Effects of the Minimum Wage on Employment Dynamics

The voluminous literature on minimum wages offers little consensus on the extent to which a wage floor impacts employment. We argue that the minimum wage will impact employment over time, through changes in growth rather than an immediate drop in relative employment levels. We conduct simulations showing that commonly-used specifications in this literature, especially those that include state-specific time trends, will not accurately capture these effects. Using three separate state panels of administrative employment data, we find that the minimum wage reduces job growth over a period of several years. These effects are most pronounced for younger workers and in industries with a higher proportion of low-wage workers

Relative magnitude of infragravity waves at coastal dikes with shallow foreshores : a prediction tool

Despite the widely recognized role of infragravity (IG) waves in many often-hazardous nearshore processes, spectral wave models, which exclude IG-wave dynamics, are often used in the design and assessment of coastal dikes. Consequently, the safety of these structures in environments where IG waves dominate remains uncertain. Here, we combine physical and numerical modeling to: (1) assess the influence of various offshore, foreshore, and dike slope conditions on the dominance of IG waves over those at sea and swell (SS) frequencies; and (2) develop a predictive model for the relative magnitude of IG waves, defined as the ratio of the IG-to-SS-wave height at the dike toe. Findings show that higher, directionally narrow-banded incident waves; shallower water depths; milder foreshore slopes; reduced vegetated cover; and milder dike slopes promote IG-wave dominance. In addition, the empirical model derived, which captures the combined effect of the varied environmental parameters, allows practitioners to quickly estimate the significance of IG waves at the coast, and may also be combined with spectral wave models to extend their applicability to areas where IG waves contribute significantly

Brucellosis serology as an alternative diagnostic test for patients with malaria-like symptoms

Background: In a low transmission zone for malaria, we explored the presence of brucellosis as an alternative diagnosis in febrile patients. Specifically, the objective of our study was to determine the proportion of patients presenting to the hospital with malaria-like febrile symptoms that were concurrently brucellosis sero-positive, and assess related risk factors.Methods: The study was done at the rural hospital in Endulen, in the Ngorongoro Conservation Area (NCA), Tanzania. Hospital patients were enrolled showing malaria-like febrile symptoms and were tested for malaria (microscopy) as well as brucellosis (agglutination test, plus commercial ELISAs for IgM and for IgG). Patient demographic characteristics and risk factors for brucellosis were determined using a questionnaire interview.Results: A total of 159 patients were enrolled, of which 57 were positive for malaria and 58 were positive by ELISA for brucellosis, with 54 (93%) of these brucellosis-positives solely positive for isotype IgG, 1 (1.7%) solely for isotype IgM, and 3 (5.2%) positive for both IgM and IgG. However, the brucellosis agglutination test was only positive in 9 of 159 samples. Co-infections of malaria and brucellosis occurred, but malaria disease status was not significantly correlated with brucellosis status. Patients serologically positive for brucellosis were more likely to have had contact with aborted animal materials (p=0.002).Conclusions: Brucellosis is a potentially missed diagnosis amongst pastoralists in rural Tanzania with malaria-like symptoms. However, concurrent and isotope-specific serology is integral to ensure detection and appropriate clinical management.  

Enzyme prodrug therapy achieves site-specific, personalized physiological responses to the locally produced nitric oxide

Nitric oxide (NO) is a highly potent but short-lived endogenous radical with a wide spectrum of physiological activities. In this work, we developed an enzymatic approach to the site-specific synthesis of NO mediated by biocatalytic surface coatings. Multilayered polyelectrolyte films were optimized as host compartments for the immobilized β-galactosidase (β-Gal) enzyme through a screen of eight polycations and eight polyanions. The lead composition was used to achieve localized production of NO through the addition of β-Gal–NONOate, a prodrug that releases NO following enzymatic bioconversion. The resulting coatings afforded physiologically relevant flux of NO matching that of the healthy human endothelium. The antiproliferative effect due to the synthesized NO in cell culture was site-specific: within a multiwell dish with freely shared media and nutrients, a 10-fold inhibition of cell growth was achieved on top of the biocatalytic coatings compared to the immediately adjacent enzyme-free microwells. The physiological effect of NO produced via the enzyme prodrug therapy was validated ex vivo in isolated arteries through the measurement of vasodilation. Biocatalytic coatings were deposited on wires produced using alloys used in clinical practice and successfully mediated a NONOate concentration-dependent vasodilation in the small arteries of rats. The results of this study present an exciting opportunity to manufacture implantable biomaterials with physiological responses controlled to the desired level for personalized treatment

Benchmarking of Numerical Models for Wave Overtopping at Dikes with Shallow Mildly Sloping Foreshores: Accuracy versus Speed

To accurately predict the consequences of nearshore waves, coastal engineers often employ numerical models. A variety of these models, broadly classified as either phase-resolving or phase-averaged, exist; each with strengths and limitations owing to the physical schematization of processes within them. Models which resolve the vertical flow structure or the full wave spectrum (i.e. sea-swell (SS) and infragravity (IG) waves) are considered more accurate, but also more computationally demanding than those with approximations. Here, we assess the speed-accuracy trade-off of six well-known wave models for overtopping (q), under shallow foreshore conditions. The results demonstrate that: i) q is underestimated by an order of magnitude when IG waves are neglected; ii) using more computationally-demanding models does not guarantee more accurate results; and iii) with empirical corrections to account for IG waves, phase-averaged models like SWAN can perform on par, if not better than, phase-resolving models but with far less computational effort

Interstellar X-Ray Absorption Spectroscopy of Oxygen, Neon, and Iron with the Chandra LETGS Spectrum of X0614+091

We find resolved interstellar O K, Ne K, and Fe L absorption spectra in the Chandra X-Ray Observatory Low-Energy Transmission Grating Spectrometer (LETGS) spectrum of the low-mass X-ray binary X0614+091. We measure the column densities in O and Ne and find direct spectroscopic constraints on the chemical state of the interstellar O. These measurements probably probe a low-density line of sight through the Galaxy, and we discuss the results in the context of our knowledge of the properties of interstellar matter in regions between the spiral arms

Most Antidepressant Use in Primary Care Is Justified; Results of the Netherlands Study of Depression and Anxiety

BACKGROUND: Depression is a common illness, often treated in primary care. Many studies have reported undertreatment with antidepressants in primary care. Recently, some studies also reported overtreatment with antidepressants. The present study was designed to assess whether treatment with antidepressants in primary care is in accordance with current guidelines, with a special focus on overtreatment. METHODOLOGY: We used baseline data of primary care respondents from the Netherlands Study of Depression and Anxiety (NESDA) (n = 1610). Seventy-nine patients with treatment in secondary care were excluded. We assessed justification for treatment with antidepressant according to the Dutch primary care guidelines for depression and for anxiety disorders. Use of antidepressants was based on drug-container inspection or, if unavailable, on self-report. Results were recalculated to the original population of primary care patients from which the participants in NESDA were selected (n = 10,677). PRINCIPAL FINDINGS: Of 1531 included primary care patients, 199 (13%) used an antidepressant, of whom 188 (94.5%) (possibly) justified. After recalculating these numbers to the original population (n = 10,677), we found 908 (95% CI 823 to 994) antidepressant users. Forty-nine (95% CI 20 to 78) of them (5.4%) had no current justification for an antidepressant, but 27 of them (54.5%) had a justified reason for an antidepressant at some earlier point in their life. CONCLUSIONS: We found that overtreatment with antidepressants in primary care is not a frequent problem. Too long continuation of treatment seems to explain the largest proportion of overtreatment as opposed to inappropriate initiation of treatment

Progressive ductile shearing during till accretion within the deforming bed of a palaeo-ice stream

This paper presents the results of a detailed microstructural study of a thick till formed beneath the Weichselian (Devensian) Odra palaeo-ice stream, west of Środa Wielkopolska, Poland. This SE-flowing ice stream was one of a number of corridors of faster flowing ice which drained the Scandinavian Ice Sheet in the Baltic region. Macroscopically, the massive, laterally extensive till which formed the bed of this ice stream lacks any obvious evidence of glaciotectonism (thrusting, folding). However, microscale analysis reveals that bed deformation was dominated by foliation development, recording progressive ductile shearing within a subhorizontal subglacial shear zone. Five successive generations of clast microfabric (S1 to S5) have been identified defining a set of up-ice and down-ice dipping Riedel shears, as well as a subhorizontal shear foliation coplanar to the ice-bed interface. Cross-cutting relationships between the shear fabrics record temporal changes in the style of deformation during this progressive shear event. Kinematic indicators (S-C and ECC-type fabrics) within the till indicate a consistent SE-directed shear sense, in agreement with the regional ice flow pattern. A model of bed deformation involving incremental progressive simple shear during till accretion is proposed. The relative age of this deformation was diachronous becoming progressively younger upwards, compatible with subglacial shearing having accompanied till accretion at the top of the deforming bed. Variation in the relative intensity of the microfabrics records changes in the magnitude of the cumulative strain imposed on the till and the degree of coupling between the ice and underlying bed during fast ice flow