A new model for supraglacial hydrology evolution and drainage for the Greenland ice sheet (SHED v1.0)

The Greenland Ice Sheet (GrIS) is losing mass as the climate warms through both increased meltwater runoff and ice discharge at marine terminating sectors. At the ice sheet surface, meltwater runoff forms a dynamic supraglacial hydrological system which includes stream/river networks and large supraglacial lakes (SGLs). Streams/rivers can route water into crevasses, or into supraglacial lakes with crevasses underneath, both of which can then hydrofracture to the ice sheet base, providing a mechanism for the surface meltwater to access the bed. Understanding where, when and how much meltwater is transferred to the bed is important because variability in meltwater supply to the bed can increase ice flow speeds, potentially impacting the hypsometry of the ice sheet in grounded sectors, and iceberg discharge to the ocean. Here we present a new, physically-based, supraglacial hydrology model for the GrIS that is able to simulate a) surface meltwater routing and SGL filling, b) rapid meltwater drainage to the ice-sheet bed via the hydrofracture of surface crevasses both in, and outside of, SGLs, c) slow SGL drainage via overflow in supraglacial meltwater channels and, by offline coupling with a second model, d) the freezing and unfreezing of SGLs from autumn to spring. We call the model Supraglacial Hydrology Evolution and Drainage (or SHED). We apply the model to three study regions in South West Greenland between 2015 and 2019 inclusive and evaluate its performance with respect to observed supraglacial lake extents, and proglacial discharge measurements. We show that the model reproduces 80 % of observed lake locations, and provides good agreement with observations in terms of the temporal evolution of lake extent. Modelled moulin density values are in keeping with those previously published and seasonal and inter-annual variability in proglacial discharge agrees well with that observed, though the observations lag the model by a few days since they include transit time through the subglacial system and the model does not. Our simulations suggest that lake drainage behaviours may be more complex than traditional models suggest, with lakes in our model draining through a combination of both overflow and hydrofracture, and some lakes draining only partially and then refreezing. This suggests that in order to simulate the evolution of Greenland&rsquo;s surface hydrological system with fidelity, then a model that includes all of these processes needs to be used. In future work we will couple our model to a subglacial model and an ice flow model, and thus use our estimates of where, when and how much meltwater gets to the bed to understand the consequences for ice flow.</p

Photoredox-catalyzed procedure for carbamoyl radical generation : 3,4-dihydroquinolin-2-one and quinolin-2-one synthesis

A reductive approach for carbamoyl radical generation from N-hydroxyphthalimido oxamides under photoredox catalysis is outlined. This strategy was applied to the synthesis of 3,4-dihydroquinolin-2-ones via the intermolecular addition/cyclization of carbamoyl radicals with electron deficient olefins in a mild, redox-neutral manner. Under a general set of reaction conditions, diversely substituted 3,4-dihydroquinolin-2-ones, including spirocyclic systems can be prepared. By using chlorine-substituted olefins, aromatic quinolin-2-ones can also be accessed

A Low-Temperature, Transition Metal-Free Cross Dehydrogenative Coupling Protocol for the Synthesis of 3,3-Disubstituted Oxindoles

A new low-temperature procedure for the synthesis of 3,3-disubstituted 2-oxindoles via cross dehydrogenative coupling (CDC) is reported. The use of a strong, non-reversible base in these reactions has been found to effect a dramatic drop in reaction temperature (to room temperature) relative to the current state-of-the-art (>100 °C). When employing iodine as an 'oxidant', new evidence suggests that this transformation may occur via a transiently stable iodinated intermediate rather than by direct single-electron oxidation

The impact of different CD4 monitoring and switching strategies on mortality in HIV-infected African adults on antiretroviral therapy; an application of dynamic marginal structural models

In Africa, antiretroviral therapy (ART) is delivered with limited laboratory monitoring, often none. In 2003–2004, investigators in the Development of Antiretroviral Therapy in Africa (DART) Trial randomized persons initiating ART in Uganda and Zimbabwe to either laboratory and clinical monitoring (LCM) or clinically driven monitoring (CDM). CD4 cell counts were measured every 12 weeks in both groups but were only returned to treating clinicians for management in the LCM group. Follow-up continued through 2008. In observational analyses, dynamic marginal structural models on pooled randomized groups were used to estimate survival under different monitoring-frequency and clinical/immunological switching strategies. Assumptions included no direct effect of randomized group on mortality or confounders and no unmeasured confounders which influenced treatment switch and mortality or treatment switch and time-dependent covariates. After 48 weeks of first-line ART, 2,946 individuals contributed 11,351 person-years of follow-up, 625 switches, and 179 deaths. The estimated survival probability after a further 240 weeks for post-48-week switch at the first CD4 cell count less than 100 cells/mm3 or non-Candida World Health Organization stage 4 event (with CD4 count <250) was 0.96 (95% confidence interval (CI): 0.94, 0.97) with 12-weekly CD4 testing, 0.96 (95% CI: 0.95, 0.97) with 24-weekly CD4 testing, 0.95 (95% CI: 0.93, 0.96) with a single CD4 test at 48 weeks (baseline), and 0.92 (95% CI: 0.91, 0.94) with no CD4 testing. Comparing randomized groups by 48-week CD4 count, the mortality risk associated with CDM versus LCM was greater in persons with CD4 counts of <100 (hazard ratio = 2.4, 95% CI: 1.3, 4.3) than in those with CD4 counts of ≥100 (hazard ratio = 1.1, 95% CI: 0.8, 1.7; interaction P = 0.04). These findings support a benefit from identifying patients immunologically failing first-line ART at 48 weeks

Trajectories of depression in sepsis survivors: an observational cohort study

Background: Advances in critical care medicine have led to a growing number of critical illness survivors. A considerable part of them suffers from long-term sequelae, also known as post-intensive care syndrome. Among these, depressive symptoms are frequently observed. Depressive symptom trajectories and associated factors of critical illness survivors have rarely been investigated. Study objective was to explore and compare different trajectories of depressive symptoms in sepsis survivors over 1 year after discharge from ICU. Methods: Data of a randomized controlled trial on long-term post-sepsis care were analyzed post hoc. Depressive symptoms were collected at 1, 6 and 12 months post-ICU discharge using the Major Depression Inventory (MDI), among others. Statistical analyses comprised descriptive analysis, univariate and multivariate, linear and logistic regression models and Growth Mixture Modeling. Results: A total of 224 patients were included into this analysis. We identified three latent classes of depressive symptom trajectories: Over the course of 1 year, 152 patients recovered from mild symptoms, 27 patients showed severe persistent symptoms, and 45 patients recovered from severe symptoms. MDI sum scores significantly differed between the three classes of depressive symptom trajectories at 1 and 6 months after ICU discharge (p = 35 on the Posttraumatic Stress Scale 10 vs. 48.1%/33.3%, p < 0.003); and higher levels of health-related quality of life (HRQOL) using the Short Form-36 scale within 1 month after ICU discharge (p < 0.035). Conclusions: In the first year after discharge from ICU, sepsis survivors showed three different trajectories of depressive symptoms. Course and severity of depressive symptoms were associated with chronic pain, posttraumatic stress and reduced HRQOL at discharge from ICU. Regular screening of sepsis survivors on symptoms of depression, chronic pain and posttraumatic stress within 1 year after ICU may be considered

Comprehensive Evaluation Of The IFloodS Radar Rainfall Products For Hydrologic Applications

This study describes the generation and testing of a reference rainfall product created from field campaign datasets collected during the NASA Global Precipitation Measurement (GPM) mission Ground Validation Iowa Flood Studies (IFloodS) experiment. The study evaluates ground-based radar rainfall (RR) products acquired during IFloodS in the context of building the reference rainfall product. The purpose of IFloodS was not only to attain a high-quality ground-based reference for the validation of satellite rainfall estimates but also to enhance understanding of flood-related rainfall processes and the predictability of flood forecasting. We assessed the six RR estimates (IFC, Q2, CSU-DP, NWS-DP, Stage IV, and Q2-Corrected) using data from rain gauge and disdrometer networks that were located in the broader field campaign area of central and northeastern Iowa. We performed the analyses with respect to time scales ranging from 1 h to the entire campaign period in order to compare the capabilities of each RR product and to characterize the error structure at scales that are frequently used in hydrologic applications. The evaluation results show that the Stage IV estimates perform superior to other estimates, demonstrating the need for gauge-based bias corrections of radar-only products. This correction should account for each product\u27s algorithm-dependent error structure that can be used to build unbiased rainfall products for the campaign reference. We characterized the statistical error structures (e.g., systematic and random components) of each RR estimate and used them for the generation of a campaign reference rainfall product. To assess the hydrologic utility of the reference product, we performed hydrologic simulations driven by the reference product over the Turkey River basin. The comparison of hydrologic simulation results demonstrates that the campaign reference product performs better than Stage IV in streamflow generation

Effects of long-term antipsychotics treatment on body weight: A population-based cohort study.

BACKGROUND: Antipsychotics are often prescribed for long-term periods, however, most evidence of their impact on body weight comes from short-term clinical trials. Particularly, impact associated with dosage has been barely studied. AIMS: The aim of this study was to describe the short- and long-term change in body weight of people initiated on high or low doses of the three most commonly prescribed second-generation antipsychotics. METHODS: Retrospective cohorts of individuals with a diagnosed psychotic disorder observed from 2005 to 2015 in the UK primary care. The exposure was the first prescription of olanzapine, quetiapine or risperidone. The main outcome was change in body weight four years before and four years after initiation of antipsychotic treatment, stratified on sex and 'low' or 'high' dose. RESULTS: In total, 22,306 women and 16,559 men were observed. Olanzapine treatment was associated with the highest change in weight, with higher doses resulting in more weight gain. After 4 years, given a high dose of olanzapine (> 5 mg), women gained on average +6.1 kg; whereas given a low dose (⩽ 5 mg), they gained +4.4 kg. During the first six weeks of olanzapine treatment, they gained on average +3.2 kg on high dose and +1.9 kg on low dose. The trends were similar for men. Individuals prescribed risperidone and quetiapine experienced less weight gain in both the short- and long-term. CONCLUSIONS: Olanzapine treatment was associated with the highest increase in weight. Higher doses were associated with more weight gain. Doctors should prescribe the lowest effective dose to balance mental-health benefits, weight gain and other adverse effects

Natural coagulates for wastewater treatment; a review for application and mechanism

The increase of water demand and wastewater generation is among the global concerns in the world. The less effective management of water sources leads to serious consequences, the direct disposal of untreated wastewater is associated with the environmental pollution, elimination of aquatic life and the spread of deadly epidemics. The flocculation process is one of the most important stages in water and wastewater treatment plants, wherein this phase the plankton, colloidal particles, and pollutants are precipitated and removed. Two major types of coagulants are used in the flocculation process included the chemical and natural coagulants. Many studies have been performed to optimize the flocculation process while most of these studies have confirmed the hazardous effects of chemical coagulants utilization on the ecosystem. This chapter reviews a summary of the coagulation/flocculation processes using natural coagulants as well as reviews one of the most effective natural methods of water and wastewater treatment

Contribution of Cystine-Glutamate Antiporters to the Psychotomimetic Effects of Phencyclidine

Altered glutamate signaling contributes to a myriad of neural disorders, including schizophrenia. While synaptic levels are intensely studied, nonvesicular release mechanisms, including cystine–glutamate exchange, maintain high steady-state glutamate levels in the extrasynaptic space. The existence of extrasynaptic receptors, including metabotropic group II glutamate receptors (mGluR), pose nonvesicular release mechanisms as unrecognized targets capable of contributing to pathological glutamate signaling. We tested the hypothesis that activation of cystine–glutamate antiporters using the cysteine prodrug N-acetylcysteine would blunt psychotomimetic effects in the rodent phencyclidine (PCP) model of schizophrenia. First, we demonstrate that PCP elevates extracellular glutamate in the prefrontal cortex, an effect that is blocked by N-acetylcysteine pretreatment. To determine the relevance of the above finding, we assessed social interaction and found that N-acetylcysteine reverses social withdrawal produced by repeated PCP. In a separate paradigm, acute PCP resulted in working memory deficits assessed using a discrete trial t-maze task, and this effect was also reversed by N-acetylcysteine pretreatment. The capacity of N-acetylcysteine to restore working memory was blocked by infusion of the cystine–glutamate antiporter inhibitor (S)-4-carboxyphenylglycine into the prefrontal cortex or systemic administration of the group II mGluR antagonist LY341495 indicating that the effects of N-acetylcysteine requires cystine–glutamate exchange and group II mGluR activation. Finally, protein levels from postmortem tissue obtained from schizophrenic patients revealed significant changes in the level of xCT, the active subunit for cystine–glutamate exchange, in the dorsolateral prefrontal cortex. These data advance cystine–glutamate antiporters as novel targets capable of reversing the psychotomimetic effects of PCP