6,158 research outputs found
An Application of HEP Track Seeding to Astrophysical Data
We apply methods of particle track reconstruction in High Energy Physics
(HEP) to the search for distinct stellar populations in the Milky Way, using
the Gaia EDR3 data set. This was motivated by analogies between the 3D space
points in HEP detectors and the positions of stars (which are also points in a
coordinate space) and the way collections of space points correspond to
particle trajectories in the HEP, while collections of stars from distinct
populations (such as stellar streams) can resemble tracks. Track reconstruction
consists of multiple steps, the first one being seeding. In this note, we
describe our implementation and results of the seeding step to the search for
distinct stellar populations, and we indicate how the next steps will proceed.
Our seeding method uses machine learning tools from the FAISS library, such as
the k-nearest neighbors (kNN) search.Comment: 9 pages, 10 figures, 1 table. Conference proceedings preprint for
Connecting the Dots (CTD) 2023. Updated figures, fixed typo
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Regulation of Mitochondrial Complex I Biogenesis in Drosophila Flight Muscles
The flight muscles of Drosophila are highly enriched with mitochondria, but the mechanism by which mitochondrial complex I (CI) is assembled in this tissue has not been described. We report the mechanism of CI biogenesis in Drosophila flight muscles and show that it proceeds via the formation of ∼315, ∼550, and ∼815 kDa CI assembly intermediates. Additionally, we define specific roles for several CI subunits in the assembly process. In particular, we show that dNDUFS5 is required for converting an ∼700 kDa transient CI assembly intermediate into the ∼815 kDa assembly intermediate. Importantly, incorporation of dNDUFS5 into CI is necessary to stabilize or promote incorporation of dNDUFA10 into the complex. Our findings highlight the potential of studies of CI biogenesis in Drosophila to uncover the mechanism of CI assembly in vivo and establish Drosophila as a suitable model organism and resource for addressing questions relevant to CI biogenesis in humans
Neuregulin repellent signaling via ErbB4 restricts GABAergic interneurons to migratory paths from ganglionic eminence to cortical destinations
<p>Abstract</p> <p>Background</p> <p>Cortical GABAergic interneurons (INs) are generated in the medial ganglionic eminence (MGE) and migrate tangentially into cortex. Because most, if not all, migrating MGE-derived INs express the neuregulin (NRG) receptor, ErbB4, we investigated influences of Nrg1 isoforms and Nrg3 on IN migration through ventral telencephalon (vTel) and within cortex.</p> <p>Results</p> <p>During IN migration, NRG expression domains and distributions of ErbB4-expressing, MGE-derived INs are complementary with minimal overlap, both in vTel and cortex. In wild-type mice, within fields of NRG expression, these INs are focused at positions of low or absent NRG expression. However, in ErbB4-/- HER4<sup>heart </sup>mutant mice in which INs lack ErbB4, these complementary patterns are degraded with considerable overlap evident between IN distribution and NRG expression domains. These findings suggest that NRGs are repellents for migrating ErbB4-expressing INs, a function supported by <it>in vitro </it>and <it>in vivo </it>experiments. First, in collagen co-cultures, MGE-derived cells preferentially migrate away from a source of secreted NRGs. Second, cells migrating from wild-type MGE explants on living forebrain slices from wild-type embryonic mice tend to avoid endogenous NRG expression domains, whereas this avoidance behavior is not exhibited by ErbB4-deficient cells migrating from MGE explants and instead they have a radial pattern with a more uniform distribution. Third, ectopic NRG expression in the IN migration pathway produced by <it>in utero </it>electroporation blocks IN migration and results in cortex distal to the blockade being largely devoid of INs. Finally, fewer INs reach cortex in ErbB4 mutants, indicating that NRG-ErbB4 signaling is required for directing IN migration from the MGE to cortex.</p> <p>Conclusions</p> <p>Our results show that NRGs act as repellents for migrating ErbB4-expressing, MGE-derived GABAergic INs and that the patterned expression of NRGs funnels INs as they migrate from the MGE to their cortical destinations.</p
A combination of methods needed to assess the actual use of provisioning ecosystem services
Failure to recognize that potential provisioning ecosystem services are not necessarily collected and used by people may have important consequences for management of land and resources. Accounting for people's actual use of ecosystem services in decision making processes requires a robust methodological approach that goes beyond mapping the presence of ecosystem services. But no such universally accepted method exists, and there are several shortcomings of existing methods such as the application of land use/cover as a proxy for provisioning ecosystem service availability and surveys based on respondents' recall to assess people's collection of e.g. wild food. By combining four complementary methods and applying these to the shifting cultivation systems of Laos, we show how people’s actual use of ecosystem services from agricultural fields differs from ecosystem service availability. Our study is the first in Southeast Asia to combine plot monitoring, collection diaries, repeat interviews, and participant observation. By applying these multiple methods borrowed from anthropology and botany among other research domains, the study illustrates that no single method is sufficient on its own. It is of key importance for scientists to adopt methods that can account for both availability of various services and actual use of those services
The characterisation of the craniofacial morphology of infants born with Zika virus:Innovative approach for public health surveillance and broad clinical applications
Background:
This study was carried out in response to the Zika virus epidemic which constituted a public health emergency and to the 2019 WHO calling for strengthened surveillance for the early detection of related microcephaly. The main aim of the study was to phenotype the craniofacial morphology of microcephaly using novel approach and new measurements, relate the characteristics to brain abnormalities in Zika infected infants in Brazil to improve clinical surveillance.
Methods:
We captured 3D images of the face and the cranial vault of 44 Zika infected infants and matched healthy controls using 3D camera. The CT scans of the brain of the infected infants were analysed.
The Principal Component Analysis (PCA) was applied to characterise the craniofacial morphology. In addition to the head circumference (HC), we introduced a new measurement, head height (HH) to measure the cranial vault. The level of brain abnormality present in the CT scans was assessed, the severity of parenchymal volume loss and ventriculomegaly was quantified.
Findings:
The PCA identified a significant difference (p <0.001) between the cranial vaults and the face of the Zika infants and that of the controls. Spearman's rank-order correlation coefficients show that the head height (HH) has a strong correlation (0.87 in Zika infants; 0.82 in Controls) with the morphology of the cranial vaults which are higher than the correlation with the routinely used head circumference (HC). Also, the head height (HH) has a moderate negative correlation (-0.48) with the brain abnormalities of parenchymal volume loss.
Interpretation:
We discovered that head height (HH), the most sensitive and discriminatory measure of the severity of cranial deformity which should be used for clinical surveillance of Zika syndrome, evaluation of other craniofacial syndromes and assessment of various treatment modalities
KMT-2018-BLG-1292: A Super-Jovian Microlens Planet in the Galactic Plane
We report the discovery of KMT-2018-BLG-1292Lb, a super-Jovian planet orbiting an F or G dwarf , which lies physically within {\cal O}(10\,\pc) of the
Galactic plane. The source star is a heavily extincted luminous
giant that has the lowest Galactic latitude, , of any planetary
microlensing event. The relatively blue blended light is almost certainly
either the host or its binary companion, with the first explanation being
substantially more likely. This blend dominates the light at band and
completely dominates at and bands. Hence, the lens system can be probed
by follow-up observations immediately, i.e., long before the lens system and
the source separate due to their relative proper motion. The system is well
characterized despite the low cadence -- of
observations and short viewing windows near the end of the bulge season. This
suggests that optical microlensing planet searches can be extended to the
Galactic plane at relatively modest cost.Comment: 35 pages, 3 Tables, 8 figure
Estimation of the charge carrier localization length from Gaussian fluctuations in the magneto-thermopower of La_{0.6}Y_{0.1}Ca_{0.3}MnO_3
The magneto-thermoelectric power (TEP) of perovskite type
manganise oxide is found to exhibit a sharp peak
at some temperature . By approximating the true shape of the
measured magneto-TEP in the vicinity of by a linear triangle of the
form , we observe that . We adopt the electron localization scenario and
introduce a Ginzburg-Landau (GL) type theory which incorporates the two
concurrent phase transitions, viz., the paramagnetic-ferromagnetic transition
at the Curie point and the "metal-insulator" (M-I) transition at
. The latter is characterized by the divergence of the field-dependent
charge carrier localization length at some characteristic field
. Calculating the average and fluctuation contributions to the total
magnetization and the transport entropy related magneto-TEP
within the GL theory, we obtain a simple relationship between and the
above two critical temperatures ( and ). The observed slope
ratio is found to be governed by the competition between
the electron-spin exchange and the induced magnetic energy . The
comparison of our data with the model predictions produce ,
, , , and for the estimates of
the Curie temperature, the exchange coupling constant, the critical
magnetization, the localization length, and the free-to-localized carrier
number density ratio, respectively.Comment: 6 pages (REVTEX), 2 PS figures (epsf.sty); submitted to Phys.Rev.
The , interaction in finite volume and the resonance
In this work the interaction of the coupled channels and
in an SU(4) extrapolation of the chiral unitary theory, where the
resonance appears as dynamically generated from that
interaction, is extended to produce results in finite volume. Energy levels in
the finite box are evaluated and, assuming that they would correspond to
lattice results, the inverse problem of determining the phase shifts in the
infinite volume from the lattice results is solved. We observe that it is
possible to obtain accurate phase shifts and the position of the
resonance, but it requires the explicit consideration of the
two coupled channels. We also observe that some of the energy levels in the box
are attached to the closed channel, such that their use to induce the phase shifts via L\"uscher's formula leads to incorrect results.Comment: 10 pages, 13 figures, accepted for publication in Eur. Phys. J.
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