La mejora y crecimiento empresarial a través de las estrategias de marketing digital

Las empresas constantemente tienen que adaptarse y afrontar los distintos cambios que se presentan en la forma de hacer negocios, y de esta forma asumir nuevas estrategias que le permitan seguir a tono con estas. Desde hace ya varios años el avance de las tecnologías ha originado un cambio brusco en la forma de operar tanto a lo interno como a lo externo de las empresas, ya que la tecnología ha permitido cambiar procesos nativos y metodológicos, en procesos dinámicos e innovadores. Uno de estos cambios es la forma de hacer marketing, para la promoción y venta de sus productos a través de plataformas digitales haciendo uso de las bondades que ofrecen el internet a través de las distintas redes sociales y la web en general, lo cual les ha permitido tener un mayor alcance en cuanto a la promoción de sus productos y por ende conducir a la empresa hacia el logro de sus objetivos planificados y lograr su crecimiento expandiéndose a nuevos mercados y captación de clientes

New Electrocardiographic Algorithm for the Diagnosis of Acute Myocardial Infarction in Patients With Left Bundle Branch Block

Background Current electrocardiographic algorithms lack sensitivity to diagnose acute myocardial infarction (AMI) in the presence of left bundle branch block. Methods and Results A multicenter retrospective cohort study including consecutive patients with suspected AMI and left bundle branch block, referred for primary percutaneous coronary intervention between 2009 and 2018. Pre-2015 patients formed the derivation cohort (n=163, 61 with AMI); patients between 2015 and 2018 formed the validation cohort (n=107, 40 with AMI). A control group of patients without suspected AMI was also studied (n=214). Different electrocardiographic criteria were tested. A total of 484 patients were studied. A new electrocardiographic algorithm (BARCELONA algorithm) was derived and validated. The algorithm is positive in the presence of ST deviation ≥1 mm (0.1 mV) concordant with QRS polarity, in any lead, or ST deviation ≥1 mm (0.1 mV) discordant with the QRS, in leads with max (R|S) voltage (the voltage of the largest deflection of the QRS, ie, R or S wave) ≤6 mm (0.6 mV). In both the derivation and the validation cohort, the BARCELONA algorithm achieved the highest sensitivity (93%-95%), negative predictive value (96%-97%), efficiency (91%-94%) and area under the receiver operating characteristic curve (0.92-0.93), significantly higher than previous electrocardiographic rules (P<0.01); the specificity was good in both groups (89%-94%) as well as the control group (90%). Conclusions In patients with left bundle branch block referred for primary percutaneous coronary intervention, the BARCELONA algorithm was specific and highly sensitive for the diagnosis of AMI, leading to a diagnostic accuracy comparable to that obtained by ECG in patients without left bundle branch block

Novel techniques for alpha/beta pulse shape discrimination in Borexino

Borexino could efficiently distinguish between alpha and beta radiation in its liquid scintillator by the characteristic time profile of their scintillation pulse. This alpha/beta discrimination, first demonstrated at the tonne scale in the Counting Test Facility prototype, was used throughout the lifetime of the experiment between 2007 and 2021. With this method, alpha events are identified and subtracted from the beta-like solar neutrino events. This is particularly important in liquid scintillator as alpha scintillation is quenched many-fold. In Borexino, the prominent Po-210 decay peak was a background in the energy range of electrons scattered from Be-7 solar neutrinos. Optimal alpha-beta discrimination was achieved with a "multi-layer perceptron neural network", which its higher ability to leverage the timing information of the scintillation photons detected by the photomultiplier tubes. An event-by-event, high efficiency, stable, and uniform pulse shape discrimination was essential in characterising the spatial distribution of background in the detector. This benefited most Borexino measurements, including solar neutrinos in the \pp chain and the first direct observation of the CNO cycle in the Sun. This paper presents the key milestones in alpha/beta discrimination in Borexino as a term of comparison for current and future large liquid scintillator detectorsComment: 13 pages, 14 figure

Borexino's search for low-energy neutrinos associated with gravitational wave events from GWTC-3 database

The search for neutrino events in correlation with gravitational wave (GW) events for three observing runs (O1, O2 and O3) from 09/2015 to 03/2020 has been performed using the Borexino data-set of the same period. We have searched for signals of neutrino-electron scattering with visible energies above 250 keV within a time window of 1000 s centered at the detection moment of a particular GW event. The search was done with three visible energy thresholds of 0.25, 0.8 and 3.0 MeV.Two types of incoming neutrino spectra were considered: the mono-energetic line and the spectrum expected from supernovae. The same spectra were considered for electron antineutrinos detected through inverse beta-decay (IBD) reaction. GW candidates originated by merging binaries of black holes (BHBH), neutron stars (NSNS) and neutron star and black hole (NSBH) were analysed separately. Additionally, the subset of most intensive BHBH mergers at closer distances and with larger radiative mass than the rest was considered. In total, follow-ups of 74 out of 93 gravitational waves reported in the GWTC-3 catalog were analyzed and no statistically significant excess over the background was observed. As a result, the strongest upper limits on GW-associated neutrino and antineutrino fluences for all flavors (\nu_e, \nu_\mu, \nu_\tau) have been obtained in the (0.5 - 5.0) MeV neutrino energy range.Comment: 13 pages, 8 figure

First Directional Measurement of sub-MeV Solar Neutrinos with Borexino

We report the measurement of sub-MeV solar neutrinos through the use of their associated Cherenkov radiation, performed with the Borexino detector at the Laboratori Nazionali del Gran Sasso. The measurement is achieved using a novel technique that correlates individual photon hits of events to the known position of the Sun. In an energy window between 0.54 to 0.74 MeV, selected using the dominant scintillation light, we have measured 10 887þ2386 ðstatÞ � 947ðsystÞ (68% confidence interval) −2103 solar neutrinos out of 19904 total events. This corresponds to a 7Be neutrino interaction rate of 51.6þ13.9 counts=ðday · 100 tonÞ, which is in agreement with the standard solar model predictions and the −12.5 previous spectroscopic results of Borexino. The no-neutrino hypothesis can be excluded with > 5σ confidence level. For the first time, we have demonstrated the possibility of utilizing the directional Cherenkov information for sub-MeV solar neutrinos, in a large-scale, high light yield liquid scintillator detector. This measurement provides an experimental proof of principle for future hybrid event reconstruction using both Cherenkov and scintillation signatures simultaneously

Modulations of the cosmic muon signal in ten years of Borexino data

We have measured the flux of cosmic muons in the Laboratori Nazionali del Gran Sasso at 3800 m w.e. to be (3.432 ± 0.003)⋅ 10−4 m−2s−1 based on ten years of Borexino data acquired between May 2007 and May 2017. A seasonal modulation with a period of (366.3 ± 0.6) d and a relative amplitude of (1.36 ±0.04)% is observed. The phase is measured to be (181.7 ± 0.4) d, corresponding to a maximum at the 1st of July. Using data inferred from global atmospheric models, we show the muon flux to be positively correlated with the atmospheric temperature and measure the effective temperature coefficient αT = 0.90 ± 0.02. The origin of cosmic muons from pion and kaon decays in the atmosphere allows to interpret the effective temperature coefficient as an indirect measurement of the atmospheric kaon-to-pion production ratio rK/π = 0.11+0.11−0.07 for primary energies above 18 TeV. We find evidence for a long-term modulation of the muon flux with a period of ~ 3000 d and a maximum in June 2012 that is not present in the atmospheric temperature data. A possible correlation between this modulation and the solar activity is investigated. The cosmogenic neutron production rate is found to show a seasonal modulation in phase with the cosmic muon flux but with an increased amplitude of (2.6 ± 0.4)%

Rooftop Gardens on Apartment Buildings: Kommentar zu Lisa Vollmer und Boris Michel „Wohnen in der Klimakrise. Die Wohnungsfrage als ökologische Frage“

Der Trend zur Urbanisierung und Verdichtung von Wohnraum in Kombination mit der globalen Erwärmung zeigt immer deutlichere Auswirkungen auf das Stadtklima. Zur Reduktion der Belastungen für die Stadtbevölkerung sind gebäudegebundene Begrünungsformen eine wirksame Strategie. Vor allem die Verlagerung der Vegetation auf die bisher kaum genutzte Dachebene hat das Potenzial, negative Auswirkungen der Flächenversieglung und Flächenkonkurrenz auszugleichen, da intensive Dachbegrünungen vielfältige soziale, ökologische und ökonomische Vorteile haben. Da diese in der täglichen Planungs- und Wohnbaupraxis noch unzureichend genutzt werden, wurde in der Stadt Graz ein transformativer Kommunikations- und Lernprozess initiiert, der unter den beteiligten Akteuren nachhaltige Handlungsänderungen anregen soll. Dazu wurde auf Basis einer qualitativen Potenzialanalyse eine Dialogplattform ins Leben gerufen, die im Rahmen von interaktiven Workshop-Formaten relevante Stakeholder vernetzt hat. Dabei konnten Vorbehalte ausgeräumt, Erfahrungen ausgetauscht und Synergieeffekte ausgelotet werden. Durch die gemeinsame Konzeption von Demonstrationsprojekten soll das Erfahren, Experimentieren und Reflektieren mit innovativen Dachbegrünungen weiter angeregt werden. Dieser kontinuierliche Aushandlungs- und Lernprozess soll dazu beitragen, dass sich Dachgärten als wirksamer Lösungsansatz für die sozial-ökologischen Herausforderungen des modernen Wohn- und Städtebaus etablieren und weitere Nachhaltigkeitstransformationen gefördert werden.The trend towards urbanization and densification of living space combined with global warming has a strong impact on the urban climate. To reduce the impairment to health of the urban population, building-related forms of greening are an effective strategy. Especially the shift of vegetation to the barely used roof level has the potential to compensate for negative effects of soil sealing and land competition, as intensive green roofs have various social, ecological and economic advantages. Since these benefits are insufficiently exploited in daily planning and housing practice, a transformative communication and learning process has been initiated in the city of Graz, which is intended to stimulate sustainable changes among the actors. Based on a qualitative potential analysis, a dialog platform was established, which linked relevant stakeholders in the context of interactive workshop formats. This enabled reservations to be resolved, experiences to be exchanged and synergy effects to be explored. The joint conception of demonstration projects is intended to further stimulate experience, experimentation, and reflection with innovative green roofs. This continuous negotiation and learning process should help to establish roof gardens as an effective solution to the socio-ecological challenges of modern housing and urban development and to promote further sustainability transformations

New Electrocardiographic Algorithm for the Diagnosis of Acute Myocardial Infarction in Patients With Left Bundle Branch Block

Current electrocardiographic algorithms lack sensitivity to diagnose acute myocardial infarction () in the presence of left bundle branch block. A multicenter retrospective cohort study including consecutive patients with suspected and left bundle branch block, referred for primary percutaneous coronary intervention between 2009 and 2018. Pre-2015 patients formed the derivation cohort (n=163, 61 with ); patients between 2015 and 2018 formed the validation cohort (n=107, 40 with ). A control group of patients without suspected was also studied (n=214). Different electrocardiographic criteria were tested. A total of 484 patients were studied. A new electrocardiographic algorithm ( algorithm) was derived and validated. The algorithm is positive in the presence of deviation ≥1 mm (0.1 mV) concordant with polarity, in any lead, or deviation ≥1 mm (0.1 mV) discordant with the , in leads with max (R $s ) voltage (the voltage of the largest deflection of the , ie, R or S wave) ≤6 mm (0.6 mV). In both the derivation and the validation cohort, the algorithm achieved the highest sensitivity (93%-95%), negative predictive value (96%-97%), efficiency (91%-94%) and area under the receiver operating characteristic curve (0.92-0.93), significantly higher than previous electrocardiographic rules (P <0.01); the specificity was good in both groups (89%-94%) as well as the control group (90%). In patients with left bundle branch block referred for , the algorithm was specific and highly sensitive for the diagnosis of , leading to a diagnostic accuracy comparable to that obtained by in patients without left bundle branch block

Kapitel I: Zusammenfassung Für Entscheidungstragende

Derzeit ist es schwierig, in Österreich klimafreundlich zu leben. In den meisten Lebensbereichen, von Arbeit über Mobilität und Wohnen bis hin zu Ernährung und Freizeitgestaltung, fördern bestehende Strukturen klimaschädigendes Verhalten und erschweren klimafreundliches Leben (hohe Übereinstimmung, starke Literaturbasis). {Kap 3-9} Der vorliegende Bericht bestärkt somit für Österreich die Aussagen des Klimarates der Vereinten Nationen (Intergovernmental Panel on Climate Change, IPCC), wonach zur Erreichung der Ziele des Pariser Klimaabkommens grundlegende Transformationen im Sinne umfassender Strukturveränderungen notwendig sind (hohe Übereinstimmung, starke Literaturbasis)

Kapitel II: Summary for Policymakers

This technical summary provides an overview of the main statements of the APCC SR Structures for Climate-Friendly Living chapters. Based on scientific literature, the report assesses different approaches for transforming structures in order to make climate-friendly living in Austria possible and make it permanently and quickly the new status quo