14 research outputs found
Personal goals of women recently diagnosed with breast cancer: Protocol for a cohort study
Objectives: This study aims to identify the personal goals of women with breast cancer, to describe the characteristics of partici- pantsâ personal goals over four months, and to identify barriers and facilitators to their pursuit.
Methods: This protocol outlines plans to conduct a prospective cohort study. We will recruit women participating in the Ottawa In- tegrative Cancer Centreâs Head Start program (an integrative oncology psychoeducational program in Ottawa, Canada), and those on the programâs waiting list if possible. We anticipate a sample size of approximately 18 to 36 women. Prior to the beginning of Head Start, participants will identify their current personal goals and rate them on various dimensions on a questionnaire. At one and three months, participants will re-assess their goals and their goal pursuit. In a one-on-one interview at three months, they will identify barriers and facilitators to the pursuit of their goals. We will analyze quantitative data using descriptive and inferential statistics, and qualitative data using thematic content analysis.
Conclusion: Findings from this study will identify important information about the personal goals of women recently diagnosed with breast cancer that can help to support the process of positive goal adjustment and enhance support to these women.Â
Résumé
Objectifs : Cette eÌtude vise aÌ identifier les objectifs personnels des femmes atteintes dâun cancer du sein, aÌ deÌcrire les caracteÌristiques des objectifs personnels des participantes sur une peÌriode de quatre mois, et aÌ identifier les obstacles et les facilitateurs aÌ leur poursuite.
MeÌthodes : Ce protocole deÌcrit les plans pour mener une eÌtude de cohorte prospective. Nous recruterons des femmes qui participeront au programme Head Start du Centre de canceÌrologie inteÌgrative dâOttawa (un programme psychopeÌdagogique inteÌgratif en oncologie aÌ Ottawa, au Canada) et celles qui sont sur la liste dâattente du programme, si possible. Nous preÌvoyons un eÌchantillon dâenviron 18 aÌ 36 femmes. Avant le deÌbut de Head Start, les participantes identifieront leurs objectifs personnels actuels et les noteront sur diffeÌrentes dimensions dans un questionnaire. AÌ un et trois mois, les participantes reÌeÌvalueront leurs objectifs et la poursuite de leur objectif. Dans une entrevue individuelle aÌ trois mois, elles identifieront les obstacles et les facilitateurs aÌ la poursuite de leurs objectifs. Nous analyserons les donneÌes quantitatives aÌ lâaide de statistiques descriptives et infeÌrentielles, et les donneÌes qualitatives aÌ lâaide dâanalyses de contenu theÌmatiques.
Conclusion : Les reÌsultats de cette eÌtude permettront dâidentifier des informations importantes sur les objectifs personnels des femmes reÌcemment diagnostiqueÌes avec un cancer du sein qui peuvent aider aÌ soutenir le processus dâajustement positif des objectifs et ameÌliorer le soutien aÌ ces femmes.Â
Medium-term Outcomes of Myocarditis and Pericarditis following BNT162b2 Vaccination among Adolescents in Hong Kong
In this study, we examined the clinical and electrophysiological outcomes of adolescents in Hong Kong who developed myocarditis or pericarditis following BNT162b2 vaccination for COVID-19, and followed-up for 60 to 180 days after their initial diagnosis. Clinical assessments included electrocardiogram (ECG) and echocardiogram at the initial admission and follow-up were compared. Treadmill testing was also performed in some cases. Between 14 June 2021 and 16 February 2022, 53 subjects were approached to participate in this follow-up study, of which 28 patients were followed up for >60 days with a median follow-up period of 100 days (range, 61-178 days) and were included in this study. On admission, 23 patients had ECG abnormalities but no high-grade atrioventricular block. Six patients had echocardiogram abnormalities, including reduced contractility, small rim pericardial effusions, and hyperechoic ventricular walls. All patients achieved complete recovery on follow-up. After discharge, 10 patients (35.7%) reported symptoms, including occasional chest pain, shortness of breath, reduced exercise tolerance, and recurrent vasovagal near-syncope. At follow-up, assessments, including ECGs, were almost all normal. Among the three patients with possible ECG abnormalities, all their echocardiograms or treadmill testings were normal. Sixteen patients (57.1%) underwent treadmill testing at a median of 117 days post-admission, which were also normal. However, at follow-up, there was a significant mean bodyweight increase of 1.81kg (95%CI 0.47-3.1 kg, p=0.01), possibly due to exercise restriction. In conclusion, most adolescents experiencing myocarditis and pericarditis following BNT162b2 vaccination achieved complete recovery. Some patients developed non-specific persistent symptoms, and bodyweight changes shall be monitored
Spoken-word recognition in 2-year-olds: The tug of war between phonological and semantic activation
Previous studies demonstrate that while toddlers can match words with their referent before the age of one, they only begin to extract phonologically- and semantically related information from speech later in the second year. However, the order and manner in which this information is extracted remains unresolved. In two experiments, we adapted the adult four-picture Visual World Paradigm (VWP) (Huettig & McQueen, 2007) for toddler testing: toddlers hear a spoken word and see pictures that are phonologicallyrelated, semantically-related or unrelated to the spoken-word. We demonstrate that, similar to adults, 24- to 30-month-old toddlers attended to a phonological match faster than a semantic match, and that these differences hold irrespective of whether the semantic
match is taxonomic or thematic in character. Our findings suggest that language shapes toddlersâ cognition by biasing their selective attention to relevant information in the visual world, which is likely to enhance the efficiency of mental activities, such as learning and making analogical inferences
Translation equivalent and cross-language semantic priming in bilingual toddlers
In adult bilinguals, a word in one language will activate a related word in the other language, with language dominance modulating the direction of these effects. To determine whether the early bilingual lexicon possesses similar properties to its adult counterpart, two experiments compared translation equivalent priming and cross-linguistic semantic priming in 27-month-old bilingual toddlers learning English and one other language. Priming effects were found in both experiments, irrespective of language dominance and distance between the childâs two languages. The time course of target word recognition revealed a similar pattern for translation equivalent priming and cross-language semantic priming. These results suggest that the early bilingual lexicon possesses properties similar to the adult one in terms of word to concept connections. However, the absence of an advantage of translation equivalent priming over semantic priming, and the lack of dominance and language distance effects, suggest that when two languages are acquired in parallel during infancy, their integration within a single dynamic system is highly robust to input variations
SSSSLEEPING
SSSSLEEPING
Summer School Study on Sleep & Learning Entailing Every Participant In Nijmegen, Gelderlan
Reproducibility Project: Cancer Biology
The Reproducibility Project: Cancer Biology was an initiative to independently replicate selected experiments from a number of high-profile papers in the field of cancer biology. In the end 50 experiments from 23 papers were repeated. The final two outputs from the project recount in detail the challenges the project team encountered while repeating these experiments ('Challenges for assessing replicability in preclinical cancer biology': https://elifesciences.org/articles/67995), and report the results of a meta-analysis that combined the results from all the experiments ('Investigating the replicability of preclinical cancer biology': https://elifesciences.org/articles/71601). The project was a collaboration between the Center for Open Science and Science Exchange with all papers published by eLife