COMBINING ECONOMIC AND BIOLOGICAL DATA TO ESTIMATE THE IMPACT OF POLLUTION ON CROP PRODUCTION

Duality methods utilizing a profit function framework are employed to estimate the output elasticity of ambient ozone levels on cash grain farms in Illinois. While duality methods have been recommended as a cure to many of the statistical problems of direct estimation of production functions, multicollinearity may still be a problem. A method for utilizing stochastic information on parameters of a seemingly unrelated system of equations, which is implied by profit function estimation, is developed and applied to measuring the impact of ozone. Such an approach may be necessary in measuring other environmental effects because of a lack of regressor variability.Crop Production/Industries, Environmental Economics and Policy,

Bootstrapping six-gluon scattering in planar N=4{\cal N}=4 super-Yang-Mills theory

We describe the hexagon function bootstrap for solving for six-gluon scattering amplitudes in the large $N_c$ limit of ${\cal N}=4$ super-Yang-Mills theory. In this method, an ansatz for the finite part of these amplitudes is constrained at the level of amplitudes, not integrands, using boundary information. In the near-collinear limit, the dual picture of the amplitudes as Wilson loops leads to an operator product expansion which has been solved using integrability by Basso, Sever and Vieira. Factorization of the amplitudes in the multi-Regge limit provides additional boundary data. This bootstrap has been applied successfully through four loops for the maximally helicity violating (MHV) configuration of gluon helicities, and through three loops for the non-MHV case.Comment: 15 pages, 3 figures, 2 tables; contribution to the proceedings of Loops and Legs in Quantum Field Theory, 27 April - 2 May 2014, Weimar, Germany; v2, reference adde

The four-loop remainder function and multi-Regge behavior at NNLLA in planar N \mathcal{N} = 4 super-Yang-Mills theory

We present the four-loop remainder function for six-gluon scattering with maximal helicity violation in planar N = 4 super-Yang-Mills theory, as an analytic function of three dual-conformal cross ratios. The function is constructed entirely from its analytic properties, without ever inspecting any multi-loop integrand. We employ the same approach used at three loops, writing an ansatz in terms of hexagon functions, and fixing coefficients in the ansatz using the multi-Regge limit and the operator product expansion in the near-collinear limit. We express the result in terms of multiple polylogarithms, and in terms of the coproduct for the associated Hopf algebra. From the remainder function, we extract the BFKL eigenvalue at next-to-next-to-leading logarithmic accuracy (NNLLA), and the impact factor at N3LLA. We plot the remainder function along various lines and on one surface, studying ratios of successive loop orders. As seen previously through three loops, these ratios are surprisingly constant over large regions in the space of cross ratios, and they are not far from the value expected at asymptotically large orders of perturbation theory

Quantum Mutual Information Capacity for High Dimensional Entangled States

High dimensional Hilbert spaces used for quantum communication channels offer the possibility of large data transmission capabilities. We propose a method of characterizing the channel capacity of an entangled photonic state in high dimensional position and momentum bases. We use this method to measure the channel capacity of a parametric downconversion state, achieving a channel capacity over 7 bits/photon in either the position or momentum basis, by measuring in up to 576 dimensions per detector. The channel violated an entropic separability bound, suggesting the performance cannot be replicated classically.Comment: 5 pages, 2 figure

Targeted interventions for patellofemoral pain syndrome (TIPPS): classification of clinical subgroups

Introduction Patellofemoral pain (PFP) can cause significant pain leading to limitations in societal participation and physical activity. An international expert group has highlighted the need for a classification system to allow targeted intervention for patients with PFP; we have developed a work programme systematically investigating this. We have proposed six potential subgroups: hip abductor weakness, quadriceps weakness, patellar hypermobility, patellar hypomobility, pronated foot posture and lower limb biarticular muscle tightness. We could not uncover any evidence of the relative frequency with which patients with PFP fell into these subgroups or whether these subgroups were mutually exclusive. The aim of this study is to provide information on the clinical utility of our classification system. Methods and analysis 150 participants will be recruited over 18 months in four National Health Services (NHS) physiotherapy departments in England. Inclusion criteria: adults 18–40 years with PFP for longer than 3 months, PFP in at least two predesignated functional activities and PFP elicited by clinical examination. Exclusion criteria: prior or forthcoming lower limb surgery; comorbid illness or health condition; and lower limb training or pregnancy. We will record medical history, demographic details, pain, quality of life, psychomotor movement awareness and knee temperature. We will assess hip abductor and quadriceps weakness, patellar hypermobility and hypomobility, foot posture and lower limb biarticular muscle tightness. The primary analytic approach will be descriptive. We shall present numbers and percentages of participants who meet the criteria for membership of (1) each of the subgroups, (2) none of the subgroups and (3) multiple subgroups. Exact (binomial) 95% CIs for these percentages will also be presented. Ethics and dissemination This study has been approved by National Research Ethics Service (NRES) Committee North West—Greater Manchester North (11/NW/0814) and University of Central Lancashire (UCLan) Built, Sport, Health (BuSH) Ethics Committee (BuSH 025). An abstract has been accepted for the third International Patellofemoral Pain Research Retreat, Vancouver, September 2013

Anisotropic winds from close-in extra-solar planets

We present two-dimensional hydrodynamic models of thermally driven winds from highly irradiated, close-in extra-solar planets. We adopt a very simple treatment of the radiative heating processes at the base of the wind, and instead focus on the differences between the properties of outflows in multidimensions in comparison to spherically symmetric models computed with the same methods. For hot (T > 2 x 10^{4} K) or highly ionized gas, we find strong (supersonic) polar flows are formed above the planet surface which produce weak shocks and outflow on the night-side. In comparison to a spherically symmetric wind with the same parameters, the sonic surface on the day-side is much closer to the planet surface in multidimensions, and the total mass loss rate is reduced by almost a factor of four. We also compute the steady-state structure of interacting planetary and stellar winds. Both winds end in a termination shock, with a parabolic contact discontinuity which is draped over the planet separating the two shocked winds. The planetary wind termination shock and the sonic surface in the wind are well separated, so that the mass loss rate from the planet is essentially unaffected. However, the confinement of the planetary wind to the small volume bounded by the contact discontinuity greatly enhances the column density close to the planet, which might be important for the interpretation of observations of absorption lines formed by gas surrounding transiting planets.Comment: ApJ accepte

Characterisation of the carboxypeptidase G2 catalytic site and design of new inhibitors for cancer therapy

The enzyme carboxypeptidase G2 (CPG2) is used in antibody‐directed enzyme prodrug therapy (ADEPT) to catalyse the formation of an active drug from an inert prodrug. Free CPG2 in the bloodstream must be inhibited before administration of the prodrug in order to avoid a systemic reaction in the patient. Although a few small‐molecule CPG2 inhibitors have been reported, none has been taken forward thus far. This lack of progress is due in part to a lack of structural understanding of the CPG2 active site as well as the absence of small molecules that can block the active site whilst targeting the complex for clearance. The work described here aimed to address both areas. We report the structural/functional impact of extensive point mutation across the putative CPG2 catalytic site and adjacent regions for the first time, revealing that residues outside the catalytic region (K208A, S210A and T357A) are crucial to enzyme activity. We also describe novel molecules that inhibit CPG2 whilst maintaining the accessibility of galactosylated moieties aimed at targeting the enzyme for clearance. This work acts as a platform for the future development of high‐affinity CPG2 inhibitors that occupy new chemical space and will advance the safe application of ADEPT in cancer treatment

The Steinmann Cluster Bootstrap for N=4 Super Yang-Mills Amplitudes

We review the bootstrap method for constructing six- and seven-particle amplitudes in planar $\mathcal{N}=4$ super Yang-Mills theory, by exploiting their analytic structure. We focus on two recently discovered properties which greatly simplify this construction at symbol and function level, respectively: the extended Steinmann relations, or equivalently cluster adjacency, and the coaction principle. We then demonstrate their power in determining the six-particle amplitude through six and seven loops in the NMHV and MHV sectors respectively, as well as the symbol of the NMHV seven-particle amplitude to four loops.Comment: 36 pages, 4 figures, 5 tables, 1 ancillary file. Contribution to the proceedings of the Corfu Summer Institute 2019 "School and Workshops on Elementary Particle Physics and Gravity" (CORFU2019), 31 August - 25 September 2019, Corfu, Greec

Controlled release of GAG-binding enhanced transduction (GET) peptides for sustained and highly efficient intracellular delivery

Controlled release systems for therapeutic molecules are vital to allow the sustained local delivery of their activities which direct cell behaviour and enable novel regenerative strategies. Direct programming of cells using exogenously delivered transcription factors can by-pass growth factor signalling but there is still a requirement to deliver such activity spatio-temporally. We previously developed a technology termed GAG-binding enhanced transduction (GET) to efficiently deliver a variety of cargoes intracellularly, using GAG-binding domains which promote cell targeting, and cell penetrating peptides (CPPs) which allow cell entry. Herein we demonstrate that GET system can be used in controlled release systems to mediate sustained intracellular transduction over one week. We assessed the stability and activity of GET peptides in poly(dl-lactic acid-co-glycolic acid) (PLGA) microparticles (MPs) prepared using a S/O/W double emulsion method. Efficient encapsulation (∼65%) and tailored protein release profiles could be achieved, however intracellular transduction was significantly inhibited post-release. To retain GET peptide activity we optimized a strategy of co-encapsulation of l-Histidine, which may form a complex with the PLGA degradation products under acidic conditions. Simulations of the polymer microclimate showed that hydrolytic acidic PLGA degradation products directly inhibited GET peptide transduction activity, and use of l-Histidine significantly enhanced released protein delivery. The ability to control the intracellular transduction of functional proteins into cells will facilitate new localized delivery methods and allow approaches to direct cellular behaviour for many regenerative medicine applications

Ice Patch Archaeology in Alaska: 2000–10

In the past decade, ice patch archaeological research has been initiated in several areas of Alaska, including Wrangell-St. Elias National Park and Preserve, the Amphitheater Mountains, Lake Clark National Park and Preserve, Denali National Park and Preserve, Gates of the Arctic National Park and Preserve, Chugach National Forest, and Katmai National Park. Although still in its formative stages, this research demonstrates that high-altitude ice patches have been an important part of the annual subsistence cycles of Alaskan people for at least 4000 years. Researchers have found cultural materials at 13 Alaskan ice patches. Most artifacts recovered are related to caribou hunting; however, a growing body of evidence demonstrates that ice patches were the foci for a wide range of subsistence activities, such as hunting birds, harvesting berries, and snaring small mammals. Site interpretations are based on ethnographically documented cultural practices, animal behavior, alpine ecology and geology, and archaeological analyses.Au cours de la dernière décennie, des recherches archéologiques ont été entreprises dans plusieurs névés de l’Alaska, notamment dans les régions suivantes : Wrangell-St. Elias National Park and Preserve, monts Amphitheater, Lake Clark National Park and Preserve, Denali National Park and Preserve, Gates of the Arctic National Park and Preserve, Chugach National Forest et Katmai National Park. Bien que ces recherches en soient toujours au stade embryonnaire, elles ont déjà permis de constater que les névés en haute altitude ont joué un rôle important dans les cycles de subsistance annuels des peuples de l’Alaska pendant au moins 4 000 ans. Les chercheurs ont récupéré du matériel culturel dans 13 névés de l’Alaska. La plupart des artefacts qui ont été trouvés se rapportent à la chasse au caribou. Cependant, de plus en plus d’artefacts prouvent que les névés étaient le point de convergence d’une vaste gamme d’activités de subsistance, comme la chasse aux oiseaux, la récolte des petits fruits et le piégeage des petits mammifères. L’interprétation des sites s’appuie sur les pratiques culturelles documentées de manière ethnographique, sur le comportement animal, sur l’écologie et la géologie alpines ainsi que sur les analyses archéologiques