a previous work, is compared with the frontal collision with different carbon neighbors. In the present work we studied the signals, due to the localized structures in the density matrix of the composed graphene plus potassium surface, that can be distinguished when the collision occurs either with the adsorbate, a nearby carbon atom, or a carbon atom that does not feel the presence of the adsorbate. The interacting system is described by the Anderson Hamiltonian which takes into account the electronic repulsion on the projectile site; the charge fractions, the energy distribution of electrons in the solid, and the electron emission after the collision are calculated by using the nonequilibrium Green-Keldysh functions formalism solved by the equation of motion method. In the binary collision with a carbon atom, the extended features of the band structure of graphene smooth the dependence of the projectile charge fractions on the incoming energy and notably decrease the negative ions formation. The localized structures of the density of matrix caused by the presence of the adsorbate are perceptible for scattered carbon atoms close to K. The intense emission of low energy electrons obtained in the case of the scattering by potassium is fundamentally associated with the very localized K-4s empty band. This characteristic, although less marked, remain in the scattering by nearby carbon atoms, due to both the interaction with K along the projectile trajectory and the perturbed local density of states on the carbon atoms due to the adsorbate presence. In addition, the extended nature of the electronic structure of graphene allows for the emission of more energetic electrons.Fil: Iglesias García, Adalberto de Jesús. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Física del Litoral. Universidad Nacional del Litoral. Instituto de Física del Litoral; ArgentinaFil: Romero, M. A.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Física del Litoral. Universidad Nacional del Litoral. Instituto de Física del Litoral; ArgentinaFil: García, Evelina Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Física del Litoral. Universidad Nacional del Litoral. Instituto de Física del Litoral; ArgentinaFil: Goldberg, Edith Catalina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Física del Litoral. Universidad Nacional del Litoral. Instituto de Física del Litoral; Argentin

Switching Costs in the European Postal Service. Are There Any Solutions?

[Abstract] This article examines the costs of switching that may exist in the European postal sector, where it is carried out an ambitious process of opening to competition since 1997. Inadequate regulation of the access to some elements of postal infrastructure or services within the scope of the universal postal service exists. This article proposes adaptations to ensure transparent and non-discriminatory access conditions to elements of postal infrastructure in line with the sectorial directives aimed at strengthening competition in the long term in the postal market. The proposed adaptations focus on services such as postcode systems, address databases, post office boxes, delivery boxes, re-direction and return to sender services. All of them can help reduce the switching cost and thus strengthen competition

Towards a fuzzy-based multi-classifier selection module for activity recognition applications

Performing activity recognition using the information provided by the different sensors embedded in a smartphone face limitations due to the capabilities of those devices when the computations are carried out in the terminal. In this work a fuzzy inference module is implemented in order to decide which classifier is the most appropriate to be used at a specific moment regarding the application requirements and the device context characterized by its battery level, available memory and CPU load. The set of classifiers that is considered is composed of Decision Tables and Trees that have been trained using different number of sensors and features. In addition, some classifiers perform activity recognition regardless of the on-body device position and others rely on the previous recognition of that position to use a classifier that is trained with measurements gathered with the mobile placed on that specific position. The modules implemented show that an evaluation of the classifiers allows sorting them so the fuzzy inference module can choose periodically the one that best suits the device context and application requirements

Estudio y análisis del sudario Judío conservado en el Museo Bíblico de León

El denominado “Sudario Judío del siglo I del Museo Bíblico de León” es una pieza textil de notable interés, toda vez que se ha conservado íntegra y prácticamente intacta, a pesar de su antigüedad. Su interés resulta ser mayor dado que el hallazgo de piezas textiles tan antiguas y de tales dimensiones es poco frecuente, y en buen estado de conservación aún menos. Se trata de una pieza de lino tejida a mano, en un telar vertical, donde los hilos también han sido hilados a mano. A pesar de que macroscópicamente aparenta estar en buen estado de conservación, el estudio microscópico pone de manifiesto una contaminación por microorganismos, por lo que se aconseja mejorar las condiciones de conservación, para evitarla progresión de su deterioro con el paso del tiempo. Presenta cierto grado de contaminación inorgánica, debida en su mayoría a partículas formadas por cristales idiomórficos de calcita, derivados de una contaminación inicial con cal que, con el tiempo, termina evolucionando in situ a carbonato de calcio. También encontramos partículas de cuarzo (redondeadas y angulosas), y sal microcristalina. Las conclusiones llevan a establecer que nos hallamos ante una tela antigua y afectada de biodegradación, que ha residido en un espacio subterráneo dentro de un ámbito de clima desértico.The denominated “Jewish Shroud of Century I of the Biblical Museum of Leon” is a textile piece of remarkable interest, since it has been preserved intact, in spite of its antiquity. Its interest turns out to be greater given that the finding of such old textile pieces and of such dimensions is rare, and in good condition even less. It is a piece of linen woven by hand, on a vertical loom, where the threads have also been spun by hand. Although macroscopically it appears to be in a good state of conservation, the microscopic study reveals a contamination by microorganisms, so it is advisable to improve the conditions of conservation, to avoid the progression of its deterioration with the passage of time. It presents a certain degree of inorganic contamination, due mostly to particles formed by calcite idiomorphic crystals, derived from an initial contamination with lime that, over time, ends up evolving in situ to calcium carbonate. We also find quartz particles (round and angular) and microcrystals of salt. The conclusions lead us to establish that we are faced with an ancient and affected fabric of biodegradation, which has resided in an underground space within a desert climate environment

Application of a Pharmacogenetics-Based Precision Medicine Model (5SPM) to Psychotic Patients That Presented Poor Response to Neuroleptic Therapy

[EN] Antipsychotics are the keystone of the treatment of severe and prolonged mental disorders. However, there are many risks associated with these drugs and not all patients undergo full therapeutic profit from them. The application of the 5 Step Precision Medicine model(5SPM), based on the analysis of the pharmacogenetic profile of each patient, could be a helpful tool to solve many of the problematics traditionally associated with the neuroleptic treatment. In order to solve this question, a cohort of psychotic patients that showed poor clinical evolution was analyzed. After evaluating the relationship between the prescribed treatment and pharmacogenetic profile of each patient, a great number of pharmacological interactions and pharmacogenetical conflicts were found. After reconsidering the treatment of the conflictive cases, patients showed a substantial reduction on mean daily doses and polytherapy cases, which may cause less risk of adverse effects, greater adherence, and a reduction on economic costs

Plant material of peach, situation in Spain

The peach species is the most important stone fruit grown in Spain. The acreage devoted to this crop has increased lightly in the last 15 years, however the production has been doubled in this period as a consequence of the use of drip irrigation and introduction of new varieties and more efficient rootstocks. The range of varieties in Spain is very dinamic, there is a substantial increase of nectarines and platicarpa types, a light increase of melting peaches and a decrease of non-melting varieties. The main problems of this crop are the bad adaptability of many varieties from foreign countries to the Spanish environment, the dependency from varieties bred in other countries, the lack of internal quality of the fruits in many commercial cultivars, the incidence of pests, diseases and abiotic stresses and the high cost of the crop management. These problems might be overcame by means of breeding programs based on specific crosses. Currently, there are 14 active peach breeding programs in Spain. in terms of accomplishing the objectives of these programs new sources of variability carrying the desired traits are needed. The search and use of new sources of variation implies a high investment in research and characterization of the new plant material along with inheritance studies of those traits of interest

Two pieces of linen with a latin inscription from the Biblical and Oriental Museum of Leon

The present article is a study of two linen fabrics that have an inscription in cursive Latin of very high interest. Both tissues are preserved in the Biblical and Oriental Museum of Leon and have an uncertain origin. The two pieces, which are decontextualized, have the same measure, 17 cm wide and 34 cm high. The text is Christian but has certain gaps. It is a repeated invocation to Jesus, who presents Him as the Beginning and the End of all, and qualifies Him repeatedly as Holy. These attributes are proper to God (Apocalypse 1,4; 1,8; 4,8), and being assigned to Jesus, seem to deny the human nature of Christ, which makes us think of a text of heretical character with a clear relationship with Monarchianism or Sabellianism (II-III centuries AD). Sabellianism spread through Libya and Egypt from the third century onwards, which can approximate the text dating between the third and fifth centuries. A technical analysis of both the linen and the ink in which papyrus remains have been found entangled, was performed, indicating that it comes from a workshop in which linen or papyrus was made indistinctly, something that was common in the workshops of Egyptian craftsmen. A textual analysis was also performed enhancing the links with some passages of Apocalypse

Diverse Large HIV-1 Non-subtype B Clusters Are Spreading Among Men Who Have Sex With Men in Spain

In Western Europe, the HIV-1 epidemic among men who have sex with men (MSM) is dominated by subtype B. However, recently, other genetic forms have been reported to circulate in this population, as evidenced by their grouping in clusters predominantly comprising European individuals. Here we describe four large HIV-1 non-subtype B clusters spreading among MSM in Spain. Samples were collected in 9 regions. A pol fragment was amplified from plasma RNA or blood-extracted DNA. Phylogenetic analyses were performed via maximum likelihood, including database sequences of the same genetic forms as the identified clusters. Times and locations of the most recent common ancestors (MRCA) of clusters were estimated with a Bayesian method. Five large non-subtype B clusters associated with MSM were identified. The largest one, of F1 subtype, was reported previously. The other four were of CRF02_AG (CRF02_1; n = 115) and subtypes A1 (A1_1; n = 66), F1 (F1_3; n = 36), and C (C_7; n = 17). Most individuals belonging to them had been diagnosed of HIV-1 infection in the last 10 years. Each cluster comprised viruses from 3 to 8 Spanish regions and also comprised or was related to viruses from other countries: CRF02_1 comprised a Japanese subcluster and viruses from 8 other countries from Western Europe, Asia, and South America; A1_1 comprised viruses from Portugal, United Kingom, and United States, and was related to the A1 strain circulating in Greece, Albania and Cyprus; F1_3 was related to viruses from Romania; and C_7 comprised viruses from Portugal and was related to a virus from Mozambique. A subcluster within CRF02_1 was associated with heterosexual transmission. Near full-length genomes of each cluster were of uniform genetic form. Times of MRCAs of CRF02_1, A1_1, F1_3, and C_7 were estimated around 1986, 1989, 2013, and 1983, respectively. MRCA locations for CRF02_1 and A1_1 were uncertain (however initial expansions in Spain in Madrid and Vigo, respectively, were estimated) and were most probable in Bilbao, Spain, for F1_3 and Portugal for C_7. These results show that the HIV-1 epidemic among MSM in Spain is becoming increasingly diverse through the expansion of diverse non-subtype B clusters, comprising or related to viruses circulating in other countries.This work was funded through Acción Estratégica en Salud Intramural (AESI), Instituto de Salud Carlos III, project “Estudios sobre vigilancia epidemiológica molecular del VIH-1 en España,” PI16CIII/00033; Red de Investigación en SIDA (RIS), Instituto de Salud Carlos III, Subdirección General de Evaluación y Fondo Europeo de Desarrollo Regional (FEDER), Plan Nacional I+D+I, project RD16ISCIII/0002/0004; scientific agreements with Consellería de Sanidade, Government of Galicia (MVI 1004/16) and Osakidetza-Servicio Vasco de Salud, Government of Basque Country (MVI 1001/16); European Research Infrastructures for Poverty Related Diseases (EURIPRED). Seventh Framework Program: FP7-Capacities-infrastructures-2012-1, grant agreement 312661; and Dirección General de Farmacia, Ministerio de Sanidad, Servicios Sociales e Igualdad, Government of Spain (grant EC11-272).S

Supporting data for the MS identification of distinct transferrin glycopeptide glycoforms and citrullinated peptides associated with inflammation or autoimmunity

This data article presents the results of all the statistical analyses applied to the relative intensities of the detected 2D-DiGE protein spots for each of the 3 performed DiGE experiments. The data reveals specific subsets of protein spots with significant differences between WT and CD38-deficient mice with either Collagen-induced arthritis (CIA), or with chronic inflammation induced by CFA, or under steady-state conditions. This article also shows the MS data analyses that allowed the identification of the protein species which serve to discriminate the different experimental groups used in this study. Moreover, the article presents MS data on the citrullinated peptides linked to specific protein species that were generated in CIA(+) or CFA-treated mice. Lastly, this data article provides MS data on the efficiency of the analyses of the transferrin (Tf) glycopeptide glycosylation pattern in spleen and serum from CIA(+) mice and normal controls. The data supplied in this work is related to the research article entitled "identification of multiple transferrin species in spleen and serum from mice with collagen-induced arthritis which may reflect changes in transferrin glycosylation associated with disease activity: the role of CD38" [1]. All mass spectrometry data have been deposited to the ProteomeXchange Consortium via the PRIDE partner repository with identifiers PRIDE: PXD002644, PRIDE: PXD002643, PRIDE: PXD003183 and PRIDE: PXD003163

Catheter-related bloodstream infections: predictive factors for Gram-negative bacteria aetiology and 30 day mortality in a multicentre prospective cohort

PROBAC REIPI/GEIH-SEIMC/SAEI.[Background] Catheter-related bloodstream infections (CRBSIs) increase morbidity and mortality, prolong hospitalization and generate considerable medical costs. Recent guidelines for CRBSI recommend empirical therapy against Gram-positive bacteria (GPB) and restrict coverage for Gram-negative bacteria (GNB) only to specific circumstances.[Objectives]To investigate predictors of GNB aetiology in CRBSI and to assess the predictors of outcome in patients with CRBSI.[Methods] Patients with CRBSI were selected from the PROBAC cohort, a prospective, observational, multicentre national cohort study including patients with bloodstream infections consecutively admitted to 26 Spanish hospitals in a 6 month period (October 2016–March 2017). Outcome variables were GNB aetiology and 30 day mortality. Adjusted analyses were performed by logistic regression.[Results] Six hundred and thirty-one episodes of CRBSI were included in the study. Risk factors independently related to GNB aetiology were central venous catheter (CVC) [OR 1.60 (95% CI: 1.05–2.44), P = 0.028], sepsis/septic shock [OR: 1.76 (95% CI: 1.11–2.80), P = 0.016], antibiotic therapy in the previous 30 days [OR: 1.56 (95% CI: 1.02–2.36), P = 0.037], neutropenia <500/μL [OR: 2.01 (95% CI: 1.04–3.87), P = 0.037] and peripheral vascular disease [OR: 2.04 (95% CI: 1.13–3.68), P = 0.018]. GNB were not associated with increased mortality in adjusted analysis, while removal of catheter [OR: 0.24 (95% CI: 0.09–0.61), P = 0.002] and adequate empirical treatment [OR: 0.37 (95% CI: 0.18–0.77), P = 0.008] were strong protective factors.[Conclusions] Our study reinforces the recommendation that empirical coverage should cover GNB in patients presenting with sepsis/septic shock and in neutropenic patients. Catheter removal and adequate empirical treatment were both protective factors against mortality in patients with CRBSI.This study was funded by Plan Nacional de I+D+i 2013–2016 and Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia, Innovación y Universidades, through the following grants: Spanish Network for Research in Infectious Diseases (REIPI RD16/0016/0001; RD16/0016/0007; RD16/0016/0008; RD16/0016/0012), co-financed by European Development Regional Fund ‘A way to achieve Europe’, Operative Program Intelligent Growth 2014–2020, and PI16/01432. F. Caló enjoyed an ESCMID Observership grant at Hospital Universitario Virgen Macarena to develop this research