269 research outputs found
Étude des problèmes d'optimisation du volume mémoire occupé par les représentations de tables de valeurs
Knowledge, attitude and perceptions about tetanus and rabies among family physicians; results of a survey at a teaching hospital in karachi, pakistan
To assess the knowledge, attitude and perception among family physicians about tetanus and rabies. Setting: This study was conducted at the International Family Physicians Conference held at the Aga Khan University. Method: It was a cross sectional study of convenient sampling. The participants were asked to fill a pre-tested questionnaire comprising of 26 questions. Both open and close ended questions were included. A total of 111 doctors fulfilling the inclusion criteria filled in the questionnaire.Result: Out of 111 doctors who participated in this study, vast majority were working in the urban area (86.5%). 59.5% had not seen a case of tetanus and 71% had not seen a case of rabies in the preceding 6 months. Only 37% would use both tetanus toxoid and tetanus immunoglobulin in case of a dirty wound; 30% would administer tetanus toxoid and anti-tetanus serum in such a case. About 65% knew the current recommendation on rabies vaccination whereas 58% knew the correct post-exposure prophylaxis in case of suspected rabies.Conclusion: The level of knowledge about tetanus and rabies was clearly found to be deficient. More than half of the doctors enrolled in the study did not show correct knowledge on tetanus and rabies vaccination. The reasons for these deficiencies in knowledge appear to be inadequate teaching about these important diseases in the medical school. In addition, lack of reading habit and non-availability of continuous medical education programmes at the government level also contributes
Maternal genital tract colonisation by Group-B Streptococcus: A hospital based study
Objectives: To determine the prevalence of Group B Streptococcus genital tract infection in pregnant women and to determine the risk factors for its colonisation.Methods: The cross-sectional study was conducted at the Aga Khan University Hospital, Karachi and Sobhraj Hospital, Karachi, from May to August 2007. Pregnant women at 35-37 weeks gestation attending antenatal clinic at these hospitals constituted the study population. Based on stratified sampling, 405 patients were recruited. High vaginal swabs of these patients were taken in order to calculate the prevalence of infection at each hospital. Logistic regression was used to evaluate the risk factor association. SPSS 11.5 was used for statistical analysis.Results: The overall prevalence of colonisation was 17% (n=69) (95% CI: 13.4-20.7). Of the 155(38.27%) women at the Aga Khan Hospital, 35(22.6%) were positive, while among the 250 (61.72%) women at Sobhraj Hospital, the prevalence was 13.6% (n=34). The colonisation was found to be significantly associated inversely with the body mass index of the patient (OR 0.91; 95% CI: 0.08-1.0).Conclusion: Group B Streptococcus screening should be an integral part of antenatal care and should be offered to all pregnant women
Investigation of furo[2,3-h]- and pyridazino[3,4-f]cinnolin-3-ol scaffolds as substrates for the development of novel HIV-1 integrase inhibitors
With the aim to develop novel HIV-1 integrase inhibitors, we obtained a set of condensed ring systems based on the furo[2,3-h]cinnolin-3(2H)-one and pyridazino[3,4-f]cinnolin-3-ol scaffolds bearing a potential chelating pharmacophore, which can be involved in the inhibition mechanism of the enzyme. Herein, we report the design, synthesis, structural investigation and preliminary biological results of these heteroaromatic systems
Prevalence of Muscle Dysmorphia and Associated Health Activities in Male Medical Students in Karachi, Pakistan
Background: Muscle Dysmorphia (MD) is a subtype of body dysmorphic disorder (BDD) and is currently classified under anxiety disorders (subheading: Obsessive-compulsive disorder) in DSM 5. MD is hypothesized to affect the self-esteem and social outlook of the younger generation. MD shows a higher rate in males and may influence their self-confidence rendering them more prone towards using steroids, supplementary proteins and other drugs to alter their physical outlooks as shown in previous studies. This problem has been on the rise lately due to revolutionary advancement in the media and film industry and the abrupt changes about the standards of physical good looks and body shapes. With the lack of studies done in our population, our study will be helpful to consider the prevalence of the disease in our setting and increase awareness in the general public and clinicians. We hope to help clinicians/ therapists find better options in managing the disease.
Materials: We performed a cross-sectional study with a sample size of 246 medical school students in Karachi to collect data through self-administered questionnaires. We used the DSM 5 criteria for the diagnosis of BDD and additional questions on the presence of MD. Nutritional habits, exercise routines, use of supplements and drugs were also obtained for exploratory analysis.
Results: Our study predicted the prevalence of MD to be 25%. Other main findings included statistical significant associations between MD and the thoughts and practice of steroid use for muscularity.
Conclusion: MD is an underdiagnosed and often unrecognized disease that we believe has significant consequences for the young male population. Further work is needed on this in our part of the world. Our research, we believe, can be a stepping stone for further studies that would incorporate wider populations
Promoter and 3'-untranslated-region haplotypes in the vitamin d receptor gene predispose to osteoporotic fracture: the rotterdam study
Polymorphisms of the vitamin D receptor gene (VDR) have been shown to be
associated with several complex diseases, including osteoporosis, but the
mechanisms are unknown and study results have been inconsistent. We
therefore determined sequence variation across the major relevant parts of
VDR, including construction of linkage disequilibrium blocks and
identification of haplotype alleles. We analyzed 15 haplotype-tagging SNPs
in relation to 937 clinical fractures recorded in 6,148 elderly whites
over a follow-up period of 7.4 years. Haplotype alleles of the 5' 1a/1e,
1b promoter region and of the 3' untranslated region (UTR) were strongly
associated with increased fracture risk. For the 16% of subjects who had
risk genotypes at both regions, their risk increased 48% for clinical
fractures (P = .0002), independent of age, sex, height, weight, and bone
mineral density. The population-attributable risk varied between 1% an
Postpartum endometritis and infection following incomplete or complete abortion: Case definition & guidelines for data collection, analysis, and presentation of maternal immunization safety data
Abstract are not provided by the author/publishe
A mutual reference shape based on information theory
International audienceIn this paper, we propose to consider the estimation of a refer-ence shape from a set of different segmentation results using both active contours and information theory. The reference shape is defined as the minimum of a criterion that benefits from both the mutual information and the joint entropy of the input segmentations and called a mutual shape. This energy criterion is here justified using similarities between informa-tion theory quantities and area measures, and presented in a continuous variational framework. This framework brings out some interesting evaluation measures such as the speci-ficity and sensitivity. In order to solve this shape optimization problem, shape derivatives are computed for each term of the criterion and interpreted as an evolution equation of an active contour. Some synthetical examples allow us to cast the light on the difference between our mutual shape and an average shape. Our framework has been considered for the estimation of a mutual shape for the evaluation of cardiac segmentation methods in MRI
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